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    Methods and Systems for Evaluating Interaction of Medical Products and Dependence on Demographic Variables
    1.
    发明申请
    Methods and Systems for Evaluating Interaction of Medical Products and Dependence on Demographic Variables 有权
    用于评估医疗产品相互作用的方法和系统以及对人口变量的依赖

    公开(公告)号：US20080215402A1

    公开(公告)日：2008-09-04

    申请号：US12065631

    申请日：2006-09-22

    申请人： Ronald K. Pearson ,  Alan M. Hochberg

    发明人： Ronald K. Pearson ,  Alan M. Hochberg

    IPC分类号： G06Q50/00

    CPC分类号： G06Q10/10 ,  G06F19/00 ,  G06Q30/0204 ,  G06Q50/22 ,  G06Q50/24

    摘要： A computer implemented method of evaluating interaction two or more medical products or conditions, in the context of a reference condition, based on a dataset of patient records includes developing a reference contingency lattice of lattice subsets from a subset of the patient records containing the reference condition, wherein the lattice subsets correspond to the number of patient records that contain each of the two or more medical products or conditions and combinations thereof. A plurality of comparison contingency lattices are developed, each of the comparison contingency lattices developed from a respective random subset of patient records not containing the reference condition, where each of the comparison contingency lattices include lattice subsets that correspond to the number of patient records that contain each of the two or more medical products or conditions and combinations thereof. The lattice subsets of the reference contingency lattice are compared to the corresponding lattice subsets of the comparison contingency lattices to determine whether a lattice subset is indicative of an interaction between the medical products or conditions with respect to the reference condition.

    摘要翻译： 在参考条件的上下文中，基于患者记录的数据集评估交互的两个或更多个医疗产品或条件的计算机实现的方法包括从包含参考条件的患者记录的子集中开发格子子集的参考偶然网格 其中，所述格子子集对应于包含所述两种或更多种医疗产品或其条件及其组合中的每一种的患者记录的数量。 开发了多个比较意外格子，每个比较意外格子从不包含参考条件的患者记录的相应随机子集开发，其中每个比较意外格子包括与包含的病人记录的数量相对应的格子子集 两种或多种医疗产品或其条件及其组合中的每一种。 将参考偶然晶格的晶格子集与比较偶然晶格的对应晶格子集进行比较，以确定晶格子集是否指示医疗产品或条件之间相对于参考条件的相互作用。

    Methods and systems for evaluating interaction of medical products and dependence on demographic variables
    2.
    发明授权
    Methods and systems for evaluating interaction of medical products and dependence on demographic variables 有权
    用于评估医疗产品相互作用的方法和系统以及对人口变量的依赖

    公开(公告)号：US08170889B2

    公开(公告)日：2012-05-01

    申请号：US12065631

    申请日：2006-09-22

    申请人： Ronald K. Pearson ,  Alan M. Hochberg

    发明人： Ronald K. Pearson ,  Alan M. Hochberg

    IPC分类号： G06F19/00

    CPC分类号： G06Q10/10 ,  G06F19/00 ,  G06Q30/0204 ,  G06Q50/22 ,  G06Q50/24

    摘要： A computer implemented method of evaluating interaction two or more medical products or conditions, in the context of a reference condition, based on a dataset of patient records includes developing a reference contingency lattice of lattice subsets from a subset of the patient records containing the reference condition, wherein the lattice subsets correspond to the number of patient records that contain each of the two or more medical products or conditions and combinations thereof. A plurality of comparison contingency lattices are developed, each of the comparison contingency lattices developed from a respective random subset of patient records not containing the reference condition, where each of the comparison contingency lattices include lattice subsets that correspond to the number of patient records that contain each of the two or more medical products or conditions and combinations thereof. The lattice subsets of the reference contingency lattice are compared to the corresponding lattice subsets of the comparison contingency lattices to determine whether a lattice subset is indicative of an interaction between the medical products or conditions with respect to the reference condition.

    摘要翻译： 在参考条件的上下文中，基于患者记录的数据集评估交互的两个或更多个医疗产品或条件的计算机实现的方法包括从包含参考条件的患者记录的子集中开发格子子集的参考偶然网格 其中，所述格子子集对应于包含所述两种或更多种医疗产品或其条件及其组合中的每一种的患者记录的数量。 开发了多个比较意外格子，每个比较意外格子从不包含参考条件的患者记录的相应随机子集开发，其中每个比较意外格子包括与包含的病人记录的数量相对应的格子子集 两种或多种医疗产品或其条件及其组合中的每一种。 将参考偶然晶格的晶格子集与比较偶然晶格的对应晶格子集进行比较，以确定晶格子集是否指示医疗产品或条件之间相对于参考条件的相互作用。

    Method for determining DNA sequences
    4.
    发明授权
    Method for determining DNA sequences 失效
    确定DNA序列的方法

    公开(公告)号：US5667971A

    公开(公告)日：1997-09-16

    申请号：US473383

    申请日：1995-06-07

    申请人： Alan M. Hochberg

    发明人： Alan M. Hochberg

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6869

    摘要： A method is disclosed for determining the sequence of DNA bases by using two electrophoretic lanes for each DNA sample to be sequenced. Each lane incorporates two dyes.

    摘要翻译： 公开了通过对待测序的每个DNA样品使用两条电泳泳道来确定DNA碱基序列的方法。 每条泳道都包含两种染料。

    Method, system, and software for analyzing pharmacovigilance data
    6.
    发明授权
    Method, system, and software for analyzing pharmacovigilance data 有权
    用于分析药物警戒数据的方法，系统和软件

    公开(公告)号：US07650262B2

    公开(公告)日：2010-01-19

    申请号：US11257395

    申请日：2005-10-25

    申请人： Ronald Pearson ,  Robert J. Kingan ,  Alan M. Hochberg

    发明人： Ronald Pearson ,  Robert J. Kingan ,  Alan M. Hochberg

    IPC分类号： G06F17/10

    CPC分类号： G06F19/326 ,  G06F19/00 ,  G06F19/324 ,  G16H50/70

    摘要： A computer-implemented method of analyzing a dataset of pharmacovigilance data, includes determining a sample size-independent measure of association between two conditions of interest in the dataset of pharmacovigilance data; using a hypergeometric distribution to determine a measure of statistical unexpectedness between the conditions of interest in said dataset, wherein the distribution is based on an urn model under a hypothesis that the conditions are statistically independent; and displaying the measure of association with the measure of the statistical unexpectedness to identify a significant association between conditions of interest.

    摘要翻译： 一种计算机实现的分析药物警戒数据数据集的方法，包括确定药物警戒数据数据集中的两个感兴趣条件之间的关联的样本大小无关度量度; 使用超几何分布来确定在所述数据集中感兴趣的条件之间的统计意外事件的度量，其中所述分布基于所述条件在统计学上独立的假设下的瓮模型; 并显示与统计意外的度量的关联度量以识别感兴趣条件之间的显着关联。

    Automated detection of platelets and reticulocytes in whole blood
    8.
    发明授权
    Automated detection of platelets and reticulocytes in whole blood 失效
    全血自动检测血小板和网织红细胞

    公开(公告)号：US4325706A

    公开(公告)日：1982-04-20

    申请号：US178486

    申请日：1980-08-15

    申请人： Russell J. Gershman ,  W. Peter Hansen ,  Alan M. Hochberg ,  J. Garland O'Connell

    发明人： Russell J. Gershman ,  W. Peter Hansen ,  Alan M. Hochberg ,  J. Garland O'Connell

    IPC分类号： G01N15/14 ,  G01N33/50 ,  G01N1/30 ,  G01N21/25

    CPC分类号： G01N33/5094 ,  G01N15/1459 ,  G01N2015/0073 ,  G01N2015/0076 ,  G01N2015/0084

    摘要： A sample of whole blood is stained with an acridine orange reagent, and is analyzed rapidly, a cell at a time, in a flow cytometry system having a sample stream dimension in the range of expected red cell dimensions. Red florescence and forward scatter data is utilized first to discriminate a cell from noise, and then to distinguish platelets from reticulocytes and red cells. The red cell and reticulocyte data is subjected to a correction such as rotational coordinate shift, and the shifted data are, by means of statistical procedures, utilized to determine threshold criteria separating red cells from reticulocytes, and to enumerate the cells on that basis.

    摘要翻译： 用吖啶橙试剂染色全血样品，并在流式细胞仪系统中快速分析细胞，流式细胞仪系统中样品流尺寸在预期的红细胞尺寸范围内。 首先利用红色荧光和前向散射数据来区分细胞与噪声，然后将血小板与网织红细胞和红细胞区分开来。 对红细胞和网状细胞数据进行诸如旋转坐标移位的校正，并且通过统计程序利用移位的数据来确定将红细胞与网织红细胞分离的阈值标准，并在此基础上枚举细胞。