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公开(公告)号：US06939540B1
公开(公告)日：2005-09-06
申请号：US09629074
申请日：2000-07-31
IPC分类号： A61K38/19 , A61K48/00 , A61P19/08 , A61P19/10 , C12N5/28 , A01N63/00 , A01N43/04 , C12N5/00 , C12N15/00
CPC分类号： A61K38/1875 , A61K38/18 , A61K38/1841 , A61K38/1866 , A61K48/00 , C12N2799/022 , A61K2300/00
摘要： The present invention is directed to a method for enhancing bone density or formation. In accordance with the method, a nucleic acid encoding an angiogenic protein is administered to a cell in a region of a bone such that the nucleic acid is expressed to produce the angiogenic protein, whereby bone density or formation is enhanced within the region. Optionally, a nucleic acid encoding an osteogenic protein is administered to a cell within the same region such that the nucleic acid is expressed to produce the osteogenic protein. The method can be employed to produce a bone graft having a cell harboring an exogenous nucleic acid encoding an angiogenic protein and, optionally, a cell harboring a nucleic acid encoding an osteogenic protein. To facilitate the inventive method, the invention also pertains to a recombinant viral vector having a nucleic acid encoding an angiogenic protein and a nucleic acid encoding an osteogenic protein.
摘要翻译： 本发明涉及一种增强骨密度或形成的方法。 根据该方法，将编码血管发生蛋白的核酸施用于骨的区域中的细胞，使得所述核酸被表达以产生血管生成蛋白，从而在该区域内增强骨密度或形成。 任选地，将编码成骨蛋白的核酸施用于相同区域内的细胞，使得所述核酸被表达以产生成骨蛋白。 该方法可以用于产生具有含有编码血管生成蛋白的外源核酸的细胞的骨移植物，以及任选的含有编码成骨蛋白的核酸的细胞。 为了促进本发明的方法，本发明还涉及具有编码血管生成蛋白的核酸和编码成骨蛋白的核酸的重组病毒载体。
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公开(公告)号：US20130013003A1
公开(公告)日：2013-01-10
申请号：US13580746
申请日：2011-02-23
IPC分类号： A61B17/86
CPC分类号： A61B17/7037 , A61B17/7004 , A61B17/7032 , A61B17/863
摘要： A bone screw assembly includes a screw, an outer housing, and an inner housing. The screw includes a shank and a head. The outer housing has a proximal end, a distal end, and a passageway extending longitudinally therethrough. The outer housing defines a saddle at the proximal end thereof for receiving at least a portion of a rod therein. The inner housing is positionable within the passageway of the outer housing. The inner housing has a recessed distal portion for receiving the head of the screw therein. The inner housing also includes a proximal surface defining a substantially V-shaped configuration for receiving rods of different diameters therein.
摘要翻译： 骨螺钉组件包括螺钉，外壳和内壳。 螺钉包括柄和头部。 外壳具有近端，远端和纵向延伸通过的通道。 外壳在其近端处限定鞍座，用于在其中容纳杆的至少一部分。 内壳可定位在外壳的通道内。 内壳体具有凹入的远端部分，用于接收螺钉的头部。 内壳体还包括限定大致V形构造的近侧表面，用于接纳不同直径的棒。
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公开(公告)号：US20100094358A1
公开(公告)日：2010-04-15
申请号：US12578259
申请日：2009-10-13
IPC分类号： A61B17/86 , A61B17/064
CPC分类号： A61B17/0642 , A61B17/7032 , A61B17/7044 , A61B17/808 , A61B17/809 , A61B17/866 , A61B2017/0641
摘要： A bone anchor assembly includes a bone fixation member and a bone screw. The bone fixation member includes at least one opening therethrough for receiving the bone screw. Two pairs of legs extend from a plate portion of the bone fixation member and are configured for insertion into bone. A lip of the opening is configured for engaging a set of threads on the bone screw such that the bone screw and the bone fixation member are affixed to one another once the bone screw is inserted through the opening of the plate portion. An installation tool for inserting the bone fixation member into bone includes a proximal region, a tubular member, a rotatable collar, and a gripping mechanism.
摘要翻译： 骨锚组件包括骨固定构件和骨螺钉。 骨固定构件包括穿过其中的至少一个开口用于接收骨螺钉。 两对腿从骨固定构件的板部分延伸并且被构造成用于插入骨中。 开口的唇部构造成用于接合骨螺钉上的一组螺纹，使得一旦骨螺钉穿过板部分的开口插入，骨螺钉和骨固定构件彼此固定。 用于将骨固定构件插入骨中的安装工具包括近端区域，管状构件，可旋转环和夹持机构。
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公开(公告)号：US20100082072A1
公开(公告)日：2010-04-01
申请号：US12413013
申请日：2009-03-27
申请人： Daryl R. Sybert , Sigurd Berven , Randal R. Betz , Oheneba Boachie-Adjei , Scott Boden , Michael F. O'Brien , Alexis P. Shelokov , John M. Winterbottom
发明人： Daryl R. Sybert , Sigurd Berven , Randal R. Betz , Oheneba Boachie-Adjei , Scott Boden , Michael F. O'Brien , Alexis P. Shelokov , John M. Winterbottom
CPC分类号： A61B17/68 , A61B17/686 , A61B2017/00004 , A61B2017/00946 , A61C8/0012
摘要： Bone anchors and related methods for their use are described. The inventive anchor is suitable for placement in bone and for use in orthopedic surgery and dentistry. The bone anchor can be made from a bone/polymer or bone substitute/polymer composite, and can provide a firm and secure base for attaching a fastening device. The bone anchor can be used in various orthopedic and dental procedures including spinal surgery, where normal, cancellous, cortical, diseased or osteoporotic bone is present. The bone anchor can be resorbed and/or replaced with native bone tissue over a period of time. In certain embodiments, the bone anchor is made malleable or flowable and formed in situ or in vivo.
摘要翻译： 描述骨锚及其使用的相关方法。 本发明的锚适用于放置在骨骼中并用于整形外科和牙科。 骨锚可以由骨/聚合物或骨替代物/聚合物复合物制成，并且可以提供用于附接紧固装置的牢固且牢固的基部。 骨锚可用于各种矫形和牙科手术，包括脊柱手术，其中存在正常的松质骨，皮层，患病或骨质疏松的骨。 骨锚可在一段时间内被天然骨组织吸收和/或替代。 在某些实施方案中，骨锚被制造为可延展的或可流动的并且在原位或体内形成。
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公开(公告)号：US08882817B2
公开(公告)日：2014-11-11
申请号：US13214331
申请日：2011-08-22
CPC分类号： A61B17/7037 , A61B17/7032
摘要： A polyaxial pedicle screw includes a housing, a bone screw member, and an anvil. The bone screw member includes a head and a threaded shaft extending from the head. The head is selectively securable within the housing. The anvil is positionable within the housing adjacent to the head of the bone screw member when the anvil and the head of the bone screw member are positioned within the housing. The anvil may define one or more grooves in an outer surface of the anvil. The groove defines a flap that is flexibly attached to the anvil to enable the anvil to flex an amount sufficient to maintain the head of the bone screw in constant contact with the anvil when the bone screw member is moved relative to the anvil.
摘要翻译： 多轴椎弓根螺钉包括壳体，骨螺钉构件和砧座。 骨螺钉构件包括头部和从头部延伸的螺纹轴。 头部可选择性地固定在壳体内。 当砧座和骨螺钉构件的头部位于壳体内时，砧座可定位在邻近骨螺钉构件的头部的壳体内。 砧座可以在砧座的外表面中限定一个或多个凹槽。 凹槽限定了一个翼片，其柔性地连接到砧座，以使得当砧座螺钉构件相对于砧座移动时，砧座能够弯曲足以保持骨螺钉的头部与砧座保持不间断的量。
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公开(公告)号：US20120083853A1
公开(公告)日：2012-04-05
申请号：US13251671
申请日：2011-10-03
申请人： Oheneba Boachie-Adjei , John Kish , Craig Kashuba , Jennifer Moore , Michael Barrus , Nicholas A. Psaltos
发明人： Oheneba Boachie-Adjei , John Kish , Craig Kashuba , Jennifer Moore , Michael Barrus , Nicholas A. Psaltos
IPC分类号： A61B17/88
CPC分类号： A61B17/7014 , A61B17/7037 , A61B17/7038 , A61B17/7043 , A61B17/7077 , A61B17/7086 , A61B17/88 , A61B2017/564
摘要： A manipulation device includes a body portion, a plurality of articulatable legs, and at least one lock member. The legs extend from the body portion. Each of the legs is configured to engage a surgical instrument at a distal end thereof. Each of the legs is transitionable between an unlocked condition, wherein the leg is free to articulate, and a locked condition, wherein the leg is fixed in position. The at least one lock member is operably disposed within the body portion and is coupled to at least one of the articulatable legs. The lock member is rotatable relative to the body portion between an unlocked position and a locked position for transitioning the at least one articulatable leg coupled thereto between the unlocked condition and the locked condition.
摘要翻译： 操纵装置包括主体部分，多个可铰接腿部和至少一个锁定构件。 腿从身体部分延伸。 每个腿构造成在其远端处接合外科器械。 每个腿可在解锁状态（其中腿部自由铰接）和锁定状态之间可转换，其中腿固定就位。 所述至少一个锁定构件可操作地设置在所述主体部分内并且联接到所述可铰接腿部中的至少一个。 锁定构件可相对于主体部分在解锁位置和锁定位置之间旋转，用于在解锁状态和锁定状态之间转换与其连接的至少一个可铰接腿。
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公开(公告)号：US20110172714A1
公开(公告)日：2011-07-14
申请号：US13000639
申请日：2009-06-29
CPC分类号： A61B17/7086 , A61B17/7076 , A61B17/7077 , A61B17/7079 , A61B17/708 , A61B17/7082 , A61B17/7083 , A61B17/7085
摘要： Systems and methods for surgical spinal correction are disclosed. A system including a plurality of bone screws, spinal rods, manipulators, and/or transverse couplers is disclosed for the manipulation of the spinal column is disclosed. A method of achieving, in a single action, manipulation and/or rotation of the spinal column using the disclosed system is disclosed. Also disclosed is a method of conducting spinal surgery to correct spinal deformities wherein spinal rods are pre-bent in a physiological sagittal plane prior to attachment of the vertebrae using bone screws.
摘要翻译： 公开了用于外科脊柱矫正的系统和方法。 公开了一种包括多个骨螺钉，脊柱杆，操纵器和/或横向联接器的系统，用于脊柱的操作。 公开了一种使用所公开的系统在单一动作中实现脊柱的操作和/或旋转的方法。 还公开了一种进行脊柱手术以矫正脊柱畸形的方法，其中在使用骨螺钉连接椎骨之前，脊柱杆在生理矢状面中预弯曲。
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公开(公告)号：US09393048B2
公开(公告)日：2016-07-19
申请号：US13580746
申请日：2011-02-23
CPC分类号： A61B17/7037 , A61B17/7004 , A61B17/7032 , A61B17/863
摘要： A bone screw assembly includes a screw, an outer housing, and an inner housing. The screw includes a shank and a head. The outer housing has a proximal end, a distal end, and a passageway extending longitudinally therethrough. The outer housing defines a saddle at the proximal end thereof for receiving at least a portion of a rod therein. The inner housing is positionable within the passageway of the outer housing. The inner housing has a recessed distal portion for receiving the head of the screw therein. The inner housing also includes a proximal surface defining a substantially V-shaped configuration for receiving rods of different diameters therein.
摘要翻译： 骨螺钉组件包括螺钉，外壳和内壳。 螺钉包括柄和头部。 外壳具有近端，远端和纵向延伸通过的通道。 外壳在其近端处限定鞍座，用于在其中容纳杆的至少一部分。 内壳可定位在外壳的通道内。 内壳体具有凹入的远端部分，用于接收螺钉的头部。 内壳体还包括限定大致V形构造的近侧表面，用于接收不同直径的棒。
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公开(公告)号：US08956360B2
公开(公告)日：2015-02-17
申请号：US13251671
申请日：2011-10-03
申请人： Oheneba Boachie-Adjei , John Kish , Craig Kashuba , Jennifer Moore , Michael Barrus , Nicholas A. Psaltos
发明人： Oheneba Boachie-Adjei , John Kish , Craig Kashuba , Jennifer Moore , Michael Barrus , Nicholas A. Psaltos
CPC分类号： A61B17/7014 , A61B17/7037 , A61B17/7038 , A61B17/7043 , A61B17/7077 , A61B17/7086 , A61B17/88 , A61B2017/564
摘要： A manipulation device includes a body portion, a plurality of articulatable legs, and at least one lock member. The legs extend from the body portion. Each of the legs is configured to engage a surgical instrument at a distal end thereof. Each of the legs is transitionable between an unlocked condition, wherein the leg is free to articulate, and a locked condition, wherein the leg is fixed in position. The at least one lock member is operably disposed within the body portion and is coupled to at least one of the articulatable legs. The lock member is rotatable relative to the body portion between an unlocked position and a locked position for transitioning the at least one articulatable leg coupled thereto between the unlocked condition and the locked condition.
摘要翻译： 操纵装置包括主体部分，多个可铰接腿部和至少一个锁定构件。 腿从身体部分延伸。 每个腿构造成在其远端处接合外科器械。 每个腿可在解锁状态（其中腿部自由铰接）和锁定状态之间可转换，其中腿固定就位。 所述至少一个锁定构件可操作地设置在所述主体部分内并且联接到所述可铰接腿部中的至少一个。 锁定构件可相对于主体部分在解锁位置和锁定位置之间旋转，用于在解锁状态和锁定状态之间转换与其连接的至少一个可铰接腿。
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公开(公告)号：US08672944B2
公开(公告)日：2014-03-18
申请号：US13000639
申请日：2009-06-29
IPC分类号： A61B17/88
CPC分类号： A61B17/7086 , A61B17/7076 , A61B17/7077 , A61B17/7079 , A61B17/708 , A61B17/7082 , A61B17/7083 , A61B17/7085
摘要： Systems and methods for surgical spinal correction are disclosed. A system including a plurality of bone screws, spinal rods, manipulators, and/or transverse couplers is disclosed for the manipulation of the spinal column is disclosed. A method of achieving, in a single action, manipulation and/or rotation of the spinal column using the disclosed system is disclosed. Also disclosed is a method of conducting spinal surgery to correct spinal deformities wherein spinal rods are pre-bent in a physiological sagittal plane prior to attachment of the vertebrae using bone screws.
摘要翻译： 公开了用于外科脊柱矫正的系统和方法。 公开了一种包括多个骨螺钉，脊柱杆，操纵器和/或横向联接器的系统，用于脊柱的操作。 公开了一种使用所公开的系统在单一动作中实现脊柱的操作和/或旋转的方法。 还公开了一种进行脊柱手术以矫正脊柱畸形的方法，其中在使用骨螺钉连接椎骨之前，脊柱杆在生理矢状面中预弯曲。
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