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公开(公告)号：US12130285B2
公开(公告)日：2024-10-29
申请号：US18608025
申请日：2024-03-18
发明人： Keunho Ahn , Zhenyu Deng , Martina De Geus , Anh Tuan Nguyen
IPC分类号： G01N33/543 , G01N15/10 , G01N15/14
CPC分类号： G01N33/5436 , G01N15/1012 , G01N15/14 , G01N2015/1006
摘要： Provided herein are hydrogel beads that mimic live, dead, and apoptotic cells. The present disclosure also provides kits and compositions of hydrogel beads. The present disclosure further comprises methods of using the kits, compositions, and hydrogel beads to determine if a target cell sample includes one or more live, dead, or apoptotic cells.
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公开(公告)号：US11761877B2
公开(公告)日：2023-09-19
申请号：US17732218
申请日：2022-04-28
发明人： Jeffrey Kim , Oliver Liu , Jeremy Agresti , Anh Tuan Nguyen
CPC分类号： G01N15/1012 , C12Q1/04 , G01N1/28 , G01N15/1434 , G01N15/1459 , G01N2001/2893 , G01N2015/0065 , G01N2015/1006 , G01N2015/1018 , G01N2015/149
摘要： Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to at least one optical property of a target cell. In this regard, the hydrogel particles provided herein, in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.
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公开(公告)号：US09714897B2
公开(公告)日：2017-07-25
申请号：US15018769
申请日：2016-02-08
发明人： Jeffrey Kim , Oliver Liu , Jeremy Agresti , Anh Tuan Nguyen
CPC分类号： G01N15/1012 , C12Q1/04 , G01N1/28 , G01N15/1434 , G01N15/1459 , G01N2001/2893 , G01N2015/0065 , G01N2015/1006 , G01N2015/1018 , G01N2015/149
摘要： Hydrogel particles and their use in cytometic applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to the at least one optical property of a target cell. In this regard, the hydrogel particles provided herein in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.
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公开(公告)号：US20160299051A1
公开(公告)日：2016-10-13
申请号：US15145856
申请日：2016-05-04
发明人： Jeffrey Kim , Oliver Liu , Jeremy Agresti , Anh Tuan Nguyen
CPC分类号： G01N15/1012 , G01N15/14 , G01N21/6428 , G01N2015/1006 , G01N2015/1018 , G01N2015/1415 , G01N2015/149 , G01N2021/6439
摘要： The present disclosure relates to compositions comprising a hydrogel particle with optical properties substantially similar to the optical properties of a target cell, and methods for their use.
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公开(公告)号：US12066369B2
公开(公告)日：2024-08-20
申请号：US18417986
申请日：2024-01-19
发明人： Jeffrey Kim , Oliver Liu , Jeremy Agresti , Anh Tuan Nguyen
IPC分类号： G01N15/10 , C12Q1/04 , G01N1/28 , G01N15/14 , G01N15/1434 , G01N15/01 , G01N15/149
CPC分类号： G01N15/1012 , C12Q1/04 , G01N1/28 , G01N15/1434 , G01N15/1459 , G01N2001/2893 , G01N15/01 , G01N2015/1006 , G01N2015/1014 , G01N15/149
摘要： Synthetic human cell mimic hydrogel particles and their use in cytometric or coulter device applications are described. The synthetic human cell mimic hydrogel particles described herein are selectively tunable to have at least one optical, volumetric, or capacitance property that is substantially similar to a corresponding optical, volumetric, or capacitance property of the human cell mimic hydrogel particle's natural biological cell counterpart.
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公开(公告)号：US11927519B2
公开(公告)日：2024-03-12
申请号：US18139741
申请日：2023-04-26
发明人： Jeffrey Kim , Oliver Liu , Jeremy Agresti , Anh Tuan Nguyen
CPC分类号： G01N15/1012 , C12Q1/04 , G01N1/28 , G01N15/1434 , G01N15/1459 , G01N2001/2893 , G01N2015/0065 , G01N2015/1006 , G01N2015/1018 , G01N2015/149
摘要： Synthetic human cell mimic hydrogel particles and their use in cytometric or coulter device applications are described. The synthetic human cell mimic hydrogel particles described herein are selectively tunable to have at least one optical, volumetric, or capacitance property that is substantially similar to a corresponding optical, volumetric, or capacitance property of the human cell mimic hydrogel particle's natural biological cell counterpart.
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公开(公告)号：US10753846B2
公开(公告)日：2020-08-25
申请号：US15625394
申请日：2017-06-16
发明人： Jeffrey Kim , Oliver Liu , Jeremy Agresti , Anh Tuan Nguyen
摘要： Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to the at least one optical property of a target cell. In this regard, the hydrogel particles provided herein in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.
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公开(公告)号：US11598768B2
公开(公告)日：2023-03-07
申请号：US17307127
申请日：2021-05-04
发明人： Jeffrey Kim , Anh Tuan Nguyen , Brandon Miller
IPC分类号： G01N33/543 , G01N33/53 , C08J3/075 , G01N15/14
摘要： Compositions comprising multiple hydrogel particles having substantially the same diameter, but with each subgrouping of particles from the multiple hydrogel particles having different associated values for one or more passive optical properties that can be deconvoluted using cytometric instrumentation. Each hydrogel particle from the multiple hydrogel particles can be functionalized with a different biochemical or chemical target from a set of targets. A method of preparing hydrogel particles includes forming droplets and polymerizing the droplets, with optional functionalization.
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公开(公告)号：US10481068B2
公开(公告)日：2019-11-19
申请号：US15895307
申请日：2018-02-13
发明人： Jeffrey Kim , Oliver Liu , Jeremy Agresti , Anh Tuan Nguyen
摘要： The present disclosure relates to compositions comprising a hydrogel particle with optical properties substantially similar to the optical properties of a target cell, and methods for their use.
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公开(公告)号：US09915598B2
公开(公告)日：2018-03-13
申请号：US15145856
申请日：2016-05-04
发明人： Jeffrey Kim , Oliver Liu , Jeremy Agresti , Anh Tuan Nguyen
CPC分类号： G01N15/1012 , G01N15/14 , G01N21/6428 , G01N2015/1006 , G01N2015/1018 , G01N2015/1415 , G01N2015/149 , G01N2021/6439
摘要： The present disclosure relates to compositions comprising a hydrogel particle with optical properties substantially similar to the optical properties of a target cell, and methods for their use.
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