公开(公告)号：US09111735B1

公开(公告)日：2015-08-18

申请号：US13753685

申请日：2013-01-30

申请人： Eugene N. Nikolaev ,  Roland Jertz ,  Anton S. Grigoryev ,  Gökhan Baykut

发明人： Eugene N. Nikolaev ,  Roland Jertz ,  Anton S. Grigoryev ,  Gökhan Baykut

IPC分类号： H01J49/00

CPC分类号： H01J49/0036 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/38 ,  H01J49/425 ,  H01J2237/223

摘要： Fine structures of isotopic peak clusters of substances are determined using ultrahigh resolution mass spectrometry, e.g, FT-ICR mass spectrometry. Resolved individual peaks in the fine structure of the non-monoisotopic peak clusters of organic substances usually contain the additional elemental isotopes 13C, 15N, 17O, 18O, 2H, 33S, 34S, and combinations thereof. In each of a series of experiments, one of the non-monoisotopic peak clusters is isolated and the corresponding fine structure spectrum acquired. Abundances of the resolved fine structure peaks and their positions on the mass scale are recorded and, after measuring some or all of the isotopic peaks, the atomic composition of the measured substance is calculated. By excluding the monoisotopic peak and isolating only one isotopic peak cluster at a time, the number of ions in the FT-ICR cell is kept low, which avoids resolving power losses due to space charge effects and ion-ion interaction phenomena.

摘要翻译： 使用超高分辨率质谱法，例如FT-ICR质谱法测定物质的同位素峰簇的精细结构。 有机物质的非单同位素峰簇的精细结构中分解的单个峰通常含有另外的元素同位素13C，15N，17O，18O，2H，33S，34S及其组合。 在一系列实验的每一个实验中，非单同位素峰簇之一被隔离，并获得相应的精细结构谱。 记录解析的精细结构峰的丰度及其在质量尺度上的位置，并测量部分或全部同位素峰后，计算被测物质的原子组成。 通过排除单同位素峰并一次隔离一个同位素峰簇，FT-ICR单元中的离子数保持较低，避免了由于空间电荷效应和离子 - 离子相互作用现象而分解功率损耗。

公开(公告)号：US08193490B2

公开(公告)日：2012-06-05

申请号：US12637184

申请日：2009-12-14

申请人： Roland Jertz ,  Gökhan Baykut

发明人： Roland Jertz ,  Gökhan Baykut

IPC分类号： G01N27/62 ,  G01N24/14

CPC分类号： H01J49/38

摘要： The compensation potentials on the compensation electrodes of an ICR measuring cell are sequentially adjusted so that an ICR measurement with the longest possible usable image current transient is produced. Then, subsequent ICR measurements are made using the ICR cell with the optimally adjusted compensation potentials. Depending on the kind of ion mixture involved, measurements with image current transients from 10 to more than 20 seconds long can be performed, from which mass spectra with a maximum mass resolution without peak coalescence can be obtained.

摘要翻译： 依次调整ICR测量单元的补偿电极上的补偿电位，使得产生具有尽可能长的可用图像电流瞬变的ICR测量。 然后，使用具有最佳调整的补偿电位的ICR单元进行随后的ICR测量。 根据所涉及的离子混合物的种类，可以进行从10秒到20秒以上的图像电流瞬变的测量，从而可以获得具有最大质量分辨率而不具有峰值聚结的质谱。

公开(公告)号：US06828549B2

公开(公告)日：2004-12-07

申请号：US10420516

申请日：2003-04-22

申请人： Lutz Schweikhard ,  Gökhan Baykut

发明人： Lutz Schweikhard ,  Gökhan Baykut

IPC分类号： B01D5944

CPC分类号： H01J49/14

摘要： The invention relates to a device and method for moving an ion source in a magnetic field by making use of the Lorentz force. The ability of the electron source to move makes it possible to extend and retract it simply by switching the operating current on and off. In mass spectrometry, this means that the entrance of a mass spectrometric analyzer is not permanently obstructed but can be made accessible any time for other applications, such as laser beams.

摘要翻译： 本发明涉及通过利用洛伦兹力来移动磁场中的离子源的装置和方法。 电子源移动的能力使得只需简单地通过切换开启和关闭工作电流来延伸和缩回电子源。 在质谱中，这意味着质谱分析仪的入口不会永久性地被遮挡，而是可以随时随地进行其他应用，例如激光束。

公开(公告)号：US06515279B1

公开(公告)日：2003-02-04

申请号：US09632833

申请日：2000-08-04

申请人： Gökhan Baykut

发明人： Gökhan Baykut

IPC分类号： H01S4900

CPC分类号： H01J49/063 ,  H01J49/107

摘要： The invention relates to a device and a method for the alternating operation of ion sources at mass spectrometers equipped with RF multipole ion guides. Designing at least one of the RF multiple ion guides movable perpendicular to the axis, makes it possible to perform a vacuum-internal source exchange, without having to vent the vacuum system.

摘要翻译： 本发明涉及一种用于在配有RF多极离子导向器的质谱仪上交替操作离子源的装置和方法。 设计能够垂直于轴线移动的至少一个RF多重离子导向器，使得可以进行真空 - 内部源交换，而不必排出真空系统。

公开(公告)号：US08704172B2

公开(公告)日：2014-04-22

申请号：US11970125

申请日：2008-01-07

申请人： Gökhan Baykut

发明人： Gökhan Baykut

IPC分类号： G01N24/14

CPC分类号： H01J49/38 ,  H01J49/0031 ,  H01J49/025

摘要： In an ion cyclotron resonance cell, which is enclosed at its ends by electrode structure elements with DC voltages of alternating polarity, longitudinal electrodes are divided so that the ICR measurement cell between the electrode structure elements consists of at least three sections. An excitation of ion cyclotron motions can be performed by applying additional trapping voltages to longitudinal electrodes located closest to the electrode structure elements and introducing ions into the center set of longitudinal electrodes. The ions are then excited into cyclotron orbits by applying radiofrequency excitation pulses to at least two rows of longitudinal electrodes to produce orbiting ion clouds. Subsequently, the additional trapping voltages are removed and an ion-attracting DC voltage is superimposed on the DC voltages. Ions excited to circular orbits can be detected using detection electrodes in the outer ICR cell sections.

摘要翻译： 在离子回旋共振电池中，其电极结构元件由具有交替极性的直流电压的端部封闭，纵向电极被分割，使得电极结构元件之间的ICR测量单元由至少三个部分组成。 可以通过向最靠近电极结构元件的纵向电极施加附加的俘获电压并将离子引入纵向电极的中心集合中来执行离子回旋加速器运动的激发。 然后通过向至少两排纵向电极施加射频激发脉冲将离子激发到回旋加速器轨道中以产生轨道离子云。 随后，去除附加的捕获电压，并且在DC电压上叠加离子吸引的DC电压。 可以使用外部ICR细胞部分中的检测电极检测到圆周轨道激发的离子。

公开(公告)号：US08410429B2

公开(公告)日：2013-04-02

申请号：US13017803

申请日：2011-01-31

申请人： Jochen Franzen ,  Gökhan Baykut ,  Oliver Räther ,  Carsten Stoermer ,  Evgenij Nikolaev

发明人： Jochen Franzen ,  Gökhan Baykut ,  Oliver Räther ,  Carsten Stoermer ,  Evgenij Nikolaev

IPC分类号： H01J49/06 ,  H01J49/36

CPC分类号： H01J49/4205 ,  H01J49/062

摘要： An ion cell having an axis includes a sheath of individual electrodes that extends along the axis and defines an internal volume. Adjacent individual electrodes are electrically insulated from each other. The individual electrodes each receive a DC potential and RF voltage. At least some of the individual electrodes have a width that varies in the axial direction such that an electrical effect on an axis potential varies along the axis of the ion cell.

摘要翻译： 具有轴的离子电池包括沿着轴线延伸并且限定内部体积的各个电极的护套。 相邻的单个电极彼此电绝缘。 各个电极各自接收DC电位和RF电压。 单个电极中的至少一些具有在轴向上变化的宽度，使得轴电位上的电效应沿离子电池的轴线变化。

公开(公告)号：US06555814B1

公开(公告)日：2003-04-29

申请号：US09607774

申请日：2000-06-30

申请人： Gökhan Baykut ,  Jochen Franzen

发明人： Gökhan Baykut ,  Jochen Franzen

IPC分类号： B01D5944

CPC分类号： H01J49/063 ,  H01J49/38 ,  H01J49/4265

摘要： The invention relates to a method and a device for controlling the number of ions in ion cyclotron resonance (ICR) mass spectrometers, whereby the ions enter a multipole ion guide after their formation and are stored there temporarily. By measuring the ion number in a predefined subset of these temporarily stored ions, the number of ions transferred into the ICR trap for mass spectrometric analysis is regulated. A mode of operation of the multipole ion guide can ensure that undesirable mass ranges are filtered out before the transfer of ions into the ICR mass spectrometer. The invention makes it possible to eliminate space charge effects, which are caused by overfilling the ICR traps.

摘要翻译： 本发明涉及一种用于控制离子回旋共振（ICR）质谱仪中的离子数的方法和装置，由此离子在其形成后进入多极离子导向器并暂时储存在其中。 通过测量这些临时存储的离子的预定子集中的离子数，调节转移到用于质谱分析的ICR阱中的离子数。 多极离子导向器的操作模式可以确保在将离子转移到ICR质谱仪之前过滤不需要的质量范围。 本发明使得可以消除由过度填充ICR陷阱引起的空间电荷效应。

公开(公告)号：US20100090102A1

公开(公告)日：2010-04-15

申请号：US12548945

申请日：2009-08-27

申请人： Oliver Räther ,  Gökhan Baykut ,  Jochen Franzen

发明人： Oliver Räther ,  Gökhan Baykut ,  Jochen Franzen

IPC分类号： B01D59/44 ,  H01J49/00

CPC分类号： H01J49/062 ,  G01N27/622

摘要： Ion mobilities are measured by entraining the ions in a gas and adiabatically expanding the ion-containing gas through a nozzle to form a gas jet. An electrical field barrier with variable height is located at the nozzle exit. The field barrier may be located adjacent to the nozzle exit or an ion guide may be located between the nozzle and the field barrier. If a continuous ion current is supplied, the height of the barrier is varied and the ion current of the ions passing over the barrier is measured, the ion current can be differentiated to generate a mobility spectrum. Alternatively, the ions can be temporarily stored in the ion guide so that measurement of the ion current of the ions passing over the barrier results in a direct measurement of the mobility spectrum.

摘要翻译： 通过夹带气体中的离子并通过喷嘴绝热地使含离子的气体膨胀以形成气体射流来测量离子迁移率。 具有可变高度的电场屏障位于喷嘴出口处。 场屏障可以位于喷嘴出口附近，或者离子引导件可以位于喷嘴和场屏障之间。 如果提供连续的离子电流，则屏障的高度变化，并且测量通过势垒的离子的离子电流，离子电流可以被微分以产生迁移谱。 或者，离子可以临时存储在离子导向器中，使得通过势垒的离子的离子电流的测量导致对迁移谱的直接测量。

公开(公告)号：US06924478B1

公开(公告)日：2005-08-02

申请号：US10848516

申请日：2004-05-18

申请人： Roman Zubarev ,  Gökhan Baykut ,  Matthias Witt

发明人： Roman Zubarev ,  Gökhan Baykut ,  Matthias Witt

IPC分类号： G01N27/62 ,  H01J49/00 ,  H01J49/02 ,  H01J49/38 ,  H01J49/40 ,  H01J49/42

CPC分类号： H01J49/424 ,  H01J49/0054 ,  H01J49/38

摘要： Multiply charged ions are trapped and accumulated in a spatially limited region before being injected into an ion trap mass spectrometer such as a Fourier transform ion cyclotron resonance mass spectrometer (FTICR MS). In the ion trap electron capture dissociation (ECD) and vibrational excitation dissociation are sequentially applied on ions of the same ion ensemble. The first dissociation process does not fragment all primary ions. Following the detection of the dissociation products, the primary ions that remain undissociated undergo the vibrational excitation and again, a part of them dissociate, and the fragments are detected. Thus, the same ion ensemble is used for two fragmentation processes. During these processes, further ions generated in the external ion source are accumulated in the spatially limited region for subsequent analyses.

摘要翻译： 倍增电荷的离子被俘获并积聚在空间有限的区域中，然后被注入离子阱质谱仪如傅里叶变换离子回旋共振质谱仪（FTICR MS）。 在离子阱中，电子捕获离解（ECD）和振动激发解离依次施加在相同离子组合的离子上。 第一个解离过程不会破坏所有的初级离子。 在解离产物的检测之后，保持未解离的主离子经历振动激发，并且再次部分解离，并检测碎片。 因此，相同的离子组合用于两个分段过程。 在这些过程中，在外部离子源中产生的另外的离子被积聚在空间有限的区域中用于随后的分析。

公开(公告)号：US06803569B2

公开(公告)日：2004-10-12

申请号：US10397634

申请日：2003-03-26

申请人： Youri O. Tsybin ,  Gökhan Baykut

发明人： Youri O. Tsybin ,  Gökhan Baykut

IPC分类号： H01J4916

CPC分类号： H01J49/38 ,  H01J49/0054 ,  H01J49/0059

摘要： The present invention relates to a method and a device for irradiating ions in a ion cyclotron resonance (ICR) trap with photons and/or electrons. For electron irradiation a hollow electron emitter is used, through the hole of which a light beam can be sent into the ICR trap. The emitter generates a hollow, tubular electron beam. In a special application low energy ions within the tubular electron beam are irradiated with photons. The ions can be cyclotron-excited mass selectively, by which they enter the electron beam and interact with electrons.

摘要翻译： 本发明涉及用光子和/或电子在离子回旋共振（ICR）阱中照射离子的方法和装置。 对于电子照射，使用中空电子发射器，通过其中可以将光束发射到ICR阱中的孔。 发射器产生中空的管状电子束。 在特殊应用中，用光子照射管状电子束内的低能量离子。 离子可以选择性地回旋激发质量，通过它们进入电子束并与电子相互作用。