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公开(公告)号：US5386025A
公开(公告)日：1995-01-31
申请号：US482384
申请日：1990-02-20
IPC分类号： A61K38/00 , A61P43/00 , C07H21/02 , C07H21/04 , C07K14/00 , C07K14/705 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/91
CPC分类号： C07K14/705 , C12Q1/6876
摘要： Calcium channel .gamma.-subunit-encoding cDNAs, and related compositions and methods, are provided.
摘要翻译： 提供钙通道γ-亚基编码cDNA，以及相关组合物和方法。
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2.发明授权Human neuronal nicotinic acetylcholine receptor compositions and methods employing same 失效人神经元烟碱乙酰胆碱受体组合物及其应用方法
公开(公告)号：US5910582A
公开(公告)日：1999-06-08
申请号：US700636
申请日：1996-07-16
IPC分类号： G01N33/50 , C07K14/705 , C07K14/715 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/00 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/15 , C07H21/02 , C07H21/04 , C12P21/00
CPC分类号： C07K14/70571
摘要： Nucleic acid encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically .alpha..sub.4 and .alpha..sub.7) and beta subunits (specifically .beta..sub.4) are provided. In addition, combinations of subunits (i.e., .alpha..sub.1, .alpha..sub.2, .alpha..sub.3, .alpha..sub.4, and/or .alpha..sub.7 subunits in combination with .beta..sub.4 subunits; or .beta..sub.2, .beta..sub.3 and/or .beta..sub.4 subunits in combination with .alpha..sub.4 and/or .alpha..sub.7 subunits) are provided.
摘要翻译： 编码人神经元烟碱乙酰胆碱受体α和β亚基的核酸，含有所述DNA的哺乳动物和两栖动物细胞，用于产生α和β亚基和重组（即，分离或基本上纯的）α亚基（特别是α4和α7）和β 亚单位（特别是beta 4）。 此外，亚单位（即α1，α2，α3，α4和/或α7亚基与β4亚基组合;或β2，β3和/或β4亚基与α组合） 4和/或α7亚基）。
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3.发明授权Human neuronal nicotinic acetylcholine receptor and cells transformed with same DNA and mRNA encoding an--subunit of 失效DNA和MRNA编码人类神经元烟碱乙酰胆碱受体的α7亚基和转化的细胞
公开(公告)号：US5837489A
公开(公告)日：1998-11-17
申请号：US466589
申请日：1995-06-05
IPC分类号： G01N33/50 , C07K14/705 , C07K14/715 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/00 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/15 , C12N15/00
CPC分类号： C07K14/70571
摘要： DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically .alpha..sub.4 and .alpha..sub.7) and beta subunits (specifically .beta..sub.4) are provided. In addition, combinations of subunits (i.e., .alpha..sub.1, .alpha..sub.2, .alpha..sub.3, .alpha..sub.4, and/or .alpha..sub.7 subunits in combination with .beta..sub.4 subunits; or .beta..sub.2, .beta..sub.3 and/or .beta..sub.4 subunits in combination with .alpha..sub.4 and/or .beta..sub.7 subunits) are provided.
摘要翻译： 编码人神经元烟碱乙酰胆碱受体α和β亚基的DNA，含有所述DNA的哺乳动物和两栖动物细胞，用于产生α和β亚基和重组（即，分离或基本上纯的）α亚基（特别是α4和α7）和β亚基的方法 （特别是beta 4）。 此外，亚单位（即α1，α2，α3，α4和/或α7亚基与β4亚基组合;或β2，β3和/或β4亚基与α组合） 4和/或β7亚基）。
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公开(公告)号：US5792846A
公开(公告)日：1998-08-11
申请号：US455543
申请日：1995-05-31
申请人： Michael M. Harpold , Steven B. Ellis , Mark E. Williams , Daniel H. Feldman , Ann F. McCue , Robert Brenner
发明人： Michael M. Harpold , Steven B. Ellis , Mark E. Williams , Daniel H. Feldman , Ann F. McCue , Robert Brenner
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , C12Q1/68 , G01N33/564 , G01N33/68 , C07H21/04
CPC分类号： G01N33/6872 , C07K14/705 , C12Q1/6876 , C12Q1/6897 , G01N33/564 , G01N33/68 , G01N33/6893 , A61K38/00 , C12Q2600/158 , G01N2500/10
摘要： Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
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公开(公告)号：US4960690A
公开(公告)日：1990-10-02
申请号：US871111
申请日：1986-06-05
CPC分类号： C12Q1/6879 , C12Q1/6813 , Y10S436/814
摘要： Nucleic acid hybridizaiton probes are provided which have sequences complementary to sequences of segments in bovine male-specific DNA and are suitable for sexing bovine embryos at the time of embryo transfer with nearly 100% accuracy.
摘要翻译： 提供核酸杂交探针，其具有与牛雄性特异性DNA中的片段序列互补的序列，并且适于在胚胎移植时以近100％的准确性对牛胚胎进行性别化。
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6.发明授权Human neuronal nicotinic acetylcholine receptor compositions and methods employing same 失效人神经元烟碱乙酰胆碱受体组合物及其应用方法公开(公告)号：US06303753B1
公开(公告)日：2001-10-16
申请号：US09217345
申请日：1998-12-21
IPC分类号： C07K100
CPC分类号： C07K14/70571
摘要： DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the DNA, methods for producing &agr; and &bgr; subunits and isolated or substantially pure &agr;4, &agr;7 and &bgr;4 subunits are provided. In addition, cells that expresses these subunits singly or combination with other subunits of nicotinic acetylcholine receptors and methods using the cells are provided.
摘要翻译： 提供了编码人神经元烟碱乙酰胆碱受体α和β亚基的DNA，含有DNA的哺乳动物和两栖动物细胞，产生α和β亚基的方法以及分离或基本上纯的α4，α7和β4亚单位。 此外，提供单独表达这些亚单位或与烟碱乙酰胆碱受体的其它亚基组合的细胞和使用细胞的方法。
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公开(公告)号：US6096514A
公开(公告)日：2000-08-01
申请号：US450562
申请日：1995-05-25
IPC分类号： A61K38/00 , C07K14/705 , C12Q1/68 , G01N33/50 , G01N33/564 , G01N33/68 , C12N15/00
CPC分类号： C12Q1/6897 , C07K14/705 , C12Q1/6876 , G01N33/5008 , G01N33/564 , G01N33/68 , G01N33/6872 , G01N33/6893 , A61K38/00 , C12Q2600/158 , G01N2500/10
摘要： Isolated DNA encoding each of human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunits, including subunits that arise as splice variants of primary transcripts, is provided. Cells and vectors containing the DNA and methods for identifying compounds that modulate the activity of human calcium channels are also provided.
摘要翻译： 提供了编码人钙通道α1-，α2-，β-和γ-亚基的每一个的分离的DNA，包括作为初级转录物的剪接变体产生的亚单位。 还提供了含有DNA的细胞和载体以及用于鉴定调节人钙通道活性的化合物的方法。
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8.发明授权DNA and mRNA encoding an .alpha..sub.4 subunit of human neuronal nicotinic acetylcholine receptor and cells transformed with same 失效编码人神经元烟碱乙酰胆碱受体的α4亚基的DNA和mRNA以及用其转化的细胞
公开(公告)号：US6022704A
公开(公告)日：2000-02-08
申请号：US467574
申请日：1995-06-05
IPC分类号： G01N33/50 , C07K14/705 , C07K14/715 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/00 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/15 , C12N15/00
CPC分类号： C07K14/70571
摘要： DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing said DNA, methods for producing alpha and beta subunits and recombinant (i.e., isolated or substantially pure) alpha subunits (specifically .alpha..sub.4 and .alpha..sub.7) and beta subunits (specifically .beta..sub.4) are provided. In addition, combinations of subunits (i.e., .alpha..sub.1, .alpha..sub.2, .alpha..sub.3, .alpha..sub.4, and/or .alpha..sub.7 subunits in combination with .beta..sub.4 subunits; or .beta..sub.2, .beta..sub.3 and/or .beta..sub.4 subunits in combination with .alpha..sub.4 and/or .alpha..sub.7 subunits) are provided.
摘要翻译： 编码人神经元烟碱乙酰胆碱受体α和β亚基的DNA，含有所述DNA的哺乳动物和两栖动物细胞，用于产生α和β亚基和重组（即，分离或基本上纯的）α亚基（特别是α4和α7）和β亚基的方法 （特别是beta 4）。 此外，亚单位（即α1，α2，α3，α4和/或α7亚基与β4亚基组合;或β2，β3和/或β4亚基与α组合） 4和/或α7亚基）。
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9.发明授权Assays of cells expressing human calcium channels containing .alpha..sub.1 .beta. subunits 失效表达含有α1b亚基的人钙通道的细胞的测定
公开(公告)号：US5876958A
公开(公告)日：1999-03-02
申请号：US311363
申请日：1994-09-23
申请人： Michael M. Harpold , Steven B. Ellis , Mark E. Williams , Daniel H. Feldman , Ann F. McCue , Robert Brenner
发明人： Michael M. Harpold , Steven B. Ellis , Mark E. Williams , Daniel H. Feldman , Ann F. McCue , Robert Brenner
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , C12Q1/68 , G01N33/564 , G01N33/68 , C12Q1/02
CPC分类号： G01N33/6872 , C07K14/705 , C12Q1/6876 , C12Q1/6897 , G01N33/564 , G01N33/68 , G01N33/6893 , A61K38/00 , C12Q2600/158 , G01N2500/10
摘要： Human calcium channel .alpha..sub.1 -, .alpha..sub.2 -, .beta.- and .gamma.-subunit encoding cDNAs, and related compositions and methods, are provided.
摘要翻译： 提供人钙通道α1-，α2-，β-和γ-亚基编码cDNA，以及相关组合物和方法。
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10.发明授权Human neuronal nicotinic acetylcholine receptor & subunit methods employing same 失效人类神经元烟碱乙酰胆碱受体和亚基方法公开(公告)号：US06664375B2
公开(公告)日：2003-12-16
申请号：US09892985
申请日：2001-06-27
IPC分类号： C07K14705
CPC分类号： C07K14/70571
摘要： DNA encoding human neuronal nicotinic acetylcholine receptor alpha and beta subunits, mammalian and amphibian cells containing the DNA, methods for producing &agr; and &bgr; subunits and isolated or substantially pure &agr;4, &agr;7 and &bgr;4 subunits are provided. In addition, cells that expresses these subunits singly or combination with other subunits of nicotinic acetylcholine receptors and methods using the cells are provided.
摘要翻译： 提供了编码人神经元烟碱乙酰胆碱受体α和β亚基的DNA，含有DNA的哺乳动物和两栖动物细胞，产生α和β亚基的方法以及分离或基本上纯的α4，α7和β4亚单位。 此外，提供单独表达这些亚单位或与烟碱乙酰胆碱受体的其它亚基组合的细胞和使用细胞的方法。
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