公开(公告)号：US20070014776A1

公开(公告)日：2007-01-18

申请号：US11450935

申请日：2006-06-09

申请人： Ruth Gimeno ,  Janet Paulsen ,  Jian-Liang Li ,  Andrew Lake ,  Wei Liu ,  Jae Eun Kim

发明人： Ruth Gimeno ,  Janet Paulsen ,  Jian-Liang Li ,  Andrew Lake ,  Wei Liu ,  Jae Eun Kim

IPC分类号： A61K38/54 ,  C12Q1/34 ,  C07H21/04 ,  C12P21/06 ,  C12N9/99

CPC分类号： C12Q1/44 ,  A61K38/28 ,  C12N9/20 ,  G01N33/543 ,  G01N2333/918 ,  G01N2500/00 ,  G01N2800/04 ,  G01N2800/32

摘要： The present invention provides methods of identifying polypeptides that have enzymatic activity associated with nutrient and/or energy homeostasis, and thus, are involved in the development of one or more cardiovascular and metabolic disorders, e.g., cardiovascular disease, obesity, insulin resistance, type 2 diabetes, dyslipidemia, nonalcoholic fatty liver disease, and metabolic syndrome. One such method comprises identifying a polypeptide as a member of the adiponutrin family of proteins. As such, the invention is related to the polynucleotides and polypeptides belonging to the adiponutrin family, and provides novel isolated and purified polynucleotides and polypeptides of a novel member of the adiponutrin family, patatin-like phospholipase domain 1 (PNPLA1). Also provided are methods of using the polynucleotides and polypeptides related to or provided by the invention for screening a test compound, e.g., a small molecule, antibody, etc., for the ability of the test compound to detect and/or modulate the activity of one or more members of the adiponutrin family of proteins. The present invention also is directed to novel methods for diagnosing, prognosing, and monitoring the progress of at least one cardiovascular and metabolic disorder using polynucleotides or polypeptides belonging to the adiponutrin family, and/or modulators of one or more members of the adiponutrin family. The present invention is further directed to novel therapeutics and therapeutic targets for the intervention (treatment) and prevention of cardiovascular and metabolic disorders arising from dysregulated energy homeostasis, as related to one or more members of the adiponutrin family of proteins.

摘要翻译： 本发明提供了鉴定具有与营养和/或能量内稳态相关的酶活性的多肽的方法，因此涉及一种或多种心血管和代谢疾病的发展，例如心血管疾病，肥胖症，胰岛素抵抗，2型 糖尿病，血脂异常，非酒精性脂肪性肝病和代谢综合征。 一种这样的方法包括鉴定多肽作为脂肪细胞蛋白家族的成员。 因此，本发明涉及属于脂肪调素素家族的多核苷酸和多肽，并且提供脂肪分泌素家族的新成员的新分离和纯化的多核苷酸和多肽，类似蛋白样磷脂酶结构域1（PNPLA1）。 还提供了使用与本发明相关或由本发明提供的多核苷酸和多肽用于筛选测试化合物（例如小分子，抗体等）以测试化合物检测和/或调节活性的能力的方法 脂肪蛋白家族蛋白的一个或多个成员。 本发明还涉及使用属于脂肪素家族的多核苷酸或多肽和/或脂肪素家族的一个或多个成员的调节剂来诊断，预测和监测至少一种心血管和代谢紊乱进展的新方法。 本发明进一步涉及用于干预（治疗）的新型治疗学和治疗靶标，以及与由脂肪蛋白家族蛋白质的一个或多个成员相关的由失调的能量稳态引起的心血管和代谢紊乱的预防。

公开(公告)号：US20050172362A1

公开(公告)日：2005-08-04

申请号：US11049619

申请日：2005-02-02

申请人： Andrew Lake ,  Rickie Drewry

发明人： Andrew Lake ,  Rickie Drewry

IPC分类号： A01H5/10 ,  A01H5/12 ,  A01H1/00 ,  C12N15/82

CPC分类号： A01H5/12 ,  A01H5/10

摘要： The present invention relates to improved cultivars, varieties, lines or plants of annual medics (Medicago genus) wherein the majority of seed pods, upon reaching maturity, remain attached to their respective pedicels. In particular, the present invention relates to improved cultivars, varieties, lines or plants of annual medics (Medicago genus), having a mutant form of the gene for pod shedding, thereby resulting in a “pod holding” trait. The invention also extends to methods for isolating such plants. A yet further aspect of the invention relates to a method of transferring the “pod holding” trait from an annual medic having this trait to another annual medic of the genus Medicago by a process of controlled cross-breeding. A still further aspect of the invention relates to a method of obtaining plants having the “pod holding” trait from a population of annual medics of the genus Medicago.

摘要翻译： 本发明涉及年度药物（苜蓿科）的改良品种，品种，品系或植物，其中大多数种子荚在成熟时保持附着于它们各自的花梗。 具体而言，本发明涉及具有荚果脱落基因突变形式的年度药物（Medicago属）的改良品种，品种，品系或植物，从而产生“荚果”特征。 本发明还涉及分离这些植物的方法。 本发明的另一方面涉及一种通过控制性杂交过程将“荚果”特征从具有这种特征的年度药物转移到Medic属的另一种年度药物的方法。 本发明的另一方面涉及从Medicago属的年度药物群体获得具有“荚”的特征的植物的方法。

公开(公告)号：US20080047658A1

公开(公告)日：2008-02-28

申请号：US11895954

申请日：2007-08-28

申请人： Andres von-Vajna ,  Andrew Lake

发明人： Andres von-Vajna ,  Andrew Lake

IPC分类号： B32B37/00 ,  B29C65/02 ,  B32B38/04

CPC分类号： B32B37/30 ,  B29C65/18 ,  B29C65/48 ,  B29C65/4815 ,  B29C66/0242 ,  B29C66/433 ,  B29C66/723 ,  B29C66/83411 ,  B29C66/83413 ,  B29C66/83513 ,  B29C2793/009 ,  B29L2009/00 ,  B29L2031/712 ,  B32B37/0053 ,  B65B9/02 ,  C09J5/06 ,  C09J2400/263 ,  Y10T156/10 ,  Y10T156/1002 ,  Y10T156/1052

摘要： Provided is a method for bonding continuous traveling webs, which allows for significant increase in web processing speeds. A method according to the present invention includes providing a web including a bonding agent that may require activation prior to adhesion. Bonding agent activation may be, for example, by heat transfer or wetting. The primary activation of the bonding agent occurs separately from any applied force required for proper adhesion. Adhesion force may be applied by a noncatalytic pressure means including a crimp roller. The method may further include the insertion of a product between web layers to be brought into adhesive engagement with one another. A further web process step may include the cutting of bonded webs.

摘要翻译： 提供了一种用于粘合连续行进幅材的方法，其允许幅材处理速度显着增加。 根据本发明的方法包括提供包含粘合剂的网，所述粘合剂可以在粘合之前需要活化。 粘合剂活化可以是例如通过热传递或润湿。 粘合剂的主要活化与适当粘合所需的任何施加力分开发生。 粘合力可以通过包括压接辊的非催化压力装置施加。 该方法还可以包括将产品插入幅材层之间以彼此粘合接合。 另外的幅材工艺步骤可以包括切割粘合的织物。

公开(公告)号：US20050064058A1

公开(公告)日：2005-03-24

申请号：US10666367

申请日：2003-09-19

申请人： Andrew Lake ,  Shelley Rasmussen ,  Jesse Pasterski ,  Wen Lay ,  Marcus Weiher ,  Michael Bott ,  Rodney Abba

发明人： Andrew Lake ,  Shelley Rasmussen ,  Jesse Pasterski ,  Wen Lay ,  Marcus Weiher ,  Michael Bott ,  Rodney Abba

IPC分类号： B31F1/07 ,  B29C59/04

CPC分类号： B31F1/07 ,  B31F2201/0776

摘要： An embossing method and apparatus (20) comprises a rotary embossing device (32) having a radial direction (28) and an outer peripheral surface (34). The embossing device (32) includes at least one embossing-component (48) which extends at least radially outward from the peripheral surface (34), and is configured to provide for a first embossing-pattern (38). The embossing device (32) also includes a rotary shaft member (46). A base embossing-segment (50) is operatively joined to the rotary shaft member (46) and configured to carry a first base-section (40) of the first embossing-component (48). In a particular aspect, a first, supplemental embossing-segment (52) is operatively joined and selectively positionable on the rotary shaft member (46), and is configured to carry a first supplemental-section (42) of the first embossing-component (48). In other aspects, a first spacing mechanism (56) can adjust a radial position of the first, supplemental embossing-segment (52), and a first, supplemental attachment-mechanism (60) can secure the radial position of the second supplemental embossing-segment (52).

摘要翻译： 压花方法和装置（20）包括具有径向方向（28）和外周表面（34）的旋转压花装置（32）。 压花装置（32）包括至少一个从圆周表面（34）至少径向向外延伸的压印部件（48），并且构造成提供第一压花图案（38）。 压花装置（32）还包括旋转轴构件（46）。 底部压花段（50）可操作地连接到旋转轴构件（46），并构造成承载第一压花部件（48）的第一基部（40）。 在特定方面，第一补充压花段（52）可操作地接合并选择性地定位在旋转轴构件（46）上，并且构造成承载第一压花部件（42）的第一补充部分（42） 48）。 在其他方面，第一间隔机构（56）可以调节第一补充压花段（52）的径向位置，并且第一附加附接机构（60）可以固定第二辅助压花段（52）的径向位置， 段（52）。

公开(公告)号：US20080050531A1

公开(公告)日：2008-02-28

申请号：US11895879

申请日：2007-08-28

申请人： Andrew Lake

发明人： Andrew Lake

IPC分类号： B05D1/02 ,  B05B13/02

CPC分类号： B05C5/027 ,  D06B1/08

摘要： An apparatus and method are provided for wetting a continuous web. An apparatus according to the present invention includes a dwell surface adapted to receive a traveling web and a fluid chamber in fluid communication with such traveling web. The fluid chamber is coupled to a fluid source. Fluid from the fluid chamber is applied to the web and the web is drawn across the dwell surface. The web may be drawn away from the dwell surface at an angle that may be adjustable. Alternatively, an embodiment of the apparatus includes a plurality of dwell surfaces, one of which may be selectively engaged with the traveling web. A method according to the present invention involves the steps of providing a continuous web, applying a fluid to the web and drawing the web across a dwell surface.

摘要翻译： 提供了用于润湿连续卷材的装置和方法。 根据本发明的装置包括适于接纳行进腹板和与这种行进腹板流体连通的流体室的停留表面。 流体室耦合到流体源。 来自流体室的流体被施加到幅材上并且幅材被拉过停留表面。 网可以以可调节的角度从驻留表面拉开。 或者，该装置的一个实施例包括多个停留表面，其中一个停留表面可以选择性地与行进网接合。 根据本发明的方法包括以下步骤：提供连续的网，将流体施加到幅材上并且将幅材拉过停留表面。

公开(公告)号：US20050035492A1

公开(公告)日：2005-02-17

申请号：US10641802

申请日：2003-08-14

申请人： Marcus Weiher ,  Shelley Rasmussen ,  Andrew Lake ,  Michael Bott

发明人： Marcus Weiher ,  Shelley Rasmussen ,  Andrew Lake ,  Michael Bott

IPC分类号： A61F13/15 ,  B31D1/04 ,  B31F1/07 ,  B29C59/04

CPC分类号： A61F13/4704 ,  A61F13/15731 ,  B31D1/04 ,  B31F1/07 ,  B31F2201/0723 ,  B31F2201/0733 ,  B31F2201/0738 ,  B31F2201/0758 ,  B31F2201/0776

摘要： An apparatus and process (20) for forming an embossed web or other article can include moving a target, composite web (26) along an appointed machine-direction (22) at a selected web speed, and operatively contacting the target web (26) with a rotary embossing device (38) to thereby form a non-linear embossment region (82) in at least a selected embossment portion of the target web (26). For example, the web speed can be at least a minimum of about 1.9 m/sec. In a particular aspect, the embossing device (38) can include an outer peripheral surface (42) having a lateral cross-direction (24) and a circumferential-direction (40), and can include a non-linear embossing member (44) located on the outer surface (42). In another aspect, the embossing member (44) can be configured to include a selected traversing occurrence along the circumferential-direction (40) of the embossing device (38). In a further aspect, the embossing member (44) can be configured to include a selected lateral traversing distance (50).

摘要翻译： 用于形成压花网或其它制品的装置和方法（20）可以包括以选定的幅材速度沿着指定的机器方向（22）移动目标复合纤维网（26），并且可操作地接触目标网（26） 具有旋转压花装置（38），从而在目标纤维网（26）的至少一个选定的压花部分中形成非线性压花区域（82）。 例如，幅材速度可以至少为约1.9m / sec。 在特定方面，压花装置（38）可以包括具有横向横向（24）和周向（40）的外周表面（42），并且可以包括非线性压花构件（44） 位于外表面（42）上。 在另一方面，压花构件（44）可以构造成包括沿着压花装置（38）的圆周方向（40）的选定横移发生。 在另一方面，压花构件（44）可以构造成包括所选择的横向横移距离（50）。

公开(公告)号：US20050025631A1

公开(公告)日：2005-02-03

申请号：US10630053

申请日：2003-07-30

申请人： Andrew Lake

发明人： Andrew Lake

IPC分类号： F04B51/00 ,  F04B49/00

CPC分类号： F04B51/00 ,  F04B2201/0604 ,  F04B2201/0802 ,  F04B2205/01 ,  F04B2205/05

摘要： A method for monitoring the mechanical condition of a reciprocating compressor having a packed-plunger cylinder is provided. An end assembly is attached to one end of the cylinder, and the strain of at least one component of the end assembly is measured as the plunger reciprocates within the cylinder. The measured strain is correlated with a crank angle to facilitate generation of a strain profile. Two pressure values related to the pressure in the cylinder are determined when the plunger is at two different locations. This facilitates generation of a cylinder pressure profile based on the correlated measured strain. The cylinder pressure profile is thus generated without the use of intrusive gauges or sensors, which may create a leak path, or create a stress concentration in the wall of the cylinder.

摘要翻译： 提供了一种用于监测具有填充柱塞缸的往复式压缩机的机械状态的方法。 端部组件附接到气缸的一端，并且当柱塞在气缸内往复运动时测量端部组件的至少一个部件的应变。 测量的应变与曲轴角度相关，以便于产生应变曲线。 当柱塞在两个不同的位置时，确定与气缸中的压力相关的两个压力值。 这有助于基于相关测量应变产生气缸压力分布。 因此，不使用可能产生泄漏路径的侵入式量规或传感器产生气缸压力分布，或在气缸的壁中产生应力集中。