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公开(公告)号：US08519125B2
公开(公告)日：2013-08-27
申请号：US12778100
申请日：2010-05-11
IPC分类号： C07D293/10 , C07D279/12 , C07D265/30 , C07D211/00
CPC分类号： C12Q1/6806 , A01N1/00 , A01N1/0231
摘要： Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.
摘要翻译： 公开了组合物和方法，用于在环境或升高的温度下使用可包含硼酸盐组合物的可溶解或可离解的干燥储存基质在生物样品例如核酸，蛋白质和细胞中以基本上回收样品的形式基本干燥储存， 所公开的稳定剂，例如许多两性离子稳定剂中的任何一种。
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公开(公告)号：US20140065627A1
公开(公告)日：2014-03-06
申请号：US13966117
申请日：2013-08-13
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , A01N1/00 , A01N1/0231
摘要： Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.
摘要翻译： 公开了组合物和方法，用于在环境或升高的温度下使用可包含硼酸盐组合物的可溶解或可离解的干燥储存基质在生物样品例如核酸，蛋白质和细胞中以基本上回收样品的形式基本干燥储存， 所公开的稳定剂，例如许多两性离子稳定剂中的任何一种。
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公开(公告)号：US20110081363A1
公开(公告)日：2011-04-07
申请号：US12778100
申请日：2010-05-11
IPC分类号： A61K39/00 , C12N5/02 , C12N1/20 , C12N1/16 , C12N7/00 , A01N1/02 , C07H21/00 , C07K14/00 , C11B5/00 , C07H1/00 , B01J20/22
CPC分类号： C12Q1/6806 , A01N1/00 , A01N1/0231
摘要： Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.
摘要翻译： 公开了组合物和方法，用于在环境或升高的温度下使用可包含硼酸盐组合物的可溶解或可离解的干燥储存基质在生物样品例如核酸，蛋白质和细胞中以基本上回收样品的形式基本干燥储存， 所公开的稳定剂，例如许多两性离子稳定剂中的任何一种。
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公开(公告)号：US20080176209A1
公开(公告)日：2008-07-24
申请号：US11876667
申请日：2007-10-22
CPC分类号： A01N1/00 , A01N1/02 , A01N1/0231 , B01L3/50255 , B01L3/5085 , B01L3/50853 , B01L3/50855 , B01L3/545 , B01L2300/022 , B01L2300/023 , B01L2300/043 , B01L2300/069 , B01L2300/0829 , B01L2400/0487 , G01N35/00871 , G01N35/028 , G01N2035/00108 , G01N2035/00782
摘要： Compositions and methods are disclosed for substantially dry storage at ambient temperatures of biological samples such as nucleic acids and cells in a form from which nucleic acids can be recovered, using a dissolvable or dissociable dry storage matrix that permits recovery of biologically active materials. Compositions and methods are also disclosed for automated storing, tracking retrieving and analyzing of nucleic acid samples. RFID-tagged biological sample storage devices featuring dissolvable or dissociable matrices are described for use as supports of biological samples, which matrices can be dried and subsequently rehydrated for sample recovery. Also disclosed are computer-implemented systems and methods for managing sample data.
摘要翻译： 公开了组合物和方法，用于在环境温度下在生物样品例如核酸和可以从其中回收核酸的形式的细胞中使用允许回收生物活性物质的可溶解或可离解的干燥储存基质进行基本上干燥的储存。 还公开了用于核酸样品的自动存储，跟踪检索和分析的组合物和方法。 描述了具有可溶解或可解离基质的RFID标记的生物样品储存装置，用作生物样品的支持物，该基质可以被干燥并随后再水化以进行样品回收。 还公开了用于管理样本数据的计算机实现的系统和方法。
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5.发明申请COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES 有权用于稳定血液中DNA，RNA和蛋白质的组合物和其他生物样品在环境温度下的运输和储存公开(公告)号：US20120052572A1
公开(公告)日：2012-03-01
申请号：US13191346
申请日：2011-07-26
申请人： Scott E. Whitney , Steven Wilkinson , Rolf Muller
发明人： Scott E. Whitney , Steven Wilkinson , Rolf Muller
CPC分类号： A01N1/021 , C12Q1/6806 , C12Q2527/125
摘要： Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA, RNA or protein components following the storage period.
摘要翻译： 公开了在与本文公开的储存组合物混合之后基本上液体，凝胶，悬浮液，浆体，半固体和/或胶体储存生物样品的组合物和方法，允许在没有冷藏的情况下储存后基本恢复生物活性。 在某些实施方案中，未分级血液或组织样品可以以几个月，几个月或几年的形式储存，而不会在保存期后允许回收完整的DNA，RNA或蛋白质组分。
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6.发明申请COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN SALIVA AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES 有权用于在环境温度下运输和储存期间稳定萨拉维亚和其他生物样品中的DNA，RNA和蛋白质的组合物公开(公告)号：US20130209997A1
公开(公告)日：2013-08-15
申请号：US13812288
申请日：2011-07-26
申请人： Scott E. Whitney , Senait Ghirmai , Rolf Muller
发明人： Scott E. Whitney , Senait Ghirmai , Rolf Muller
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , A01N1/021 , C12Q2527/137
摘要： Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated saliva samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA following the storage period.
摘要翻译： 公开了在与本文公开的储存组合物混合之后基本上液体，凝胶，悬浮液，浆体，半固体和/或胶体储存生物样品的组合物和方法，允许在没有冷藏的情况下储存后基本恢复生物活性。 在某些实施方案中，未分级唾液样品可以以几个月，几个月或几年的形式储存而不冷却，其形式是允许在储存期后恢复完整的DNA。
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公开(公告)号：US09845489B2
公开(公告)日：2017-12-19
申请号：US13812288
申请日：2011-07-26
申请人： Scott E. Whitney , Senait Ghirmai , Rolf Muller
发明人： Scott E. Whitney , Senait Ghirmai , Rolf Muller
CPC分类号： C12Q1/6806 , A01N1/021 , C12Q2527/137
摘要： Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated saliva samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA following the storage period.
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8.发明授权Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures 有权用于在环境温度下运输和储存期间稳定血液和其他生物样品中的DNA和RNA的组合物公开(公告)号：US09376709B2
公开(公告)日：2016-06-28
申请号：US13191346
申请日：2011-07-26
申请人： Scott E. Whitney , Steven Wilkinson , Rolf Muller
发明人： Scott E. Whitney , Steven Wilkinson , Rolf Muller
CPC分类号： A01N1/021 , C12Q1/6806 , C12Q2527/125
摘要： Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration in a form that permits recovery of intact DNA or RNA components following the storage period.
摘要翻译： 公开了与本文公开的储存组合物混合后基本上液体，凝胶，悬浮液，浆体，半固体和/或胶体储存生物样品的组合物和方法，其允许在没有冷藏的情况下储存后基本恢复生物活性。 在某些实施方案中，未分级血液或组织样品可以在冷藏后以可以在储存期后回收完整DNA或RNA组分的形式储存。
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公开(公告)号：US08153783B2
公开(公告)日：2012-04-10
申请号：US12906710
申请日：2010-10-18
申请人： Rolf Muller , Federico Innerebner , Paul Smith , Theo A. Tervoort
发明人： Rolf Muller , Federico Innerebner , Paul Smith , Theo A. Tervoort
CPC分类号： C08L3/02 , A61J3/077 , A61K9/4816 , A61K9/5036 , C08B31/003 , C08L2666/02
摘要： The production of polysaccharide networks, especially starch networks, having a high network density, high solidity, a low swelling degree, and exhibiting reduced water absorption and to the uses thereof, especially, in the filed of biodegradable plastics.
摘要翻译： 具有高网络密度，高固体度，低溶胀度和显示减少的吸水性的多糖网络，特别是淀粉网络的生产，尤其是在可生物降解的塑料领域。
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公开(公告)号：US20070283827A1
公开(公告)日：2007-12-13
申请号：US11811432
申请日：2007-06-08
IPC分类号： B41F35/00
CPC分类号： B41F23/00 , B41F23/0426 , B41F23/044 , F26B21/06 , F26B25/004 , F26B25/22
摘要： A printing press, in particular a sheet-fed offset printing press, includes at least one control device, a plurality of printing units, one or more varnishing units, and one or more dryers. Variables determining a dryness of the printing material are determined and used to optimize the drying process. For that purpose, the important material streams influencing the drying process are determined at least for the region of the printing press that contains the drying device(s).
摘要翻译： 印刷机，特别是单张胶版印刷机包括至少一个控制装置，多个印刷单元，一个或多个上光单元和一个或多个干燥器。 测定确定印刷材料干燥度的变量并用于优化干燥过程。 为此，至少对于包含干燥装置的印刷机的区域来确定影响干燥过程的重要材料流。
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