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公开(公告)号：US20100105140A1
公开(公告)日：2010-04-29
申请号：US12504286
申请日：2009-07-16
CPC分类号： C12N9/22
摘要： This document describes the Passport transposon system and methods of making and using the same.
摘要翻译： 本文档描述了护照转座子系统及其使用方法。
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公开(公告)号：US08518701B2
公开(公告)日：2013-08-27
申请号：US13467588
申请日：2012-05-09
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/108 , A01K2267/03 , A01K2267/0306 , C07K14/4702 , C07K14/4708 , C07K14/705 , C12N15/873 , C12N15/907 , C12N2015/8536
摘要： Swine animal models comprising a genomic disruption of an endogenous gene chosen from the group consisting of a Low-Density Lipoprotein Receptor gene LDLR, Duchene's Muscular Dystrophy (DMD) gene, and hairless gene (HR). Methods of preparing transfected cells useful for making a transgenic animal comprising exposing a first group of cells to a transfection agent and reseeding the group with additional cells that have not been exposed to the agent. The transgenic animals are useful for medical and scientific animal models of human diseases and conditions, as well as sources for cells, tissues, and biomaterials.
摘要翻译： 包括选自低密度脂蛋白受体基因LDLR，杜丝肌营养不良（DMD）基因和无毛基因（HR））的内源基因的基因组破坏的猪动物模型。 制备用于制备转基因动物的转染细胞的方法，包括将第一组细胞暴露于转染试剂，并用未暴露于该试剂的另外的细胞重新接种该组。 转基因动物可用于人类疾病和病症的医学和科学动物模型，以及细胞，组织和生物材料的来源。
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3.发明授权公开(公告)号：US08309791B2
公开(公告)日：2012-11-13
申请号：US12504364
申请日：2009-07-16
IPC分类号： A01K67/027 , C12N15/00
CPC分类号： C12N15/8509 , A01K67/0273 , A01K67/0275 , A01K2217/058 , A01K2217/203 , A01K2227/101 , A01K2227/103 , A01K2227/105 , A01K2227/108 , A01K2267/03 , A01K2267/035 , A61D19/00 , C07K14/4712 , C12N15/1138 , C12N2015/8527 , C12N2310/14 , C12N2800/30 , C12N2800/90
摘要： Transgenic artiodactyls are described as well as methods of making and using such artiodactyls.
摘要翻译： 本发明描述了转基因偶蹄菌，以及制备和使用这些偶氮酰基的方法。
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公开(公告)号：US20120220037A1
公开(公告)日：2012-08-30
申请号：US13467588
申请日：2012-05-09
IPC分类号： C12N15/87
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/108 , A01K2267/03 , A01K2267/0306 , C07K14/4702 , C07K14/4708 , C07K14/705 , C12N15/873 , C12N15/907 , C12N2015/8536
摘要： Swine animal models comprising a genomic disruption of an endogenous gene chosen from the group consisting of a Low-Density Lipoprotein Receptor gene LDLR, Duchene's Muscular Dystrophy (DMD) gene, and hairless gene (HR). Methods of preparing transfected cells useful for making a transgenic animal comprising exposing a first group of cells to a transfection agent and reseeding the group with additional cells that have not been exposed to the agent. The transgenic animals are useful for medical and scientific animal models of human diseases and conditions, as well as sources for cells, tissues, and biomaterials.
摘要翻译： 包括选自低密度脂蛋白受体基因LDLR，杜丝肌营养不良（DMD）基因和无毛基因（HR））的内源基因的基因组破坏的猪动物模型。 制备用于制备转基因动物的转染细胞的方法，包括将第一组细胞暴露于转染试剂，并用未暴露于该试剂的另外的细胞重新接种该组。 转基因动物可用于人类疾病和病症的医学和科学动物模型，以及细胞，组织和生物材料的来源。
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公开(公告)号：US20130117870A1
公开(公告)日：2013-05-09
申请号：US13594694
申请日：2012-08-24
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2227/101 , A01K2227/108 , A61D19/04 , C12N15/85 , C12N15/907
摘要： Compositions and methods for use of TALENs to make genetically modified livestock or other animals are set forth. Some of the embodiments of the invention provide for making an founder animal that is completely free of all unplanned genetic modifications. Some embodiments are directed to removing genetic faults in established breeds without making other alterations to the genome. Other embodiments are directed to particular tools or processes such as a TALENs with a preferred truncation.
摘要翻译： 阐述了使用TALEN制作转基因家禽或其他动物的组合物和方法。 本发明的一些实施方案提供了制造完全没有所有非计划遗传修饰的创始动物。 一些实施方案涉及去除已确定品种的遗传缺陷而不对基因组进行其它改变。 其他实施方案涉及特定的工具或过程，例如具有优选截断的TALEN。
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公开(公告)号：US20110197290A1
公开(公告)日：2011-08-11
申请号：US13025373
申请日：2011-02-11
IPC分类号： A01K67/027 , C12N5/07 , C12N5/10 , C12N15/87
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/108 , A01K2267/03 , A01K2267/0306 , C07K14/4702 , C07K14/4708 , C07K14/705 , C12N15/873 , C12N15/907 , C12N2015/8536
摘要： Swine animal models comprising a genomic disruption of an endogenous gene chosen from the group consisting of a Low-Density Lipoprotein Receptor gene LDLR, Duchene's Muscular Dystrophy (DMD) gene, and hairless gene (HR). Methods of preparing transfected cells useful for making a transgenic animal comprising exposing a first group of cells to a transfection agent and reseeding the group with additional cells that have not been exposed to the agent. The transgenic animals are useful for medical and scientific animal models of human diseases and conditions, as well as sources for cells, tissues, and biomaterials.
摘要翻译： 包括选自低密度脂蛋白受体基因LDLR，杜丝肌营养不良（DMD）基因和无毛基因（HR））的内源基因的基因组破坏的猪动物模型。 制备用于制备转基因动物的转染细胞的方法，包括将第一组细胞暴露于转染试剂，并用未暴露于该试剂的另外的细胞重新接种该组。 转基因动物可用于人类疾病和病症的医学和科学动物模型，以及细胞，组织和生物材料的来源。
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公开(公告)号：US20190194687A1
公开(公告)日：2019-06-27
申请号：US16294619
申请日：2019-03-06
IPC分类号： C12N15/85 , C12N15/90 , A01K67/027 , C12N15/877 , C07K14/47 , C07K14/715
CPC分类号： C12N15/85 , A01K67/0275 , C07K14/47 , C07K14/715 , C12N15/8509 , C12N15/8771 , C12N15/8778 , C12N15/907 , C12N2750/14143 , C12N2800/30 , C12N2800/90
摘要： Methods, uses, and animals for introgression of alleles between animals, including SNPs. One embodiment involves introducing a targeted targeting endonuclease system and a HDR template into a cell with a mismatch in the binding of the targeting endonuclease and the targeted site.
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公开(公告)号：US20120222143A1
公开(公告)日：2012-08-30
申请号：US13404662
申请日：2012-02-24
IPC分类号： A01K67/027 , C12N5/10 , C12N15/85
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2227/101 , A01K2227/108 , A61D19/04 , C12N15/85 , C12N15/907
摘要： Compositions and methods for use of TALENs to make genetically modified livestock are set forth. The methods may include reporters for selecting cells or embryos that have been modified by TALENs for use as progenitor cells to make founder animals.
摘要翻译： 阐述了使用TALENs制作转基因家畜的组合物和方法。 方法可以包括用于选择已被TALEN修饰以用作祖细胞以制造创始动物的细胞或胚胎的记者。
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9.发明授权Nucleic acid transfer vector for the introduction of nucleic acid into the DNA of a cell 有权用于将核酸引入细胞DNA的核酸转移载体公开(公告)号：US07160682B2
公开(公告)日：2007-01-09
申请号：US10191698
申请日：2002-07-09
CPC分类号： C12N15/90 , A01K2217/05 , A01K2227/40 , C12N9/22 , C12N2800/60 , C12N2800/90 , C12N2830/006 , C12N2830/80 , C12N2840/203 , C12N2840/44
摘要： The present invention provides for transposon vectors encoding expression control region-traps and gene-traps. Also provided are dicistronic vectors. Certain embodiments of the invention contain internal ribosome entry sites.
摘要翻译： 本发明提供编码表达控制区 - 陷阱和基因陷阱的转座子载体。 还提供了双顺反子载体。 本发明的某些实施方案含有内部核糖体进入位点。
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公开(公告)号：US09074224B2
公开(公告)日：2015-07-07
申请号：US12869232
申请日：2010-08-26
CPC分类号： C12N15/85 , A61K48/00 , C07K14/00 , C07K2319/09 , C07K2319/81 , C12N15/90 , C12N2770/14022 , C12N2800/30
摘要： Disclosed herein are methods and compositions for gene targeting utilizing fusion molecules comprising a recombinase domain and a sequence-specific DNA-binding domain.
摘要翻译： 本文公开了利用包含重组酶结构域和序列特异性DNA结合结构域的融合分子进行基因靶向的方法和组合物。
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