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    Transmission of Audio Signals Via Fibre Optic
    6.
    发明申请
    Transmission of Audio Signals Via Fibre Optic 审中-公开
    通过光纤传输音频信号

    公开(公告)号：US20100003033A1

    公开(公告)日：2010-01-07

    申请号：US11992004

    申请日：2006-09-12

    申请人： David Holmes

    发明人： David Holmes

    IPC分类号： H04B10/12 ,  H04B3/00

    CPC分类号： H04B10/00

    摘要： A system received an analogue electrical signal having content between 20 Hz and 20 kHz representing an analogue audio signal; amplitude modulates the analogue electrical signal onto an optical signal; transmits the modulated optical signal over an optical waveguide; receives. The modulated optical signal; and demodulates the modulated optical signal to reproduce the analogue electrical signal. The system may be incorporated within a cable arrangement.

    摘要翻译： 系统接收到具有20Hz和20kHz之间的内容的模拟电信号，表示模拟音频信号; 将模拟电信号的幅度调制到光信号上; 通过光波导传输经调制的光信号; 收到。 调制光信号; 并解调调制的光信号以再现模拟电信号。 该系统可以结合在电缆装置中。

    COMBINATIONS COMPRISING DEPEPTIDYPEPTIDASE-IV INHIBITORS AND ANTIDIABETIC AGENTS
    7.
    发明申请
    COMBINATIONS COMPRISING DEPEPTIDYPEPTIDASE-IV INHIBITORS AND ANTIDIABETIC AGENTS 审中-公开
    包含抑肽酶IV抑制剂和抗生素的组合

    公开(公告)号：US20080076811A1

    公开(公告)日：2008-03-27

    申请号：US11868129

    申请日：2007-10-05

    申请人： Bork Balkan ,  Thomas Hughes ,  David Holmes ,  Edwin Villhauer

    发明人： Bork Balkan ,  Thomas Hughes ,  David Holmes ,  Edwin Villhauer

    IPC分类号： A61K31/427 ,  A61K31/40 ,  A61P3/04 ,  A61P3/10

    CPC分类号： A61K31/40 ,  A61K31/421 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention relates to a combination which comprises a DPP-IV inhibitor and at least one further antidiabetic compound, preferably selected from the group consisting of insulin signalling pathway modulators, like inhibitors of protein tyrosine phosphatases (PTPases), non-small molecule mimetic compounds and inhibitors of glutamine-fructose-6-phosphate amidotransferase (GFAT), compounds influencing a dysregulated hepatic glucose production, like inhibitors of glucose-6-phosphatase (G6Pase), inhibitors of fructose-1,6-bisphosphatase (F-1,6-BPase), inhibitors of glycogen phosphorylase (GP), glucagon receptor antagonists and inhibitors of phosphoenolpyruvate carboxykinase (PEPCK), pyruvate dehydrogenase kinase (PDHK) inhibitors, insulin sensitivity enhancers, insulin secretion enhancers, α-glucosidase inhibitors, inhibitors of gastric emptying, insulin, and α2-adrenergic antagonists, for simultaneous, separate or sequential use in the prevention, delay of progression or treatment of conditions mediated by dipeptidylpeptidase-IV (DPP-IV), in particular diabetes, more especially type 2 diabetes mellitus, conditions of impaired glucose tolerance (IGT), conditions of impaired fasting plasma glucose, metabolic acidosis, ketosis, arthritis, obesity and osteoporosis; and the use of such combination for the cosmetic treatment of a mammal in order to effect a cosmetically beneficial loss of body weight.

    摘要翻译： 本发明涉及包含DPP-IV抑制剂和至少一种另外的抗糖尿病化合物的组合，其优选选自胰岛素信号通路调节剂，如蛋白酪氨酸磷酸酶（PTPases）的抑制剂，非小分子模拟化合物和 谷氨酰胺 - 果糖-6-磷酸酰胺转移酶（GFAT）的抑制剂，影响失调的肝脏葡萄糖产生的化合物，如葡萄糖-6-磷酸酶（G6Pase）的抑制剂，果糖-1,6-二磷酸酶抑制剂（F-1,6- BPA），糖原磷酸化酶（GP）的抑制剂，胰高血糖素受体拮抗剂和磷酸烯醇丙酮酸羧激酶（PEPCK），丙酮酸脱氢酶激酶（PDHK）抑制剂，胰岛素敏感性增强剂，胰岛素分泌增强剂，α-葡糖苷酶抑制剂，胃排空抑制剂，胰岛素 和α2 - 肾上腺素能拮抗剂，用于同时，分开或顺序使用以预防，延迟进展o 治疗由二肽基肽酶-IV（DPP-IV）介导的病症，特别是糖尿病，特别是2型糖尿病，葡萄糖耐量降低的病症（IGT），空腹血浆葡萄糖受损的病症，代谢性酸中毒，酮症，关节炎，肥胖 和骨质疏松症; 以及使用这种组合来进行哺乳动物的美容治疗，以实现美容上有益​​的体重损失。

    Use of branched polyethylenes in multilayer films and resealable closures
    9.
    发明申请
    Use of branched polyethylenes in multilayer films and resealable closures 审中-公开
    支链聚乙烯在多层薄膜和可重复密封的封闭中的应用

    公开(公告)号：US20060019112A1

    公开(公告)日：2006-01-26

    申请号：US11080759

    申请日：2005-03-15

    申请人： David Holmes ,  Dewey Kerbow ,  Slawomir Opuszko ,  Tina Lorenzo-Moore

    发明人： David Holmes ,  Dewey Kerbow ,  Slawomir Opuszko ,  Tina Lorenzo-Moore

    IPC分类号： B32B27/00

    CPC分类号： B32B27/32 ,  Y10T428/31855

    摘要： Branched polyethylenes of density up to about 0.875 g/cc are used as a component in articles that can be pressure-sealed and unsealed repeatedly. Such articles include multilayer films that contain the branched polyethylene and another thermoplastic and pressure-resealable closures comprising a sealing surface that comprises the branched polyethylene and a sealing surface that comprises a thermoplastic. The multilayer film and closures are particularly useful in packaging, especially plastic packaging, such as bags, pouches, and vacuum skin packaging, to package a large variety of goods.

    摘要翻译： 密度高达约0.875g / cc的分支聚乙烯可用作可以重复压力密封和开封的制品中的组分。 这样的制品包括含有支化聚乙烯的多层膜和另一种热塑性和可重压密封的封闭件，其包括包含支化聚乙烯的密封表面和包含热塑性塑料的密封表面。 多层膜和封闭物在包装，特别是塑料包装，例如袋，袋和真空皮肤包装中特别有用，可以包装各种各样的商品。