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公开(公告)号：US07202071B2
公开(公告)日：2007-04-10
申请号：US10437581
申请日：2003-05-14
申请人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
发明人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
摘要： The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用第p多肽筛选抗菌化合物的方法。
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公开(公告)号：US06261817B1
公开(公告)日：2001-07-17
申请号：US09197063
申请日：1998-11-20
申请人： Sanjoy Biswas , James Raymond Brown , Lisa Kathleen Shilling , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Lisa Kathleen Shilling , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12P2106
CPC分类号： C12N9/93 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K14/3156 , G01N33/56944 , G01N33/573 , G01N33/9446 , Y10S435/822
摘要： The invention provides guaA polypeptides and polynucleotides encoding guaA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing guaA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了guaA多肽和编码guaA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用guaA多肽筛选抗菌化合物的方法。
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公开(公告)号：US06303771B1
公开(公告)日：2001-10-16
申请号：US09080643
申请日：1998-05-18
申请人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
发明人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
IPC分类号： C12N1531
摘要： The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用第p多肽筛选抗菌化合物的方法。
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公开(公告)号：US06225457B1
公开(公告)日：2001-05-01
申请号：US09305001
申请日：1999-05-04
申请人： Sanjoy Biswas , James Raymond Brown , Martin K R Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Martin K R Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C07H2104
CPC分类号： C07K14/3156 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The invention provides murF2 polypeptides and polynucleotides encoding murF2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing murF2 polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码murF2多肽的murF2多肽和多核苷酸以及通过重组技术产生这种多肽的方法。 还提供了利用murF2多肽筛选抗菌化合物的方法。
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公开(公告)号：US06228625B1
公开(公告)日：2001-05-08
申请号：US09273686
申请日：1999-03-22
申请人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N900
CPC分类号： C12Q1/6876 , A61K38/00 , C07K14/3156
摘要： The invention provides metK polypeptides and polynucleotides encoding metK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing metK polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了metK多肽和编码metK多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用metK多肽来筛选抗菌化合物的方法。
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公开(公告)号：US06268177B1
公开(公告)日：2001-07-31
申请号：US09285576
申请日：1999-04-02
申请人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N1500
CPC分类号： C12N9/1077
摘要： The invention provides ndp polypeptides and polynucleotides encoding ndp polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ndp polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了ndp多肽和编码ndp多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ndp多肽筛选抗菌化合物的方法。
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公开(公告)号：US06245891B1
公开(公告)日：2001-06-12
申请号：US09285515
申请日：1999-04-02
申请人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C07K100
CPC分类号： C07K14/3156
摘要： The invention provides nusB polypeptides and polynucleotides encoding nusB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nusB polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码nusB多肽的nusB多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用nusB多肽筛选抗菌化合物的方法。
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8.发明授权Polynucleotides encoding tRNA methyl transferases from Streptococcus pneumoniae 有权编码来自肺炎链球菌的tRNA甲基转移酶的多核苷酸
公开(公告)号：US6165764A
公开(公告)日：2000-12-26
申请号：US274825
申请日：1999-03-23
申请人： David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain , Sanjoy Biswas , James Raymond Brown , Chi Young So , Alison Francis Chalker
发明人： David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain , Sanjoy Biswas , James Raymond Brown , Chi Young So , Alison Francis Chalker
CPC分类号： C12N9/1007 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention provides tRNA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing trmD polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供tRNA甲基转移酶（trmD）多肽和编码trmD多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用trmD多肽筛选抗菌化合物的方法。
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公开(公告)号：US06399343B1
公开(公告)日：2002-06-04
申请号：US09574912
申请日：2000-05-19
申请人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , Richard Lloyd Warren , Magdalena Zalacain , Chi Young So , Christopher M Traini , David John Holmes , Karen Anne Ingraham , Thomas B Mathie
发明人： Sanjoy Biswas , James Raymond Brown , Martin Karl Russel Burnham , Alison Francis Chalker , Richard Lloyd Warren , Magdalena Zalacain , Chi Young So , Christopher M Traini , David John Holmes , Karen Anne Ingraham , Thomas B Mathie
IPC分类号： C12N900
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , A61K48/00 , Y10S435/885
摘要： The invention provides infB polypeptides and polynucleotides encoding infB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing in polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供编码infB多肽的infB多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了在多肽中利用筛选抗菌化合物的方法。
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公开(公告)号：US06350600B1
公开(公告)日：2002-02-26
申请号：US09627769
申请日：2000-07-28
申请人： Sanjoy Biswas , James Raymond Brown , Chi Young So , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Chi Young So , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N900
CPC分类号： C12N9/1007 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention provides trmA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recominant techniques from strepococcus pneumoniae. Also provided are methods for utilizing polypepides to screen for antibacterial compounds.
摘要翻译： 本发明提供trmA甲基转移酶（trmD）多肽和编码trmD多肽的多核苷酸以及通过来自肺炎链球菌的重组技术产生此类多肽的方法。 还提供了利用多肽来筛选抗菌化合物的方法。
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