公开(公告)号：US06732144B1

公开(公告)日：2004-05-04

申请号：US09713249

申请日：2000-11-16

申请人： Sachio Kizu ,  Tetsuro Muranaga ,  Yoshiaki Takabatake ,  Shigeyasu Natsubori ,  Toru Imai ,  Shinya Amano

发明人： Sachio Kizu ,  Tetsuro Muranaga ,  Yoshiaki Takabatake ,  Shigeyasu Natsubori ,  Toru Imai ,  Shinya Amano

IPC分类号： G06F1516

CPC分类号： H04L41/0893 ,  H04L29/06 ,  H04L67/14 ,  H04L69/329 ,  Y10S707/99952

摘要： At member registration step, a master transmits a certificate and a priority to a slave. The certificate indicates that the slave receiving it belongs to the same data synchronization group as the master. The priority is used to solve a data conflict. At data synchronization, after it is determined that members belong to the same data synchronization group by the certificate, data synchronization processing is performed between arbitrary members in which an input device and a display device such as a wrist watch are limited. Data synchronization does not require a specific server.

摘要翻译： 在会员注册步骤中，主服务器向从设备发送证书和优先级。 证书表示接收到的从属属于与主机相同的数据同步组。 优先级用于解决数据冲突。 在数据同步时，在通过证书确定成员属于同一数据同步组之后，在诸如手表的输入装置和显示装置受限的任意构件之间执行数据同步处理。 数据同步不需要特定的服务器。

公开(公告)号：US07189708B2

公开(公告)日：2007-03-13

申请号：US10252057

申请日：2002-09-23

申请人： Yasuto Suzuki ,  Mikako Watanabe ,  Naoko Tsuji ,  Shigeru Moriwaki ,  Shinya Amano

发明人： Yasuto Suzuki ,  Mikako Watanabe ,  Naoko Tsuji ,  Shigeru Moriwaki ,  Shinya Amano

IPC分类号： A61K31/545

CPC分类号： C07C237/20 ,  A61K38/05

摘要： A topical skin composition containing a dipeptide compound represented by formula (1) or a salt of the dipeptide: wherein R1 represents a hydrogen atom, an alkyl group, an alkanoyl group, or —CH(R6)COOR7 (wherein R6 represents a hydrogen atom or a lower alkyl group, and R7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group); R2 represents a hydrogen atom or an alkyl group which may have a substituent; R3 represents a lower alkyl group or a phenyl group; R4 represents a hydrogen atom or a lower alkyl group, and may form a heterocyclic ring together with R5 and an adjacent nitrogen atom; R5 represents a hydrogen atom, an alkyl group which may have a substituent, or an aralkyl group which may have a substituent, and may form the heterocyclic ring together with R4; X represents —COOR8 (wherein R8 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group) or —SO3H; and n is an integer of 0-4; and a pharmaceutically acceptable carrier therefor.

摘要翻译： 含有由式（1）表示的二肽化合物或二肽盐的局部皮肤组合物：其中R 1表示氢原子，烷基，烷酰基或-CH（R' 其中R 6表示氢原子或低级烷基，R 7表示氢原子或低级烷基， 氢原子，低级烷基，低级烯基或芳烷基）。 R 2表示氢原子或可以具有取代基的烷基; R 3表示低级烷基或苯基; R 4表示氢原子或低级烷基，并且可以与R 5和相邻的氮原子一起形成杂环; R 5表示氢原子，可以具有取代基的烷基或可具有取代基的芳烷基，并且可以与R 4一起形成杂环， ; X表示-COOR 8（其中R 8表示氢原子，低级烷基，低级烯基或芳烷基）或-SO 3 H; 并且n是0-4的整数; 和其药学上可接受的载体。

公开(公告)号：US07371740B2

公开(公告)日：2008-05-13

申请号：US10930773

申请日：2004-09-01

申请人： Shinya Amano ,  Tomohiko Sano ,  Hiromitsu Kawada ,  Takashi Kawata

发明人： Shinya Amano ,  Tomohiko Sano ,  Hiromitsu Kawada ,  Takashi Kawata

IPC分类号： A61K31/66 ,  C07F9/02

CPC分类号： A61K8/556 ,  A61K8/26 ,  A61Q19/00 ,  A61Q19/08 ,  C07F9/091

摘要： The present invention relates to a phosphorylated glyceryl ether aluminum salt represented by the general formula (1): (wherein R1 represents an alkyl or an alkenyl group with 8 to 32 carbon atoms; R2 represents a hydrogen atom, a phosphoric acid residue or —CH2CH(OR2)CH2OR1 (wherein R1 and R2 are the same as described above, provided that a repeated binding number is 4 at the most when R2 is —CH2CH(OR2)CH2OR1); X1 represents a hydrogen atom or a phosphoric acid residue, and at least one of X1 and R2 is a phosphoric acid residue; Y represents an alkali metal atom or an alkaline earth metal atom; m represents a number from 0.3 to 1, and n represents a number from 0 to 1), and an external dermatological agent containing the same. The compound has benefits such as an excellent pore contracting activity and also a good solubility in oil.

摘要翻译： 本发明涉及由通式（1）表示的磷酸化甘油醚铝盐：（其中R 1表示具有8至32个碳原子的烷基或烯基; R 2 表示氢原子，磷酸残基或-CH 2 CH 2（OR 2）CH 2或OR 1 （其中R 1和R 2）与上述相同，条件是当R 2为重复结合数最多为4时， / SUP>是-CH 2 CH 2（OR 2）CH 2或OR 1）; X < 1 表示氢原子或磷酸残基，X 1和R 2 2中的至少一个为磷酸残基; Y表示碱金属 原子或碱土金属原子; m表示0.3〜1的数，n表示0〜1的数），以及含有该原子的外用皮肤病药。 该化合物具有优异的孔收缩活性和在油中的良好的溶解性。

公开(公告)号：US06489291B1

公开(公告)日：2002-12-03

申请号：US09678615

申请日：2000-10-04

申请人： Yasuto Suzuki ,  Mikako Watanabe ,  Naoko Tsuji ,  Shigeru Moriwaki ,  Shinya Amano

发明人： Yasuto Suzuki ,  Mikako Watanabe ,  Naoko Tsuji ,  Shigeru Moriwaki ,  Shinya Amano

IPC分类号： A01N3718

CPC分类号： C07C237/20 ,  A61K38/05

摘要： A topical skin composition containing a dipeptide compound represented by, formula (1) or a salt of the dipeptide: wherein R1 represents a, hydrogen atom, an alkyl group, an alkanoyl group, or —CH(R6)COOR7 (wherein R6 represents a hydrogen atom or a lower alkyl group, and R7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group); R2 represents a hydrogen atom or an alkyl group which may have a substituent; R3 represents a lower alkyl group or a phenyl group; R4 represents a hydrogen atom or a lower alkyl group, and may form a heterocyclic ring together with R5 and an adjacent nitrogen atom; R5 represents a hydrogen atom, an alkyl group which may have a substituent, or an aralkyl group which may have a substituent, and may form the heterocyclic ring together with R4; X represents —COOR8 (wherein R8 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group) or —SO3H; and n is an integer of 0-4; and a pharmaceutically acceptable carrier therefor.

摘要翻译： 含有由式（1）表示的二肽化合物或二肽盐的局部皮肤组合物：其中R1表示氢原子，烷基，烷酰基或-CH（R6）COOR7（其中R6表示 氢原子或低级烷基，R7表示氢原子，低级烷基，低级烯基或芳烷基）; R2表示氢原子或可具有取代基的烷基; R3表示低级 烷基或苯基; R 4表示氢原子或低级烷基，并且可以与R 5和相邻的氮原子一起形成杂环; R 5表示氢原子，可以具有取代基的烷基或 可以具有取代基的芳烷基，也可以与R4形成杂环; X表示-COOR8（其中R8表示氢原子，低级烷基，低级烯基或芳烷基）或-SO3H; andn是0-4的整数; 和其药学上可接受的载体。

公开(公告)号：US08440645B2

公开(公告)日：2013-05-14

申请号：US13001701

申请日：2009-07-30

申请人： Yoshiya Sugai ,  Hiroshi Hashimoto ,  Shinya Amano ,  Shotaro Ito ,  Yoshie Shimotoyodome ,  Yoriko Nakagiri

发明人： Yoshiya Sugai ,  Hiroshi Hashimoto ,  Shinya Amano ,  Shotaro Ito ,  Yoshie Shimotoyodome ,  Yoriko Nakagiri

IPC分类号： A61K8/55 ,  A61Q19/00 ,  C07F9/06

CPC分类号： A61K8/55 ,  A61K8/553 ,  A61K31/661 ,  A61Q19/00 ,  A61Q19/007

摘要： Provided are a drug, a cosmetic, etc. for promoting production of ceramide.Provided is a ceramide production promoter including a compound represented by the formula (1) or salts thereof as an active ingredient (in the formula, R1 represents a phosphono group or a hydrogen atom, R2 represents an alkyl group having 8 to 24 carbon atoms or an acyl group having 8 to 24 carbon atoms, and R3 represents an alkyl group having 1 to 24 carbon atoms when R1 represents a phosphono group or represents a phosphono group when R1 represents a hydrogen atom, or a salt thereof as an active ingredient.

摘要翻译： 提供促进神经酰胺生产的药物，化妆品等。 本发明提供含有式（1）表示的化合物或其盐作为活性成分的神经酰胺生产促进剂（式中，R1表示膦酰基或氢原子，R2表示碳原子数8〜24的烷基或 或其盐作为活性成分，当R 1表示膦酰基时，R 3表示碳原子数为1〜24的烷基，R 1表示氢原子时的膦酰基。

公开(公告)号：US20050234023A1

公开(公告)日：2005-10-20

申请号：US10930773

申请日：2004-09-01

申请人： Shinya Amano ,  Tomohiko Sano ,  Hiromitsu Kawada ,  Takashi Kawata

发明人： Shinya Amano ,  Tomohiko Sano ,  Hiromitsu Kawada ,  Takashi Kawata

IPC分类号： A61K8/00 ,  A61K8/26 ,  A61K8/55 ,  A61K8/58 ,  A61K31/66 ,  A61K31/661 ,  A61P17/16 ,  A61Q19/00 ,  A61Q19/08 ,  C07F9/06 ,  C07F9/08 ,  C07F9/09

CPC分类号： A61K8/556 ,  A61K8/26 ,  A61Q19/00 ,  A61Q19/08 ,  C07F9/091

摘要： The present invention relates to a phosphorylated glyceryl ether aluminum salt represented by the general formula (1): (wherein R1 represents an alkyl or an alkenyl group with 8 to 32 carbon atoms; R2 represents a hydrogen atom, a phosphoric acid residue or —CH2CH(OR2)CH2OR1 (wherein R1 and R2 are the same as described above, provided that a repeated binding number is 4 at the most when R2 is —CH2CH(OR2)CH2OR1); X1 represents a hydrogen atom or a phosphoric acid residue, and at least one of X1 and R2 is a phosphoric acid residue; Y represents an alkali metal atom or an alkaline earth metal atom; m represents a number from 0.3 to 1, and n represents a number from 0 to 1), and an external dermatological agent containing the same. The compound has benefits such as an excellent pore contracting activity and also a good solubility in oil.

摘要翻译： 本发明涉及由通式（1）表示的磷酸化甘油醚铝盐：（其中R 1表示具有8至32个碳原子的烷基或烯基; R 2 表示氢原子，磷酸残基或-CH 2 CH 2（OR 2）CH 2或OR 1 （其中R 1和R 2）与上述相同，条件是当R 2为重复结合数最多为4时， / SUP>是-CH 2 CH 2（OR 2）CH 2或OR 1）; X < 1 表示氢原子或磷酸残基，X 1和R 2 2中的至少一个为磷酸残基; Y表示碱金属 原子或碱土金属原子; m表示0.3〜1的数，n表示0〜1的数），以及含有该原子的外用皮肤病药。 该化合物具有优异的孔收缩活性和在油中的良好的溶解性。

公开(公告)号：US5349368A

公开(公告)日：1994-09-20

申请号：US799884

申请日：1991-12-02

申请人： Kimihito Takeda ,  Hideki Hirakawa ,  Hisahiro Adachi ,  Shinya Amano

发明人： Kimihito Takeda ,  Hideki Hirakawa ,  Hisahiro Adachi ,  Shinya Amano

IPC分类号： G06F17/27 ,  G06F17/28 ,  G09G5/34

CPC分类号： G06F17/274 ,  G06F17/2872

摘要： This invention relates to a display method, and in particularly, to an output display method for a machine translation system, Display section has a predetermined portion for translated sections, and identifies original sentences or characters when a referring request is made to a part of the translated sentences. Highlight display of original sentences may be scrolled synchronously with the scrolling of the translated sentences or independently.

摘要翻译： 本发明涉及一种显示方法，特别地涉及一种机器翻译系统的输出显示方法，显示部分具有用于翻译部分的预定部分，并且当向所述机器翻译系统的一部分进行推荐请求时，识别原始句子或字符 翻译句子。 原文句子的显示可以与翻译的句子的滚动或独立滚动同步滚动。

公开(公告)号：US20110105439A1

公开(公告)日：2011-05-05

申请号：US13001701

申请日：2009-07-30

申请人： Yoshiya Sugai ,  Hiroshi Hashimoto ,  Shinya Amano ,  Shotaro Ito ,  Yoshie Shimotoyodome ,  Yoriko Nakagiri

发明人： Yoshiya Sugai ,  Hiroshi Hashimoto ,  Shinya Amano ,  Shotaro Ito ,  Yoshie Shimotoyodome ,  Yoriko Nakagiri

IPC分类号： A61K8/55 ,  C07F9/09 ,  A61Q19/00

CPC分类号： A61K8/55 ,  A61K8/553 ,  A61K31/661 ,  A61Q19/00 ,  A61Q19/007

摘要： Provided are a drug, a cosmetic, etc. for promoting production of ceramide.Provided is a ceramide production promoter including a compound represented by the formula (1) or salts thereof as an active ingredient (in the formula, R1 represents a phosphono group or a hydrogen atom, R2 represents an alkyl group having 8 to 24 carbon atoms or an acyl group having 8 to 24 carbon atoms, and R3 represents an alkyl group having 1 to 24 carbon atoms when R1 represents a phosphono group or represents a phosphono group when R1 represents a hydrogen atom, or a salt thereof as an active ingredient.

摘要翻译： 提供用于促进神经酰胺生产的药物，化妆品等。 本发明提供含有式（1）表示的化合物或其盐作为活性成分的神经酰胺生产促进剂（式中，R1表示膦酰基或氢原子，R2表示碳原子数8〜24的烷基或 或其盐作为活性成分，当R 1表示膦酰基时，R 3表示碳原子数为1〜24的烷基，R 1表示氢原子时的膦酰基。

公开(公告)号：US5862403A

公开(公告)日：1999-01-19

申请号：US603759

申请日：1996-02-16

申请人： Tatsunori Kanai ,  Shigehiro Asano ,  Takeshi Aikawa ,  Shinya Amano

发明人： Tatsunori Kanai ,  Shigehiro Asano ,  Takeshi Aikawa ,  Shinya Amano

IPC分类号： G06F3/06 ,  G06F11/10 ,  H04L12/54 ,  H04L12/861 ,  H04L12/883 ,  G06F15/02

CPC分类号： H04L12/5693 ,  G06F11/1076 ,  G06F11/1088 ,  G06F3/0601 ,  H04L49/90 ,  H04L49/9021 ,  H04L49/9047 ,  H04L49/9073 ,  G06F2003/0692

摘要： A continuous data server apparatus incorporating a plurality of buffer memory units for storing the continuous data read out by the data memory control units and to be given to the communication control unit, at least one buffer memory unit being provided dedicatedly for each combination of one data memory control unit group formed by at least one data memory control unit and one communication control unit group formed by at least one communication control unit. The apparatus may further incorporate a plurality of calculation units connected in series, where each calculation unit is connected between corresponding one data memory control unit group and at least one buffer memory unit, and carrying out a prescribed calculation processing. The continuous data can be arranged over a plurality of data memory control units in word units, such that the data memory control units read out the continuous data in block units, the buffer memory units store the continuous data in block units, and the communication control unit transfers the continuous data obtained by reading out data the buffer memory units sequentially in word units.

摘要翻译： 一种连续数据服务器装置，其包括多个缓冲存储器单元，用于存储由数据存储器控制单元读出的连续数据，并被提供给通信控制单元，至少一个缓冲存储器单元专门为一个数据的每个组合提供 由至少一个数据存储器控制单元形成的存储器控​​制单元组和由至少一个通信控制单元形成的一个通信控制单元组。 该装置还可以包括串联连接的多个计算单元，其中每个计算单元连接在相应的一个数据存储器控制单元组和至少一个缓冲存储器单元之间，并执行规定的计算处理。 连续数据可以以单位单位布置在多个数据存储器控制单元上，使得数据存储器控制单元以块为单位读出连续数据，缓冲存储器单元以块为单位存储连续数据，并且通信控制 单元通过以字为单位顺序地读出缓冲存储器单元的数据而获得的连续数据。

公开(公告)号：US5783601A

公开(公告)日：1998-07-21

申请号：US631987

申请日：1996-04-15

申请人： Masanori Tanahashi ,  Takahide Minami ,  Yukihiro Ohashi ,  Shinya Amano ,  Kouichi Niinaka

发明人： Masanori Tanahashi ,  Takahide Minami ,  Yukihiro Ohashi ,  Shinya Amano ,  Kouichi Niinaka

IPC分类号： A61K8/30 ,  A61K8/00 ,  A61K8/02 ,  A61K8/36 ,  A61K8/365 ,  A61K8/37 ,  A61K8/42 ,  A61K31/19 ,  A61Q19/00

CPC分类号： A61K8/365 ,  A61K8/0212 ,  A61K8/37 ,  A61K8/375 ,  A61K8/42 ,  A61Q19/00 ,  Y10S514/844 ,  Y10S514/847 ,  Y10S514/873

摘要： Disclosed herein is an external skin-care composition comprising hydroxycarboxylic acids or derivatives thereof represented by the general formulae (1), (2), and (3), or the salts thereof: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are each independently a hydroxyl group, an amino group or an alkoxyl group which may be substituted by 1-3 hydroxyl groups, l is a number of 7-11, m is a number of 6-10, and n is a number of 5-9. This composition exhibits an excellent moisturizing effect, moisturizes the skin, has a great effect in preventing skin roughness and shows excellent effects in enhancing the clear skin tone of the skin and reducing skin dullness, and is hence particularly useful for cosmetic skin-care compositions.

摘要翻译： 本文公开了包含由通式（1），（2）和（3）表示的羟基羧酸或其衍生物或其盐的外用护肤组合物：其中（1） （3）其中R1，R2和R3各自独立地是羟基，氨基或可被1-3个羟基取代的烷氧基，l是7-11的数，m是 数量6-10，n为5-9。 该组合物表现出优异的保湿效果，保湿皮肤，对预防皮肤粗糙度具有很大的效果，并且在增强皮肤的清晰肤色和减少皮肤暗淡方面具有优异的效果，因此特别适用于化妆品护肤组合物。