摘要:
A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the formula IA and IB. IA and IB have the following structures where Z has the formula shown below and the rest of the variables are defined herein
摘要:
A vestibular implant comprising a stimulation unit to generate electric stimuli and deliver to electrode arrays is disclosed. The stimulation unit generates electric stimuli in response to a user input or continuously generates electrical stimuli. The electrode arrays comprise electrodes and are adapted for placement within a semicircular canal of an ear. The electric stimuli is delivered from the stimulation unit to the electrode so that the electrodes apply electric stimuli. A predetermined electric stimulus is applied to restore spontaneous vestibular activity during a Meniere's attack. A continuous, unmodulated electric stimulus is applied to suppress the symptoms of unilateral loss of vestibular function. Additionally, the electrodes record electrically evoked compound action potentials (eCAP). An appropriate location for the placement of the electrode array is determined based on the recorded eCAP.
摘要:
Described are selectable notch filter circuits comprising at least two different notch filter capabilities, each of which is capable of filtering interference of a designated fundamental frequency and a second harmonic of the designated fundamental frequency from an electrical signal. Each of the notch filters of the circuit is specific for real time filtering of a different designated fundamental frequency and a second harmonic thereof from digitized signal data input into the circuit. The filtering capability of each filter is dictated by control logic, which uses a coefficient set specific for the designated fundamental frequency and harmonics thereof. By using different coefficient sets, different designated fundamental frequencies and at least their second harmonic frequencies can be filtered from digitized signal data input into the circuit. Because the control logic can utilize at a given time any one (or, if desired, none) of the coefficient sets available to it, different interfering fundamental frequencies can be filtered, if and as necessary, from digitized input signal data collected over time at a substantially equivalent sampling rate. Also described are devices including one or more such selectable notch filter circuits, including implantable medical devices such as implantable cardioverter/defibrillators, as well as methods of using such devices.
摘要:
Methods and apparatus to control electro-mechanical brakes are disclosed. A disclosed example method of controlling a brake actuator comprises receiving a value representative of a velocity of a piston associated with the brake actuator relative to a pressure plate mounted on a wheel, and determining a control input for the brake actuator based on the velocity value.
摘要:
An electronic device, like a mobile telephone, has a first section and a second section. The first section and second section are coupled together by a mechanical connection, for example a hinge, swivel or sliding connector. Electronic components in the first section are coupled to electronic components in the second section by conductors capable of transferring power between the first and second sections. A current detector is capable of detecting currents, like surface currents, while a controller is responsive to the current detector. A plurality of reactive elements, like capacitors for example, are coupled to a plurality of switches such that the controller may selectively couple any of the plurality of reactive elements to the conductors by actuating a corresponding switch. When the current detector detects a current in excess of a predetermined threshold, the controller alters the complex impedance between the first and second sections by actuating one or more of the switches, thereby coupling one or more of the reactive elements to the conductors.
摘要:
The cooling system for the nozzle edges includes a chamber containing a cooling medium. First and second elongated plenums are disposed along opposite side edges of each platform. Inlet passages communicate cooling medium from the chamber into each plenum. Outlet passages from each plenum terminate in outlet holes in the side edges of the platform to cool the gap between adjacent nozzle segments. Passageways communicate with each plenum and terminate in film cooling holes to film cool platform surfaces. In each plenum, the inlet passages are not in direct line-of-sight flow communication with the outlet passages and passageways.
摘要:
Inventive systems and methods for remotely controlling infrared controlled devices by using addressed radio frequency control signals. Radio frequency signals propagate through most obstructions to infrared control signals. Augmenting each control signal with an address allows for great selectivity in an environment with several transmitters and receivers.
摘要:
Inventive systems and methods for remotely controlling infrared controlled devices by using addressed radio frequency control signals. Radio frequency signals propagate through most obstructions to infrared control signals. Augmenting each control signal with an address allows for great selectivity in an environment with several transmitters and receivers.
摘要:
A remote control for learning a macro routine of optical signals is provided. An optical receiver is arranged to receive optical signals from one or more original equipment remote controls. The optical receiver outputs electrical signals. A microprocessor receives the electrical signals from the optical receiver. A memory device stores the electrical signals from the optical receiver. An operator interface is electrically coupled to the microprocessor. The operator interface receives operator input to designate a macro routine of operator-selectable optical signals from the original equipment remote control. The microprocessor causes the electrical signals from the optical receiver that correspond to the operator-selectable optical signals from the original equipment remote control to be associated with the designated macro routine and stored in the memory device. Electrical signals associated with a macro designation are retrieved from the memory device and electrically coupled to an optical transmitter.
摘要:
The present invention provides a method for purifying ruthenium sources to obtain high purity ruthenium metal and form a ruthenium metal pattern on a semiconductor substrate without the need for high temperature processing or a complex series of wet processes. A gas stream including ozone (O3) is brought into contact with a ruthenium source in one or more reaction vessels to form ruthenium tetraoxide (RuO4), a compound that is a gas at the reaction conditions. The ruthenium tetraoxide, along with unreacted ozone and the remainder of the gas stream is then fed into a collection vessel where the gaseous ruthenium tetraoxide is reduced to form a ruthenium dioxide (RuO2) layer on a semiconductor substrate. The deposited ruthenium dioxide is then reduced, preferably with hydrogen, to produce highly pure ruthenium metal that may be, in turn, patterned and dry etched using ozone as an etchant gas.
摘要翻译:本发明提供一种用于纯化钌源以获得高纯度钌金属并在半导体衬底上形成钌金属图案的方法,而不需要高温处理或复杂的一系列湿法。 使包含臭氧(O 3 3 N)的气流与一个或多个反应容器中的钌源接触以形成四氧化钌(RuO 4 S 4),其为化合物 反应条件下的气体。 然后将四氧化钌,以及未反应的臭氧和气流的其余部分进料到收集容器中,在该收集容器中,气态钌四氧化物被还原以在半导体衬底上形成二氧化钌(RuO 2 N 2)层 。 然后沉积的二氧化钌优选用氢气还原,以产生高纯度的钌金属,其可以使用臭氧作为蚀刻剂气体进行图案化和干蚀刻。