公开(公告)号：US20170121373A1

公开(公告)日：2017-05-04

申请号：US15315257

申请日：2015-05-29

申请人： SANOFI PASTEUR INC.

发明人： Guadalupe CORTES-GARCIA ,  Timothy ALEFANTIS ,  Mark PARRINGTON

IPC分类号： C07K14/005 ,  A61K39/145 ,  G01N33/569

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/57 ,  C07K16/1018 ,  C07K2317/76 ,  C12N7/00 ,  C12N2760/16022 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16151 ,  G01N33/56983 ,  G01N2333/11

摘要： The present invention provides, among other things, compositions and methods for analyzing the expression and conformation of engineered influenza hemagglutinin In particular, the present invention provides methods of screening in silico designed HA antigens using neutralizing antibody panels specific to conserved epitopes. In some embodiments, the HAs are down selected for inclusion in universal influenza vaccines based upon their binding to neutralizing antibody panels in immunostaining assays.

公开(公告)号：US20240277828A1

公开(公告)日：2024-08-22

申请号：US18653422

申请日：2024-05-02

申请人： SANOFI PASTEUR INC

发明人： Timothy ALEFANTIS ,  Mario BARRO ,  Anthony BYERS ,  Guadalupe CORTES-GARCIA ,  Philippe-Alexandre GILBERT ,  Harold KLEANTHOUS ,  Armaghan NAIK ,  Konstantin PUGACHEV ,  Saranya SRIDHAR ,  Thorsten VOGEL ,  William WARREN

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61P37/04

CPC分类号： A61K39/145 ,  A61P37/04 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/70

摘要： Disclosed herein are multivalent vaccine or immunogenic compositions comprising one or more recombinant influenza virus hemagglutinin (HA), one or more recombinant influenza virus neuraminidase (NA), and an optional adjuvant. Also disclosed are methods of using the vaccine or immunogenic composition.

公开(公告)号：US20240285750A1

公开(公告)日：2024-08-29

申请号：US18653458

申请日：2024-05-02

申请人： SANOFI

发明人： Timothy ALEFANTIS ,  Mario BARRO ,  Saranya SRIDHAR ,  Thorsten VOGEL ,  William WARREN

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61P31/16

CPC分类号： A61K39/145 ,  A61P31/16 ,  A61K2039/53 ,  A61K2039/70

摘要： Disclosed herein are hybrid multivalent vaccine or immunogenic compositions comprising (i) one or more influenza virus proteins selected from one or more influenza virus hemagglutinin (HA) proteins, one or more influenza virus neuraminidase (NA) proteins, or a combination thereof; and (ii) one or more ribonucleic acid molecules encoding one or more influenza virus proteins selected from one or more influenza virus HA proteins, one or more influenza virus NA proteins, or a combination thereof. Also disclosed are methods of using the vaccine or immunogenic compositions.

公开(公告)号：US20240269258A1

公开(公告)日：2024-08-15

申请号：US18627824

申请日：2024-04-05

申请人： SANOFI PASTEUR INC.

发明人： Timothy ALEFANTIS ,  Mario BARRO ,  Anthony BYERS ,  Philip DAVIDSON ,  Maryann GIEL-MOLONEY ,  Philippe-Alexandre GILBERT ,  Harold KLEANTHOUS ,  Armaghan NAIK ,  Konstantin PUGACHEV ,  Saranya SRIDHAR ,  William WARREN ,  Konstantin ZELDOVICH

IPC分类号： A61K39/145 ,  A61K9/00 ,  A61K39/00 ,  C07K14/005

CPC分类号： A61K39/145 ,  A61K9/0019 ,  C07K14/005 ,  A61K2039/55555 ,  A61K2039/70 ,  C12N2760/16322 ,  C12N2760/16334

摘要： Disclosed are multivalent vaccine or immunogenic compositions comprising influenza virus hemagglutinin (HA) from standard of care influenza virus strains, or ribonucleic acid molecules encoding the same; and one or more influenza virus HA identified or designed by machine learning, or one or more ribonucleic acid molecules that encode the influenza virus HA identified or designed by machine learning. Also disclosed are methods of using the vaccine or immunogenic compositions.