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公开(公告)号：US08440645B2
公开(公告)日：2013-05-14
申请号：US13001701
申请日：2009-07-30
申请人： Yoshiya Sugai , Hiroshi Hashimoto , Shinya Amano , Shotaro Ito , Yoshie Shimotoyodome , Yoriko Nakagiri
发明人： Yoshiya Sugai , Hiroshi Hashimoto , Shinya Amano , Shotaro Ito , Yoshie Shimotoyodome , Yoriko Nakagiri
CPC分类号： A61K8/55 , A61K8/553 , A61K31/661 , A61Q19/00 , A61Q19/007
摘要： Provided are a drug, a cosmetic, etc. for promoting production of ceramide.Provided is a ceramide production promoter including a compound represented by the formula (1) or salts thereof as an active ingredient (in the formula, R1 represents a phosphono group or a hydrogen atom, R2 represents an alkyl group having 8 to 24 carbon atoms or an acyl group having 8 to 24 carbon atoms, and R3 represents an alkyl group having 1 to 24 carbon atoms when R1 represents a phosphono group or represents a phosphono group when R1 represents a hydrogen atom, or a salt thereof as an active ingredient.
摘要翻译： 提供促进神经酰胺生产的药物，化妆品等。 本发明提供含有式（1）表示的化合物或其盐作为活性成分的神经酰胺生产促进剂（式中，R1表示膦酰基或氢原子，R2表示碳原子数8〜24的烷基或 或其盐作为活性成分，当R 1表示膦酰基时，R 3表示碳原子数为1〜24的烷基，R 1表示氢原子时的膦酰基。
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公开(公告)号：US20110105439A1
公开(公告)日：2011-05-05
申请号：US13001701
申请日：2009-07-30
申请人： Yoshiya Sugai , Hiroshi Hashimoto , Shinya Amano , Shotaro Ito , Yoshie Shimotoyodome , Yoriko Nakagiri
发明人： Yoshiya Sugai , Hiroshi Hashimoto , Shinya Amano , Shotaro Ito , Yoshie Shimotoyodome , Yoriko Nakagiri
CPC分类号： A61K8/55 , A61K8/553 , A61K31/661 , A61Q19/00 , A61Q19/007
摘要： Provided are a drug, a cosmetic, etc. for promoting production of ceramide.Provided is a ceramide production promoter including a compound represented by the formula (1) or salts thereof as an active ingredient (in the formula, R1 represents a phosphono group or a hydrogen atom, R2 represents an alkyl group having 8 to 24 carbon atoms or an acyl group having 8 to 24 carbon atoms, and R3 represents an alkyl group having 1 to 24 carbon atoms when R1 represents a phosphono group or represents a phosphono group when R1 represents a hydrogen atom, or a salt thereof as an active ingredient.
摘要翻译： 提供用于促进神经酰胺生产的药物，化妆品等。 本发明提供含有式（1）表示的化合物或其盐作为活性成分的神经酰胺生产促进剂（式中，R1表示膦酰基或氢原子，R2表示碳原子数8〜24的烷基或 或其盐作为活性成分，当R 1表示膦酰基时，R 3表示碳原子数为1〜24的烷基，R 1表示氢原子时的膦酰基。
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公开(公告)号：US09445987B2
公开(公告)日：2016-09-20
申请号：US13499810
申请日：2010-09-27
IPC分类号： A61K31/58 , A61K8/97 , A23L1/00 , A23L1/30 , A61K8/63 , A61K36/185 , A61K36/28 , A61K36/48 , A61Q19/00 , C07D493/08
CPC分类号： A61K8/63 , A23L33/105 , A23P10/30 , A23V2002/00 , A61K8/042 , A61K8/064 , A61K8/97 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K31/58 , A61K36/185 , A61K36/28 , A61K36/48 , A61K2800/805 , A61Q19/00 , A61Q19/007 , C07D493/08
摘要： A ceramide production enhancer and a moisturizer containing, as an active ingredient, an extract of at least one plant selected from the group consisting of Chenopodium hybridum, Melia toosendan, Indigofera tinctoria, Cirsium japonicum, Catalpa ovate, and Tagetes erecta, or a compound represented by the following Formula (1): wherein, R represents an acyl group having 1 to 5 carbon atom(s).
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公开(公告)号：US20120196841A1
公开(公告)日：2012-08-02
申请号：US13499810
申请日：2010-09-27
CPC分类号： A61K8/63 , A23L33/105 , A23P10/30 , A23V2002/00 , A61K8/042 , A61K8/064 , A61K8/97 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K31/58 , A61K36/185 , A61K36/28 , A61K36/48 , A61K2800/805 , A61Q19/00 , A61Q19/007 , C07D493/08
摘要： A ceramide production enhancer and a moisturizer containing, as an active ingredient, an extract of at least one plant selected from the group consisting of Chenopodium hybridum, Melia toosendan, Indigofera tinctoria, Cirsium japonicum, Catalpa ovate, and Tagetes erecta, or a compound represented by the following Formula (1): wherein, R represents an acyl group having 1 to 5 carbon atom(s).
摘要翻译： 一种神经酰胺生产增强剂和保湿剂，其含有至少一种植物的提取物作为活性成分，所述植物提取物选自杂Chen藜，美洲梧桐，靛蓝，日本C um，梓vate和万寿菊，或代表 通过下式（1）表示：其中，R表示碳原子数为1〜5的酰基。
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公开(公告)号：US20050112082A1
公开(公告)日：2005-05-26
申请号：US10967481
申请日：2004-10-19
申请人： Masahide Hoshino , Hiroaki Saito , Yoshiya Sugai , Mituru Sugiyama , Yoshinori Nishizawa , Yasushi Katayama
发明人： Masahide Hoshino , Hiroaki Saito , Yoshiya Sugai , Mituru Sugiyama , Yoshinori Nishizawa , Yasushi Katayama
摘要： The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): (wherein, R1a and R1b are the same or different and each represents a C1-23 hydrocarbon group, R2a and R2b are the same or different and each represents a divalent C1-6 hydrocarbon group, R3s are the same or different and each represents a divalent C2-6 hydrocarbon group and n stands for 1 to 100). The composition for external application, humectant and skin barrier function reinforcing agent basically improve the water retaining ability and barrier functions of the horny layer, are excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.
摘要翻译： 本发明涉及外用的组合物，保湿剂和皮肤屏障功能增强剂，其各自含有下式（1）表示的二酰胺衍生物：（其中，R 1a和R“ SUP> 1b相同或不同，分别表示C 1-13烃基，R 2a和R 2b均为 相同或不同，并且各自表示二价C 1-6 - 烃基，R 3相同或不同，并且各自表示二价C 2-6 烃基，n表示1〜100）。 外用组合物，保湿剂和皮肤屏障功能增强剂基本上提高了角质层的保水能力和阻隔功能，具有优异的混溶性和混合稳定性，可以以低成本高效制备。
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公开(公告)号：US5753707A
公开(公告)日：1998-05-19
申请号：US708974
申请日：1996-09-06
申请人： Masahide Hoshino , Hiroshi Kusuoku , Tadashi Hase , Atsuko Otsuka , Ichiro Tokimitsu , Akira Yamamuro , Yoshiya Sugai , Koji Yoshino , Youichi Arai , Shinichi Meguro
发明人： Masahide Hoshino , Hiroshi Kusuoku , Tadashi Hase , Atsuko Otsuka , Ichiro Tokimitsu , Akira Yamamuro , Yoshiya Sugai , Koji Yoshino , Youichi Arai , Shinichi Meguro
IPC分类号： A61K8/68 , A61K31/16 , A61K31/335 , A61Q17/00 , A61Q19/00 , C07C233/18 , C07C235/08 , C07C237/14 , C07C237/22 , C07D317/30 , A61K6/00 , C07C233/00
CPC分类号： A61Q17/00 , A61K8/68 , A61Q19/00 , C07C237/22 , C07D317/30 , Y10S514/847
摘要： An amide derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents a C.sub.1-40 hydrocarbon; R.sup.2 represents a C.sub.1-6 alkylene; R.sup.3 represents H, OH or alkoxyl; R.sup.4 represents a C.sub.1-39 hydrocarbon; R.sup.5 represents ##STR2## with the proviso that when R.sup.5 represents ##STR3## R.sup.3 does not represent OH; and a composition of the amide derivative for topical application to human skin. The composition improves the barrier function of the stratum corneum, providing improvement and prevention of dermatitis, skin roughness, or similar disorders.
摘要翻译： 由下式（1）表示的酰胺衍生物：其中R1表示C1-40烃; R2代表C1-6亚烷基; R3表示H，OH或烷氧基; R4代表C1-39烃; R5表示
，条件是当R 5表示R 3不表示OH时; 以及用于局部施用于人皮肤的酰胺衍生物的组合物。 该组合物改善角质层的屏障功能，提供改善和预防皮炎，皮肤粗糙度或类似疾病。 -
公开(公告)号：US07550135B2
公开(公告)日：2009-06-23
申请号：US10967481
申请日：2004-10-19
申请人： Masahide Hoshino , Hiroaki Saito , Yoshiya Sugai , Mituru Sugiyama , Yoshinori Nishizawa , Yasushi Katayama
发明人： Masahide Hoshino , Hiroaki Saito , Yoshiya Sugai , Mituru Sugiyama , Yoshinori Nishizawa , Yasushi Katayama
IPC分类号： A61K8/88
摘要： The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): (wherein, R1a and R1b are the same or different and each represents a C1-23 hydrocarbon group, R2a and R2b are the same or different and each represents a divalent C1-6 hydrocarbon group, R3s are the same or different and each represents a divalent C2-6 hydrocarbon group and n stands for 1 to 100). The composition for external application, humectant and skin barrier function reinforcing agent basically improve the water retaining ability and barrier functions of the horny layer, are excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.
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公开(公告)号：US07528171B2
公开(公告)日：2009-05-05
申请号：US10730048
申请日：2003-12-09
申请人： Masahide Hoshino , Hiroaki Saito , Yoshiya Sugai , Mituru Sugiyama , Yoshinori Nishizawa , Yasushi Katayama
发明人： Masahide Hoshino , Hiroaki Saito , Yoshiya Sugai , Mituru Sugiyama , Yoshinori Nishizawa , Yasushi Katayama
摘要： The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): (wherein, R1a and R1b are the same or different and each represents a C1-23 hydrocarbon group, R2a and R2b are the same or different and each represents a divalent C1-6 hydrocarbon group, R3s are the same or different and each represents a divalent C2-6 hydrocarbon group and n stands for 1 to 100). The composition for external application, humectant and skin barrier function reinforcing agent basically improve the water retaining ability and barrier functions of the horny layer, are excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.
摘要翻译： 本发明涉及外用的组合物，保湿剂和皮肤屏障功能增强剂，其各自含有下式（1）表示的二酰胺衍生物：（其中，R 1a和R 1b相同或不同，各自表示 C1-23烃基，R2a和R2b相同或不同，各自表示二价C1-6烃基，R3相同或不同，表示二价C 2-6烃基，n表示1〜100）。 外用组合物，保湿剂和皮肤屏障功能增强剂基本上提高了角质层的保水能力和阻隔功能，具有优异的混溶性和混合稳定性，可以以低成本高效制备。
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公开(公告)号：US07351716B2
公开(公告)日：2008-04-01
申请号：US10731249
申请日：2003-12-10
申请人： Masahide Hoshino , Yoshiya Sugai , Akiyo Kameyama , Hiroaki Saito , Yoshinori Nishizawa , Yutaka Takagi
发明人： Masahide Hoshino , Yoshiya Sugai , Akiyo Kameyama , Hiroaki Saito , Yoshinori Nishizawa , Yutaka Takagi
IPC分类号： A61K7/48 , A61K7/00 , A61K7/06 , C07C233/18
CPC分类号： C07C233/20 , A61K8/42 , A61Q5/00 , A61Q5/02 , A61Q17/00 , A61Q19/00 , A61Q19/007 , A61Q19/08 , C07C233/18
摘要： The present invention relates to a dermatologic preparation containing a diamide derivative represented by the following formula (1): (wherein, R1 represents a linear or branched hydrocarbon group having 1 to 22 carbon atoms which may be substituted by one or more hydroxy and/or alkoxy groups, R2 represents a linear or branched divalent hydrocarbon group having 1 to 12 carbon atoms, and R3 represents a linear or branched divalent hydrocarbon group having 1 to 42 carbon atoms). This diamide derivative (1) is capable of fundamentally improving the water retention capacity and barrier functions of the horny layer, is excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.
摘要翻译： 本发明涉及含有下式（1）表示的二酰胺衍生物的皮肤病学制剂：（其中，R 1表示可被取代的具有1〜22个碳原子的直链或支链烃基 通过一个或多个羟基和/或烷氧基，R 2表示具有1至12个碳原子的直链或支链二价烃基，R 3表示直链或支链的 具有1至42个碳原子的二价烃基）。 该二酰胺衍生物（1）能够从根本上提高角质层的保水能力和阻隔功能，混溶性和混合稳定性优异，可以低成本有效地制备。
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公开(公告)号：US07087646B2
公开(公告)日：2006-08-08
申请号：US10082115
申请日：2002-02-26
申请人： Masahide Hoshino , Hiroaki Saito , Yoshiya Sugai , Mituru Sugiyama , Yoshinori Nishizawa , Yasushi Katayama
发明人： Masahide Hoshino , Hiroaki Saito , Yoshiya Sugai , Mituru Sugiyama , Yoshinori Nishizawa , Yasushi Katayama
IPC分类号： A01N37/18 , A61K6/00 , C07C233/00
摘要： The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): (wherein, R1a and R1b are the same or different and each represents a C1-23 hydrocarbon group, R2a and R2b are the same or different and each represents a divalent C1-6 hydrocarbon group, R3s are the same or different and each represents a divalent C2-6 hydrocarbon group and n stands for 1 to 100). The composition for external application, humectant and skin barrier function reinforcing agent basically improve the water retaining ability and barrier functions of the horny layer, are excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.
摘要翻译： 本发明涉及外用的组合物，保湿剂和皮肤屏障功能增强剂，其各自含有下式（1）表示的二酰胺衍生物：（其中，R 1a和R“ SUP> 1b相同或不同，分别表示C 1-13烃基，R 2a和R 2b均为 相同或不同，并且各自表示二价C 1-6 - 烃基，R 3相同或不同，并且各自表示二价C 2-6 烃基，n表示1〜100）。 外用组合物，保湿剂和皮肤屏障功能增强剂基本上提高了角质层的保水能力和阻隔功能，具有优异的混溶性和混合稳定性，可以以低成本高效制备。
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