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公开(公告)号：US06274737B1
公开(公告)日：2001-08-14
申请号：US09574413
申请日：2000-05-19
申请人： Russell Donovan Cousins , John Duncan Elliott , Maria Amparo Lago , Jack Dale Leber , Catherine Elizabeth Peishoff
发明人： Russell Donovan Cousins , John Duncan Elliott , Maria Amparo Lago , Jack Dale Leber , Catherine Elizabeth Peishoff
IPC分类号： C07D40510
CPC分类号： C07D307/79 , C07C45/71 , C07C49/84 , C07C62/30 , C07C62/32 , C07C62/34 , C07C69/734 , C07C69/738 , C07C69/757 , C07D317/60 , C07D405/08 , C07D405/12 , C07F9/65517
摘要： Novel indane and indene derivatives are described which are endothelin receptor antagonists.
摘要翻译： 描述了作为内皮素受体拮抗剂的新型茚满和茚衍生物
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公开(公告)号：US06448260B2
公开(公告)日：2002-09-10
申请号：US09901951
申请日：2001-07-10
申请人： Russell Donovan Cousins , John Duncan Elliott , Maria Amparo Lago , Jack Dale Leber , Catherine Elizabeth Peishoff
发明人： Russell Donovan Cousins , John Duncan Elliott , Maria Amparo Lago , Jack Dale Leber , Catherine Elizabeth Peishoff
IPC分类号： A61K3144
CPC分类号： C07D307/79 , C07C45/71 , C07C49/84 , C07C62/30 , C07C62/32 , C07C62/34 , C07C69/734 , C07C69/738 , C07C69/757 , C07D317/60 , C07D405/08 , C07D405/12 , C07F9/65517
摘要： Novel indane and indene derivatives are described which are endothelin receptor antagonists.
摘要翻译： 描述了作为内皮素受体拮抗剂的新型茚满和茚衍生物。
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公开(公告)号：US5719182A
公开(公告)日：1998-02-17
申请号：US442443
申请日：1995-05-16
申请人： Russell Donovan Cousins , John Duncan Elliott , Maria Amparo Lago , Jack Dale Leber , Catherine Elizabeth Peishoff
发明人： Russell Donovan Cousins , John Duncan Elliott , Maria Amparo Lago , Jack Dale Leber , Catherine Elizabeth Peishoff
IPC分类号： C07C45/71 , C07C49/84 , C07C62/30 , C07C62/32 , C07C62/34 , C07C69/734 , C07C69/738 , C07C69/757 , C07D307/79 , C07D317/60 , C07D405/08 , C07D405/12 , C07F9/655 , A61K31/36 , A61K31/19 , A61K31/335 , A61K31/44 , C07D317/64 , C07D317/70
CPC分类号： C07D307/79 , C07C45/71 , C07C49/84 , C07C62/30 , C07C62/32 , C07C62/34 , C07C69/734 , C07C69/738 , C07C69/757 , C07D317/60 , C07D405/08 , C07D405/12 , C07F9/65517
摘要： Novel indane and indene derivatives are described which are endothelin receptor antagonists.
摘要翻译： 描述了作为内皮素受体拮抗剂的新型茚满和茚衍生物。
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公开(公告)号：US06271399B1
公开(公告)日：2001-08-07
申请号：US08459985
申请日：1995-06-02
申请人： Russell Donovan Cousins , John Duncan Elliott , Maria Amparo Lago , Jack Dale Leber , Catherine Elizabeth Peishoff
发明人： Russell Donovan Cousins , John Duncan Elliott , Maria Amparo Lago , Jack Dale Leber , Catherine Elizabeth Peishoff
IPC分类号： C07D31754
CPC分类号： C07D307/79 , C07C45/71 , C07C49/84 , C07C62/30 , C07C62/32 , C07C62/34 , C07C69/734 , C07C69/738 , C07C69/757 , C07D317/60 , C07D405/08 , C07D405/12 , C07F9/65517
摘要： Indane and indene compounds are described which are endothelin receptor antagonists.
摘要翻译： 描述了吲哚和茚化合物，其是内皮素受体拮抗剂
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公开(公告)号：US5817693A
公开(公告)日：1998-10-06
申请号：US336444
申请日：1994-11-09
申请人： Russell Donovan Cousins , John Duncan Elliott , Maria Amparo Lago , Jack Dale Leber , Catherine Elizabeth Peishoff
发明人： Russell Donovan Cousins , John Duncan Elliott , Maria Amparo Lago , Jack Dale Leber , Catherine Elizabeth Peishoff
IPC分类号： C07C45/71 , C07C49/84 , C07C62/30 , C07C62/32 , C07C62/34 , C07C69/734 , C07C69/738 , C07C69/757 , C07D307/79 , C07D317/60 , C07D405/08 , C07D405/12 , C07F9/655 , A61K31/36 , C07D317/54
CPC分类号： C07D307/79 , C07C45/71 , C07C49/84 , C07C62/30 , C07C62/32 , C07C62/34 , C07C69/734 , C07C69/738 , C07C69/757 , C07D317/60 , C07D405/08 , C07D405/12 , C07F9/65517
摘要： Novel indane and indene derivatives are described which are endothelin receptor antagonists.
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公开(公告)号：US6087389A
公开(公告)日：2000-07-11
申请号：US99373
申请日：1998-06-18
申请人： Russell Donovan Cousins , John Duncan Elliott , Maria Amparo Lago , Jack Dale Leber , Catherine Elizabeth Peishoff
发明人： Russell Donovan Cousins , John Duncan Elliott , Maria Amparo Lago , Jack Dale Leber , Catherine Elizabeth Peishoff
IPC分类号： C07C45/71 , C07C49/84 , C07C62/30 , C07C62/32 , C07C62/34 , C07C69/734 , C07C69/738 , C07C69/757 , C07D307/79 , C07D317/60 , C07D405/08 , C07D405/12 , C07F9/655 , A61K31/335 , C07C255/03 , C07C317/04 , C07D319/14
CPC分类号： C07D307/79 , C07C45/71 , C07C49/84 , C07C62/30 , C07C62/32 , C07C62/34 , C07C69/734 , C07C69/738 , C07C69/757 , C07D317/60 , C07D405/08 , C07D405/12 , C07F9/65517
摘要： Novel indane and indene derivatives are described which are endothelin receptor antagonists.
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公开(公告)号：US5719183A
公开(公告)日：1998-02-17
申请号：US459686
申请日：1995-06-02
申请人： Russell Donovan Cousins , John Duncan Elliott , Maria Amparo Lago , Jack Dale Leber , Catherine Elizabeth Peishoff
发明人： Russell Donovan Cousins , John Duncan Elliott , Maria Amparo Lago , Jack Dale Leber , Catherine Elizabeth Peishoff
IPC分类号： C07C45/71 , C07C49/84 , C07C62/30 , C07C62/32 , C07C62/34 , C07C69/734 , C07C69/738 , C07C69/757 , C07D307/79 , C07D317/60 , C07D405/08 , C07D405/12 , C07F9/655 , A61K31/36 , A61K31/19 , A61K31/335 , A61K31/44
CPC分类号： C07D307/79 , C07C45/71 , C07C49/84 , C07C62/30 , C07C62/32 , C07C62/34 , C07C69/734 , C07C69/738 , C07C69/757 , C07D317/60 , C07D405/08 , C07D405/12 , C07F9/65517
摘要： Novel indane and indene derivatives are described which are endothelin receptor antagonists.
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公开(公告)号：US5716985A
公开(公告)日：1998-02-10
申请号：US450938
申请日：1995-05-23
IPC分类号： C07C45/71 , C07C49/84 , C07C62/30 , C07C62/32 , C07C62/34 , C07C69/734 , C07C69/738 , C07C69/757 , C07D307/79 , C07D317/60 , C07D405/08 , C07D405/12 , C07F9/655 , A61K31/36 , A61K31/19 , A61K31/335 , A61K31/44
CPC分类号： C07C45/71 , C07C49/84 , C07C62/30 , C07C62/32 , C07C62/34 , C07C69/734 , C07C69/738 , C07C69/757 , C07D307/79 , C07D317/60 , C07D405/08 , C07D405/12 , C07F9/65517
摘要： Novel indane and indene derivatives are described which are endothelin receptor antagonists.
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公开(公告)号：US5716984A
公开(公告)日：1998-02-10
申请号：US442038
申请日：1995-05-16
IPC分类号： C07C45/71 , C07C49/84 , C07C62/30 , C07C62/32 , C07C62/34 , C07C69/734 , C07C69/738 , C07C69/757 , C07D307/79 , C07D317/60 , C07D405/08 , C07D405/12 , C07F9/655 , A61K31/36 , C07D317/54
CPC分类号： C07D307/79 , C07C45/71 , C07C49/84 , C07C62/30 , C07C62/32 , C07C62/34 , C07C69/734 , C07C69/738 , C07C69/757 , C07D317/60 , C07D405/08 , C07D405/12 , C07F9/65517
摘要： Novel indane and indene derivatives are described which are endothelin receptor antagonists.
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公开(公告)号：US5935859A
公开(公告)日：1999-08-10
申请号：US124802
申请日：1998-07-29
IPC分类号： G01N37/00 , B01F13/02 , B01J19/00 , B01J19/24 , C07B61/00 , C40B60/14 , G01N35/00 , G01N35/02 , G01N35/10
CPC分类号： G01N35/028 , B01F13/0233 , B01J19/0046 , B01J2219/00315 , B01J2219/00459 , B01J2219/00468 , B01J2219/005 , B01J2219/00659 , C40B60/14 , G01N2035/00574 , G01N35/0099 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： A mixture of beads from a combinatorial library is held in suspension either by inducing circulating flow of a liquid in a tapered vessel by rising air bubbles or by floating the beads at the interface between two immiscible liquids. Beads are selected individually from the suspension by drawing liquid into the tip of a needle having a circular opening smaller than the diameter of a bead. After a bead is captured on the tip of a needle, excess beads are jarred loose or washed away by flow of a solvent through a sheath surrounding the needle, and the needle is moved by a robotic manipulator to a well into which the bead is released.
摘要翻译： 来自组合文库的珠子的混合物通过在气泡中升高而使锥形容器中的液体循环流动或通过在两种不混溶的液体之间的界面处漂浮珠子来保持悬浮液。 通过将液体引入具有比珠的直径小的圆形开口的针的尖端中，从悬浮液中分别选择珠粒。 在针尖上捕获珠粒后，通过溶剂流过围绕针的护套使多余的珠子松动或冲洗掉，并且针由机器人操纵器移动到珠被释放的孔中 。
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