公开(公告)号：US20070014776A1

公开(公告)日：2007-01-18

申请号：US11450935

申请日：2006-06-09

申请人： Ruth Gimeno ,  Janet Paulsen ,  Jian-Liang Li ,  Andrew Lake ,  Wei Liu ,  Jae Eun Kim

发明人： Ruth Gimeno ,  Janet Paulsen ,  Jian-Liang Li ,  Andrew Lake ,  Wei Liu ,  Jae Eun Kim

IPC分类号： A61K38/54 ,  C12Q1/34 ,  C07H21/04 ,  C12P21/06 ,  C12N9/99

CPC分类号： C12Q1/44 ,  A61K38/28 ,  C12N9/20 ,  G01N33/543 ,  G01N2333/918 ,  G01N2500/00 ,  G01N2800/04 ,  G01N2800/32

摘要： The present invention provides methods of identifying polypeptides that have enzymatic activity associated with nutrient and/or energy homeostasis, and thus, are involved in the development of one or more cardiovascular and metabolic disorders, e.g., cardiovascular disease, obesity, insulin resistance, type 2 diabetes, dyslipidemia, nonalcoholic fatty liver disease, and metabolic syndrome. One such method comprises identifying a polypeptide as a member of the adiponutrin family of proteins. As such, the invention is related to the polynucleotides and polypeptides belonging to the adiponutrin family, and provides novel isolated and purified polynucleotides and polypeptides of a novel member of the adiponutrin family, patatin-like phospholipase domain 1 (PNPLA1). Also provided are methods of using the polynucleotides and polypeptides related to or provided by the invention for screening a test compound, e.g., a small molecule, antibody, etc., for the ability of the test compound to detect and/or modulate the activity of one or more members of the adiponutrin family of proteins. The present invention also is directed to novel methods for diagnosing, prognosing, and monitoring the progress of at least one cardiovascular and metabolic disorder using polynucleotides or polypeptides belonging to the adiponutrin family, and/or modulators of one or more members of the adiponutrin family. The present invention is further directed to novel therapeutics and therapeutic targets for the intervention (treatment) and prevention of cardiovascular and metabolic disorders arising from dysregulated energy homeostasis, as related to one or more members of the adiponutrin family of proteins.

摘要翻译： 本发明提供了鉴定具有与营养和/或能量内稳态相关的酶活性的多肽的方法，因此涉及一种或多种心血管和代谢疾病的发展，例如心血管疾病，肥胖症，胰岛素抵抗，2型 糖尿病，血脂异常，非酒精性脂肪性肝病和代谢综合征。 一种这样的方法包括鉴定多肽作为脂肪细胞蛋白家族的成员。 因此，本发明涉及属于脂肪调素素家族的多核苷酸和多肽，并且提供脂肪分泌素家族的新成员的新分离和纯化的多核苷酸和多肽，类似蛋白样磷脂酶结构域1（PNPLA1）。 还提供了使用与本发明相关或由本发明提供的多核苷酸和多肽用于筛选测试化合物（例如小分子，抗体等）以测试化合物检测和/或调节活性的能力的方法 脂肪蛋白家族蛋白的一个或多个成员。 本发明还涉及使用属于脂肪素家族的多核苷酸或多肽和/或脂肪素家族的一个或多个成员的调节剂来诊断，预测和监测至少一种心血管和代谢紊乱进展的新方法。 本发明进一步涉及用于干预（治疗）的新型治疗学和治疗靶标，以及与由脂肪蛋白家族蛋白质的一个或多个成员相关的由失调的能量稳态引起的心血管和代谢紊乱的预防。

公开(公告)号：US11866156B1

公开(公告)日：2024-01-09

申请号：US17531766

申请日：2021-11-21

申请人： Wei Liu

发明人： Wei Liu

IPC分类号： B64C23/06 ,  B64C21/10

CPC分类号： B64C23/065 ,  B64C21/10

摘要： This invention is an apparatus for vortex generation by combining the function of means for vortex generation with the functions of the leading-edge aerodynamic surface, the airfoil, and/or the trailing-edge aerodynamic surface.

公开(公告)号：US11686448B1

公开(公告)日：2023-06-27

申请号：US17699103

申请日：2022-03-19

申请人： Wei Liu

发明人： Wei Liu

IPC分类号： B60Q1/00 ,  F21S41/683 ,  F21S41/32 ,  F21S41/43 ,  F21S41/25 ,  F21W102/135

CPC分类号： F21S41/683 ,  F21S41/25 ,  F21S41/32 ,  F21S41/43 ,  F21W2102/135

摘要： This invention is a projector headlight that, while offering dual beam patterns, boasts a 100% utilization of the light emitted from a light source by one of the following methods: (1) employing a reflective cutoff shield means to reflect the incoming light from said light source back to the reflector to enhance the illumination in low-beam pattern, (2) using reversible cutoff shield means to reflect the incoming light from said light source back to the reflector to enhance the illumination in low-beam pattern with no moving part involved, (3) utilizing a selective light-filter cutoff means to selectively reflect the incoming light from said light source back to the reflector to enhance the illumination in low-beam pattern without making use of any moving part, (4) using a low-beam light-emitting subassembly and a high-beam light-emitting subassembly that are separated by partition means to achieve dual beam patterns with no moving part, or (5) adopting a low-beam light-emitting subassembly in low-beam pattern and a high-beam light-emitting subassembly in high-beam pattern without any moving part.

公开(公告)号：USD952959S1

公开(公告)日：2022-05-24

申请号：US29778103

申请日：2021-04-10

申请人： Wei Liu

设计人： Wei Liu

公开(公告)号：US09588205B2

公开(公告)日：2017-03-07

申请号：US13582800

申请日：2011-03-10

申请人： Stefanie Remmele ,  Wei Liu ,  Tobias Ratko Voigt ,  Christian Stehning

发明人： Stefanie Remmele ,  Wei Liu ,  Tobias Ratko Voigt ,  Christian Stehning

IPC分类号： G01R33/50 ,  G01R33/56 ,  G01R33/561

CPC分类号： G01R33/50 ,  G01R33/5601 ,  G01R33/5613 ,  G01R33/5616

摘要： The invention relates to a magnetic resonance imaging method for simultaneous and dynamic determination of a longitudinal relaxation time T1 and a transversal relaxation time T2 of the nuclear spin system of an object, in the context of DCE or DSE MRI. In this respect, the invention makes use of a steady-state gradient echo pulse sequence comprising an EPI readout module.

摘要翻译： 本发明涉及一种用于在DCE或DSE MRI的背景下同时和动态地确定物体的核自旋系统的纵向弛豫时间T1和横向弛豫时间T2的磁共振成像方法。 在这方面，本发明利用包括EPI读出模块的稳态梯度回波脉冲序列。

公开(公告)号：US09349561B2

公开(公告)日：2016-05-24

申请号：US13340701

申请日：2011-12-30

申请人： Jinshu Wang ,  Wei Liu ,  Fan Yang ,  Xiang Liu ,  Hongyi Li ,  Meiling Zhou ,  Tieyong Zuo

发明人： Jinshu Wang ,  Wei Liu ,  Fan Yang ,  Xiang Liu ,  Hongyi Li ,  Meiling Zhou ,  Tieyong Zuo

IPC分类号： H01J1/14 ,  H01J1/142 ,  H01J1/13 ,  H01J1/144 ,  H01J9/04 ,  H01J23/05

CPC分类号： H01J1/142 ,  H01J1/13 ,  H01J1/14 ,  H01J1/144 ,  H01J9/047 ,  H01J23/05

摘要： Impregnated rare earth metal-containing barium-aluminum-scandate cathodes with a rare earth oxide doped tungsten matrix and methods for the fabrication thereof are described. In one aspect, an impregnated rare earth metal-containing barium-aluminum-scandate cathode comprises: a rare earth oxide doped tungsten matrix, and an impregnated active substance. The active substance comprises scandium oxide (Sc2O3), a second rare earth oxide, and barium calcium aluminate, wherein the molar ratio of Ba:Ca:Al is about 4:1:1.

摘要翻译： 描述了具有稀土氧化物掺杂钨基体的含浸稀土金属的钡 - 铝 - 钪酸盐阴极及其制造方法。 一方面，含浸稀土金属的钡 - 铝 - 钪酸盐阴极包括：掺杂稀土氧化物的钨基体和浸渍的活性物质。 活性物质包含氧化钪（Sc 2 O 3），第二稀土氧化物和铝酸钡钙，其中Ba:Ca:Al的摩尔比为约4:1:1。

公开(公告)号：US09248430B2

公开(公告)日：2016-02-02

申请号：US13510216

申请日：2010-07-22

申请人： Fuling Huang ,  Puke Mi ,  Sihan Wang ,  Jinhua Qian ,  Qian Chen ,  Sheng Xu ,  Jianzhong Li ,  Gang Wang ,  Baojun Zhang ,  Min Liu ,  Guizhi Wang ,  Xuemei Han ,  Jiabo Qu ,  Panfeng Lu ,  Shukun Sun ,  Xiuhui Wang ,  Yuxin Gao ,  Deshun Zhang ,  Ling Jiang ,  Buwei Yu ,  Libo Wang ,  Yali Wang ,  Lingting Fan ,  Peng Wei ,  Wei Liu ,  Guiyue Guo

发明人： Fuling Huang ,  Puke Mi ,  Sihan Wang ,  Jinhua Qian ,  Qian Chen ,  Sheng Xu ,  Jianzhong Li ,  Gang Wang ,  Baojun Zhang ,  Min Liu ,  Guizhi Wang ,  Xuemei Han ,  Jiabo Qu ,  Panfeng Lu ,  Shukun Sun ,  Xiuhui Wang ,  Yuxin Gao ,  Deshun Zhang ,  Ling Jiang ,  Buwei Yu ,  Libo Wang ,  Yali Wang ,  Lingting Fan ,  Peng Wei ,  Wei Liu ,  Guiyue Guo

IPC分类号： C07C6/10 ,  B01J21/04 ,  B01J37/02 ,  C07C2/22

CPC分类号： B01J21/04 ,  B01J37/0205 ,  B01J37/0207 ,  C07C2/22 ,  C07C2521/04 ,  C07C2527/126 ,  C07C11/02

摘要： A method for synthesis of 1-decene oligomer is provided, wherein 1-decene is polymerized at 80-120° C., 0.8-1.4 MPa in the presence of aluminum trichloride catalyst supported on gamma-alumina and n-hexane solvent where the volume ratio of 1-decene to n-hexane is 3:8-4:1. The catalyst is treated as follows: impregnating gamma-alumina carrier in 0.5-2.0 M of hydrochloric acid, sulfuric acid, nitric acid or mixtures thereof, then vacuum drying at 80-100° C. and calcining at 400-800° C.; dissolving 5-10 g of anhydrous aluminum trichloride in 100 ml of tetrachloromethane, trichloromethane or dichloromethane solvent; adding the obtained solution into 10-20 g of activated alumina carrier and obtaining the catalyst after vacuum drying. The conversion of 1-decene is 50 wt % or more. The oligomer has a kinematic viscosity at 40° C. of 6.0-25 mm2/s and a viscosity index of 160-262.

摘要翻译： 提供1-癸烯低聚物的合成方法，其中1-癸烯在负载在γ-氧化铝和正己烷溶剂上的三氯化铝催化剂存在下，在80-120℃，0.8-1.4MPa下聚合，其中体积 1-癸烯与正己烷的比例为3：8-4：1。 催化剂的处理如下：将γ-氧化铝载体浸入0.5-2.0M盐酸，硫酸，硝酸或其混合物中，然后在80-100℃真空干燥并在400-800℃下煅烧。 将5-10g无水三氯化铝溶于100ml四氯甲烷，三氯甲烷或二氯甲烷溶剂中; 将得到的溶液加入10-20g活性氧化铝载体中，真空干燥后得到催化剂。 1-癸烯的转化率为50重量％以上。 低聚物在40℃下的运动粘度为6.0-25mm 2 / s，粘度指数为160-262。

公开(公告)号：US09152932B2

公开(公告)日：2015-10-06

申请号：US12970994

申请日：2010-12-17

申请人： Mohammad Reza Shafiee ,  Hongfang Li ,  Wei Liu ,  Anurag Gupta ,  Ashutosh K. Sureka ,  Satya S. Raju

发明人： Mohammad Reza Shafiee ,  Hongfang Li ,  Wei Liu ,  Anurag Gupta ,  Ashutosh K. Sureka ,  Satya S. Raju

IPC分类号： G06F17/30 ,  G06Q10/06

CPC分类号： G06Q10/06

摘要： A system may create work units, each work unit including at least one of an input port or output port, each work unit configured to modify data that is received via the input port. In addition, the system may compose a workflow by connecting an output port of a first of the work units to an input port of a second of the work units, receive a work order, select the workflow in response to the work order, decompose the workflow into constituent work units, instantiate tasks that correspond to the constituent work units, and execute a work unit process for each of the tasks.

摘要翻译： 系统可以创建工作单元，每个工作单元包括输入端口或输出端口中的至少一个，每个工作单元被配置为修改经由输入端口接收的数据。 此外，系统可以通过将第一工作单元的输出端口连接到第二工作单元的输入端口来组合工作流程，接收工作单，响应于工作顺序选择工作流程，分解工作单元 工作流组成工作单元，实例化与组成单位对应的任务，并执行每个任务的工作单元处理。

公开(公告)号：US09079136B2

公开(公告)日：2015-07-14

申请号：US13032752

申请日：2011-02-23

申请人： Wei Liu ,  Xiaohong Shari Li ,  Nathan L. Canfield

发明人： Wei Liu ,  Xiaohong Shari Li ,  Nathan L. Canfield

IPC分类号： B01D67/00 ,  B01D39/20 ,  B01D69/10 ,  B01D71/02 ,  B01J20/32 ,  B22F3/11 ,  B22F3/22 ,  B22F5/00 ,  C22C19/00 ,  C22C19/03 ,  C22C38/08 ,  B01D69/06

CPC分类号： B01D67/0041 ,  B01D39/2051 ,  B01D67/0046 ,  B01D67/0058 ,  B01D69/06 ,  B01D69/10 ,  B01D71/022 ,  B01D2239/10 ,  B01D2239/1216 ,  B01D2323/08 ,  B01D2323/18 ,  B01D2325/10 ,  B01D2325/12 ,  B01D2325/24 ,  B01J20/3204 ,  B01J20/3297 ,  B22F3/1121 ,  B22F3/22 ,  B22F5/006 ,  B22F2998/10 ,  C22C19/002 ,  C22C19/03 ,  C22C38/08 ,  Y10T428/12014 ,  Y10T428/31678 ,  B22F3/10 ,  B22F3/18 ,  B22F9/30

摘要： Thin, porous metal sheets and methods for forming them are presented to enable a variety of applications and devices. The thin, porous metal sheets are less than or equal to approximately 200 μm thick, have a porosity between 25% and 75% by volume, and have pores with an average diameter less than or equal to approximately 2 μm. The thin, porous metal sheets can be fabricated by preparing a slurry having between 10 and 50 wt % solvent and between 20 and 80 wt % powder of a metal precursor. The average particle size in the metal precursor powder should be between 100 nm and 5 μm.

摘要翻译： 提供薄的多孔金属片和用于形成它们的方法，以实现各种应用和装置。 薄多孔金属板的厚度小于或等于约200μm，孔隙率为25体积％至75体积％，并且具有平均直径小于或等于约2微米的孔。 可以通过制备具有10至50重量％溶剂和20至80重量％的金属前体粉末的浆料来制造薄的多孔金属片。 金属前体粉末中的平均粒径应在100nm和5μm之间。

公开(公告)号：US09068169B2

公开(公告)日：2015-06-30

申请号：US12114604

申请日：2008-05-02

申请人： Wen-Ghih Tsang ,  Tianli Zheng ,  Wei Liu

发明人： Wen-Ghih Tsang ,  Tianli Zheng ,  Wei Liu

IPC分类号： C12N5/071 ,  A61K35/12

CPC分类号： C12N5/0678 ,  A61K35/12 ,  C12N2500/34 ,  C12N2501/117 ,  C12N2501/12 ,  C12N2501/599 ,  C12N2533/54

摘要： The invention relates to the discovery of a selective cell surface marker that permits the selection of a unique subset of pancreatic stems cells having a high propensity to differentiate into insulin producing cells or into insulin producing cell aggregates.

摘要翻译： 本发明涉及选择性细胞表面标志物的发现，其允许选择具有高分化为胰岛素产生细胞或产生胰岛素的细胞聚集体的高倾向的胰腺干细胞的唯一子集。