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    METHOD AND KIT FOR ASSISTING DIAGNOSIS OF DISEASE IN SUBJECT
    1.
    发明申请
    METHOD AND KIT FOR ASSISTING DIAGNOSIS OF DISEASE IN SUBJECT 有权

    公开(公告)号：US20210041448A1

    公开(公告)日：2021-02-11

    申请号：US17048278

    申请日：2019-04-02

    Applicant: The University of Tokyo ,  Saraya Co., Ltd.

    Inventor： Takeo Minematsu ,  Hiromi Sanada ,  Nao Tamai ,  Yoshihiko Hirata ,  Yuka Oda

    IPC: G01N33/68 ,  G01N1/30 ,  G01N33/573 ,  A61B10/00

    Abstract: A problem to be solved by the present invention is to provide a method of assisting diagnosis of the health condition of a subject by correcting variation in an amount of a collected disease marker, which is caused by variation in the skin barrier function of the subject, and acquiring information reflecting the health condition of the subject accurately, and to solve the problem, the present invention provides a method of assisting diagnosis of a disease in a subject using a disease marker and a reference marker, the method including: applying, to a skin surface of the subject, a sheet capable of generating an attractive force due to electrostatic interaction between the sheet and each of the disease and reference markers; detaching the sheet from the skin surface; measuring the amount of each of the disease and reference markers that are attached to the sheet; and acquiring information on the disease in the subject based on a value obtained by correcting the measured amount of the disease marker with the measured amount of the reference marker, wherein the reference marker is annexin A2.

    Reagent kit for detecting biofilm and method for detecting biofilm
    2.
    发明授权
    Reagent kit for detecting biofilm and method for detecting biofilm 有权

    公开(公告)号：US11572578B2

    公开(公告)日：2023-02-07

    申请号：US17263851

    申请日：2019-07-31

    Applicant: SARAYA CO., LTD.

    Inventor： Yoriko Kato ,  Yuka Oda ,  Emiko Kawamukai ,  Yoshihiko Hirata

    IPC: C12Q1/04

    Abstract: The present invention relates to a reagent kit for detecting biofilm in test tissue, the reagent kit comprising: (a) a pretreatment liquid comprising at least one surfactant selected, from the group consisting of nonionic surfactants, amphoteric surfactants, and cationic surfactants, (b) a staining liquid comprising a dye, and (c) a decolorizing liquid comprising at least one surfactant selected from the group consisting of nonionic surfactants, amphoteric surfactants, and cationic surfactants; wherein after a membrane is brought into contact with the test tissue and released from contact, the pretreatment liquid (a), the staining liquid (b), and the decolorizing liquid (c) are brought into contact with the contact surface of the membrane in this order.

    Sophorolipid compound and composition comprising same
    6.
    发明授权
    Sophorolipid compound and composition comprising same 有权

    公开(公告)号：US10752650B2

    公开(公告)日：2020-08-25

    申请号：US14911174

    申请日：2014-08-06

    Applicant: SARAYA CO., LTD.

    Inventor： Michiaki Araki ,  Yoshihiko Hirata

    IPC: C07H15/10 ,  A61K8/60 ,  C07H15/04 ,  C07H15/06 ,  A21D2/16 ,  A23L2/52 ,  C12P19/44 ,  A61Q19/00 ,  A23L29/10 ,  A61Q19/10

    Abstract: The subject invention provides a novel SL that is widely applicable to various fields including food or beverages, cosmetics, pharmaceuticals, and quasi-drugs.A sophorolipid compound represented by Formula (I) below: (in Formula (I), R1 represents H or a methyl group; R3 and R4 each represents H or an acetyl group; one of five R5 is a saturated or unsaturated fatty acid residue that may have an OH group, and the remaining four R5 are H; R2 represents a C9-18 alkylene group, or C9-18 alkenylene group having 1 to 3 double bonds; R6 represents hydroxy, or may form a single bond together with one of five R7 in the compound represented by Formula (II) below) (in Formula (II), R1′ represents H or methyl group; R3′ and R4′ each represents H or an acetyl group; R2′ represents a C9-18 alkylene group, or C9-18 alkenylene group having 1 to 3 double bonds).

    HIGH-PURITY ACID-FORM SOPHOROLIPID (SL) CONTAINING COMPOSITION AND PROCESS FOR PREPARING SAME
    7.
    发明申请
    HIGH-PURITY ACID-FORM SOPHOROLIPID (SL) CONTAINING COMPOSITION AND PROCESS FOR PREPARING SAME 审中-公开
    包含组合物的高纯酸型磺酸（SL）及其制备方法

    公开(公告)号：US20150112049A1

    公开(公告)日：2015-04-23

    申请号：US14382480

    申请日：2013-03-01

    Applicant: Saraya Co., Ltd.

    Inventor： Yoshihiko Hirata ,  Mizuyuki Ryu ,  Hitoshi Ito ,  Michiaki Araki

    IPC: C07H15/10

    CPC classification number: C07H15/10 ,  A23L29/10 ,  A23L33/12 ,  A61K8/602 ,  A61K2800/10 ,  A61Q19/00 ,  C07H15/04

    Abstract: The present invention provides a high-purity acid-form sophorolipid (SL)-containing composition characterized by substantially not containing acetic acid. The high-purity acid-form SL-containing composition can be produced, for example, by the following method: (i) adjusting the pH of a partially purified acid-form SL-containing composition to an acidic range; and (ii-a) subjecting an acidified partially purified acid-form SL-containing composition obtained in step (i) to chromatography to acquire a fraction containing an acid-form SL, or (ii-b) leaving the acidified partially purified acid-form SL-containing composition obtained in step (i) to stand under a low-temperature condition to acquire a resulting gelled object.

    Abstract translation: 本发明提供了一种含有基本上不含乙酸的高纯度酸形式的含有喔疮脂（SL）的组合物。 高纯度酸形式的含SL的组合物可以通过例如以下方法制备：（i）将部分纯化的含酸型SL的组合物的pH调节至酸性范围; 和（ii-a）将步骤（i）中获得的酸化的部分纯化的含酸形式的含SL的组合物进行色谱以获得含有酸型SL的级分，或（ii-b）将酸化的部分纯化的酸 - 将步骤（i）中获得的含SL的组合物置于低温条件下以获得所得胶凝物。

    LOW-TOXICITY SOPHOROLIPID-CONTAINING COMPOSITION AND USE THEREFOR
    10.
    发明申请
    LOW-TOXICITY SOPHOROLIPID-CONTAINING COMPOSITION AND USE THEREFOR 审中-公开
    低毒性含SOPHOROLIPID的组合物及其用途

    公开(公告)号：US20160324747A1

    公开(公告)日：2016-11-10

    申请号：US15061330

    申请日：2016-03-04

    Applicant: Saraya Co., Ltd.

    Inventor： Hitoshi Ito ,  Michiaki Araki ,  Yoshihiko Hirata

    IPC: A61K8/60 ,  A61Q19/10 ,  A61Q5/02 ,  A61K9/00 ,  A61K47/26 ,  A61Q5/00 ,  A61Q11/00 ,  A61L15/42 ,  A61L15/20 ,  A61Q19/00 ,  A61Q19/02 ,  A61K8/34 ,  A61K47/12

    Abstract: The present invention provides a low-toxicity sophorolipid-containing composition. The low-toxicity sophorolipid-containing composition contains at least a coloring component, an acidic sophorolipid, a fatty acid, and a hydroxy fatty acid that are derived from an SL-producing yeast culture. The composition contains the following components in the following proportions, in terms of dry weight, based on the total amount of the acidic sophorolipid, a lactonic sophorolipid, the fatty acid, and the hydroxy fatty acid in the composition taken as 100 mass %: (1) acidic sophorolipid: 94 to 99.99 mass %, (2) lactonic sophorolipid: 0 to 2 mass %, (3) total amount of fatty acid and hydroxy fatty acid: 0.01 to 4 mass %

    Abstract translation: 本发明提供了一种含有低毒性的含槐糖脂的组合物。 含有毒性的含槐糖脂的组合物至少含有来自SL产生酵母培养物的着色成分，酸性SL，脂肪酸和羟基脂肪酸。 以组合物中的酸性SL，内酯SL，脂肪酸和羟基脂肪酸的总量为100质量％，以干重计，按以下比例含有以下组分：（ 1）酸性SL：94〜99.99质量％，（2）内酯性SL：0〜2质量％，（3）脂肪酸和羟基脂肪酸的总量：0.01〜4质量％。

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