公开(公告)号：US5690893A

公开(公告)日：1997-11-25

申请号：US461160

申请日：1995-06-05

申请人： Satoshi Ozawa ,  Takafumi Kikuchi ,  Yoshiki Murakami ,  Masaaki Nakai ,  Koutarou Yamashita ,  Toshiko Fujii ,  Yuji Miyahara ,  Yoshio Watanabe

发明人： Satoshi Ozawa ,  Takafumi Kikuchi ,  Yoshiki Murakami ,  Masaaki Nakai ,  Koutarou Yamashita ,  Toshiko Fujii ,  Yuji Miyahara ,  Yoshio Watanabe

IPC分类号： G01N35/00 ,  G01N27/333

CPC分类号： G01N35/00732 ,  G01N2035/00683 ,  G01N2035/00782 ,  G01N35/00663 ,  Y10T436/11 ,  Y10T436/115831 ,  Y10T436/2575

摘要： An analyzer includes an exchangeable and consumable element such as a sensor, column or reagent the characteristic of which specifies an analyzing condition. The element is provided with a non-volatile semiconductor memory which holds an analyzing condition adapted for the element as data. When the element is mounted on an analyzer body, a controller of the analyzer reads the analyzing condition from the memory to update an analyzing condition inherently provided in the analyzer body. The result of analysis and/or operational history information of use of the element may be written into the memory with which the element is provided.

摘要翻译： 分析仪包括可交换和可消耗元件，例如传感器，色谱柱或试剂，其特性指定分析条件。 该元件设置有非易失性半导体存储器，其将适合该元件的分析条件保持为数据。 当元件安装在分析器本体上时，分析器的控制器从存储器读取分析条件，以更新分析器主体中固有地提供的分析条件。 可以将元素的使用的分析和/或操作历史信息的结果写入到提供元件的存储器中。

公开(公告)号：US5472590A

公开(公告)日：1995-12-05

申请号：US354643

申请日：1994-12-13

申请人： Koutarou Yamashita ,  Mamoru Taki ,  Yuji Miyahara ,  Toshiko Fujii ,  Satoshi Ozawa ,  Yoshio Watanabe

发明人： Koutarou Yamashita ,  Mamoru Taki ,  Yuji Miyahara ,  Toshiko Fujii ,  Satoshi Ozawa ,  Yoshio Watanabe

IPC分类号： G01N27/333 ,  G01N27/414 ,  G01N27/26

CPC分类号： G01N27/414 ,  G01N27/3335

摘要： An ion sensor having an ion selectivity, which comprises an internal electrode of metal/metal salt, composed of an electroconductive layer of at least one metal and a layer of an insoluble salt of the metal in contact with the electroconductive layer, an ion selective membrane whose supporting membrane is composed of a hydrophobic polymer, and an intermediate layer capable of keeping water molecules, provided between the internal solid electrode and the ion selective membrane, where the organic compound having a water-keeping property is polymethylene glycol, polyethylene glycol or polypropylene glycol, each having a molecular weight of 200 to 600, and the inorganic compound having a water-keeping property is calcium chloride, gold chloride, magnesium perchlorate, magnesium fluoride or vanadium chloride dioxide, is suitable for analysis of specific ion species in a biological fluid with practically prolonged maintenance of properties of electrode.

摘要翻译： 一种具有离子选择性的离子传感器，其包括金属/金属盐的内部电极，其由至少一种金属的导电层和与导电层接触的金属的不溶性盐层，离子选择性膜 其内部固体电极与离子选择性膜之间具有疏水性聚合物和能够保持水分子的中间层，其中具有保水性的有机化合物为聚亚甲基二醇，聚乙二醇或聚丙烯 乙二醇，分子量为200〜600，具有保水性的无机化合物为氯化钙，氯化金，高氯酸镁，氟化镁或二氯化钒，适用于分析生物中的特定离子种类 流体与电极性能几乎延长。

公开(公告)号：US5413685A

公开(公告)日：1995-05-09

申请号：US128236

申请日：1993-09-29

申请人： Satoshi Ozawa ,  Yuji Miyahara ,  Mamoru Taki ,  Koutarou Yamashita ,  Yoshio Watanabe

发明人： Satoshi Ozawa ,  Yuji Miyahara ,  Mamoru Taki ,  Koutarou Yamashita ,  Yoshio Watanabe

IPC分类号： G01N27/333

CPC分类号： G01N27/333

摘要： An ion-selective electrode comprises an ion-sensing membrane, an internal electrode adhered to the ion-sensing membrane, and a lead connected to said internal electrode. The internal electrode used comprises a plurality of metallic wires arranged into a grating or a mesh. The wires comprises a metal core and a surface layer of a salt of the metal. The metal of the core is silver and the salt of the metal is a silver halide selected from the group consisting of silver bromide, silver chloride and silver iodide. At least a part of the internal electrode is buried inside the ion-sensing membrane. Various components, the ion-sensing membrane, the internal electrode, the lead, an external terminal, are disposed in a flow-through cell having a flow path formed therein, through which path a sample solution is passed, to constitute the ion-selective electrode. In the flow-through cell is disposed a means of maintaining the humidity to feed water vapor therefrom to the ion-sensing membrane. This structure, even when the ion-sensing membrane has a complicated configuration such as concave or convex surface, enables the establishment of good adhering conditions between the internal electrode and the ion-sensing membrane while retaining the complicated configuration of the ion-sensing membrane without reducing the effective contact areas of the ion-sensing membrane and the internal electrode.

摘要翻译： 离子选择性电极包括离子感测膜，粘附到离子感测膜的内部电极和连接到所述内部电极的引线。 使用的内部电极包括布置成光栅或网格的多根金属线。 电线包括金属芯和金属盐的表面层。 芯的金属是银，金属的盐是选自溴化银，氯化银和碘化银的卤化银。 内部电极的至少一部分被埋在离子感测膜的内部。 各种成分，离子感测膜，内部电极，引线，外部端子配置在具有形成在其中的流路的流通池中，通过该流路通过样品溶液以构成离子选择性 电极。 在流通池中设置有保持湿度以将水蒸汽从其中供给到离子感测膜的手段。 这种结构即使当离子感测膜具有诸如凹凸表面的复杂构造时，也能够在保持离子感测膜的复杂结构而在内部电极和离子感测膜之间建立良好的粘附条件而没有 减少离子感测膜和内部电极的有效接触面积。

公开(公告)号：US5505836A

公开(公告)日：1996-04-09

申请号：US219259

申请日：1994-03-29

申请人： Yuji Miyahara ,  Satoshi Ozawa ,  Koutarou Yamashita ,  Yoshio Watanabe

发明人： Yuji Miyahara ,  Satoshi Ozawa ,  Koutarou Yamashita ,  Yoshio Watanabe

IPC分类号： G01N27/414 ,  G01N27/333 ,  G01N27/403

CPC分类号： G01N27/3335 ,  G01N27/403

摘要： The solid-state ion sensor of the present invention comprises an inner electrode comprising a metal and a water-insoluble salt of the metal which covers at least a part of the surface of the metal, an ion-selective membrane selectively responsive to the ion species to be determined, and an intermediate layer comprising a hydrophilic polymeric membrane provided between the inner electrode and the ion-selective membrane. The inner electrode comprises a metal and a halogenide of the metal which covers at least a part of the surface of the metal. In the hydrophilic polymeric membrane is dispersed a hydrophilic electrolyte having halogen ions same as or different from those constituting the halogenide with the weight ratio of the electrolyte and the polymer [(electrolyte) wt. %/(polymer) wt. %] being at least 1/100. A polymeric ion-conductor can be used as the hydrophilic polymeric membrane.

摘要翻译： 本发明的固体离子传感器包括内部电极，其包含覆盖金属表面的至少一部分的金属和金属的水不溶性盐，选择性地响应离子种类的离子选择膜 以及包含设置在内部电极和离子选择性膜之间的亲水性聚合物膜的中间层。 内部电极包括覆盖金属表面的至少一部分的金属的金属和卤化物。 在亲水性聚合物膜中分散有具有与构成卤化物的卤素离子相同或不同的卤素离子的亲水电解质，其电解质和聚合物的重量比[（电解质）wt。 ％/（聚合物）wt。 ％]至少为1/100。 聚合物离子导体可用作亲水性聚合物膜。

公开(公告)号：US5362445A

公开(公告)日：1994-11-08

申请号：US73640

申请日：1993-05-17

申请人： Yuji Miyahara ,  Toshiko Fujii ,  Thomas Buhrer ,  Yoshio Watanabe

发明人： Yuji Miyahara ,  Toshiko Fujii ,  Thomas Buhrer ,  Yoshio Watanabe

IPC分类号： G01N21/03 ,  G01N21/55 ,  G01N33/543 ,  G01N21/00

CPC分类号： G01N21/552 ,  G01N33/54373 ,  G01N2021/0385

摘要： A biochemistry analyzer includes, an attenuated total reflection prism, a sample cell disposed on a surface of the prism, a sample supplier, a device for disposing more objective molecules in the liquid sample to a near portion of the sample which is near the surface of the prism, an infrared light source for generating an infrared light which is transmitted to the attenuated total reflection prism, a detector for detecting the infrared light which is reflected from the prism after the far portion of the sample is solidified, and a computer for calculating signals from the detector. As the objective molecules are gathered near the prism, accuracy of the biochemistry analyzer becomes higher.

摘要翻译： 生物化学分析仪包括衰减的全反射棱镜，设置在棱镜表面上的样品池，样品供应商，用于将液体样品中的更客观分子设置在靠近表面的样品的接近部分的装置 棱镜，用于产生传输到衰减全反射棱镜的红外光的红外光源，用于检测在样品的远部固化之后从棱镜反射的红外光的检测器，以及计算机 来自检测器的信号。 当目标分子聚集在棱镜附近时，生化分析仪的精度变高。

公开(公告)号：US5434411A

公开(公告)日：1995-07-18

申请号：US58610

申请日：1993-05-06

申请人： Yuji Miyahara ,  Toshiko Fujii ,  Yoshio Watanabe

发明人： Yuji Miyahara ,  Toshiko Fujii ,  Yoshio Watanabe

IPC分类号： G01N21/27 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/552

CPC分类号： G01N21/552

摘要： Infrared radiation is incident on a total reflection plane of a prism and penetrates a liquid sample through a metal layer put between the total reflection plane and the liquid sample in close contact therewith whereby the infrared radiation is partially absorbed by the liquid sample. Alternatively, the liquid sample may be put between the total reflection plane and the metal layer in close contact therewith so that part of the light penetrates the sample from the prism through the total reflection plane to interact with the metal layer and then is caused to reenter into the prism whereby it is partly absorbed by the liquid sample. The metal layer is for enhancing the intensity of the electric field component of the infrared radiation. The incident angle of the infrared radiation on the total reflection plane is so set that the partially absorbed infrared radiation is total-reflected. The total-reflected infrared radiation is detected by a detector so as to obtain an absorption spectrum of the liquid sample by the infrared radiation.

摘要翻译： 红外线辐射入射在棱镜的全反射面上，并通过与全反射面和液体样品紧密接触的金属层穿透液体样品，由此红外辐射被液体样品部分地吸收。 或者，液体样品可以放置在全反射面和金属层之间，与其紧密接触，使得光的一部分光从棱镜穿过样品通过全反射平面与金属层相互作用，然后被重新进入 进入棱镜，由此部分地被液体样品吸收。 金属层用于增强红外辐射的电场分量的强度。 红外线辐射对全反射面的入射角设定为部分吸收的红外辐射被全反射。 通过检测器检测全反射红外线辐射，以便通过红外辐射获得液体样品的吸收光谱。

公开(公告)号：US5988857A

公开(公告)日：1999-11-23

申请号：US916667

申请日：1997-08-22

申请人： Satoshi Ozawa ,  Kootaroo Yamashita ,  Yuji Miyahara ,  Toshiyuki Ikeda

发明人： Satoshi Ozawa ,  Kootaroo Yamashita ,  Yuji Miyahara ,  Toshiyuki Ikeda

IPC分类号： G01N35/00 ,  G01N35/02 ,  G06F19/00 ,  G06G7/66

CPC分类号： G01N35/00732 ,  G01N35/0092 ,  G01N35/0095 ,  G01N35/02 ,  G01N2035/00782 ,  G01N2035/00881 ,  G01N2035/0093

摘要： An automatic processing system and method which has high flexibility, extendibility and failure resistance. An automatic processing system and method that provides for the decentralized control of processings of plural samples. The invention combines a plurality of processing instruments and makes use of sample containers for each sample. Each sample container includes an information processing mechanism, a memory mechanism and a communication mechanism. The sample container has stored therein an abstract processing procedure, and determines, based on information concerning the processing instruments obtained from the processing instruments and the abstract processing procedure, a processing procedure for processing the sample. Thereafter, the processing instruments process the sample based on the processing procedure determined by the sample container. The processing procedure of each sample container can allow for performing priority, and cooperative and concerted operations among the processing instruments and the sample containers.

摘要翻译： 具有高灵活性，可扩展性和抗破坏性的自动处理系统和方法。 一种自动处理系统和方法，其提供对多个样品的处理的分散控制。 本发明组合了多个处理设备并且使用每个样品的样品容器。 每个样本容器包括信息处理机构，存储机构和通信机制。 样本容器在其中存储抽象处理过程，并且基于从处理工具获得的处理设备和抽象处理过程的信息确定处理样本的处理过程。 此后，处理工具基于由样品容器确定的处理过程处理样品。 每个样品容器的处理程序可以在处理设备和样品容器之间执行优先级和协作一致的操作。

公开(公告)号：US5250168A

公开(公告)日：1993-10-05

申请号：US723952

申请日：1991-07-01

申请人： Keiji Tsukada ,  Yuji Miyahara ,  Yasuhisa Shibata ,  Yoshio Watanabe

发明人： Keiji Tsukada ,  Yuji Miyahara ,  Yasuhisa Shibata ,  Yoshio Watanabe

IPC分类号： G01N27/28 ,  G01N27/26

CPC分类号： G01N27/414

摘要： Disclosed is an integrated ion sensor, which comprises at least one ion selective membrane sensitive to ions contained in a solution to be measured for detecting the concentration of the ions, a signal processing circuit for inputting a detected signal obtained by the ion selective membrane through a conductive member and fetching the detected signal through MOSFETs or the like included in an input stage to process the same, a reference electrode disposed in the measuring environment made by the solution to be measured and to be set to a predetermined voltage relationship between the reference electrode and the ion selective membrane, and a power supply having negative and positive terminals for supplying a driving power to the signal processing circuit through the terminals, one of the terminals being connected to the reference electrode, wherein the signal processing circuit is set to an active state at a voltage set to the reference electrode by controlling the threshold value of at least one of the MOSFETs of the signal processing circuit.

摘要翻译： 公开了一种集成离子传感器，其包括对待测溶液中包含的离子敏感的至少一种离子选择性膜，用于检测离子的浓度;信号处理电路，用于输入由离子选择性膜获得的检测信号通过 导电构件，并通过包含在输入级中的MOSFET等获取检测到的信号，以处理由待测量溶液制成的测量环境中的参考电极，并将其设置为参考电极之间的预定电压关系 和离子选择膜，以及具有用于通过端子向信号处理电路提供驱动电力的负极和正极端子的电源，其中一个端子连接到参考电极，其中信号处理电路被设置为有源 通过控制at的阈值将电压设置在参考电极的电压 信号处理电路中的至少一个MOSFET。

公开(公告)号：US5344545A

公开(公告)日：1994-09-06

申请号：US817653

申请日：1992-01-07

申请人： Keiji Tsukada ,  Yuji Miyahara ,  Yasuhisa Shibata ,  Yoshio Watanabe

发明人： Keiji Tsukada ,  Yuji Miyahara ,  Yasuhisa Shibata ,  Yoshio Watanabe

IPC分类号： G01N27/28 ,  B01J19/00 ,  G01N27/404 ,  G01N27/49

CPC分类号： G01N27/404 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00853

摘要： A gas sensor e.g. an oxygen sensor for testing body fluids, has a laminated structure with a cavity for holding a gel or liquid electrolyte in contact with a cathode and anodes formed by deposition on layers of the structure. The cathode contacts the electrolyte cavity only at a small-volume reaction region defined e.g. in a groove which communicates with a larger, laminar volume of the cavity formed e.g. by a spacer layer having through apertures. A small gas-permeable window opposes the cathode at the reaction region. The laminar construction can be mass-produced. The enlarged electrolyte reservoir lengthens the sensor life.

摘要翻译： 气体传感器 用于测试体液的氧传感器具有层压结构，其具有用于保持凝胶或液体电解质与阴极接触的空腔和通过沉积在该结构的层上形成的阳极。 阴极仅在限定的小体积反应区域处接触电解质腔。 在与形成的较大的层状体积的空腔连通的凹槽中。 通过具有通孔的间隔层。 小的透气窗在反应区域与阴极相对。 层状结构可以批量生产。 扩大的电解质储存器延长了传感器的使用寿命。

公开(公告)号：US5352352A

公开(公告)日：1994-10-04

申请号：US948646

申请日：1992-09-23

申请人： Keiji Tsukada ,  Yuji Miyahara ,  Yasuhisa Shibata ,  Yoshio Watanabe

发明人： Keiji Tsukada ,  Yuji Miyahara ,  Yasuhisa Shibata ,  Yoshio Watanabe

IPC分类号： G01N27/404 ,  A61B5/00 ,  G01N27/49 ,  G01N33/49

CPC分类号： A61B5/14542 ,  A61B5/14539 ,  A61B5/1468 ,  G01N27/4045 ,  G01N33/4925

摘要： A sensor for detecting a carbonic acid gas dissolved in body fluids has a laminated structure including an outer plate having a carbonic acid gas permeable window, a plate for a pH-electrode having a pH sensitive membrane, an intermediate plate having a cavity for accommodating an electrolyte, and a plate for a reference electrode. The plate for the pH-electrode is constituted in a manner that a pH sensitive membrane constituted by a membrane of an oxide of a platinum group metal is formed on an insulating substrate and the electrolyte contacts with the pH sensitive membrane in a groove. The pH sensitive membrane is disposed so as to oppose to the carbonic acid gas permeable window.

摘要翻译： 用于检测溶解在体液中的碳酸气体的传感器具有包括具有碳酸气体透过窗的外板，具有pH敏感膜的pH电极的板，具有用于容纳 电解质和用于参考电极的板。 用于pH电极的板构成为在绝缘基板上形成由铂族金属的氧化物的膜构成的pH敏感膜，电解液与沟槽中的pH敏感膜接触。 将pH敏感膜设置成与碳酸气体透过窗口相对。