公开(公告)号：US20080113399A1

公开(公告)日：2008-05-15

申请号：US11981488

申请日：2007-10-31

申请人： Rosana Kapeller-Libermann ,  David White ,  Keith Robison ,  Kyle MacBeth ,  Joseph Carroll ,  William Cook ,  Rachel Meyers ,  Miyoung Chun ,  Mark Williamson

发明人： Rosana Kapeller-Libermann ,  David White ,  Keith Robison ,  Kyle MacBeth ,  Joseph Carroll ,  William Cook ,  Rachel Meyers ,  Miyoung Chun ,  Mark Williamson

IPC分类号： C12Q1/37

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/6489 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/04017 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/56983 ,  G01N33/56994 ,  G01N33/57426 ,  G01N33/5761 ,  G01N33/5767 ,  G01N33/68 ,  G01N2333/916 ,  G01N2333/96486 ,  G01N2500/04

摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为27875,22025,27420,16319,55092和10218核酸分子。 本发明还提供反义核酸分子，含有27875,22025,27420,16319,55092和10218核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中27875,22025， 27420,16319,55092和10218基因已被引入或破坏。 本发明还进一步提供了分离的27875,22025,27420,17906,16319,55092或10218蛋白，融合蛋白，抗原肽和抗27875,22025,27420,17906,16319,55092或10218抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20080108093A1

公开(公告)日：2008-05-08

申请号：US11981786

申请日：2007-10-31

申请人： Rosana Kapeller-Libermann ,  David White ,  Keith Robison ,  Kyle MacBeth ,  Joseph Carroll ,  William Cook ,  Rachel Meyers ,  Miyoung Chun ,  Mark Williamson

发明人： Rosana Kapeller-Libermann ,  David White ,  Keith Robison ,  Kyle MacBeth ,  Joseph Carroll ,  William Cook ,  Rachel Meyers ,  Miyoung Chun ,  Mark Williamson

IPC分类号： G01N33/53 ,  G01N33/68

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/6489 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/04017 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/56983 ,  G01N33/56994 ,  G01N33/57426 ,  G01N33/5761 ,  G01N33/5767 ,  G01N33/68 ,  G01N2333/916 ,  G01N2333/96486 ,  G01N2500/04

摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

公开(公告)号：US20060009632A1

公开(公告)日：2006-01-12

申请号：US11226701

申请日：2005-09-14

申请人： Rosana Kapeller-Libermann ,  David White ,  Keith Robison ,  Kyle MacBeth ,  Joseph Carroll ,  William Cook ,  Rachel Meyers ,  Miyoung Chun ,  Mark Williamson

发明人： Rosana Kapeller-Libermann ,  David White ,  Keith Robison ,  Kyle MacBeth ,  Joseph Carroll ,  William Cook ,  Rachel Meyers ,  Miyoung Chun ,  Mark Williamson

IPC分类号： C07H21/04

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/6489 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/04017 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/56983 ,  G01N33/56994 ,  G01N33/57426 ,  G01N33/5761 ,  G01N33/5767 ,  G01N33/68 ,  G01N2333/916 ,  G01N2333/96486 ,  G01N2500/04

摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为27875,22025,27420,16319,55092和10218核酸分子。 本发明还提供反义核酸分子，含有27875,22025,27420,16319,55092和10218核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中27875,22025， 27420,16319,55092和10218基因已被引入或破坏。 本发明还进一步提供了分离的27875,22025,27420,17906,16319,55092或10218蛋白，融合蛋白，抗原肽和抗27875,22025,27420,17906,16319,55092或10218抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20070037203A1

公开(公告)日：2007-02-15

申请号：US11583766

申请日：2006-10-19

申请人： Rosana Kapeller-Libermann ,  John Hunter ,  Rachel Meyers ,  Laura Rudolph-Owen ,  Rory Curtis ,  Peter Olandt ,  Fong-Ying Tsai ,  Katherine Galvin ,  Miyoung Chun ,  Mark Williamson ,  Inmaculada Silos-Santiago ,  Rajasekhar Bandaru

发明人： Rosana Kapeller-Libermann ,  John Hunter ,  Rachel Meyers ,  Laura Rudolph-Owen ,  Rory Curtis ,  Peter Olandt ,  Fong-Ying Tsai ,  Katherine Galvin ,  Miyoung Chun ,  Mark Williamson ,  Inmaculada Silos-Santiago ,  Rajasekhar Bandaru

IPC分类号： C12Q1/68 ,  C07H21/04 ,  A61K48/00 ,  C07K14/705

CPC分类号： C07K14/47 ,  A01K2217/05 ,  C12N9/1235

摘要： The invention provides isolated nucleic acids molecules, designated 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 and 593 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 and 593 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 gene has been introduced or disrupted. The invention still further provides isolated 21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 proteins, fusion proteins, antigenic peptides and anti-21910, 56634, 55053, 2504, 15977, 14760, 25501, 17903, 3700, 21529, 26176, 26343, 56638, 18610, 33217, 21967, h1983, m1983, 38555 or 593 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为21910,5663,55053,2504,15977,14760,25501,17903,3720,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,38555和593核酸 分子。 本发明还提供反义核酸分子，含有21910,5663,55053,2504,15977,14760,25501,17903,3700,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,3855的重组表达载体 和593个核酸分子，其中引入了表达载体的宿主细胞，以及非人类转基因动物，其中21910,5663,5553,2504,15977,14760,25501,17903,3720,21529,26176， 已经引入或破坏了18610,33217,21967，h1983，m1983,38555或593基因。 本发明还进一步提供分离的21910,5563,4560,25501,17903,3720,21529,26176,26343,5663,18610,33217,21967，h1983，m1983,38555或593蛋白，融合蛋白， 抗原肽和抗-19910,563634,55053,2504,15977,14760,25501,17903,3720,21529,26176,26343,56638,18610,33217,21967，h1983，m1983,38555或593抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20070065848A1

公开(公告)日：2007-03-22

申请号：US11493347

申请日：2006-07-26

申请人： Rachel Meyers ,  Kyle MacBeth ,  Rory Curtis ,  Laura Rudolph-Owen ,  Nadine Weich ,  Peter Olandt ,  Fong-Ying Tsai ,  Rosana Kapeller-Libermann ,  Joseph Carroll

发明人： Rachel Meyers ,  Kyle MacBeth ,  Rory Curtis ,  Laura Rudolph-Owen ,  Nadine Weich ,  Peter Olandt ,  Fong-Ying Tsai ,  Rosana Kapeller-Libermann ,  Joseph Carroll

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C12N9/001 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/0006 ,  C12N9/10 ,  C12N9/1048 ,  C12N9/1096 ,  C12N9/12 ,  C12N9/1205 ,  C12N9/16 ,  C12N9/48 ,  C12N9/80 ,  C12N2799/021 ,  C12Q1/32 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57449 ,  G01N2500/10 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 gene has been introduced or disrupted. The invention still further provides isolated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 proteins, fusion proteins, antigenic peptides and anti-26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子。 本发明还提供反义核酸分子，包含26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子的重组表达载体，其中宿主细胞 已经引入了表达载体，并且已引入或破坏其中26199,33530,3399,47148,50216,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843基因的非人转基因动物。 本发明还进一步提供了分离的26199,33530,3949,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843蛋白，融合蛋白，抗原肽和抗-26199,33530,3399 ，47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20060088907A1

公开(公告)日：2006-04-27

申请号：US10370959

申请日：2003-02-20

申请人： Rachel Meyers ,  Mark Williamson ,  Rosana Kapeller-Libermann ,  Kyle MacBeth ,  John Hunter ,  Laura Rudolph-Owen ,  Rajasekhar Bandaru ,  Fong-Ying Tsai

发明人： Rachel Meyers ,  Mark Williamson ,  Rosana Kapeller-Libermann ,  Kyle MacBeth ,  John Hunter ,  Laura Rudolph-Owen ,  Rajasekhar Bandaru ,  Fong-Ying Tsai

IPC分类号： C07K14/705 ,  C12P21/02 ,  C12N5/06 ,  C07H21/04

CPC分类号： C12N9/1205 ,  A01K2217/05 ,  A61K48/00 ,  C07K2319/00

摘要： The invention provides isolated nucleic acids molecules, designated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 gene has been introduced or disrupted. The invention still further provides isolated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 proteins, fusion proteins, antigenic peptides and anti-13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 or 32252 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

公开(公告)号：US20060240464A1

公开(公告)日：2006-10-26

申请号：US11429599

申请日：2006-05-05

申请人： Rachel Meyers ,  Joseph Carroll ,  William Cook ,  Rosana Kapeller-Libermann ,  Nadine Weich ,  Rajasekhar Bandaru

发明人： Rachel Meyers ,  Joseph Carroll ,  William Cook ,  Rosana Kapeller-Libermann ,  Nadine Weich ,  Rajasekhar Bandaru

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： A61K38/16 ,  A01K2217/05 ,  A61K38/4813 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/47 ,  C07K2319/00 ,  C12N9/0008 ,  C12N9/12 ,  C12N9/16 ,  C12N9/20 ,  C12N9/6416 ,  C12N9/6424 ,  C12N9/6491 ,  C12N9/93 ,  C12Q1/25 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y603/02019 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/573 ,  G01N33/68 ,  G01N2500/10 ,  Y10T436/143333 ,  A61K2300/00

摘要： The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 gene has been introduced or disrupted. The invention still further provides isolated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 proteins, fusion proteins, antigenic peptides and anti-27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为27877,18080,14081,32140,50352,16658,14223,16002,50566,65552和65577核酸分子。 本发明还提供反义核酸分子，含有27877,18080,14081,32140,50502,16658,14223,16002,50566,65552和65577核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及 已经引入或破坏了27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577基因的非人类转基因动物。 本发明还进一步提供分离的27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577蛋白，融合蛋白，抗原肽和抗27877,18080,14081,32140,50352,16658,14223 ，16002,50566,65552或65577抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20060014244A1

公开(公告)日：2006-01-19

申请号：US11040595

申请日：2005-01-21

申请人： Miyoung Chun ,  Maria Glucksmann ,  Rosana Kapeller-Libermann ,  Rachel Meyers

发明人： Miyoung Chun ,  Maria Glucksmann ,  Rosana Kapeller-Libermann ,  Rachel Meyers

IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N9/12

CPC分类号： C12N9/1229 ,  C07K14/47 ,  C12N9/1288 ,  C12N9/14 ,  G01N33/574 ,  G01N33/6896

摘要： The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the invention has been introduced or disrupted. The invention still further provides isolated proteins, fusion proteins, antigenic peptides and antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

公开(公告)号：US07288392B2

公开(公告)日：2007-10-30

申请号：US10649156

申请日：2003-08-27

申请人： Rachel Meyers ,  Rosana Kapeller-Libermann ,  Mark Williamson

发明人： Rachel Meyers ,  Rosana Kapeller-Libermann ,  Mark Williamson

IPC分类号： C12P21/04 ,  C12P21/06 ,  C07H21/04 ,  C07K14/00

CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07C51/215 ,  C07C57/04

摘要： The invention relates to novel kinase nucleic acid sequences and proteins. Also provided are vectors, host cells, and recombinant methods for making and using the novel molecules.

摘要翻译： 本发明涉及新型激酶核酸序列和蛋白质。 还提供了用于制备和使用新分子的载体，宿主细胞和重组方法。

公开(公告)号：US20070099274A1

公开(公告)日：2007-05-03

申请号：US11636948

申请日：2006-12-11

申请人： Rachel Meyers ,  Peter Olandt ,  Rosana Kapeller-Libermann ,  Rory Curtis ,  Mark Williamson ,  Nadine Weich

发明人： Rachel Meyers ,  Peter Olandt ,  Rosana Kapeller-Libermann ,  Rory Curtis ,  Mark Williamson ,  Nadine Weich

IPC分类号： C12P21/06 ,  C12N9/12 ,  C12N9/16 ,  C12N9/64 ,  C07H21/04

CPC分类号： C12N9/1205 ,  A61K38/00 ,  C07K16/40 ,  C12N9/12 ,  C12N9/16 ,  C12N9/48 ,  C12N9/6424 ,  C12N9/6427 ,  C12N9/6472 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156

摘要： The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为53070,15985,26583,21953，m32404,14089和23436核酸分子，其编码新的人蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员 ，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。 本发明还提供反义核酸分子，含有53070,15985,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中53070 ，15985,26583,21953，m32404,14089或23436基因已被引入或破坏。 本发明还进一步提供了分离的53070,15985,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗-53070,15985,26583,21953，m32404,14089或23436抗体。 还提供了利用本发明组合物的诊断方法。