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公开(公告)号：US4065615A
公开(公告)日：1977-12-27
申请号：US487226
申请日：1974-07-10
IPC分类号： C07H15/23 , C07H15/222 , C07H15/232 , C07H15/234 , C07H15/236 , C07H15/22
CPC分类号： C07H15/222 , Y02P20/55 , Y02P20/582
摘要： A new deoxystreptamine-containing aminoglycoside antibiotic derivative in which all the amino groups other than the amino group at the 1-position of the deoxystreptamine moiety are formylated is obtained in a high yield by treating a deoxystreptamine-containing aminoglycoside antibiotic derivative in which all the amino groups are formylated with a basic substance. The new derivatives are very important for production of 1-N-modified deoxystreptamine-containing aminoglycoside antibiotics.
摘要翻译： 通过处理含有脱氧神经氨酸的氨基糖苷类抗生素衍生物，其中所有氨基糖苷类抗生素衍生物，其中通过处理含有脱氧神经丝氨酸的氨基糖苷类抗生素衍生物，以高产率获得其中所有除去脱氧神经纤维素部分1位氨基以外的所有氨基甲酰化的抗脱敏神经胺抗生素衍生物， 基团被甲酰基化。 新的衍生物对于生产1-N-修饰的含有抗菌素的氨基糖苷类抗生素非常重要。
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2.发明授权Process for producing 2-methyl cephem-2-em and 2-methylcephem-3-em derivitaves 失效制备2-甲基头孢烯-2-em和2-甲基头孢-3-em衍生物的方法
公开(公告)号：US4463172A
公开(公告)日：1984-07-31
申请号：US235998
申请日：1981-02-19
申请人： Satoshi Horii , Nariakira Mizokami , Yutaka Kuwada
发明人： Satoshi Horii , Nariakira Mizokami , Yutaka Kuwada
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/00 , C07D501/04 , C07D501/14 , C07D501/16 , C07D501/18 , C07D501/36 , C07D501/60
CPC分类号： C07D501/04 , C07D501/14
摘要： Novel 2-methylcephalosporin derivatives and production thereof. These cephalosporin derivatives exhibit excellent antibacterial activities against gram-positive and gram-negative bacteria, thus being of value as a prophylactic or therapeutic agent for infections observed in man and animals.
摘要翻译： 新型2-甲基头孢菌素衍生物及其制备方法。 这些头孢菌素衍生物对革兰氏阳性菌和革兰氏阴性细菌表现出优异的抗菌活性，因此作为在人和动物中观察到的感染的预防或治疗剂是有价值的。
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公开(公告)号：US4011391A
公开(公告)日：1977-03-08
申请号：US245135
申请日：1972-04-18
CPC分类号： C07H15/22 , Y10S435/898
摘要： Novel antibiotics, termed validamycins C, D, E and F, and acid salts thereof, are prepared by cultivating a validamycin-producing strain of microorganism of the genus Streptomyces, and optionally converting the free base to its acid salt.
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4.发明授权N-substituted pseudo-aminosugars and pharmaceutical compositions containing same 失效N-取代的假氨基糖和含有它们的药物组合物
公开(公告)号：US4595678A
公开(公告)日：1986-06-17
申请号：US475615
申请日：1983-03-15
申请人： Satoshi Horii , Yukihiko Kameda , Hiroshi Fukase
发明人： Satoshi Horii , Yukihiko Kameda , Hiroshi Fukase
IPC分类号： C07C45/27 , C07C49/497 , C07H15/22 , A61K31/73 , C07H5/06
CPC分类号： C07H15/22 , C07C45/27 , C07C49/497
摘要： A compound of the general formula: ##STR1## wherein A is hydrogen or a hydroxyl group; B is (1) a group of the formula; ##STR2## (2) a group of the formula; ##STR3## or (3) a group of the formula; ##STR4## or a pharmaceutically acceptable salt thereof is novel and possesses excellent inhibitory activity against .alpha.-glucoside hydrolase and are useful for hyperglycemic symptoms and various disorders caused by hyperglycemia.
摘要翻译： 一种通式如下的化合物：其中A是氢或羟基; B是（1）一组公式; （2）一组公式; 或（3）一组公式; 或其药学上可接受的盐是新颖的，对α-葡糖苷水解酶具有优异的抑制活性，并且可用于高血糖症状和由高血糖引起的各种疾病。
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公开(公告)号：US4923975A
公开(公告)日：1990-05-08
申请号：US855407
申请日：1986-04-24
申请人： Yukihiko Kameda , Satoshi Horii
发明人： Yukihiko Kameda , Satoshi Horii
IPC分类号： C07H15/22 , A01N43/16 , A61K31/13 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P3/04 , A61P3/08 , C07C215/44 , C07H15/224 , C12P13/00 , C12P19/46 , C12R1/465
CPC分类号： C07H15/224 , C12P19/46 , C12R1/55
摘要： A novel valiolamine derivative of the formula (I): ##STR1## where R stands for hydrogen or .beta.-D-glucopyranosyl group is useful for a starting material of valiolamine which can be converted to more potent .alpha.-glucosidase inhibiting compounds. The valiolamine derivative is obtained by cultivating Streptomyces hygroscopics in a culture medium and recovering the valiolamine derivative produced and accumulated from the culture broth.
摘要翻译： 式（I）的新型戊酰胺衍生物：其中R代表氢或β-D-吡喃葡萄糖基，其可用于可以转化为更有效的α-葡萄糖苷酶抑制化合物的假乙酰胺的起始物质。 戊酰胺衍生物通过在培养基中培养链霉菌吸湿剂并回收从培养液中产生和积聚的戊醇胺衍生物而获得。
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公开(公告)号：US4803303A
公开(公告)日：1989-02-07
申请号：US39277
申请日：1987-04-17
申请人： Satoshi Horii , Yukihiko Kameda , Hiroshi Fukase
发明人： Satoshi Horii , Yukihiko Kameda , Hiroshi Fukase
IPC分类号： C07D213/38 , C07D307/52 , C07D333/20 , C07C87/36 , C07C87/452
CPC分类号： C07D213/38 , C07D307/52 , C07D333/20
摘要： A compound of the formula: ##STR1## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms optionally substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or an optionally substituted phenyl group, or a cyclic hydrocarbon group having 3 to 7 carbon atoms optionally substituted by hydroxyl, B is hydrogen or hydroxyl, and their production and use.These compounds exhibit excellent inhibitory activity against .alpha.-glucoside hydrolase, thus are useful for hyperglycemic symptoms and various disorders caused by hyperglycemia.
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公开(公告)号：US4777294A
公开(公告)日：1988-10-11
申请号：US39278
申请日：1987-04-17
申请人： Satoshi Horii , Yukihiko Kameda , Hiroshi Fukase
发明人： Satoshi Horii , Yukihiko Kameda , Hiroshi Fukase
IPC分类号： C07D213/38 , C07D307/52 , C07D333/20 , C07C91/16
CPC分类号： C07D213/38 , C07D307/52 , C07D333/20
摘要： A compound of the formula: ##STR1## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms optionally substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or an optionally substituted phenyl group, or a cyclic hydrocarbon group having 3 to 7 carbon atoms optionally substituted by hydroxyl, B is hydrogen or hydroxyl, and their production and use.These compounds exhibit excellent inhibitory activity against .alpha.-glucoside hydrolase, thus are useful for hyperglycemic symptoms and various disorders caused by hyperglycemia.
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公开(公告)号：US4486602A
公开(公告)日：1984-12-04
申请号：US306774
申请日：1981-09-29
申请人： Satoshi Horii , Yukihiko Kameda , Hiroshi Fukase
发明人： Satoshi Horii , Yukihiko Kameda , Hiroshi Fukase
IPC分类号： A61K31/13 , A61K31/135 , A61K31/195 , A61K31/33 , A61P43/00 , C07C67/00 , C07C213/00 , C07C215/44 , C07C215/76 , C07C217/16 , C07C217/70 , C07C217/84 , C07C229/38 , C07C229/54 , C07C229/64 , C07C237/22 , C07C237/30 , C07C239/12 , C07D213/36 , C07D213/38 , C07D307/52 , C07D333/20 , C07C91/18 , C12N9/96
CPC分类号： C07D307/52 , C07D213/38 , C07D333/20
摘要： A compound of the formula: ##STR1## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms optionally substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or an optionally substituted phenyl group; or a cyclic hydrocarbon group having 3 to 7 carbon atoms optionally substituted by hydroxyl, and their production and use.These compounds exhibit excellent inhibitory activity against glucoside hydrolase, thus are useful for hyperglycemic symptoms and various disorders caused by hyperglycemia.
摘要翻译： 下式的化合物：其中A是任选被羟基，苯氧基，噻吩基，呋喃基，吡啶基，环己基或任选取代的苯基取代的具有1-10个碳原子的链烃基; 或任选被羟基取代的碳原子数为3〜7的环状烃基及其制造和用途。 这些化合物对葡萄糖苷水解酶表现出优异的抑制活性，因此可用于高血糖症状和由高血糖引起的各种疾病。
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公开(公告)号：US4089947A
公开(公告)日：1978-05-16
申请号：US710238
申请日：1976-07-30
CPC分类号： C07H15/22 , A01N43/16 , Y10S435/898
摘要： Novel antibiotics, termed validamycins C, D, E and F, and acid salts thereof, are prepared by cultivating a validamycin-producing strain of microorganism of the genus Streptomyces, and optionally converting the free base to its acid salt. These antibiotics, as well as validoxylamines A and B, are useful for controlling plant diseases, and can be applied to the plants in the form of the cultured broth, filtrate or concentrate thereof, or purified preparation thereof.
摘要翻译： 称为有效霉素C，D，E和F的新型抗生素及其酸式盐通过培养产生链霉菌属的微生物的有效霉素菌株，并任选地将游离碱转化为其酸盐来制备。 这些抗生素以及有效的甲氧基胺A和B可用于控制植物病害，并且可以以培养的肉汤，滤液或浓缩物或其纯化制剂的形式施用于植物。
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公开(公告)号：US4946779A
公开(公告)日：1990-08-07
申请号：US343586
申请日：1989-04-27
申请人： Yukihiko Kameda , Satoshi Horii
发明人： Yukihiko Kameda , Satoshi Horii
IPC分类号： C12P13/00
CPC分类号： C12P13/001 , C12R1/55 , Y10S435/898
摘要： Novel pseudo-aminosugars, or 5-amino-1-hydroxymethyl-1,2,3,4-cyclohexanetetrol, their production and use.These pseudo-aminosugars exhibit excellent .alpha.-glucosidase inhibitory activity and are useful for hyperglycemic symptoms and various disorders caused by hyperglycemia.
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