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1.发明授权公开(公告)号：US09063136B2
公开(公告)日：2015-06-23
申请号：US13388654
申请日：2010-07-30
IPC分类号： G01N33/543 , B01L3/00 , C12M3/06 , C12M1/12 , C12M1/00 , C12M1/42 , C12M1/34 , C12N1/06 , C12N11/14 , C12N13/00 , G01N33/50
CPC分类号： G01N33/5438 , B01L3/502715 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2300/0645 , B01L2300/0809 , C12M23/16 , C12M25/00 , C12M25/04 , C12M29/10 , C12M35/02 , C12M41/38 , C12N1/066 , C12N11/14 , C12N13/00 , G01N33/5005
摘要： The present invention provides a microfluidic devices and methods of use thereof for the concentration and capture of cells. A pulsed non-Faradaic electric field is applied relative to a sample under laminar flow, which results to the concentration and capture of charged analyte. Advantageously, pulse timing is selected to avoid problems associated with ionic screening within the channel. At least one of the electrodes within the channel is coated with an insulating layer to prevent a Faradaic current from flowing in the channel. Under pulsed application of a unipolar voltage to the electrodes, charged analyte within the sample is moved towards one of the electrodes via a transient electrophoretic force.
摘要翻译： 本发明提供一种微流体装置及其用于浓缩和捕获细胞的方法。 在层流下相对于样品施加脉冲非法拉第电场，这导致带电分析物的浓度和捕获。 有利地，选择脉冲定时以避免与通道内的离子屏蔽相关的问题。 通道内的至少一个电极涂有绝缘层，以防止法拉第电流在通道中流动。 在脉冲施加单极电压给电极的情况下，样品内的带电分析物经由瞬时电泳力朝向其中一个电极移动。
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2.发明申请公开(公告)号：US20120190040A1
公开(公告)日：2012-07-26
申请号：US13388654
申请日：2010-07-30
CPC分类号： G01N33/5438 , B01L3/502715 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2300/0645 , B01L2300/0809 , C12M23/16 , C12M25/00 , C12M25/04 , C12M29/10 , C12M35/02 , C12M41/38 , C12N1/066 , C12N11/14 , C12N13/00 , G01N33/5005
摘要： The present invention provides a microfluidic devices and methods of use thereof for the concentration and capture of cells. A pulsed non-Faradic electric field is applied relative to a sample under laminar flow, which results to the concentration and capture of charged analyte. Advantageously, pulse timing is selected to avoid problems associated with ionic screening within the channel. At least one of the electrodes within the channel is coated with an insulating layer to prevent a Faradic current from flowing in the channel. Under pulsed application of a unipolar voltage to the electrodes, charged analyte within the sample is moved towards one of the electrodes via a transient electrophoretic force.
摘要翻译： 本发明提供一种微流体装置及其用于浓缩和捕获细胞的方法。 在层流下相对于样品施加脉冲非法拉第电场，这导致带电分析物的浓度和捕获。 有利地，选择脉冲定时以避免与通道内的离子屏蔽相关的问题。 通道内的至少一个电极涂有绝缘层，以防止法拉第电流在通道中流动。 在脉冲施加单极电压给电极的情况下，样品内的带电分析物经由瞬时电泳力朝向其中一个电极移动。
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公开(公告)号：US07666355B2
公开(公告)日：2010-02-23
申请号：US11369204
申请日：2006-03-07
申请人： Tino Alavie , Keith Beckley , Andrew Hudson , Stephen W. Leonard , Robert Maaskant , Samad Talebpour , William Yang
发明人： Tino Alavie , Keith Beckley , Andrew Hudson , Stephen W. Leonard , Robert Maaskant , Samad Talebpour , William Yang
IPC分类号： G01N21/00
CPC分类号： G01N35/0092 , G01N21/253 , G01N35/028 , G01N35/109 , G01N2001/288 , G01N2035/00326 , G01N2035/0422 , G01N2035/0465 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/2575
摘要： The present invention provides a bar-code driven, completely automated, microplate-based analyzer system for performing chemical, biochemical or biological assays. The analyzer is a modular, bench-top instrument that compactly integrates subsystems for sample dispensing, liquid handling, microplate transport, thermal incubation, vortexing, solid phase separation and optical reading. An internal processor is included for automating the instrument, and a user interface to facilitate communication with the operator via a touch-sensitive liquid-crystal display (LCD), and communicating with a remote network via multiple protocols. The analyzer includes firmware resident within the processing system and the user interface allows the operator to select pre-defined assay batch protocols and the user interface is configured in such as way so as to restrict an operator from programming the firmware.
摘要翻译： 本发明提供了用于进行化学，生物化学或生物测定的条形码驱动的，完全自动化的基于微孔板的分析仪系统。 分析仪是一种模块化的台式仪器，可紧凑集成样品分配，液体处理，微孔板输送，热孵育，涡旋，固相分离和光学读取的子系统。 包括用于使仪器自动化的内部处理器，以及用于通过触敏液晶显示器（LCD）促进与操作者通信的用户接口，以及经由多个协议与远程网络通信。 分析器包括驻留在处理系统内的固件，用户界面允许操作员选择预定义的测试批处理协议，并且用户界面被配置为以限制操作者编程固件的方式。
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公开(公告)号：US20060210435A1
公开(公告)日：2006-09-21
申请号：US11369204
申请日：2006-03-07
申请人： Tino Alavie , Keith Beckley , Andrew Hudson , Stephen Leonard , Robert Maaskant , Samad Talebpour , William Yang
发明人： Tino Alavie , Keith Beckley , Andrew Hudson , Stephen Leonard , Robert Maaskant , Samad Talebpour , William Yang
IPC分类号： G01N35/00
CPC分类号： G01N35/0092 , G01N21/253 , G01N35/028 , G01N35/109 , G01N2001/288 , G01N2035/00326 , G01N2035/0422 , G01N2035/0465 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/2575
摘要： The present invention provides a bar-code driven, completely automated, microplate-based analyzer system for performing chemical, biochemical or biological assays. The analyzer is a modular, bench-top instrument that compactly integrates subsystems for sample dispensing, liquid handling, microplate transport, thermal incubation, vortexing, solid phase separation and optical reading. An internal processor is included for automating the instrument, and a user interface to facilitate communication with the operator via a touch-sensitive liquid-crystal display (LCD), and communicating with a remote network via multiple protocols. The analyzer includes firmware resident within the processing system and the user interface allows the operator to select pre-defined assay batch protocols and the user interface is configured in such as way so as to restrict an operator from programming the firmware.
摘要翻译： 本发明提供了用于进行化学，生物化学或生物测定的条形码驱动的，完全自动化的基于微孔板的分析仪系统。 分析仪是一种模块化的台式仪器，可紧凑集成样品分配，液体处理，微孔板输送，热孵育，涡旋，固相分离和光学读取的子系统。 包括用于使仪器自动化的内部处理器，以及用于通过触敏液晶显示器（LCD）促进与操作者通信的用户接口，以及经由多个协议与远程网络通信。 分析器包括驻留在处理系统内的固件，用户界面允许操作员选择预定义的测试批处理协议，并且用户界面被配置为以限制操作者编程固件的方式。
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公开(公告)号：US5694501A
公开(公告)日：1997-12-02
申请号：US550565
申请日：1995-10-31
申请人： A. Tino Alavie , Shangyuan Huang , Michael J. LeBlanc , Robert Maaskant , Raymond M. Measures , Myo Myint Ohn
发明人： A. Tino Alavie , Shangyuan Huang , Michael J. LeBlanc , Robert Maaskant , Raymond M. Measures , Myo Myint Ohn
CPC分类号： G02B6/022 , G02B6/02085 , G02F1/0134 , G02F1/0147 , G02F2201/307
摘要： The present invention provides a method and apparatus for controlling the detailed strain field imposed on a guided-wave Bragg grating. The spectral and temporal form of radiant energy traveling down optical fibers is important in many fields, including communications and sensing. The spectral distribution and center wavelength of short optical pulses is of particular importance. In the communication field the information carrying capacity of an optical fiber can be limited by the dispersion experienced by short pulses as they propagate along an optical fiber. Chirped fiber optic intracore Bragg gratings can be used to compensate for this dispersion. However, a grating with a different degree of chirp would be required for each particular communication system. This control of the intra-grating strain distribution allows the grating to be tuned over a broad spectral range or chirped in a manner that permits it to compensate for a wide range of dispersion with or without a shift in the grating center wavelength. In addition, precise control of the strain distribution along a grating can be used to manufacture a variety of spectral filters.
摘要翻译： 本发明提供一种用于控制施加在导波布拉格光栅上的详细应变场的方法和装置。 辐射能量的光谱和时间形式沿着光纤行进是许多领域的重要内容，包括通信和传感。 短光脉冲的光谱分布和中心波长是特别重要的。 在通信领域中，光纤的信息承载能力可以通过短脉冲沿着光纤传播而经历的色散受到限制。 啁啾光纤内腔布拉格光栅可用于补偿此色散。 然而，对于每个特定通信系统，将需要具有不同啁啾程度的光栅。 光栅内应变分布的这种控制允许光栅在宽的光谱范围内被调谐，或者以允许光栅在光栅中心波长有或没有偏移的情况下补偿宽范围的色散的方式进行啁啾。 此外，可以使用沿着光栅的应变分布的精确控制来制造各种光谱滤波器。
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公开(公告)号：US20070202010A1
公开(公告)日：2007-08-30
申请号：US11363521
申请日：2006-02-28
IPC分类号： B01L3/00
CPC分类号： B01L3/50853 , B01L2200/148 , B01L2200/16 , B01L2300/044 , B01L2300/0829
摘要： The present invention provides a microplate-based assay kit that incorporates all assay reagents and standards in a simple and efficient format and may be used in biochemical assays. The assay kit includes pre-filled, pre-sealed and barcoded microplates with a standard physical footprint for use in a microplate-based automated analyzer system which enables simple and efficient operation by an unskilled user via per-use factory-sealed and barcoded reagent and calibrator microplates. Such microplates allow the user to run a broad test menu without the need to monitor the arrangement and supply of internally stored reagents and standards, thus greatly simplifying the user experience and eliminating the need for highly skilled users.
摘要翻译： 本发明提供了一种基于微板的测定试剂盒，其以简单且有效的形式并入所有测定试剂和标准品，并可用于生物化学测定。 测定试剂盒包括预填充的预密封和条形码微孔板，具有用于基于微孔板的自动分析仪系统的标准物理尺寸，使得非熟练使用者能够通过使用工厂密封和条形码的试剂进行简单有效的操作， 校准器微孔板。 这样的微板允许用户运行广泛的测试菜单，而不需要监视内部存储的试剂和标准的布置和供应，从而大大简化了用户体验并且消除了对高技能用户的需要。
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公开(公告)号：US06671434B2
公开(公告)日：2003-12-30
申请号：US10124653
申请日：2002-04-17
申请人： Nigel Copner , Frank Liang , Robert Maaskant , Keith Beckley , A. Tino Alavie
发明人： Nigel Copner , Frank Liang , Robert Maaskant , Keith Beckley , A. Tino Alavie
IPC分类号： G02B634
CPC分类号： G02B6/4215 , G02B6/2932 , G02B6/29322 , G02B6/29385 , G02B6/29395 , H04J14/02
摘要： An optical performance monitor having a tunable fiber grating sandwiched between the first and second reflective surfaces of a fiber etalon provides high sensitivity, while simultaneously monitoring an optical data signal. Individual channels within the optical data signal are monitored by tuning the fiber grating over the wavelength range of the optical data signal to measure an intensity of each channel. As the tunable grating scans the wavelength range of interest, it simultaneously changes the resonant cavity length of the etalon, thus allowing the etalon to effectively monitor the tunable grating with a wavelength outside the wavelength range of the optical data signal.
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