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公开(公告)号：US08545871B2
公开(公告)日：2013-10-01
申请号：US13129658
申请日：2009-08-31
IPC分类号： A61F13/00
CPC分类号： A61K9/70 , A61K47/32 , A61K47/36 , A61L24/0031 , A61L24/043
摘要： Disclosed herein is a fibrous tissue sealant in the form of an anhydrous fibrous sheet comprising a first component which is a fibrous polymer containing electrophilic or nucleophilic groups and a second component capable of crosslinking the first component when the sheet is exposed to an aqueous medium, thereby forming a crosslinked hydrogel that is adhesive to biological tissue. The fibrous tissue sealant may be useful as a general tissue adhesive for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures, tissue repair, and to prevent post-surgical adhesions. The fibrous tissue sealant may be particularly suitable for use as a hemostatic sealant to stanch bleeding from surgical or traumatic wounds.
摘要翻译： 本文公开了一种无水纤维片形式的纤维组织密封剂，其包含第一组分，其是含有亲电子基团或亲核基团的纤维聚合物，以及当片材暴露于水性介质时能够交联第一组分的第二组分，因此 形成与生物组织粘合的交联水凝胶。 纤维组织密封剂可用作用于医疗和兽医应用的一般组织粘合剂，例如在内部手术过程中的伤口闭合，补充或替换缝合线或缝钉，组织修复，并且防止手术后粘连。 纤维组织密封剂可特别适合用作止血密封剂以从外科手术或创伤性创伤中止血。
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公开(公告)号：US20130337036A1
公开(公告)日：2013-12-19
申请号：US13968503
申请日：2013-08-16
CPC分类号： A61K9/70 , A61K47/32 , A61K47/36 , A61L24/0031 , A61L24/043
摘要： Disclosed herein is a fibrous tissue sealant in the form of an anhydrous fibrous sheet comprising a first component which is a fibrous polymer containing electrophilic or nucleophilic groups and a second component capable of crosslinking the first component when the sheet is exposed to an aqueous medium, thereby forming a crosslinked hydrogel that is adhesive to biological tissue. The fibrous tissue sealant may be useful as a general tissue adhesive for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures, tissue repair, and to prevent post-surgical adhesions. The fibrous tissue sealant may be particularly suitable for use as a hemostatic sealant to stanch bleeding from surgical or traumatic wounds.
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公开(公告)号：US20110250257A1
公开(公告)日：2011-10-13
申请号：US13129658
申请日：2009-08-31
IPC分类号： A61K9/70 , A61P17/02 , A61K31/765 , A61K9/00 , A61K47/36
CPC分类号： A61K9/70 , A61K47/32 , A61K47/36 , A61L24/0031 , A61L24/043
摘要： Disclosed herein is a fibrous tissue sealant in the form of an anhydrous fibrous sheet comprising a first component which is a fibrous polymer containing electrophilic or nucleophilic groups and a second component capable of crosslinking the first component when the sheet is exposed to an aqueous medium, thereby forming a crosslinked hydrogel that is adhesive to biological tissue. The fibrous tissue sealant may be useful as a general tissue adhesive for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures, tissue repair, and to prevent post-surgical adhesions. The fibrous tissue sealant may be particularly suitable for use as a hemostatic sealant to stanch bleeding from surgical or traumatic wounds.
摘要翻译： 本文公开了一种无水纤维片形式的纤维组织密封剂，其包含第一组分，其是含有亲电子基团或亲核基团的纤维聚合物，以及当片材暴露于水性介质时能够交联第一组分的第二组分，因此 形成与生物组织粘合的交联水凝胶。 纤维组织密封剂可用作用于医疗和兽医应用的一般组织粘合剂，例如在内部手术过程中的伤口闭合，补充或替换缝合线或缝钉，组织修复，并且防止手术后粘连。 纤维组织密封剂可特别适合用作止血密封剂以从外科手术或创伤性创伤中止血。
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公开(公告)号：US08431114B2
公开(公告)日：2013-04-30
申请号：US11244756
申请日：2005-10-06
IPC分类号： A61K31/765
CPC分类号： C08B37/00 , A61K31/09 , A61K31/715 , A61K31/765 , A61K31/785 , A61K45/00 , A61K45/06 , A61L24/046 , A61L24/08 , C08B9/00 , C08B37/0021 , C08G65/33306 , C08G2650/50 , C08L2203/02 , C08L2666/26 , C09J105/02 , C09J171/02 , C08L71/02
摘要： Tissue adhesives formed by reacting an oxidized polysaccharide with a water-dispersible multi-arm polyether amine, wherein at least three of the arms are terminated by primary amine groups, are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; anti-adhesive applications; and as a bulking agent to treat urinary incontinence are described.
摘要翻译： 公开了通过使氧化多糖与水分散性多臂聚醚胺反应形成的组织粘合剂，其中至少三个臂被伯胺基团封端。 使用组织粘合剂进行医疗和兽医应用，如局部伤口闭合; 和外科手术，如肠吻合，血管吻合，组织修复和眼科手术; 药物递送 防粘应用; 并且描述了用作治疗尿失禁的填充剂。
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公开(公告)号：US08715636B2
公开(公告)日：2014-05-06
申请号：US13790336
申请日：2013-03-08
IPC分类号： A61K31/765
CPC分类号： C08B37/00 , A61K31/09 , A61K31/715 , A61K31/765 , A61K31/785 , A61K45/00 , A61K45/06 , A61L24/046 , A61L24/08 , C08B9/00 , C08B37/0021 , C08G65/33306 , C08G2650/50 , C08L2203/02 , C08L2666/26 , C09J105/02 , C09J171/02 , C08L71/02
摘要： Tissue adhesives formed by reacting an oxidized polysaccharide with a water-dispersible multi-arm polyether amine, wherein at least three of the arms are terminated by primary amine groups, are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; anti-adhesive applications; and as a bulking agent to treat urinary incontinence are described.
摘要翻译： 公开了通过使氧化多糖与水分散性多臂聚醚胺反应形成的组织粘合剂，其中至少三个臂被伯胺基团封端。 使用组织粘合剂进行医疗和兽医应用，如局部伤口闭合; 和外科手术，如肠吻合，血管吻合，组织修复和眼科手术; 药物递送 防粘应用; 并且描述了用作治疗尿失禁的填充剂。
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公开(公告)号：US5248864A
公开(公告)日：1993-09-28
申请号：US738220
申请日：1991-07-30
申请人： George K. Kodokian
发明人： George K. Kodokian
IPC分类号： B29C35/12 , B29C35/08 , B29C41/12 , B29C41/20 , B29C65/36 , B29C70/10 , B29K105/06 , H05B6/02
CPC分类号： B29C35/08 , H05B6/105 , H05B6/106 , B29C2035/0811 , B29K2105/06 , B29K2105/16 , B29K2307/00 , Y10T428/257
摘要： A method for heating a composite comprising a nonconductive material that is a thermoplastic or a thermoset reinforced with conductive materials such as carbon fibers, by incorporating coupling particles in the structure. The structure is oriented in the plane of a magnetic field induced at frequencies from 3 kHz to 7 MHz, whereby the coupling particles respond as susceptors to the induced magnetic field and are preferentially heated (carbon fibers are not heated).
摘要翻译： 一种用于加热包含非导电材料的复合材料的方法，该复合材料是通过在该结构中引入耦合颗粒，该非导电材料是热塑性材料或由导电材料如碳纤维增强的热固性材料。 该结构定向在3kHz至7MHz频率感应的磁场的平面内，由此耦合粒子作为感应磁场的感受器作出响应并被优先加热（碳纤维不被加热）。
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公开(公告)号：US06797222B2
公开(公告)日：2004-09-28
申请号：US10284924
申请日：2002-10-31
IPC分类号： B29C4118
CPC分类号： C08L23/08 , B29C41/003 , B29C41/18 , B29C67/246 , B29K2033/00 , C08L23/0869 , C08L23/0884 , C08L2205/02 , Y10S525/934 , C08L2666/04
摘要： A slush molding process in which the moldable thermoplastic composition powder dosed to the mold is prepared by blending ethylene carboxylic acid copolymers or ionomers with ethylene/glycidyl acrylate or methacrylate copolymer and cross-linking promoter at a temperature and for a time that does not cause significant cross-linking prior to dosing to mold, which is held for sufficient time and temperature to cause cross-linking in-situ, and optionally, other additives including release agents.
摘要翻译： 通过将乙烯羧酸共聚物或离聚物与乙烯/丙烯酸缩水甘油酯或甲基丙烯酸缩水甘油酯共聚物和交联促进剂在一定温度和不导致显着的温度下混合制备其中可模塑的热塑性组合物粉末配给模具的搪塑成型方法 在给予模具之前交联，其保持足够的时间和温度以原位交联，以及任选的其它添加剂，包括脱模剂。
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公开(公告)号：US6020034A
公开(公告)日：2000-02-01
申请号：US970513
申请日：1997-11-14
IPC分类号： C09D201/02 , C09D5/03 , C09D5/08 , C09D5/46 , C09D123/08 , B05D1/04 , B05D1/22
CPC分类号： C09D5/084 , C09D123/08
摘要： This invention concerns a process for imparting corrosion and creep resistance to a coating prepared from a particulate polymer composition and applied from a fluidized bed or by electrostatic spraying over metal substrates. The process of the present invention provides for maintaining the content of acid functionality of an acid-functionalized semicrystalline or acid-functionalized amorphous particulate polymer of the particulate polymer composition within a desired range. The acid functionality on the particulate polymer can be maintained, by crosslinking and/or neutralizing, within a desired range of the acid content which results in imparting corrosion and creep resistance to the coating applied over the metal substrates. Neutralizing the acid functionality of the polymer component results in hardening the coatings resulting therefrom. The process further provides for adding anticorrosive pigments to the composition for further improving corrosion resistance of the resultant coatings.
摘要翻译： 本发明涉及一种赋予由颗粒聚合物组合物制备的涂层和从流化床施加或通过静电喷涂在金属基底上的涂层的腐蚀和抗蠕变性的方法。 本发明的方法提供将颗粒状聚合物组合物的酸官能化半结晶或酸官能化无定形颗粒聚合物的酸官能度含量保持在所需范围内。 粒状聚合物上的酸官能度可以通过交联和/或中和在所需的酸含量范围内保持，这导致对施加在金属基底上的涂层赋予腐蚀和抗蠕变性。 中和聚合物组分的酸官能团导致硬化由此产生的涂层。 该方法进一步提供了将抗腐蚀颜料添加到组合物中，以进一步提高所得涂层的耐腐蚀性。
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公开(公告)号：US5470656A
公开(公告)日：1995-11-28
申请号：US270861
申请日：1994-07-05
CPC分类号： D07B7/145 , B29C47/003 , B29C47/027 , B29C47/28 , B29C70/50 , B29K2105/0097 , B29K2105/101 , B29K2105/256 , Y10T428/2924 , Y10T428/2929 , Y10T428/2931
摘要： This invention is a moisture-stable, flexible, structural adhesive strand which is suitable for use in the manufacture of an elongated pile article. The strand of this invention is comprised of a core of reinforcing multifilaments and a sheath of moisture-sensitive thermoplastic resin. The cross-sectional area ratio of reinforcing filaments to thermoplastic resin is in the range of about 0.04 to less than 0.3.
摘要翻译： 本发明是一种湿润稳定的，柔性的结构粘合剂线，其适用于制造细长桩制品。 本发明的绞线由增强复丝的芯和湿敏热塑性树脂的鞘组成。 增强纤维与热塑性树脂的横截面积比在约0.04至小于0.3的范围内。
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公开(公告)号：US5466423A
公开(公告)日：1995-11-14
申请号：US170968
申请日：1993-12-21
CPC分类号： B29C59/10 , H01T19/00 , Y10S422/907
摘要： An apparatus for corona discharge treatment of an article, and in particular an article comprising a conductive composite, includes a first electrode, which is a rotating, high-frequency voltage electrode and a second electrode, which is preferably a translation table, disposed with respect to the high-frequency voltage electrode so as to provide a return path to ground. The translation table supports the article to be treated, and oscillates with respect to the first electrode. Since translation table supports the article to be treated, the article itself is grounded, which is important when treating conductive composite articles. An adjustment mechanism provides a constant gap between the high-frequency voltage electrode and the article, so that the voltage does not seek the article. This enhances the efficiency of the corona treatment of the article. The first electrode rotates continuously and independently of the motion of the article in order to dissipate heat from the high-frequency voltage electrode. This arrangement makes the apparatus particularly useful for treating articles comprising conductive fibers, since such articles have relatively high power requirements.
摘要翻译： 一种用于制品的电晕放电处理装置，特别是包括导电复合材料的制品的装置包括：第一电极，其是旋转的高频电压电极和第二电极，其优选为平移台，其相对于 到高频电压电极，以提供到地的返回路径。 翻译台支持要处理的物品，并相对于第一电极振荡。 由于翻译台支持待处理的文章，文章本身是接地的，这在处理导电复合材料时非常重要。 调节机构在高频电压电极和制品之间提供恒定的间隙，使得电压不会寻找物品。 这提高了制品的电晕处理效率。 第一电极连续地旋转并且独立于制品的运动，以便从高频电压电极散发热量。 这种布置使得该设备对于处理包含导电纤维的物品特别有用，因为这样的物品具有相对高的功率要求。
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