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104 条记录 (耗时 0.041 秒)

    CRYSTAL STRUCTURE OF AURORA-2 PROTEIN AND BINDING POCKETS THEREOF
    5.
    发明申请
    CRYSTAL STRUCTURE OF AURORA-2 PROTEIN AND BINDING POCKETS THEREOF 失效
    AURORA-2蛋白质的结晶结构及其结合点

    公开(公告)号：US20110104782A1

    公开(公告)日：2011-05-05

    申请号：US12890826

    申请日：2010-09-27

    申请人： Graham Cheetham ,  Ronald Knegtel ,  Lovorka Swenson ,  Joyce T. Coll ,  Suzanne Renwick ,  Peter Weber

    发明人： Graham Cheetham ,  Ronald Knegtel ,  Lovorka Swenson ,  Joyce T. Coll ,  Suzanne Renwick ,  Peter Weber

    IPC分类号： C12N9/96 ,  C12N9/12

    CPC分类号： C12N9/1205 ,  C07K2299/00

    摘要： The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data storage medium encoded with the structural coordinates of Aurora-2 binding pockets and methods of using a computer to evaluate the ability of a compound to bind to the molecule or molecular complex. This invention also provides methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention provides methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Aurora-2 or homologues thereof.

    摘要翻译： 本发明提供包含Aurora-2或其同系物的结合口袋的结晶分子或分子复合物。 本发明还提供了包含Aurora-2的晶体。 本发明还涉及包含用Aurora-2结合口袋的结构座标编码的数据存储介质的计算机，以及使用计算机评价化合物结合分子或分子复合物的能力的方法。 本发明还提供了使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明提供了使用结构坐标筛选和设计结合Aurora-2或其同系物的化合物（包括抑制性化合物）的方法。

    Method and plant for producing low-temperature coke
    6.
    发明授权
    Method and plant for producing low-temperature coke 失效
    生产低温焦炭的方法和装置

    公开(公告)号：US07803268B2

    公开(公告)日：2010-09-28

    申请号：US10540073

    申请日：2003-12-01

    申请人： Andreas Orth ,  Martin Hirsch ,  Peter Weber

    发明人： Andreas Orth ,  Martin Hirsch ,  Peter Weber

    IPC分类号： C10G9/14 ,  B01J8/18

    CPC分类号： C10B49/10 ,  C10B53/04

    摘要： The present invention relates to a method and a plant for producing low 15 temperature coke, in which granular coal and possibly further solids are heated to a temperature of 700 to 1050° C. in a fluidized-bed reactor (2) by means of an oxygen-containing gas. To improve the utilization of energy it is proposed to introduce a first gas or gas mixture from below through at least one gas supply tube (3) into a mixing chamber region (8) of the reactor (2), the gas supply tube (3) being at least partly surrounded by a stationary annular fluidized bed (6) which is fluidized by supplying fluidizing gas. The gas velocities of the first gas or gas mixture and of the fluidizing gas for the annular fluidized bed (6) are adjusted such that the Particle-Froude-Numbers in the gas supply tube (3) are between 1 and 100, in the annular fluidized bed (6) between 0.02 and 2 and in the 25 mixing chamber (8) between 0.3 and 30.

    摘要翻译： 本发明涉及一种用于生产低温度焦炭的方法和设备，其中颗粒煤和可能的其它固体在流化床反应器（2）中通过以下方式加热至700至1050℃的温度： 含氧气体。 为了提高能量利用率，建议从下方将至少一个气体供给管（3）的第一气体或气体混合物引入反应器（2）的混合室区域（8），气体供给管（3） ）至少部分地被固定的环形流化床（6）包围，所述固定环形流化床通过供应流化气体而被流化。 调整第一气体或气体混合物和用于环形流化床（6）的流化气体的气体速度，使得气体供应管（3）中的“微粒 - 弗劳德数”为1至100，在环形 流化床（6）在0.02和2之间，在25混合室（8）中在0.3和30之间。

    Shaping Tool
    7.
    发明申请
    Shaping Tool 有权
    整形工具

    公开(公告)号：US20090293571A1

    公开(公告)日：2009-12-03

    申请号：US11991512

    申请日：2006-09-08

    申请人： Robert Vehof ,  Peter Weber ,  Armin Meier ,  Dieter Hartmann ,  Falk Leitner ,  Mathieu Brand ,  Reiner Kelsch

    发明人： Robert Vehof ,  Peter Weber ,  Armin Meier ,  Dieter Hartmann ,  Falk Leitner ,  Mathieu Brand ,  Reiner Kelsch

    IPC分类号： B21D37/16

    CPC分类号： B21D37/16 ,  B21D22/02 ,  Y10T29/49805

    摘要： The invention relates to a shaping tool which is used to shape a workpiece, in particular, a sheet steel component, comprising at least two shaping tool halves. Contoured regions are provided in the region of the shaping tool halves in order to give the workpiece a corresponding contour, at least in sections. Each shaping tool half has a shaping surface shell which is oriented towards the workpiece and a support shaping half. The shaping surface shell is arranged on the support shaping half and comprises a shaping surface, which is oriented towards the workpiece, and a rear side which is oriented away from the workpiece. The support shaping half comprises a contoured area which essentially corresponds to the contour of the workpiece which is to be produced and the contoured area is surrounded by a flange area. Grooves are provided in the contoured area in the region of the rear side of the shaping surface shell. The support shaping half comprises receiving surfaces which receive the support shaping half in a positive fit and the receiving surfaces and the grooves form cooling channels. The support shaping half comprises supply channels and discharge channels such that a coolant can be guided through the channels.

    摘要翻译： 本发明涉及一种成形工具，其用于成形工件，特别是包括至少两个成形工具半部的钢板组件。 轮廓区域设置在成型工具半部分的区域中，以便至少在部分中给予工件相应的轮廓。 每个成型工具一半具有朝向工件定向的成形表面壳和形成一半的支撑件。 成形表面壳体布置在支撑成形半部上，并且包括朝向工件定向的成形表面和远离工件的后侧。 支撑成形半部包括基本上对应于待生产的工件的轮廓并且轮廓区域被凸缘区域包围的轮廓区域。 在成形表面壳的后侧的区域中的轮廓区域中设置槽。 支撑成形半部包括以正配合接收支撑成形半部的接收表面，并且接收表面和槽形成冷却通道。 支撑成形半部包括供应通道和排出通道，使得可以将冷却剂引导通过通道。

    3D Ultrasonic imaging method
    8.
    发明申请
    3D Ultrasonic imaging method 审中-公开
    3D超声波成像方法

    公开(公告)号：US20080139937A1

    公开(公告)日：2008-06-12

    申请号：US11974689

    申请日：2007-10-15

    申请人： Timothy J. Nohara ,  Peter Weber ,  Richard Bernardi

    发明人： Timothy J. Nohara ,  Peter Weber ,  Richard Bernardi

    IPC分类号： A61B8/00

    CPC分类号： G01S15/8927 ,  A61B8/483 ,  G01S7/52044 ,  G01S7/52047 ,  G01S15/8925 ,  G01S15/8993 ,  G10K11/346

    摘要： A probe for electronic volume data acquisition using ultrasound incorporates a plurality of transducer elements arranged in a two dimensional array having an azimuth direction and an elevation direction. The transducer elements have a first element size in the azimuth dimension and a second element size in the elevation dimension. At least one of the first and second element sizes is at least twice a characteristic wavelength of a waveform used to drive the array of transducer elements, where the characteristic wavelength is defined as the wavelength corresponding to a center frequency of the waveform. Image data is generated in a scanning process using a CAC-BF technique in an azimuth dimension and/or an elevation dimension, to form an ultrasound image line, image plane, or image data cube.

    摘要翻译： 用于使用超声波的电子体积数据采集的探头包括以具有方位角方向和仰角方向的二维阵列排列的多个换能器元件。 换能器元件具有方位角尺寸中的第一元件尺寸和高度尺寸中的第二元件尺寸。 第一和第二元件尺寸中的至少一个是用于驱动换能器元件阵列的波形的特征波长的至少两倍，其中特征波长被定义为对应于波形的中心频率的波长。 图像数据在使用CAC-BF技术的方位角尺寸和/或仰角尺寸的扫描过程中产生，以形成超声图像线，图像平面或图像数据立方体。

    3D ultrasonic imaging apparatus and method
    9.
    发明授权
    3D ultrasonic imaging apparatus and method 有权
    3D超声波成像设备及方法

    公开(公告)号：US07285094B2

    公开(公告)日：2007-10-23

    申请号：US10353152

    申请日：2003-01-28

    申请人： Timothy J. Nohara ,  Peter Weber ,  Richard Bernardi

    发明人： Timothy J. Nohara ,  Peter Weber ,  Richard Bernardi

    IPC分类号： A61B8/00

    CPC分类号： G01S15/8927 ,  A61B8/483 ,  G01S7/52044 ,  G01S7/52047 ,  G01S15/8925 ,  G01S15/8993 ,  G10K11/346

    摘要： A probe for electronic volume data acquisition using ultrasound incorporates a plurality of transducer elements arranged in a two dimensional array having an azimuth direction and an elevation direction. The transducer elements have a first element size in the azimuth dimension and a second element size in the elevation dimension. At least one of the first and second element sizes is at least twice a characteristic wavelength of a waveform used to drive the array of transducer elements, where the characteristic wavelength is defined as the wavelength corresponding to a center frequency of the waveform. Image data is generated in a scanning process using a CAC-BF technique in an azimuth dimension and/or an elevation dimension, to form an ultrasound image line, image plane, or image data cube.

    摘要翻译： 用于使用超声波的电子体积数据采集的探头包括以具有方位角方向和仰角方向的二维阵列排列的多个换能器元件。 换能器元件具有方位角尺寸中的第一元件尺寸和高度尺寸中的第二元件尺寸。 第一和第二元件尺寸中的至少一个是用于驱动换能器元件阵列的波形的特征波长的至少两倍，其中特征波长被定义为对应于波形的中心频率的波长。 图像数据在使用CAC-BF技术的方位角尺寸和/或仰角尺寸的扫描过程中产生，以形成超声图像线，图像平面或图像数据立方体。