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公开(公告)号：US5885840A
公开(公告)日：1999-03-23
申请号：US798488
申请日：1997-02-10
CPC分类号： G01N33/52 , G01N15/1475 , G01N2015/1006
摘要： A method for increasing the accuracy and the types of data measurements of laser scanned dye stained cells, in a single sample, by means of multiple assays, utilizing cell positions as a factor in merging data measurements. Change in lasers, use of different cell dye stains and different treating reagents provide additional data regarding cells of the sample and fixing of cell positions in the first assay permits merging of the data obtained in subsequent assays.
摘要翻译： 在单个样品中，通过多次测定，利用细胞位置作为合并数据测量的因素，增加激光扫描的染色染色细胞的数据测量的精度和类型的方法。 改变激光，使用不同的细胞染料污渍和不同的处理试剂提供关于样品细胞的另外的数据，并且在第一次测定中固定细胞位置允许合并后续测定中获得的数据。
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公开(公告)号：US5657369A
公开(公告)日：1997-08-12
申请号：US428044
申请日：1995-04-25
申请人： Jay A. Stein , Steven Teta , Richard E. Cabral , Tracy L. Ramsdell , Tina LeFebvre , Russell J. Gershman
发明人： Jay A. Stein , Steven Teta , Richard E. Cabral , Tracy L. Ramsdell , Tina LeFebvre , Russell J. Gershman
CPC分类号： A61B6/06 , A61B6/0421 , A61B6/0457 , A61B6/08 , A61B6/482 , A61B6/488 , A61B6/505 , G21K1/10 , A61B6/405 , A61B6/548 , A61B6/583
摘要： An x-ray bone densitometry system having an apparatus for positioning body parts is provided. The system includes a patient table having a length extending along a Y-axis and a width extending along an X-axis, a C-arm supporting an x-ray source at one side and an x-ray detector at an opposite side of the table, wherein the source and detector are aligned along a source-detector axis which is transverse to the Y-axis. The source is selectively energized and emits a fan beam of x-rays which conforms to a beam plane which is transverse to the Y-axis and contains the source-detector axis. A forearm positioner is removably supported on the table and includes an arm rest portion positioned at a selected distance along the X-axis from an edge of the table. A hand supporting member is configured to fit within the arm rest portion to maintain the position of a patient's hand in a predetermined shape when the source is energized.
摘要翻译： 提供了具有用于定位身体部位的装置的x射线骨密度测定系统。 该系统包括具有沿着Y轴延伸的长度和沿X轴延伸的宽度的患者台，支撑一侧的x射线源的C形臂和在一侧的X射线检测器 表格，其中源和检测器沿着横向于Y轴的源 - 检测器轴对齐。 源被选择性地通电并且发射符合垂直于Y轴并且包含源检测器轴线的束平面的X射线的扇形束。 前臂定位器可移除地支撑在工作台上，并且包括从桌子的边缘沿着X轴定位在选定距离的扶手部分。 手部支撑构件配置成装配在扶手部分内，以在源被激励时将患者的手的位置保持在预定的形状。
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3.发明授权Whole-body dual-energy bone densitometry using a narrow angle fan beam to cover the entire body in successive scans 失效全身双能骨密度测定法使用窄角风扇束在连续扫描中覆盖整个身体
公开(公告)号：US5432834A
公开(公告)日：1995-07-11
申请号：US156287
申请日：1993-11-22
申请人： Russell J. Gershman
发明人： Russell J. Gershman
CPC分类号： G21K1/10 , A61B6/0421 , A61B6/0457 , A61B6/06 , A61B6/08 , A61B6/482 , A61B6/488 , A61B6/505 , A61B6/405 , A61B6/548 , A61B6/583
摘要： A dual energy bone densitometer scans the whole body of a patient in successive passes with a narrow fan beam of x-rays and, between passes, moves the patient table along multiple axes and rotates the C-arm about a rotation axis spaced from the focal spot. The coordinated multi-axes motion of the table and C-arm helps in piecing together the x-ray data from different passes and helps reduce the footprint of the instrument.
摘要翻译： 双能量骨密度计在连续通过中扫描患者的整个身体，其具有窄的X射线扇形束，并且在通过之间沿多个轴线移动患者台并围绕与焦点间隔开的旋转轴旋转C形臂 点。 桌子和C型臂的协调多轴运动有助于将来自不同通道的X射线数据拼接在一起，并有助于减少仪器的占地面积。
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公开(公告)号：US07116407B2
公开(公告)日：2006-10-03
申请号：US10076363
申请日：2002-02-15
申请人： W. Peter Hansen , Anthony A. Ferrante , Russell J. Gershman , Petra B. Krauledat , Donald F. Perrault, Jr.
发明人： W. Peter Hansen , Anthony A. Ferrante , Russell J. Gershman , Petra B. Krauledat , Donald F. Perrault, Jr.
IPC分类号： G01N21/00 , G01N33/553 , B07C5/36
CPC分类号： G01N33/5085 , G01N15/1427 , G01N15/1429 , G01N15/147 , G01N15/1475 , G01N2015/145 , G01N2015/1477 , G01N2015/149 , G01N2015/1497
摘要： A method of using elongate multicellular organisms in conjunction with a specialized flow cytometer for drug discovery and compound screening. A stable, optically detectable linear marker pattern on each organism is used to construct a longitudinal map of each organism as it passes through the analysis region of the flow cytometer. This pattern is used to limit complex data analysis to particular regions of each organism thereby simplifying and speeding analysis. The longitudinal marker pattern can be used to alter signal detection modes at known regions of the organism to enhance sensitivity and overall detection effectiveness. A repeating pattern can also be used to add a synchronous element to data analysis. The marker patterns are established using known methods of molecular biology to express various indicator molecules. Inherent features of the organism can be rendered detectable to serve as marker patterns.
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5.发明授权Whole-body x-ray bone densitometry using a narrow-angle fan beam, including variable fan beam displacement between scan passes 失效全身x射线骨密度测定使用窄角扇形束，包括扫描通道之间的可变扇形光束位移
公开(公告)号：US5838765A
公开(公告)日：1998-11-17
申请号：US486368
申请日：1995-06-07
CPC分类号： A61B6/06 , A61B6/0421 , A61B6/0457 , A61B6/08 , A61B6/482 , A61B6/488 , A61B6/505 , G21K1/10 , A61B6/405 , A61B6/548 , A61B6/583
摘要： A whole body x-ray bone densitometry system includes a table extending parallel to a Y-axis of an XYZ coordinate system for supporting a patient at a patient position; an x-ray source for emitting a narrow angle fan beam of x-rays to irradiate at any one time a scan line which is transverse to the Y-axis and is substantially shorter than the width of a body cross-section of a typical adult patient occupying the patient position. An x-ray detector is aligned with the source along a source-detector axis which is transverse to the Y-axis, for receiving x-rays from the source within the angle of the fan beam after passage thereof through the patient position. The detector has a number of detecting elements arranged along a direction transverse to the Y-axis and to the source-detector axis. A source-detector support on which the source and detector are mounted at opposite sides of the patient position is coupled with a scanning mechanism moving at least one of the patient table and the source-detector support relative to the other to scan the patient position with the narrow angle fan beam in successive scans parallel to the Y-axis in which the source-detector axis is at different angles relative to the patient position as between different ones of successive scans, but in each of the successive scans, an origin of the fan beam in the source is at the same vertical distance from the patient table. The distance between the fan beam origin and the table may be selectively varied between scan passes, in order to vary scan pass magnification.
摘要翻译： 全身x射线骨密度测定系统包括平行于XYZ坐标系的Y轴延伸的表，用于将病人支撑在患者位置; x射线源，用于发射X射线的窄角扇形束，以在任何一个时刻照射横向于Y轴的扫描线，并且基本上比典型成年人的身体横截面的宽度短 患者占据病人的位置。 X射线检测器沿着横向于Y轴的源 - 检测器轴与源对准，用于在通过患者位置之后在扇形束的角度内从源收到X射线。 检测器具有沿横向于Y轴和源检测器轴线的方向布置的多个检测元件。 源和检测器安装在患者位置的相对侧处的源检测器支撑件与扫描机构联接，扫描机构相对于另一个移动患者台和源检测器支撑件中的至少一个，以扫描患者位置， 平行于Y轴的连续扫描中的窄角风扇光束，其中源 - 检测器轴线相对于患者位置处于不同的连续扫描之间的不同角度，但是在每个连续扫描中， 源中的扇形光束与患者台处于相同的垂直距离。 可以在扫描通过之间选择性地改变风扇光束原点和台之间的距离，以便改变扫描通过倍率。
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公开(公告)号：US4665553A
公开(公告)日：1987-05-12
申请号：US605732
申请日：1984-05-01
CPC分类号： G01N15/1456 , G01N2021/4704 , G01N21/59 , G01N2201/04
摘要： Samples are prepared and applied to a cuvette, and the cuvette is translated in a given direction. Laser light is coupled to the sample through a Bragg cell, which causes the beam to scan the sample transversely to the given direction. Select optical parameters are monitored, and when they occur, the scan is stopped or slowed for a more complete analysis of the illuminated cell.
摘要翻译： 制备样品并将其应用于比色皿，并将反应杯沿给定方向平移。 激光通过布拉格细胞耦合到样品，这使得光束横向于给定方向扫描样品。 选择光学参数进行监控，当它们发生时，扫描被停止或减慢，以便对照明单元进行更完整的分析。
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公开(公告)号：US4325706A
公开(公告)日：1982-04-20
申请号：US178486
申请日：1980-08-15
CPC分类号： G01N33/5094 , G01N15/1459 , G01N2015/0073 , G01N2015/0076 , G01N2015/0084
摘要： A sample of whole blood is stained with an acridine orange reagent, and is analyzed rapidly, a cell at a time, in a flow cytometry system having a sample stream dimension in the range of expected red cell dimensions. Red florescence and forward scatter data is utilized first to discriminate a cell from noise, and then to distinguish platelets from reticulocytes and red cells. The red cell and reticulocyte data is subjected to a correction such as rotational coordinate shift, and the shifted data are, by means of statistical procedures, utilized to determine threshold criteria separating red cells from reticulocytes, and to enumerate the cells on that basis.
摘要翻译： 用吖啶橙试剂染色全血样品，并在流式细胞仪系统中快速分析细胞，流式细胞仪系统中样品流尺寸在预期的红细胞尺寸范围内。 首先利用红色荧光和前向散射数据来区分细胞与噪声，然后将血小板与网织红细胞和红细胞区分开来。 对红细胞和网状细胞数据进行诸如旋转坐标移位的校正，并且通过统计程序利用移位的数据来确定将红细胞与网织红细胞分离的阈值标准，并在此基础上枚举细胞。
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公开(公告)号：US5070519A
公开(公告)日：1991-12-03
申请号：US592841
申请日：1990-10-04
CPC分类号： A61B6/488 , A61B6/00 , A61B6/542 , G21K1/10 , A61B6/4291
摘要： An equalization radiography system automatically identifies the lung field in a pre-scan and then carries out an imaging scan in which it equalizes the X-ray exposure but only outside the lung field.
摘要翻译： 均衡射线照相系统在预扫描中自动识别肺场，然后执行成像扫描，其中X射线曝光是均衡的，但是仅在肺野外。
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公开(公告)号：US4202625A
公开(公告)日：1980-05-13
申请号：US934938
申请日：1978-08-18
CPC分类号： A61B5/7242 , G01N2015/0073 , G01N2015/0084
摘要： Signals including noise, platelet pulses, and red cell pulses are amplified and compared to a noise threshold. If larger than the threshold, the signals are integrated and the integrated signals are compared to respective red cell and platelet references.
摘要翻译： 包括噪声，血小板脉冲和红细胞脉冲的信号被放大并与噪声阈值进行比较。 如果大于阈值，则信号被积分，并且将积分信号与相应的红细胞和血小板参考进行比较。
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公开(公告)号：US06217214B1
公开(公告)日：2001-04-17
申请号：US08968777
申请日：1997-11-10
IPC分类号： A61B604
CPC分类号： G21K1/10 , A61B6/0421 , A61B6/0457 , A61B6/06 , A61B6/08 , A61B6/405 , A61B6/482 , A61B6/488 , A61B6/505 , A61B6/548 , A61B6/583
摘要： Radiological apparatus, such as bone densitometry measurement systems that utilize a penetrating radiation source, such as an x-ray source is provided. The apparatus includes a patient table with a length extending along a Y-axis and a width extending along an X-axis and a C-arm supporting, for example, an x-ray source at one side of the table and an x-ray detector at an opposite side of the table such that the source and detector are aligned along a source-detector axis. The source is energized to emit a fan beam of x-rays which conform to a beam plane which is transverse to the Y-axis and contains the source-detector axis. Either, or both, the C-arm or the table are selectively movable relative to the other along the X-axis, along the Y-axis, and along a Z-axis which is transverse to both the X-axis and the Y-axis, so that selected regions of a patient on the table can be selectively scanned with the fan beam of X-rays. In addition, the C-arm is selectively rotatable around a rotational axis extending along the Y-axis to selectively change the angle of the fan beam relative to a patient on the table.
摘要翻译： 提供放射学装置，例如利用穿透性辐射源（例如x射线源）的骨密度测量系统。 该装置包括具有沿着Y轴延伸的长度和沿X轴延伸的宽度的患者台，以及支撑例如桌子一侧的x射线源的C形臂以及X射线 检测器在工作台的相对侧，使得源和检测器沿着源检测器轴对准。 源被激励以发射符合横向于Y轴并且包含源检测器轴线的束平面的X射线的扇形束。 C形臂或台面中的任一个或两者可沿Y轴沿着X轴相对于另一个选择性地移动，并且沿着横向于X轴和Y轴的Z轴可选择地移动， 使得可以用X射线的扇形束选择性地扫描台上的患者的选定区域。 此外，C形臂可围绕沿着Y轴延伸的旋转轴线选择性地旋转，以选择性地改变风扇梁相对于桌子上的患者的角度。
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