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    Ion sensor
    2.
    发明授权
    Ion sensor 失效
    离子传感器

    公开(公告)号：US5472590A

    公开(公告)日：1995-12-05

    申请号：US354643

    申请日：1994-12-13

    申请人： Koutarou Yamashita ,  Mamoru Taki ,  Yuji Miyahara ,  Toshiko Fujii ,  Satoshi Ozawa ,  Yoshio Watanabe

    发明人： Koutarou Yamashita ,  Mamoru Taki ,  Yuji Miyahara ,  Toshiko Fujii ,  Satoshi Ozawa ,  Yoshio Watanabe

    IPC分类号： G01N27/333 ,  G01N27/414 ,  G01N27/26

    CPC分类号： G01N27/414 ,  G01N27/3335

    摘要： An ion sensor having an ion selectivity, which comprises an internal electrode of metal/metal salt, composed of an electroconductive layer of at least one metal and a layer of an insoluble salt of the metal in contact with the electroconductive layer, an ion selective membrane whose supporting membrane is composed of a hydrophobic polymer, and an intermediate layer capable of keeping water molecules, provided between the internal solid electrode and the ion selective membrane, where the organic compound having a water-keeping property is polymethylene glycol, polyethylene glycol or polypropylene glycol, each having a molecular weight of 200 to 600, and the inorganic compound having a water-keeping property is calcium chloride, gold chloride, magnesium perchlorate, magnesium fluoride or vanadium chloride dioxide, is suitable for analysis of specific ion species in a biological fluid with practically prolonged maintenance of properties of electrode.

    摘要翻译： 一种具有离子选择性的离子传感器，其包括金属/金属盐的内部电极，其由至少一种金属的导电层和与导电层接触的金属的不溶性盐层，离子选择性膜 其内部固体电极与离子选择性膜之间具有疏水性聚合物和能够保持水分子的中间层，其中具有保水性的有机化合物为聚亚甲基二醇，聚乙二醇或聚丙烯 乙二醇，分子量为200〜600，具有保水性的无机化合物为氯化钙，氯化金，高氯酸镁，氟化镁或二氯化钒，适用于分析生物中的特定离子种类 流体与电极性能几乎延长。

    Ion-selective electrode
    3.
    发明授权
    Ion-selective electrode 失效
    离子选择电极

    公开(公告)号：US5413685A

    公开(公告)日：1995-05-09

    申请号：US128236

    申请日：1993-09-29

    申请人： Satoshi Ozawa ,  Yuji Miyahara ,  Mamoru Taki ,  Koutarou Yamashita ,  Yoshio Watanabe

    发明人： Satoshi Ozawa ,  Yuji Miyahara ,  Mamoru Taki ,  Koutarou Yamashita ,  Yoshio Watanabe

    IPC分类号： G01N27/333

    CPC分类号： G01N27/333

    摘要： An ion-selective electrode comprises an ion-sensing membrane, an internal electrode adhered to the ion-sensing membrane, and a lead connected to said internal electrode. The internal electrode used comprises a plurality of metallic wires arranged into a grating or a mesh. The wires comprises a metal core and a surface layer of a salt of the metal. The metal of the core is silver and the salt of the metal is a silver halide selected from the group consisting of silver bromide, silver chloride and silver iodide. At least a part of the internal electrode is buried inside the ion-sensing membrane. Various components, the ion-sensing membrane, the internal electrode, the lead, an external terminal, are disposed in a flow-through cell having a flow path formed therein, through which path a sample solution is passed, to constitute the ion-selective electrode. In the flow-through cell is disposed a means of maintaining the humidity to feed water vapor therefrom to the ion-sensing membrane. This structure, even when the ion-sensing membrane has a complicated configuration such as concave or convex surface, enables the establishment of good adhering conditions between the internal electrode and the ion-sensing membrane while retaining the complicated configuration of the ion-sensing membrane without reducing the effective contact areas of the ion-sensing membrane and the internal electrode.

    摘要翻译： 离子选择性电极包括离子感测膜，粘附到离子感测膜的内部电极和连接到所述内部电极的引线。 使用的内部电极包括布置成光栅或网格的多根金属线。 电线包括金属芯和金属盐的表面层。 芯的金属是银，金属的盐是选自溴化银，氯化银和碘化银的卤化银。 内部电极的至少一部分被埋在离子感测膜的内部。 各种成分，离子感测膜，内部电极，引线，外部端子配置在具有形成在其中的流路的流通池中，通过该流路通过样品溶液以构成离子选择性 电极。 在流通池中设置有保持湿度以将水蒸汽从其中供给到离子感测膜的手段。 这种结构即使当离子感测膜具有诸如凹凸表面的复杂构造时，也能够在保持离子感测膜的复杂结构而在内部电极和离子感测膜之间建立良好的粘附条件而没有 减少离子感测膜和内部电极的有效接触面积。

    Solid-state ion sensor
    4.
    发明授权
    Solid-state ion sensor 失效
    固态离子传感器

    公开(公告)号：US5505836A

    公开(公告)日：1996-04-09

    申请号：US219259

    申请日：1994-03-29

    申请人： Yuji Miyahara ,  Satoshi Ozawa ,  Koutarou Yamashita ,  Yoshio Watanabe

    发明人： Yuji Miyahara ,  Satoshi Ozawa ,  Koutarou Yamashita ,  Yoshio Watanabe

    IPC分类号： G01N27/414 ,  G01N27/333 ,  G01N27/403

    CPC分类号： G01N27/3335 ,  G01N27/403

    摘要： The solid-state ion sensor of the present invention comprises an inner electrode comprising a metal and a water-insoluble salt of the metal which covers at least a part of the surface of the metal, an ion-selective membrane selectively responsive to the ion species to be determined, and an intermediate layer comprising a hydrophilic polymeric membrane provided between the inner electrode and the ion-selective membrane. The inner electrode comprises a metal and a halogenide of the metal which covers at least a part of the surface of the metal. In the hydrophilic polymeric membrane is dispersed a hydrophilic electrolyte having halogen ions same as or different from those constituting the halogenide with the weight ratio of the electrolyte and the polymer [(electrolyte) wt. %/(polymer) wt. %] being at least 1/100. A polymeric ion-conductor can be used as the hydrophilic polymeric membrane.

    摘要翻译： 本发明的固体离子传感器包括内部电极，其包含覆盖金属表面的至少一部分的金属和金属的水不溶性盐，选择性地响应离子种类的离子选择膜 以及包含设置在内部电极和离子选择性膜之间的亲水性聚合物膜的中间层。 内部电极包括覆盖金属表面的至少一部分的金属的金属和卤化物。 在亲水性聚合物膜中分散有具有与构成卤化物的卤素离子相同或不同的卤素离子的亲水电解质，其电解质和聚合物的重量比[（电解质）wt。 ％/（聚合物）wt。 ％]至少为1/100。 聚合物离子导体可用作亲水性聚合物膜。

    Automatic processing system
    5.
    发明授权
    Automatic processing system 失效
    自动处理系统

    公开(公告)号：US5988857A

    公开(公告)日：1999-11-23

    申请号：US916667

    申请日：1997-08-22

    申请人： Satoshi Ozawa ,  Kootaroo Yamashita ,  Yuji Miyahara ,  Toshiyuki Ikeda

    发明人： Satoshi Ozawa ,  Kootaroo Yamashita ,  Yuji Miyahara ,  Toshiyuki Ikeda

    IPC分类号： G01N35/00 ,  G01N35/02 ,  G06F19/00 ,  G06G7/66

    CPC分类号： G01N35/00732 ,  G01N35/0092 ,  G01N35/0095 ,  G01N35/02 ,  G01N2035/00782 ,  G01N2035/00881 ,  G01N2035/0093

    摘要： An automatic processing system and method which has high flexibility, extendibility and failure resistance. An automatic processing system and method that provides for the decentralized control of processings of plural samples. The invention combines a plurality of processing instruments and makes use of sample containers for each sample. Each sample container includes an information processing mechanism, a memory mechanism and a communication mechanism. The sample container has stored therein an abstract processing procedure, and determines, based on information concerning the processing instruments obtained from the processing instruments and the abstract processing procedure, a processing procedure for processing the sample. Thereafter, the processing instruments process the sample based on the processing procedure determined by the sample container. The processing procedure of each sample container can allow for performing priority, and cooperative and concerted operations among the processing instruments and the sample containers.

    摘要翻译： 具有高灵活性，可扩展性和抗破坏性的自动处理系统和方法。 一种自动处理系统和方法，其提供对多个样品的处理的分散控制。 本发明组合了多个处理设备并且使用每个样品的样品容器。 每个样本容器包括信息处理机构，存储机构和通信机制。 样本容器在其中存储抽象处理过程，并且基于从处理工具获得的处理设备和抽象处理过程的信息确定处理样本的处理过程。 此后，处理工具基于由样品容器确定的处理过程处理样品。 每个样品容器的处理程序可以在处理设备和样品容器之间执行优先级和协作一致的操作。

    Endoscope apparatus
    6.
    发明授权
    Endoscope apparatus 有权
    内窥镜装置

    公开(公告)号：US09232883B2

    公开(公告)日：2016-01-12

    申请号：US13017349

    申请日：2011-01-31

    申请人： Satoshi Ozawa ,  Takayuki Iida ,  Yasuhiro Minetoma ,  Akihiko Erikawa

    发明人： Satoshi Ozawa ,  Takayuki Iida ,  Yasuhiro Minetoma ,  Akihiko Erikawa

    IPC分类号： A61B1/06 ,  A61B1/00 ,  A61B1/04 ,  A61B1/07

    CPC分类号： A61B1/00188 ,  A61B1/043 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0653 ,  A61B1/0684 ,  A61B1/07

    摘要： To provide an endoscope apparatus in which the observation image can be varied continuously as the observation magnification is varied by a zoom magnification varying manipulation so that an observation image suitable for an endoscope diagnosis is obtained at each observation magnification, and to thereby prevent the operator from feeling uncomfortable and increase the accuracy of a diagnosis. An endoscope apparatus is equipped with illuminating unit having plural light sources which generate light beams having different spectra, for illuminating an observation subject; imaging unit for imaging the observation subject; observation magnification varying unit for varying observation magnification of the imaging of the imaging unit; and light quantity ratio varying unit for continuously varying an emission light quantity ratio between the plural light sources according to the observation magnification that is set by the observation magnification varying unit.

    摘要翻译： 为了提供一种内窥镜装置，其中，随着观察倍率通过变焦倍率变化操作而变化，观察图像可以连续变化，从而在每个观察放大倍数下获得适合于内窥镜诊断的观察图像，从而防止操作者 感觉不舒服，提高了诊断的准确性。 一种内窥镜装置具备：具有多个光源的照明单元，该光源产生具有不同光谱的光束，用于照明观察对象物; 用于对观察对象成像的成像单元; 用于改变所述成像单元的成像的观察倍率的观察倍率变化单元; 以及光量比变化单元，用于根据由观察倍率变化单元设定的观察倍率连续地改变多个光源之间的发射光量比。

    Method of controlling endoscope and endoscope
    7.
    发明授权
    Method of controlling endoscope and endoscope 有权
    内窥镜和内窥镜控制方法

    公开(公告)号：US08936548B2

    公开(公告)日：2015-01-20

    申请号：US12890357

    申请日：2010-09-24

    申请人： Satoshi Ozawa ,  Akihiko Erikawa ,  Azuchi Endo

    发明人： Satoshi Ozawa ,  Akihiko Erikawa ,  Azuchi Endo

    IPC分类号： A61B1/06 ,  A61B6/00 ,  A61B1/05

    CPC分类号： A61B1/0638 ,  A61B1/05 ,  A61B1/063 ,  A61B1/0646 ,  A61B1/0653

    摘要： An endoscope 100 includes a first light source 45 that emits white illumination light, a second light source 47 that emits narrow-band light and an imaging section that has an imaging device 21 having plural detection pixels and images a region to be observed. The imaging section is caused to output a captured image signal including both a return light component of the white illumination light from the region to be observed by and a return light component of the narrow-band light the white illumination light. From the captured image signal, the return light component of the narrow-band light is selectively extracted, and a brightness level of the extracted return light component of the narrow-band light is changed by changing a light amount of light emitted from the second light source 47.

    摘要翻译： 内窥镜100包括发射白色照明光的第一光源45，发射窄带光的第二光源47和具有多个检测像素的成像装置21和要观察的区域的图像的摄像部。 使得成像部分输出包括来自待观察区域的白色照明光的返回光分量和窄带光的白光照明光的返回光分量的捕获图像信号。 从拍摄图像信号中，选择性地提取窄带光的返回光分量，并且通过改变从第二光发射的光的光量来改变所提取的窄带光的返回光分量的亮度水平 来源47。

    Substrate with Photo-Controllable Cell Adhesion Property, Method for Analyzing and Fractionating Cells, and Device for Analysis and Fractionation of Cells
    8.
    发明申请
    Substrate with Photo-Controllable Cell Adhesion Property, Method for Analyzing and Fractionating Cells, and Device for Analysis and Fractionation of Cells 审中-公开
    具有光可控细胞粘附性质的基质，分析细胞分离方法和分离细胞分离装置

    公开(公告)号：US20120225448A1

    公开(公告)日：2012-09-06

    申请号：US13509338

    申请日：2010-11-04

    申请人： Hisashi Sugiyama ,  Satoshi Takahashi ,  Kenko Uchida ,  Satoshi Ozawa

    发明人： Hisashi Sugiyama ,  Satoshi Takahashi ,  Kenko Uchida ,  Satoshi Ozawa

    IPC分类号： C12Q1/02 ,  C12M1/34

    CPC分类号： C12M47/04 ,  C12N1/02 ,  C12N11/02

    摘要： When cells are analyzed, fractionated, and incubated while keeping the cells alive, real-time operations can be performed more easily and the cells can be incubated while removing unnecessary cells from the incubated cells to purify the cells being incubated. Furthermore, desired cells are separated through analysis from the incubated cells, and the purity, recovery, and viability of the cells are heightened. Use is made of a substrate having photo-controllable cell adhesion properties, the substrate comprising a transparent base and, formed thereon, a film of a material which has photo-controllable cell adhesion properties and has been obtained by bonding a cell-adhesive material to a cell-non-adhesive material through photo-dissociable groups. Cell images are detected and analyzed to obtain information about the location of desired cells. On the basis of the information, a space is formed between cells and the material having photo-controllable cell adhesion properties is cut, by means of second light irradiation. Meanwhile, by means of first light irradiation, the surface of the substrate is changed from a cell-adhesive surface to a cell-non-adhesive surface, thereby separating the cell(s) from the substrate. Thus, cells can be analyzed and fractionated while keeping the cells alive.

    摘要翻译： 当细胞分析，分级和孵育同时保持细胞活着时，可以更容易地进行实时操作，并且可以孵育细胞，同时从培养的细胞中除去不需要的细胞以纯化待孵育的细胞。 此外，通过从培养的细胞的分析分离所需的细胞，并且提高细胞的纯度，回收率和存活力。 使用具有光可控细胞粘附性质的基材，所述基材包括透明基材，并且在其上形成具有光可控细胞粘附性的材料的膜，并且通过将细胞粘合剂材料粘合到 通过光解离基团的细胞非粘合材料。 检测和分析细胞图像以获得关于所需细胞位置的信息。 基于该信息，在单元之间形成空间，通过第二次光照射切断具有光可控细胞粘附性的材料。 同时，通过第一光照射，将基板的表面从电池 - 粘合剂表面改变为电池非粘合剂表面，从而将电池与基板分离。 因此，可以在保持细胞活着的同时分析和分级细胞。