摘要:
A bispecific antibody format providing ease of isolation is provided, comprising immunoglobulin heavy chain variable domains that are differentially modified in the CH3 domain, wherein the differential modifications are non-immunogenic or substantially non-immunogenic with respect to the CH3 modifications, and at least one of the modifications results in a differential affinity for the bispecific antibody for an affinity reagent such as Protein A, and the bispecific antibody is isolable from a disrupted cell, from medium, or from a mixture of antibodies based on its affinity for Protein A.
摘要:
An human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human proprotein convertase subtilisin/kexin type 9 (hPCSK9) characterized by the ability to reduce serum LDL cholesterol by 40-80% over a 24, 60 or 90 day period relative to predose levels, with little or no reduction in serum HDL cholesterol and/or with little or no measurable effect on liver function, as determined by ALT and AST measurements.
摘要:
Electronic display systems include mobile units for remotely modifying a displayed image. An electronic display system can include a display surface, a processing device, a mobile unit, and an input device. The display surface can receive and display an image rendered by the processing device. The display image on the display surface can be modified through interaction of the input device and the mobile unit. The input device can sense its position relative to the mobile unit and can transmit data relating to its position to the processing device. The processing device can interpret the position data as operations on the displayed image. Accordingly, the processing device can modify the displayed image on the display surface based on interactions between the input device and the mobile unit.
摘要:
Mounting systems can releasably secure display devices to preexisting surfaces for convenient installation and removal without external tools. A mounting system can comprise lower magnetic assemblies, upper magnetic assemblies, and a mounting sheet. The lower magnetic assemblies can be secured to a rear surface of a display device, for releasably attaching the display device to a preexisting surface. A bottom portion of the mounting sheet can be secured to the rear surface of the display device, while a top portion of the mounting sheet can remain loose from the rear surface. The upper magnetic assemblies can be provided along the loose top portion of the mounting sheet, for releasably attaching the display device to the preexisting surface. The upper magnetic assemblies can retain their connection to the preexisting surface as the display device is pulled away from the preexisting surface, until a threshold condition is met.
摘要:
An human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human proprotein convertase subtilisin/kexin type 9 (hPCSK9) characterized by the ability to reduce serum LDL cholesterol by 40-80% over a 24, 60 or 90 day period relative to predose levels, with little or no reduction in serum HDL cholesterol and/or with little or no measurable effect on liver function, as determined by ALT and AST measurements.
摘要:
Processes for the removal of a layer or region from a workpiece material by contact with a process gas in the manufacture of a microstructure are enhanced by the ability to accurately determine the endpoint of the removal step. A vapor phase etchant is used to remove a material that has been deposited on a substrate, with or without other deposited structure thereon. By creating an impedance at the exit of an etching chamber (or downstream thereof), as the vapor phase etchant passes from the etching chamber, a gaseous product of the etching reaction is monitored; and the endpoint of the removal process can be determined. The vapor phase etching process can be flow through, a combination of flow through and pulse, or recirculated back to the etching chamber
摘要:
Described is a configuration module useful for configuring modules of a modular application platform during run-time of the modular application platform. The configuration module produces a graphical dialog that displays a sequence of one or more configuration pages to a user to obtain from the user configuration information for each displayed configuration page. The configuration module defines an abstraction of a configuration page, and other modules of the modular application platform provide implementations of the configuration page abstraction to include at least one configuration page in the graphical dialog produced by the configuration module.
摘要:
An office panel partition includes a panel frame having at least two uprights and a horizontal structural member rigidly interconnecting the uprights. The panel frame has a first side and a second opposite side, and the panel frame defines at least four apertures on the first side thereof. The partition also includes a cover member having a major planar surface defining an exterior surface of the partition. The cover member includes at least four projections that are removably insertable into the at least four apertures to removably secure the cover member to the frame. The apertures are arranged in at least two vertically spaced horizontal rows and at least two horizontally spaced vertical columns. The apertures in a first one of the columns have different horizontal dimensions than those of the apertures located in the other of the columns. Each of the projections has a range of lateral positions when inserted into a respective one of the apertures. The range of lateral positions provided by the apertures in the first one of the columns is less than the range of lateral positions provided by the apertures in the other row of the columns. The apertures located in a first one of the rows has vertical dimensions that are different than those located in the other of the rows. The range of vertical positions provided by the apertures in the first one of the rows is less than the range of vertical positions provided by the apertures in the other of the rows.
摘要:
Mounting systems can releasably secure display devices to preexisting surfaces for convenient installation and removal without external tools. A mounting system can comprise lower magnetic assemblies, upper magnetic assemblies, and a mounting sheet. The lower magnetic assemblies can be secured to a rear surface of a display device, for releasably attaching the display device to a preexisting surface. A bottom portion of the mounting sheet can be secured to the rear surface of the display device, while a top portion of the mounting sheet can remain loose from the rear surface. The upper magnetic assemblies can be provided along the loose top portion of the mounting sheet, for releasably attaching the display device to the preexisting surface. The upper magnetic assemblies can retain their connection to the preexisting surface as the display device is pulled away from the preexisting surface, until a threshold condition is met.
摘要:
Interactive systems can include various components that are packaged together and easily assemblable. An interactive system can comprise a mount, a display device, a projector, an input device, and a processing device. The display device, the projector, the input device, and the processing device can together provide an electronic display system, while the mount can carry these other various components and assist in connecting them to one another. The mount and the other components of the interactive system can be conveniently packaged and sold as group for convenient installation by one or two persons.