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公开(公告)号：US09523118B2
公开(公告)日：2016-12-20
申请号：US14189762
申请日：2014-02-25
Applicant: Samsung Electronics Co., Ltd.
Inventor： Dong-hyun Park , Yeon-jeong Kim , Kyung-yeon Han
IPC: C12Q1/68
CPC classification number: C12Q1/6858 , C12Q2537/163
Abstract: Provided are a composition or a kit for detecting a nucleic acid with genetic variation including a first amplification blocking nucleic acid and a second amplification blocking nucleic acid, and a method of detecting a nucleic acid with genetic variation by using the same. Based on the above, a nucleic acid with genetic variation can be detected with high sensitivity and accuracy.
Abstract translation: 提供了用于检测具有遗传变异的核酸的组合物或试剂盒，包括第一扩增阻断核酸和第二扩增阻断核酸，以及通过使用该核酸检测具有遗传变异的核酸的方法。 基于上述，可以以高灵敏度和准确度检测出具有遗传变异的核酸。
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2.发明申请COMPOSITION AND KIT FOR SEPARATING CANCER CELL, AND METHOD OF SEPARATING CANCER CELL BY USING THE COMPOSITION AND KIT 审中-公开用于分离癌细胞的组合物和试剂盒，以及使用组合物和试剂盒分离癌细胞的方法公开(公告)号：US20150064721A1
公开(公告)日：2015-03-05
申请号：US14252284
申请日：2014-04-14
Inventor： Yeon-jeong KIM , Kyung-yeon Han , You-Sun Kim , Hui-sung Moon , Dong-hyun Park , Jong-myeon Park
IPC: G01N33/574 , C07K16/30 , C07K16/40
CPC classification number: G01N33/57492 , C07K16/2851 , C07K16/30 , G01N33/57415 , G01N33/57423 , G01N33/57434 , G01N2333/70596
Abstract: Provided is a composition and a kit for separating a cancer stem cell or a circulating tumor cell, a method of separating a cancer stem cell or a circulating tumor cell in a biological sample, and a method for diagnosing metastatic cancer.
Abstract translation: 提供了用于分离癌症干细胞或循环肿瘤细胞的组合物和试剂盒，分离生物样品中的癌症干细胞或循环肿瘤细胞的方法，以及诊断转移性癌症的方法。
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Patent Agency Ranking
3.发明授权公开(公告)号：US08911954B2
公开(公告)日：2014-12-16
申请号：US13768988
申请日：2013-02-15
Applicant: Samsung Electronics Co., Ltd.
Inventor： Kyung-yeon Han , Yeon-jeong Kim , Jae-il Lee , Jeong-gun Lee
Abstract: A polypeptide linker comprising an antibody-binding region and an enzyme cleavage region, and related compositions, kits, and methods of using same.
Abstract translation: 包含抗体结合区和酶切割区的多肽接头，以及相关组合物，试剂盒和使用它们的方法。
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4.发明授权Compositions and kits for separating cells and method of separating cells using the same 有权用于分离细胞的组合物和试剂盒以及使用其分离细胞的方法公开(公告)号：US09194778B2
公开(公告)日：2015-11-24
申请号：US13868824
申请日：2013-04-23
Applicant: Samsung Electronics Co., Ltd.
Inventor： Kyung-yeon Han , Yeon-jeong Kim , Jong-myeon Park , Chang-eun Yoo
IPC: G01N33/53 , G01N1/34 , G01N33/543 , G01N33/574
CPC classification number: G01N1/34 , G01N33/54326 , G01N33/574
Abstract: Provided are compositions, kits, and methods for separating cells including complexes of at least one type of linker capable of binding to an antibody or antigen binding fragment and a solid phase.
Abstract translation: 提供了用于分离细胞的组合物，试剂盒和方法，包括能够结合抗体或抗原结合片段和固相的至少一种类型连接体的复合物。
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公开(公告)号：US20150044725A1
公开(公告)日：2015-02-12
申请号：US14222314
申请日：2014-03-21
Applicant: Samsung Electronics Co., Ltd.
Inventor： Chang-eun YOO , Yeon-jeong Kim , Dong-hyun Park , Kyung-yeon Han
IPC: C12Q1/68
CPC classification number: C12N15/1013 , C12N15/1006
Abstract: A method of separating nucleic acids from cells, the method comprising incubating a sample comprising cells with a solid substrate that binds to the cells, whereby the cells adhere to the solid substrate; suspending the solid substrate adhered to the cells in a lysis composition comprising about 100 mM to about 300 mM of alkaline metal salt, and having a pH of about 6 to about 8; lysing the cells in the lysis composition to obtain a lysed solution; and obtaining the nucleic acids from the lysed solution; as well as related compositions and kits.
Abstract translation: 一种从细胞中分离核酸的方法，所述方法包括将包含细胞的样品与固定于细胞上的固体底物孵育，由此所述细胞粘附到固体基质上; 将固体底物悬浮在包含约100mM至约300mM碱金属盐并且pH为约6至约8的裂解组合物中的细胞上; 裂解裂解组合物中的细胞以获得裂解溶液; 从裂解的溶液中获得核酸; 以及相关组合物和试剂盒。
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公开(公告)号：US20150037801A1
公开(公告)日：2015-02-05
申请号：US14180931
申请日：2014-02-14
Applicant: Samsung Electronics Co., Ltd.
Inventor： Dong-hyun PARK , Yeon-jeong Kim , Kyung-yeon Han
IPC: C12Q1/68
CPC classification number: C12Q1/6806 , C12Q2521/537 , C12Q2523/301
Abstract: Provided is a method of amplifying a nucleic acid of a cell involving applying ultrasonic waves to lyse a cell bound to a solid support to provide a cell lysate comprising a nucleic acid; separating the cell lysate from the solid support; adding a protease to the cell lysate; and amplifying the nucleic acid.
Abstract translation: 提供一种扩增细胞核酸的方法，所述方法包括施加超声波以裂解与固体支持物结合的细胞，以提供包含核酸的细胞裂解物; 将细胞裂解物与固体支持物分离; 向细胞裂解物中加入蛋白酶; 并扩增核酸。
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公开(公告)号：US20150031023A1
公开(公告)日：2015-01-29
申请号：US14189762
申请日：2014-02-25
Applicant: Samsung Electronics Co., Ltd.
Inventor： Dong-hyun PARK , Yeon-jeong Kim , Kyung-yeon Han
IPC: C12Q1/68
CPC classification number: C12Q1/6858 , C12Q2537/163
Abstract: Provided are a composition or a kit for detecting a nucleic acid with genetic variation including a first amplification blocking nucleic acid and a second amplification blocking nucleic acid, and a method of detecting a nucleic acid with genetic variation by using the same. Based on the above, a nucleic acid with genetic variation can be detected with high sensitivity and accuracy.
Abstract translation: 提供了用于检测具有遗传变异的核酸的组合物或试剂盒，包括第一扩增阻断核酸和第二扩增阻断核酸，以及通过使用该核酸检测具有遗传变异的核酸的方法。 基于上述，可以以高灵敏度和准确度检测出具有遗传变异的核酸。
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