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公开(公告)号:US20080213377A1
公开(公告)日:2008-09-04
申请号:US11952614
申请日:2007-12-07
申请人: Sangeeta N. Bhatia , Todd Harris , Amit Agrawal , Dal-Hee Min , Austin M. Derfus , Geoffrey von Maltzahn
发明人: Sangeeta N. Bhatia , Todd Harris , Amit Agrawal , Dal-Hee Min , Austin M. Derfus , Geoffrey von Maltzahn
CPC分类号: B82Y5/00 , A61K47/62 , A61K47/6923 , A61K49/0067
摘要: The present invention provides systems, methods, and compositions for targeted delivery of nanoparticles and/or agents to tissues, cells, and/or subcellular locales. In general, compositions comprise a nanoparticle (e.g. quantum dot, polymeric particle, etc.), at least one modulating entity (such as a targeting moiety, transfection reagent, protective entity, etc.), and at least one agent to be delivered (e.g. therapeutic, prophylactic, and/or diagnostic agent). The present invention provides methods of making and using nanoparticle entities in accordance with the present invention.
摘要翻译: 本发明提供用于将组织,细胞和/或亚细胞区域的纳米颗粒和/或试剂靶向递送的系统,方法和组合物。 通常,组合物包含纳米颗粒(例如量子点,聚合物颗粒等),至少一个调节实体(例如靶向部分,转染试剂,保护性实体等)和至少一种待递送的试剂( 例如治疗,预防和/或诊断试剂)。 本发明提供了制备和使用根据本发明的纳米颗粒实体的方法。
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公开(公告)号:US20090093551A1
公开(公告)日:2009-04-09
申请号:US11952993
申请日:2007-12-07
IPC分类号: A61K47/48
CPC分类号: B82Y5/00 , A61K47/62 , A61K47/6923 , A61K49/0067
摘要: The present invention provides particle conjugates for drug delivery. Such conjugates comprise one or more heatable surfaces, one or more thermally-responsive linkers, and one or more agents to be delivered. In some embodiments, conjugates and populations of conjugates can be used to treat and/or diagnose a disease, disorder, and/or condition. The present invention provides methods for producing and/or using thermally-responsive conjugates.
摘要翻译: 本发明提供用于药物递送的颗粒缀合物。 这种缀合物包含一个或多个可加热表面,一个或多个热响应性接头和一种或多种要递送的试剂。 在一些实施方案中,缀合物和缀合物群可用于治疗和/或诊断疾病,病症和/或病症。 本发明提供了用于产生和/或使用热响应性缀合物的方法。
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公开(公告)号:US20090246142A1
公开(公告)日:2009-10-01
申请号:US12282462
申请日:2007-03-09
IPC分类号: A61K49/00 , A61K9/127 , A61K9/14 , A61K39/395 , A61K31/7088 , A61K38/02
CPC分类号: B82Y5/00 , A61K47/65 , A61K49/1833 , A61K49/186 , A61K49/1866 , A61K49/1887
摘要: The present invention provides triggered self-assembly nanosystems. Such nanosystems comprise a population of triggered self-assembly conjugates, each conjugate comprising one or more monomeric units and one or more complementary binding moieties. In some embodiments, inventive nanosystems and conjugates can be used to treat and/or diagnose a disease, disorder, and/or condition.
摘要翻译: 本发明提供了触发的自组装纳米系统。 这样的纳米系统包括触发的自组装共轭物的群体,每个缀合物包含一个或多个单体单元和一个或多个互补结合部分。 在一些实施方案中,本发明的纳米系统和缀合物可用于治疗和/或诊断疾病,病症和/或病症。
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公开(公告)号:US20150011482A1
公开(公告)日:2015-01-08
申请号:US14374127
申请日:2013-03-15
申请人: David Arthur Berry , Brett Adam Boghigian , Nathaniel W. Silver , Geoffrey von Maltzahn , Rajeev Chillakuru , Michael Hamill
发明人: David Arthur Berry , Brett Adam Boghigian , Nathaniel W. Silver , Geoffrey von Maltzahn , Rajeev Chillakuru , Michael Hamill
IPC分类号: C07K14/435 , A23L1/305
CPC分类号: C07K14/435 , A23L33/17 , A23L33/18 , A23V2002/00 , A61K38/1709 , A23V2200/332 , A23V2250/54
摘要: Nutritive proteins are provided. In some embodiments the nutritive proteins comprise a first polypeptide sequence comprising a fragment of a naturally-occurring nutritive protein. In some embodiments the fragment comprises at least one of a) an enhanced ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein; b) an enhanced ratio of leucine residues to total amino acid residues present in the nutritive protein; and c) an enhanced ratio of essential amino acid residues to total amino acid residues present in the nutritive protein. In some embodiments, the fragment comprises at least one of a) a ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein; b) a ratio of leucine residues to total amino acid residues present in the nutritive protein; and c) a ratio of essential amino acid residues to total amino acid residues present in the nutritive protein, that is equal to or greater than the corresponding ratio present in a benchmark protein such as whey, egg or soy protein. Also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things.
摘要翻译: 提供营养蛋白质。 在一些实施方案中,营养蛋白包含包含天然存在营养蛋白片段的第一多肽序列。 在一些实施方案中,片段包含以下至少一种:a)增强的分支链氨基酸残基与存在于营养蛋白中的总氨基酸残基的比例; b)营养蛋白中存在的亮氨酸残基与总氨基酸残基的比例增加; 和c)营养蛋白中存在的必需氨基酸残基与总氨基酸残基的比例增加。 在一些实施方案中,所述片段包含a)支链氨基酸残基与营养蛋白中存在的总氨基酸残基的比例中的至少一个; b)营养蛋白中存在的亮氨酸残基与总氨基酸残基的比例; 和c)营养蛋白中存在的必需氨基酸残基与总氨基酸残基的比例,其等于或大于基准蛋白如乳清,蛋或大豆蛋白中存在的相应比例。 还提供编码蛋白质的核酸,制备蛋白质的重组微生物,使用重组微生物制备蛋白质的方法,包含蛋白质的组合物,以及使用蛋白质的方法等。
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公开(公告)号:US08790901B2
公开(公告)日:2014-07-29
申请号:US13326211
申请日:2011-12-14
申请人: Subhayu Basu , Gaozhong Shen , Brett Boghigian , David Young , David Berry , Geoffrey von Maltzahn
发明人: Subhayu Basu , Gaozhong Shen , Brett Boghigian , David Young , David Berry , Geoffrey von Maltzahn
CPC分类号: A61K31/201 , C12N9/0071 , C12N9/16 , C12P7/6472 , C12Y114/19 , C12Y114/19001 , C12Y114/19006 , C12Y301/02014 , Y02A50/473
摘要: Methods of producing an unsaturated free fatty acid comprising at least 18 carbon atoms are provided. In some embodiments, the methods comprise culturing an engineered microorganism in a culture medium, wherein the engineered microorganism comprises at least one recombinant enzyme selected from acyl-lipid desaturase delta-9 (EC:1.14.19.1), acyl-lipid desaturase delta-12 (EC:1.14.19.6), acyl-lipid desaturase delta-15 (EC:1.14.19.-), and thioesterase (EC:3.1.2.14). Engineered microorganisms comprising at least one of those recombinant enzymes are also provided. The methods and organisms can be used to produce at least one free fatty acid selected from oleic acid, linoleic acid and α-linolenic acid.
摘要翻译: 提供了包含至少18个碳原子的不饱和游离脂肪酸的生产方法。 在一些实施方案中,所述方法包括在培养基中培养工程微生物,其中所述工程化微生物包含至少一种选自酰基 - 脂质去饱和酶δ-9(EC:1.14.19.1),酰基 - 脂质去饱和酶Δ-12 (EC:1.14.19.6),酰基 - 脂肪去饱和酶Δ-15(EC:1.14.19.-)和硫酯酶(EC:3.1.2.14)。 还提供了包含这些重组酶中的至少一种的工程微生物。 所述方法和生物体可用于产生至少一种选自油酸,亚油酸和α-亚麻酸的游离脂肪酸。
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