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公开(公告)号：US20050055017A1
公开(公告)日：2005-03-10
申请号：US10896749
申请日：2004-07-21
申请人： Sanford Damasco , Dennis Bui , Xiaoyu Yu
发明人： Sanford Damasco , Dennis Bui , Xiaoyu Yu
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2017/00092 , A61B2017/00243 , A61B2018/00041 , A61B2018/00101 , A61B2018/0212 , A61B2018/0262
摘要： The malleable cryosurgical probe includes a cryostat assembly and a cryoprobe assembly. The cryostat assembly includes an elongated shaft assembly having a bellows portion thereof and a closed distal end. The shaft assembly includes at least one freezing portion comprising the bellows portion, at least one thermally insulated portion and a thermally insulating element positioned about the thermally insulated portion. A cryostat is operably associated with the elongated shaft assembly. It includes a cryostat inlet for receiving gas entering the cryostat, a cryostat outlet and a heat exchanger positioned between the cryostat outlet and the cryostat inlet. The heat exchanger receives gas from the cryostat inlet and provides heat transfer between gas flowing within the cryostat and fluid exterior thereto. At least one Joule-Thomson nozzle is in fluid communication with the cryostat outlet. The at least one Joule-Thomson nozzle expands gas expelled therefrom. The expanded cold fluid communicates with the freezing portion to provide cooling thereof. The cryoprobe assembly includes a handle assembly for supporting the cryostat assembly and a fluid supply line assembly connectable to a fluid source at one end and to the cryostat inlet at a second end. The heat exchanger is positioned at a location longitudinally spaced from the freezing portion(s).
摘要翻译： 可延展的冷冻手术探头包括低温恒温器组件和冷冻探针组件。 低温恒温器组件包括细长轴组件，其具有波纹部分和封闭的远端。 轴组件包括至少一个包括波纹管部分的冷冻部分，至少一个热绝缘部分和围绕隔热部分定位的隔热元件。 低温恒温器与细长轴组件可操作地相关联。 其包括用于接收进入低温恒温器的气体的低温恒温器入口，低温恒温器出口和位于低温恒温器出口和低温恒温器入口之间的热交换器。 热交换器从低温恒温器入口接收气体，并在低温恒温器内流动的气体和外部流体之间提供热传递。 至少一个焦耳汤姆逊喷嘴与低温恒温器出口流体连通。 至少一个焦耳汤姆逊喷嘴扩大从其排出的气体。 膨胀的冷流体与冷冻部分连通以提供冷却。 冷冻探头组件包括用于支撑低温恒温器组件的手柄组件和可在一端连接到流体源的流体供应管线组件和在第二端处连接到低温恒温器入口的流体供应管线组件。 热交换器定位在与冷冻部分纵向间隔开的位置处。
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公开(公告)号：US5910104A
公开(公告)日：1999-06-08
申请号：US774148
申请日：1996-12-26
申请人： John D. Dobak, III , Kambiz Ghaerzadeh , Xiaoyu Yu
发明人： John D. Dobak, III , Kambiz Ghaerzadeh , Xiaoyu Yu
IPC分类号： A61B19/02 , A61B17/00 , A61B17/42 , A61B18/00 , A61B18/02 , A61B18/24 , A61B19/00 , A61B1/00
CPC分类号： A61B18/02 , A61B17/42 , A61B18/0206 , A61B18/24 , A61B2017/00084 , A61B2017/0023 , A61B2017/00336 , A61B2018/00041 , A61B2018/00095 , A61B2018/00101 , A61B2018/00166 , A61B2018/0212 , A61B2018/0262 , A61B2090/306 , A61B2090/378 , A61B2218/002
摘要： A disposable, sterilizable sheath for use on a closed loop Joule-Thomson cryosurgical probe, and the combination of the disposable sheath and the closed loop probe. The sheath is slipped over the probe, thereby separating the probe from the environment. The sheath has a grip which fits over the handle of the cryosurgical probe, and an extendible shroud which can be longitudinally extended to cover tubing and which are attached to the handle. The sheath has a hollow multi-lumen catheter shaped and sized to fit snugly over the cannula of the cryosurgical probe. The catheter is not thermally conductive, preventing transfer of heat from the ambient to the gas mixture, and preventing the freezing of tissues at undesired locations along the catheter. A thermally conductive cap or tip is attached to the distal end of the hollow catheter. The thermally conductive cap or tip fits snugly over the cold tip on the probe, and it efficiently transfers heat from the target tissue to the cold tip, which in turn transfers heat to the expanded gas mixture. Various forms of auxiliary instrumentation can be mounted on the catheter or conductive tip, such as a temperature sensor, a heater, an ultrasonic transducer, or an optical element of a viewing, illumination, or laser system. Connections between the instrumentation near the distal end of the catheter and the probe are made via a plurality of lumens passing longitudinally through the wall of the catheter.
摘要翻译： 用于闭环焦耳汤姆逊冷冻手术探针的一次性灭菌鞘，以及一次性鞘和闭环探针的组合。 护套滑过探头，从而将探头与环境分开。 护套具有装配在冷冻手术探针的手柄上的把手，以及可延伸的护罩，其可以纵向延伸以覆盖管道并且附接到手柄。 护套具有中空的多腔导管，其形状和尺寸适于紧贴在冷冻手术探针的套管上方。 导管不是导热的，防止热量从环境转移到气体混合物，并且防止沿着导管在不期望的位置处冷冻组织。 导热帽或尖端连接到中空导管的远端。 导热盖或尖端紧贴在探针上的冷尖端上，并且有效地将热量从目标组织传递到冷尖端，冷尖端又将热量传递到膨胀气体混合物。 各种形式的辅助仪器可以安装在导管或导电尖端上，例如温度传感器，加热器，超声波换能器或观察，照明或激光系统的光学元件。 在导管远端附近的仪器与探针之间的连接通过纵向穿过导管的壁的多个管腔制成。
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公开(公告)号：US06530234B1
公开(公告)日：2003-03-11
申请号：US09075374
申请日：1998-05-07
IPC分类号： F17C702
CPC分类号： C09K5/045 , A61B18/02 , A61B2018/0212 , A61B2018/0275 , A61B2018/0281 , C09K2205/22 , F25B7/00 , F25B9/006 , F25B9/02 , F25B2309/003 , F25B2309/021 , F25B2309/022 , F25B2309/023 , F25B2400/12
摘要： A miniature refrigeration system and method of operation. A primary refrigerant is pressurized by a compressor to a relatively low pressure, for safety reasons. The compressed primary refrigerant is passed through a primary-to-secondary heat exchanger, to precool the gas mixture. The secondary side of the primary-to-secondary heat exchanger is cooled by a secondary refrigeration system. The primary refrigerant exiting the primary outlet of the primary-to-secondary heat exchanger passes to a primary Joule-Thomson expansion element where the high pressure gas is expanded to a lower temperature. This low temperature gas cools a heat transfer element mounted in the outer wall of the catheter or cryoprobe, to cool surrounding tissue. Return gas can flow back through a distal primary-to-primary heat exchanger to further cool the incoming high pressure gas mixture. A proximal primary-to-primary heat exchanger can be added between the primary-to-secondary heat exchanger and the primary compressor.
摘要翻译： 微型制冷系统及其操作方法。 出于安全原因，一级制冷剂被压缩机加压至较低的压力。 压缩的一次制冷剂通过一次 - 二次热交换器，以预冷气体混合物。 一级到二级热交换器的次级侧由二次制冷系统冷却。 从初级到二级热交换器的主出口排出的主要制冷剂通过一次焦耳汤姆森膨胀元件，其中高压气体膨胀到较低的温度。 该低温气体冷却安装在导管或冷冻探针的外壁中的传热元件以冷却周围的组织。 回流气体可以通过远端主 - 原热交换器回流，以进一步冷却进入的高压气体混合物。 可以在初级到二级热交换器和主压缩机之间添加近端的初级至主要的热交换器。
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公开(公告)号：US06193644B1
公开(公告)日：2001-02-27
申请号：US09262588
申请日：1999-03-04
申请人： John D. Dobak, III , Kambiz Ghaerzadeh , Xiaoyu Yu
发明人： John D. Dobak, III , Kambiz Ghaerzadeh , Xiaoyu Yu
IPC分类号： A61F558
CPC分类号： A61B18/02 , A61B17/42 , A61B18/0206 , A61B18/24 , A61B2017/00084 , A61B2017/0023 , A61B2017/00336 , A61B2018/00041 , A61B2018/00095 , A61B2018/00101 , A61B2018/00166 , A61B2018/0212 , A61B2018/0262 , A61B2090/306 , A61B2090/378 , A61B2218/002
摘要： A sheath for use on a closed loop Joule-Thomson cryosurgical probe, and the combination of the and the closed loop probe. The sheath is slipped over the probe, thereby separating the probe from the environment. The sheath has a grip which fits over the handle of the cryosurgical probe, and an extendible shroud which can be longitudinally extended to cover tubing and which are attached to the handle. The sheath has a hollow multi-lumen catheter shaped and sized to fit snugly over the cannula of the cryosurgical probe. The catheter is not thermally conductive, preventing transfer of heat from the ambient to the gas mixture, and preventing the freezing of tissues at undesired locations along the catheter. A thermally conductive cap or tip is attached to the distal end of the hollow catheter. The thermally conductive cap or tip fits snugly over the cold tip on the probe, and it efficiently transfers heat from the target tissue to the cold tip, which in turn transfers heat to the expanded gas mixture. Various forms of auxiliary instrumentation can be mounted on the catheter or conductive tip, such as a temperature sensor, a heater, an ultrasonic transducer, or an optical element of a viewing, illumination, or laser system. Connections between the instrumentation near the distal end of the catheter and the probe are made via a plurality of lumens passing longitudinally through the wall of the catheter.
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公开(公告)号：US5758505A
公开(公告)日：1998-06-02
申请号：US726770
申请日：1996-10-07
CPC分类号： F25B9/006 , A61B18/02 , C09K5/045 , F25B9/02 , A61B2018/0212 , A61B2018/0275 , A61B2018/0281 , C09K2205/12 , C09K2205/122 , C09K2205/13 , C09K2205/132 , F25B2309/003 , F25B2309/021 , F25B2309/022 , F25B2309/023 , F25B2400/12 , F25B7/00
摘要： A miniature mixed gas refrigeration system and method of operation are disclosed. An optimum gas mixture is formulated from a group of component fluids, according to calculated thermodynamic properties of a group of candidate fluid mixtures. The gas mixture is pressurized by a compressor to a pressure less than 420 psia, for safety reasons. The compressed gas mixture is passed through a primary heat exchanger, and then through a primary-to-secondary heat exchanger, to precool the gas mixture. The secondary side of the primary/secondary heat exchanger is cooled by a secondary Joule-Thomson refrigeration system. Properly sized flow restrictions in the primary side of the primary/secondary heat exchanger can solidify and trap liquid contaminants that may be in the gas mixture. The gas mixture exiting the primary outlet of the primary/secondary heat exchanger passes to a primary Joule-Thomson expansion element where the high pressure gas is expanded isenthalpically to a lower temperature at least as low as 183K. This low temperature gas cools a heat transfer element mounted in the outer wall of the catheter, to cool an external object. Return gas flows back through the primary heat exchanger to further pre-cool the incoming high pressure gas mixture. A distal primary heat exchanger can be added between the primary/secondary heat exchanger and the primary Joule-Thomson expansion element.
摘要翻译： 公开了一种微型混合气体制冷系统和操作方法。 根据一组候选流体混合物的计算的热力学性质，从一组组分流体配制最佳气体混合物。 为了安全起见，气体混合物被压缩机压力低于420psia。 将压缩气体混合物通过主要热交换器，然后通过初级 - 二级热交换器，以预冷气体混合物。 一次/二次热交换器的二次侧通过二次焦耳 - 汤姆森制冷系统进行冷却。 主/二次换热器初级侧的适当尺寸的流量限制可以凝固并捕获可能在气体混合物中的液体污染物。 离开初级/二级热交换器的主出口的气体混合物通过到焦耳 - 汤姆逊膨胀元件，其中高压气体在等温下扩展至至少低至183K的较低温度。 该低温气体冷却安装在导管的外壁中的传热元件，以冷却外部物体。 回流气体通过主热交换器回流，以进一步预冷进入的高压气体混合物。 可以在主/辅助热交换器和初级焦耳 - 汤姆森膨胀元件之间添加远端主热交换器。
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公开(公告)号：US06936045B2
公开(公告)日：2005-08-30
申请号：US09957337
申请日：2001-09-20
申请人： Xiaoyu Yu , Jay J. Eum , David J. Battles
发明人： Xiaoyu Yu , Jay J. Eum , David J. Battles
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2017/00092 , A61B2017/00243 , A61B2018/00041 , A61B2018/00101 , A61B2018/0262
摘要： The malleable cryosurgical probe includes a cryostat assembly and a cryoprobe assembly. The cryostat assembly includes an elongated shaft assembly having at least one malleable segment thereof and a closed distal end. The shaft assembly includes at least one freezing portion, at least one thermally insulated portion and a thermally insulating element positioned about the thermally insulated portion. A cryostat is operably associated with the elongated shaft assembly. It includes a cryostat inlet for receiving gas entering the cryostat, a cryostat outlet and a heat exchanger positioned between the cryostat outlet and the cryostat inlet. The heat exchanger receives gas from the cryostat inlet and provides heat transfer between gas flowing within the cryostat and fluid exterior thereto. At least one Joule-Thomson nozzle is in fluid communication with the cryostat outlet. The at least one Joule-Thomson nozzle expands gas expelled therefrom. The expanded cold fluid communicates with the freezing portion to provide cooling thereof. The cryoprobe assembly includes a handle assembly for supporting the cryostat assembly and a fluid supply line assembly connectable to a fluid source at one end and to the cryostat inlet at a second end. The heat exchanger is positioned at a location longitudinally spaced from the freezing portion(s).
摘要翻译： 可延展的冷冻手术探头包括低温恒温器组件和冷冻探针组件。 低温恒温器组件包括细长轴组件，其具有至少一个可延展段和封闭的远端。 轴组件包括至少一个冷冻部分，至少一个绝热部分和围绕该绝热部分定位的隔热元件。 低温恒温器与细长轴组件可操作地相关联。 其包括用于接收进入低温恒温器的气体的低温恒温器入口，低温恒温器出口和位于低温恒温器出口和低温恒温器入口之间的热交换器。 热交换器从低温恒温器入口接收气体，并在低温恒温器内流动的气体和外部流体之间提供热传递。 至少一个焦耳汤姆逊喷嘴与低温恒温器出口流体连通。 至少一个焦耳汤姆逊喷嘴扩大从其排出的气体。 膨胀的冷流体与冷冻部分连通以提供冷却。 冷冻探头组件包括用于支撑低温恒温器组件的手柄组件和可在一端连接到流体源的流体供应管线组件和在第二端处连接到低温恒温器入口的流体供应管线组件。 热交换器定位在与冷冻部分纵向间隔开的位置处。
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公开(公告)号：US06475212B2
公开(公告)日：2002-11-05
申请号：US09791415
申请日：2001-02-22
申请人： John D. Dobak, III , Kambiz Ghaerzadeh , Xiaoyu Yu
发明人： John D. Dobak, III , Kambiz Ghaerzadeh , Xiaoyu Yu
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B17/42 , A61B18/0206 , A61B18/24 , A61B2017/00084 , A61B2017/0023 , A61B2017/00336 , A61B2018/00041 , A61B2018/00095 , A61B2018/00101 , A61B2018/00166 , A61B2018/0212 , A61B2018/0262 , A61B2090/306 , A61B2090/378 , A61B2218/002
摘要： A sheath for use on a closed loop Joule-Thomson cryosurgical probe, and the combination of the and the closed loop probe. The sheath is slipped over the probe, thereby separating the probe from the environment. The sheath has a grip which fits over the handle of the cryosurgical probe, and an extendible shroud which can be longitudinally extended to cover tubing and which are attached to the handle. The sheath has a hollow multi-lumen catheter shaped and sized to fit snugly over the cannula of the cryosurgical probe. The catheter is not thermally conductive, preventing transfer of heat from the ambient to the gas mixture, and preventing the freezing of tissues at undesired locations along the catheter. A thermally conductive cap or tip is attached to the distal end of the hollow catheter. The thermally conductive cap or tip fits snugly over the cold tip on the probe, and it efficiently transfers heat from the target tissue to the cold tip, which in turn transfers heat to the expanded gas mixture. Various forms of auxiliary instrumentation can be mounted on the catheter or conductive tip, such as a temperature sensor, a heater, an ultrasonic transducer, or an optical element of a viewing, illumination, or laser system. Connections between the instrumentation near the distal end of the catheter and the probe are made via a plurality of lumens passing longitudinally through the wall of the catheter.
摘要翻译： 用于闭环焦耳汤姆逊冷冻手术探针的鞘，以及闭环探针的组合。 护套滑过探头，从而将探头与环境分开。 护套具有装配在冷冻手术探针的手柄上的把手，以及可延伸的护罩，其可以纵向延伸以覆盖管道并且附接到手柄。 护套具有中空的多腔导管，其形状和尺寸适于紧贴在冷冻手术探针的套管上方。 导管不是导热的，防止热量从环境转移到气体混合物，并且防止沿着导管在不期望的位置处冷冻组织。 导热帽或尖端连接到中空导管的远端。 导热盖或尖端紧贴在探针上的冷尖端上，并且有效地将热量从目标组织传递到冷尖端，冷尖端又将热量传递到膨胀气体混合物。 各种形式的辅助仪器可以安装在导管或导电尖端上，例如温度传感器，加热器，超声波换能器或观察，照明或激光系统的光学元件。 在导管远端附近的仪器与探针之间的连接通过纵向穿过导管的壁的多个管腔制成。
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公开(公告)号：US20130035551A1
公开(公告)日：2013-02-07
申请号：US13563992
申请日：2012-08-01
申请人： Xiaoyu Yu , Christopher McCollam , Jack Auld
发明人： Xiaoyu Yu , Christopher McCollam , Jack Auld
CPC分类号： A61F9/00736 , A61B1/00073 , A61B1/00165 , A61B1/0052 , A61B1/0055 , A61B1/0057 , A61B2017/00309
摘要： An articulating optical surgical probe includes a handle sized to fit in a single hand and a single rigid cannula extending from the handle having a diameter of 20 Ga or less. The probe further includes a slotted tip at a distal end of the cannula and at least one optical fiber extending through the handle, the single rigid cannula and the slotted tip, and a pull-wire secured to the slotted tip. When the pull-wire exerts tension on the slotted tip, the slotted tip will deviate from straight to a bend angle controlled by the tension in the pull-wire. The slotted tip is formed from a resilient material that will restore to the straight position when the tension exerted by the pull-wire is released.
摘要翻译： 关节式光学手术探针包括尺寸适于单手的手柄和从手柄延伸的直径为20Ga或更小的单个刚性套管。 探针还包括在套管的远端处的开槽尖端和延伸穿过手柄的至少一根光纤，单个刚性插管和开槽尖端，以及固定到开槽尖端的拉线。 当拉线在开槽尖端上施加张力时，开槽的尖端将从直线偏离到由拉线中的张力控制的弯曲角度。 开槽尖端由弹性材料形成，当拉线施加的张力被释放时，弹性材料将恢复到直线位置。
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公开(公告)号：US06767346B2
公开(公告)日：2004-07-27
申请号：US10057033
申请日：2002-01-23
申请人： Sanford D. Damasco , Dennis M. Bui , Xiaoyu Yu
发明人： Sanford D. Damasco , Dennis M. Bui , Xiaoyu Yu
IPC分类号： A61B1736
CPC分类号： A61B18/02 , A61B2017/00084 , A61B2017/00092 , A61B2017/00243 , A61B2018/00041 , A61B2018/00101 , A61B2018/0212 , A61B2018/0262
摘要： The malleable cryosurgical probe includes a cryostat assembly and a cryoprobe assembly. The cryostat assembly includes an elongated shaft assembly having a bellows portion thereof and a closed distal end. The shaft assembly includes at least one freezing portion comprising the bellows portion, at least one thermally insulated portion and a thermally insulating element positioned about the thermally insulated portion. A cryostat is operably associated with the elongated shaft assembly. It includes a cryostat inlet for receiving gas entering the cryostat, a cryostat outlet and a heat exchanger positioned between the cryostat outlet and the cryostat inlet. The heat exchanger receives gas from the cryostat inlet and provides heat transfer between gas flowing within the cryostat and fluid exterior thereto. At least one Joule-Thomson nozzle is in fluid communication with the cryostat outlet. The at least one Joule-Thomson nozzle expands gas expelled therefrom. The expanded cold fluid communicates with the freezing portion to provide cooling thereof. The cryoprobe assembly includes a handle assembly for supporting the cryostat assembly and a fluid supply line assembly connectable to a fluid source at one end and to the cryostat inlet at a second end. The heat exchanger is positioned at a location longitudinally spaced from the freezing portion(s).
摘要翻译： 可延展的冷冻手术探头包括低温恒温器组件和冷冻探针组件。 低温恒温器组件包括细长轴组件，其具有波纹部分和封闭的远端。 轴组件包括至少一个包括波纹管部分的冷冻部分，至少一个热绝缘部分和围绕隔热部分定位的隔热元件。 低温恒温器与细长轴组件可操作地相关联。 其包括用于接收进入低温恒温器的气体的低温恒温器入口，低温恒温器出口和位于低温恒温器出口和低温恒温器入口之间的热交换器。 热交换器从低温恒温器入口接收气体，并在低温恒温器内流动的气体和外部流体之间提供热传递。 至少一个焦耳汤姆逊喷嘴与低温恒温器出口流体连通。 至少一个焦耳汤姆逊喷嘴扩大从其排出的气体。 膨胀的冷流体与冷冻部分连通以提供冷却。 冷冻探头组件包括用于支撑低温恒温器组件的手柄组件和可在一端连接到流体源的流体供应管线组件和在第二端处连接到低温恒温器入口的流体供应管线组件。 热交换器定位在与冷冻部分纵向间隔开的位置处。
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公开(公告)号：US09795505B2
公开(公告)日：2017-10-24
申请号：US13563992
申请日：2012-08-01
申请人： Xiaoyu Yu , Christopher McCollam , Jack Auld
发明人： Xiaoyu Yu , Christopher McCollam , Jack Auld
CPC分类号： A61F9/00736 , A61B1/00073 , A61B1/00165 , A61B1/0052 , A61B1/0055 , A61B1/0057 , A61B2017/00309
摘要： An articulating optical surgical probe includes a handle sized to fit in a single hand and a single rigid cannula extending from the handle having a diameter of 20 Ga or less. The probe further includes a slotted tip at a distal end of the cannula and at least one optical fiber extending through the handle, the single rigid cannula and the slotted tip, and a pull-wire secured to the slotted tip. When the pull-wire exerts tension on the slotted tip, the slotted tip will deviate from straight to a bend angle controlled by the tension in the pull-wire. The slotted tip is formed from a resilient material that will restore to the straight position when the tension exerted by the pull-wire is released.
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