公开(公告)号：US20080113399A1

公开(公告)日：2008-05-15

申请号：US11981488

申请日：2007-10-31

申请人： Rosana Kapeller-Libermann ,  David White ,  Keith Robison ,  Kyle MacBeth ,  Joseph Carroll ,  William Cook ,  Rachel Meyers ,  Miyoung Chun ,  Mark Williamson

发明人： Rosana Kapeller-Libermann ,  David White ,  Keith Robison ,  Kyle MacBeth ,  Joseph Carroll ,  William Cook ,  Rachel Meyers ,  Miyoung Chun ,  Mark Williamson

IPC分类号： C12Q1/37

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/6489 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/04017 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/56983 ,  G01N33/56994 ,  G01N33/57426 ,  G01N33/5761 ,  G01N33/5767 ,  G01N33/68 ,  G01N2333/916 ,  G01N2333/96486 ,  G01N2500/04

摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为27875,22025,27420,16319,55092和10218核酸分子。 本发明还提供反义核酸分子，含有27875,22025,27420,16319,55092和10218核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中27875,22025， 27420,16319,55092和10218基因已被引入或破坏。 本发明还进一步提供了分离的27875,22025,27420,17906,16319,55092或10218蛋白，融合蛋白，抗原肽和抗27875,22025,27420,17906,16319,55092或10218抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20080108093A1

公开(公告)日：2008-05-08

申请号：US11981786

申请日：2007-10-31

申请人： Rosana Kapeller-Libermann ,  David White ,  Keith Robison ,  Kyle MacBeth ,  Joseph Carroll ,  William Cook ,  Rachel Meyers ,  Miyoung Chun ,  Mark Williamson

发明人： Rosana Kapeller-Libermann ,  David White ,  Keith Robison ,  Kyle MacBeth ,  Joseph Carroll ,  William Cook ,  Rachel Meyers ,  Miyoung Chun ,  Mark Williamson

IPC分类号： G01N33/53 ,  G01N33/68

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/6489 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/04017 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/56983 ,  G01N33/56994 ,  G01N33/57426 ,  G01N33/5761 ,  G01N33/5767 ,  G01N33/68 ,  G01N2333/916 ,  G01N2333/96486 ,  G01N2500/04

摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

公开(公告)号：US20060009632A1

公开(公告)日：2006-01-12

申请号：US11226701

申请日：2005-09-14

申请人： Rosana Kapeller-Libermann ,  David White ,  Keith Robison ,  Kyle MacBeth ,  Joseph Carroll ,  William Cook ,  Rachel Meyers ,  Miyoung Chun ,  Mark Williamson

发明人： Rosana Kapeller-Libermann ,  David White ,  Keith Robison ,  Kyle MacBeth ,  Joseph Carroll ,  William Cook ,  Rachel Meyers ,  Miyoung Chun ,  Mark Williamson

IPC分类号： C07H21/04

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/6489 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/04017 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/56983 ,  G01N33/56994 ,  G01N33/57426 ,  G01N33/5761 ,  G01N33/5767 ,  G01N33/68 ,  G01N2333/916 ,  G01N2333/96486 ,  G01N2500/04

摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为27875,22025,27420,16319,55092和10218核酸分子。 本发明还提供反义核酸分子，含有27875,22025,27420,16319,55092和10218核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中27875,22025， 27420,16319,55092和10218基因已被引入或破坏。 本发明还进一步提供了分离的27875,22025,27420,17906,16319,55092或10218蛋白，融合蛋白，抗原肽和抗27875,22025,27420,17906,16319,55092或10218抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20070065848A1

公开(公告)日：2007-03-22

申请号：US11493347

申请日：2006-07-26

申请人： Rachel Meyers ,  Kyle MacBeth ,  Rory Curtis ,  Laura Rudolph-Owen ,  Nadine Weich ,  Peter Olandt ,  Fong-Ying Tsai ,  Rosana Kapeller-Libermann ,  Joseph Carroll

发明人： Rachel Meyers ,  Kyle MacBeth ,  Rory Curtis ,  Laura Rudolph-Owen ,  Nadine Weich ,  Peter Olandt ,  Fong-Ying Tsai ,  Rosana Kapeller-Libermann ,  Joseph Carroll

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C12N9/001 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/0006 ,  C12N9/10 ,  C12N9/1048 ,  C12N9/1096 ,  C12N9/12 ,  C12N9/1205 ,  C12N9/16 ,  C12N9/48 ,  C12N9/80 ,  C12N2799/021 ,  C12Q1/32 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57449 ,  G01N2500/10 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 gene has been introduced or disrupted. The invention still further provides isolated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 proteins, fusion proteins, antigenic peptides and anti-26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 or 8843 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子。 本发明还提供反义核酸分子，包含26199,33530,3399,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206和8843核酸分子的重组表达载体，其中宿主细胞 已经引入了表达载体，并且已引入或破坏其中26199,33530,3399,47148,50216,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843基因的非人转基因动物。 本发明还进一步提供了分离的26199,33530,3949,47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843蛋白，融合蛋白，抗原肽和抗-26199,33530,3399 ，47148,50226,58764,62113,32144,32235,23565,13305,14911,86216,25206或8843抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20060240464A1

公开(公告)日：2006-10-26

申请号：US11429599

申请日：2006-05-05

申请人： Rachel Meyers ,  Joseph Carroll ,  William Cook ,  Rosana Kapeller-Libermann ,  Nadine Weich ,  Rajasekhar Bandaru

发明人： Rachel Meyers ,  Joseph Carroll ,  William Cook ,  Rosana Kapeller-Libermann ,  Nadine Weich ,  Rajasekhar Bandaru

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： A61K38/16 ,  A01K2217/05 ,  A61K38/4813 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/47 ,  C07K2319/00 ,  C12N9/0008 ,  C12N9/12 ,  C12N9/16 ,  C12N9/20 ,  C12N9/6416 ,  C12N9/6424 ,  C12N9/6491 ,  C12N9/93 ,  C12Q1/25 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y603/02019 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/573 ,  G01N33/68 ,  G01N2500/10 ,  Y10T436/143333 ,  A61K2300/00

摘要： The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 gene has been introduced or disrupted. The invention still further provides isolated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 proteins, fusion proteins, antigenic peptides and anti-27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 or 65577 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为27877,18080,14081,32140,50352,16658,14223,16002,50566,65552和65577核酸分子。 本发明还提供反义核酸分子，含有27877,18080,14081,32140,50502,16658,14223,16002,50566,65552和65577核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及 已经引入或破坏了27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577基因的非人类转基因动物。 本发明还进一步提供分离的27877,18080,14081,32140,50352,16658,14223,16002,50566,65552或65577蛋白，融合蛋白，抗原肽和抗27877,18080,14081,32140,50352,16658,14223 ，16002,50566,65552或65577抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20190206248A1

公开(公告)日：2019-07-04

申请号：US16157239

申请日：2018-10-11

申请人： Joseph Carroll

发明人： Joseph Carroll

IPC分类号： G08G1/095 ,  E01F9/615 ,  F21S9/03 ,  F21V23/04 ,  F21S10/06 ,  F21S4/20 ,  G08G1/07 ,  G08B5/38

CPC分类号： G08G1/095 ,  E01F9/615 ,  F21S4/20 ,  F21S9/032 ,  F21S10/06 ,  F21V23/0471 ,  F21W2111/02 ,  F21Y2113/13 ,  F21Y2115/10 ,  G08B5/38 ,  G08G1/07

摘要： A roadway safety system that alerts drivers that animals, especially deer, or humans, have entered a roadway so that the driver can avoid accidents resulting therefrom, such as hitting or killing the animal, or human, or damaging his or her vehicle or other vehicles, or harming himself or herself or his or her passengers in an attempt to avoid a collision.

公开(公告)号：US20060099656A1

公开(公告)日：2006-05-11

申请号：US11242505

申请日：2005-10-03

申请人： Joseph Carroll ,  Aileen Healy

发明人： Joseph Carroll ,  Aileen Healy

IPC分类号： G01N33/567

CPC分类号： G01N33/6893 ,  G01N2800/22 ,  Y02A50/58

摘要： The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 232, 2059, 10630, 12848, 13875, 14395, 14618, 17692, 58874, 252, 304, 1980, 14717, 9941, 19310, or 17832 genes in tissues relating to hematological disorders sensation, relative to their expression in normal, or non-hematological disorders disease states, and/or in response to manipulations relevant to hematological disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hematological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating hematological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of hematological disorders.

摘要翻译： 本发明涉及诊断和治疗血液学疾病的方法。 具体地，本发明鉴定了与血液学疾病感觉有关的组织中的232,2059,10630,12848,13875,14395,14618,17712,58874,252,304,1980,14717,9941,19310或17832基因的差异表达 相对于它们在正常或非血液学疾病疾病状态中的表达，和/或响应于与血液学疾病相关的操作。 本发明描述了各种血液学疾病的诊断评价和预后的方法，以及用于鉴定表现出对这种病症倾向的受试者。 本发明还提供了鉴定能够调节血液学疾病的化合物的方法。 本发明还提供了用于鉴定和治疗化合物作为血液学疾病治疗的方法。

公开(公告)号：US11344022B2

公开(公告)日：2022-05-31

申请号：US16166129

申请日：2018-10-21

申请人： Jonathan A Jackson ,  Christopher Hoffman ,  Norman Novotney ,  Joseph Carroll ,  Patrick A Jackson ,  Mark J Elting

发明人： Jonathan A Jackson ,  Christopher Hoffman ,  Norman Novotney ,  Joseph Carroll ,  Patrick A Jackson ,  Mark J Elting

IPC分类号： A01M21/04 ,  A01M21/00 ,  H05B3/00 ,  H05B35/00 ,  G21K5/00

摘要： Plant eradication and stressing of plants using illumination signaling where a short-time dual component, low energy, unnatural set of irradiances is applied, with no mutagenic or high radiative energy transfers in any wavelength for eradication by substantial high temperature thermally-induced leaf and plant component failure or incineration. An Indigo Region Illumination Distribution of wavelength 300 nm to 550 nm is directed to plant foliage and/or a plant root crown, while infrared radiation that is substantially Medium Wavelength Infrared radiation of 2-20 microns wavelength, 2.4-8.0 microns preferred, is directed to a plant root crown and/or soil immediately adjacent the root crown. The Indigo Region Illumination Distribution can pass through the MWIR emitter to form a compact illuminator. The MWIR emitter can comprise borosilicate glass at 400° F. to 1000° F.

公开(公告)号：US20070185049A1

公开(公告)日：2007-08-09

申请号：US11592039

申请日：2006-11-02

申请人： Vasant Jadhav ,  Joseph Carroll

发明人： Vasant Jadhav ,  Joseph Carroll

IPC分类号： A61K48/00 ,  C07H21/02

CPC分类号： C12N15/1137 ,  A61K48/00 ,  C07H21/02 ,  C12N2310/14 ,  C12N2310/318 ,  C12N2310/321 ,  C12N2310/53 ,  C12N2310/3521

摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, disease and conditions that respond to the modulation of histone deacetylase (HDAC) gene expression and/or activity. The present invention is also directed to compounds, compositions, and methods relating to traits, diseases and conditions that respond to the modulation of expression and/or activity of genes involved in HDAC gene expression pathways or other cellular processes that mediate the maintenance or development of such traits, diseases and conditions. Specifically, the invention relates to double stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating or that mediate RNA interference (RNAi) against HDAC gene expression, including cocktails of such small nucleic acid molecules and lipid nanoparticle (LNP) formulations of such small nucleic acid molecules. The present invention also relates to small nucleic acid molecules, such as siNA, siRNA, and others that can inhibit the function of endogenous RNA molecules, such as endogenous HDAC micro-RNA (miRNA) (e.g., miRNA inhibitors) or endogenous HDAC short interfering RNA (siRNA), (e.g., siRNA inhibitors) or that can inhibit the function of RISC (e.g., RISC inhibitors), to modulate HDAC gene expression by interfering with the regulatory function of such endogenous RNAs or proteins associated with such endogenous RNAs (e.g., RISC), including cocktails of such small nucleic acid molecules and lipid nanoparticle (LNP) formulations of such small nucleic acid molecules. Such small nucleic acid molecules are useful, for example, in providing compositions for treatment of traits, diseases and conditions that can respond to modulation of HDAC gene expression in a subject or organism, such as cancer and other proliferative diseases or conditions that are associated with HDAC gene expression or activity.

公开(公告)号：US20060078947A1

公开(公告)日：2006-04-13

申请号：US11288493

申请日：2005-11-29

申请人： Louise Kelly ,  Joseph Carroll ,  Deborah Farlow ,  Aileen Healy

发明人： Louise Kelly ,  Joseph Carroll ,  Deborah Farlow ,  Aileen Healy

IPC分类号： G01N33/567 ,  G01N33/53

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 9118, 990, 17662, 81982, 630, 21472, 17692, 19290, 21620, 21689, 28899, 53659, 64549, 9465, 23544, 7366, 27417, 57259, 21844, 943, 2061, 5891, 9137, 13908, 14310, 17600, 25584, 27824, 28469, 38947, 53003, 965, 56639, 9661, 16052, 1521, 6662, 13913, 12405 and 5014 genes in tissues relating to hematological disorders sensation, relative to their expression in normal, or non-hematological disorders disease states, and/or in response to manipulations relevant to hematological disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hematological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating hematological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of hematological disorders.

摘要翻译： 本发明涉及诊断和治疗血液学疾病的方法。 具体而言，本发明鉴定了9118,990,17662,81982,630,2172,27892,19290,21620,21689,28899,53659,64549,9465,23544,7366,27417,57259,21844,943的差异表达， 2061,5981,9137,13908,14310,1769,25584,27824,28469,38947,53003,965,5666,99661,16052,1521,6662,13913,12405和5014与血液学疾病感觉有关的组织中的基因，相对于 它们在正常或非血液学疾病疾病状态中的表达，和/或响应于与血液学疾病相关的操作。 本发明描述了各种血液学疾病的诊断评价和预后的方法，以及用于鉴定表现出对这种病症倾向的受试者。 本发明还提供了鉴定能够调节血液学疾病的化合物的方法。 本发明还提供了用于鉴定和治疗化合物作为血液学疾病治疗的方法。