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1.发明申请公开(公告)号：US20170032947A1
公开(公告)日：2017-02-02
申请号：US15039924
申请日：2013-11-28
Applicant: SHIMADZU CORPORATION
Inventor： Yuko KOBAYASHI , Tairo OGURA
CPC classification number: H01J49/005 , G01N30/7266 , H01J49/0036 , H01J49/0045 , H01J49/4215
Abstract: In a mass spectrometric method of the invention, a mass spectrometer (2) is used having a mass separation unit (231, 234) before and after a collision cell (232) for fragmenting ions. When a product ion corresponding to a precursor ion set for a sample is selected by performing product ion scan with respect to the precursor ion, an exclusion range of mass-to-charge ratios is set based on information on non-selection ions input by a user, and a product ion that satisfies a predefined criterion is selected within a range of mass-to-charge ratios excluding the exclusion range in a product ion spectrum. According to the mass spectrometric method of the invention, product ions suited for measurement on a target compound can be selected.
Abstract translation: 在本发明的质谱法中，使用质谱分离装置（2），在质子分离单元（231,234）之前和之后，用于使离子分离。 当通过相对于前体离子进行产物离子扫描来选择对应于为样品设定的前体离子的产物离子时，基于由输入的非选择离子的信息设置质荷比的排除范围 用户和满足预定标准的产物离子在除乘积离子谱中的排除范围之外的质荷比范围内选择。 根据本发明的质谱法，可以选择适合于目标化合物的测定的产物离子。
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公开(公告)号：US20230184643A1
公开(公告)日：2023-06-15
申请号：US17916499
申请日：2021-04-03
Applicant: SHIMADZU CORPORATION , JP SCIENTIFIC LIMITED
Inventor： Janusz B. PAWLISZYN , Milaan THIRUKUMARAN , Varoon SINGH , Yohei ARAO , Yuka FUJITO , Masayuki NISHIMURA , Tairo OGURA
CPC classification number: G01N1/405 , H01J49/165
Abstract: A method for identifying a target component of interest in a specimen by probe electrospray ionization mass spectrometry, including: (1) adsorbing the target component of interest onto an extraction phase for adsorbing the target component of interest from the specimen by immersing a probe into the specimen, wherein the probe is at least partially coated with the extraction phase; (2) removing the probe from the specimen and optionally quick rising it by dipping in or spraying water or acetone/water mixtures; (3) adhering solvent to the extraction phase; (4) desorbing the target component of interest into the solvent from the extraction phase; (5) electrospraying the target component of interest desorbed in the solvent adhered to the probe on the ionization source at atmospheric pressure by applying a voltage to the probe to spray aerosolized ionized droplets out of the probe; and (6) identifying the target component of interest present in the aerosolized ionized droplets.
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公开(公告)号：US20170343519A1
公开(公告)日：2017-11-30
申请号：US15536273
申请日：2014-12-15
Applicant: SHIMADZU CORPORATION
Inventor： Tairo OGURA , Mikael LEVI
CPC classification number: G01N30/08 , G01N30/14 , G01N30/26 , G01N30/462 , G01N30/468 , G01N2030/027 , G01N2030/085 , G01N2030/143
Abstract: A liquid chromatograph includes: a concentration column for capturing a target component; an analysis column for separating the target component from other components; first passage-switching units for switching between the state of forming a passage through which a sample-introduction mobile phase containing the liquid sample is fed to the concentration column, and the state of forming a passage through which an eluant for eluting the target component captured in the concentration column is fed to the concentration column; a storage unit for storing the eluant; and a second passage-switching unit for switching between the state of forming a passage through which an analysis mobile phase is fed to the analysis column and a passage through which the eluant from the concentration column is fed to the storage unit, and the state of forming a passage through which analysis mobile phase is fed to the analysis column via the storage unit.
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公开(公告)号：US20160209378A1
公开(公告)日：2016-07-21
申请号：US14914354
申请日：2013-08-26
Applicant: SHIMADZU CORPORATION
Inventor： Yuko KOBAYASHI , Hiroshi SUGAWARA , Tairo OGURA
CPC classification number: G01N30/72 , G01N30/8644 , H01J49/0031 , H01J49/4225
Abstract: When setting analysis conditions, an analysis operator sets, on a dwell-time calculation/loop-time listing window, the target value of a loop time corresponding to the measurement-time interval to repeat an analysis for one ion, and clicks a dwell time calculation button. Then, a dwell time calculator computes the dwell time for each event, based on the target value of the loop time, the arrangement of events set at that point in time, the number of target ion species set in each event, and other conditional factors. The calculated result is displayed in a dwell time calculation result display field in a listing table. The largest and smallest values of the dwell time are displayed in the largest/smallest dwell time display field. The analysis operator checks this display and changes the target value of the loop time and/or the measurement time of the event so as to achieve an appropriate dwell time.
Abstract translation: 在设置分析条件时，分析算子在停留时间计算/循环时间列表窗口上设置与测量时间间隔相对应的循环时间的目标值，以重复对一个离子的分析，并且点击停留时间 计算按钮。 然后，驻留时间计算器基于循环时间的目标值，在该时间点设置的事件的排列，每个事件中设定的目标离子种类的数量以及其他条件因子来计算每个事件的停留时间 。 计算结果显示在列表表中的停留时间计算结果显示字段中。 驻留时间的最大和最小值显示在最大/最小的停留时间显示字段中。 分析操作员检查该显示并改变循环时间的目标值和/或事件的测量时间，以便达到适当的停留时间。
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Patent Agency Ranking
公开(公告)号：US20160042929A1
公开(公告)日：2016-02-11
申请号：US14780077
申请日：2013-03-26
Applicant: SHIMADZU CORPORATION
Inventor： Tairo OGURA
CPC classification number: H01J49/005 , G01N30/7206 , G01N30/7233 , H01J49/0031 , H01J49/0045
Abstract: A mass spectrometer including a memory unit storing information indicating combinations of precursor ions for CIDs in respective stages. If an MS1 spectrum on which CID is not performed is obtained during execution of an analysis, a precursor ion selector determines whether an ion registered as a precursor ion for the first-stage CID exists on the MS1 spectrum, based on the list held in the memory unit. If the ion exists, an MS2 analysis in which the ion is set as a precursor ion is immediately executed. Subsequently, the precursor ion selector determines whether or not an ion registered as a precursor ion for the second-stage CID in association with the precursor ion for the first-stage CID exists on an MS2 spectrum. If the ion exists, an MS3 analysis in which the ion is set as a precursor ion is immediately executed, so that an MS3 spectrum is acquired.
Abstract translation: 一种质谱仪，包括存储单元，其存储指示各阶段中用于CID的前体离子的组合的信息。 如果在执行分析期间获得不执行CID的MS1频谱，则前体离子选择器基于保存在MS1频谱中的列表来确定在MS1频谱上是否存在注册为第一级CID的前体离子的离子 存储单元 如果离子存在，则立即执行离子被设置为前体离子的MS2分析。 随后，前体离子选择器确定在MS2光谱上是否存在与第一级CID的前体离子相关联的作为第二级CID的前体离子注册的离子。 如果离子存在，则立即执行其中离子被设置为前体离子的MS3分析，从而获得MS3光谱。
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6.发明公开公开(公告)号：US20230400440A1
公开(公告)日：2023-12-14
申请号：US18021717
申请日：2020-08-24
Applicant: SHIMADZU CORPORATION
Inventor： Tairo OGURA
CPC classification number: G01N30/7266 , G01N30/8606 , G01N2800/24 , G01N2030/027
Abstract: A mass spectrometry control device includes a deriver that derives, based on a set of allergens that are detectable without being distinguished from one another among a plurality of allergens to be detected and data that indicates a plurality of peptides produced by subjecting each allergen to a cleavage process, first peptides produced in common when the plurality of allergens included in the set are subjected to the cleavage process and at least one of parameters for detecting the first peptides, and a setter that sets a condition of mass spectrometry to detect at least one of the first peptides.
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公开(公告)号：US20230384263A1
公开(公告)日：2023-11-30
申请号：US18021082
申请日：2020-08-24
Applicant: SHIMADZU CORPORATION
Inventor： Tairo OGURA
IPC: G01N27/62
CPC classification number: G01N27/62
Abstract: An analysis device for data obtained in mass spectrometry, includes an information acquirer that acquires detection information representing a peptide that is detected when a sample is subjected to a cleavage process and then subjected to mass spectrometry, and an information producer that produces allergen information in regard to an allergen included in the sample based on the detection information and data representing a peptide that is produced when each allergen is subjected to the cleavage process, wherein the information producer produces the allergen information based on a combination of a plurality of peptides in a case in which the plurality of peptides produced from one allergen in the data are detected.
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公开(公告)号：US20210151311A1
公开(公告)日：2021-05-20
申请号：US16618660
申请日：2018-06-04
Applicant: SHIMADZU CORPORATION , PHYTRONIX TECHNOLOGIES INC.
Inventor： Tairo OGURA , Jean LACOURSIERE , Pierre PICARD
Abstract: A mass spectrometer having a triple ionization interface for ionizing sample components is provided. The ionization interface of the mass spectrometer includes a means for ionizing sample components via electrostatic ionization, atmospheric pressure chemical ionization, and laser diode thermal desorption.
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公开(公告)号：US20200025725A1
公开(公告)日：2020-01-23
申请号：US16485006
申请日：2017-03-17
Applicant: SHIMADZU CORPORATION
Inventor： Yuka FUJITO , Tairo OGURA , Kenichiro TANAKA
Abstract: A supercritical fluid device includes an analytical channel, a liquid delivery part for delivering a mobile phase constituting a supercritical fluid in the analytical channel, a back pressure regulator for controlling a pressure of the analytical channel so as to cause the mobile phase in the analytical channel to reach a supercritical state, a sample injecting device that includes a sample holder for holding a sample and a switching valve for switching between a state where the sample holder is arranged on the analytical channel and a state where the sample holder is not arranged on the analytical channel, a bypass channel whose one end is connected to a position upstream of the sample injecting device and whose other end is connected to a position downstream of the sample injecting device on the analytical channel, and an analytical column for separating a sample introduced by the sample injecting device into individual components, the analytical column is provided downstream of the position to which the other end of the bypass channel is connected on the analytical channel.
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