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公开(公告)号：US08519125B2
公开(公告)日：2013-08-27
申请号：US12778100
申请日：2010-05-11
IPC分类号： C07D293/10 , C07D279/12 , C07D265/30 , C07D211/00
CPC分类号： C12Q1/6806 , A01N1/00 , A01N1/0231
摘要： Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.
摘要翻译： 公开了组合物和方法，用于在环境或升高的温度下使用可包含硼酸盐组合物的可溶解或可离解的干燥储存基质在生物样品例如核酸，蛋白质和细胞中以基本上回收样品的形式基本干燥储存， 所公开的稳定剂，例如许多两性离子稳定剂中的任何一种。
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公开(公告)号：US20140065627A1
公开(公告)日：2014-03-06
申请号：US13966117
申请日：2013-08-13
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , A01N1/00 , A01N1/0231
摘要： Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.
摘要翻译： 公开了组合物和方法，用于在环境或升高的温度下使用可包含硼酸盐组合物的可溶解或可离解的干燥储存基质在生物样品例如核酸，蛋白质和细胞中以基本上回收样品的形式基本干燥储存， 所公开的稳定剂，例如许多两性离子稳定剂中的任何一种。
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公开(公告)号：US20110081363A1
公开(公告)日：2011-04-07
申请号：US12778100
申请日：2010-05-11
IPC分类号： A61K39/00 , C12N5/02 , C12N1/20 , C12N1/16 , C12N7/00 , A01N1/02 , C07H21/00 , C07K14/00 , C11B5/00 , C07H1/00 , B01J20/22
CPC分类号： C12Q1/6806 , A01N1/00 , A01N1/0231
摘要： Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.
摘要翻译： 公开了组合物和方法，用于在环境或升高的温度下使用可包含硼酸盐组合物的可溶解或可离解的干燥储存基质在生物样品例如核酸，蛋白质和细胞中以基本上回收样品的形式基本干燥储存， 所公开的稳定剂，例如许多两性离子稳定剂中的任何一种。
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4.发明申请COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES 有权用于稳定血液中DNA，RNA和蛋白质的组合物和其他生物样品在环境温度下的运输和储存公开(公告)号：US20120052572A1
公开(公告)日：2012-03-01
申请号：US13191346
申请日：2011-07-26
申请人： Scott E. Whitney , Steven Wilkinson , Rolf Muller
发明人： Scott E. Whitney , Steven Wilkinson , Rolf Muller
CPC分类号： A01N1/021 , C12Q1/6806 , C12Q2527/125
摘要： Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA, RNA or protein components following the storage period.
摘要翻译： 公开了在与本文公开的储存组合物混合之后基本上液体，凝胶，悬浮液，浆体，半固体和/或胶体储存生物样品的组合物和方法，允许在没有冷藏的情况下储存后基本恢复生物活性。 在某些实施方案中，未分级血液或组织样品可以以几个月，几个月或几年的形式储存，而不会在保存期后允许回收完整的DNA，RNA或蛋白质组分。
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5.发明申请COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN SALIVA AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES 有权用于在环境温度下运输和储存期间稳定萨拉维亚和其他生物样品中的DNA，RNA和蛋白质的组合物公开(公告)号：US20130209997A1
公开(公告)日：2013-08-15
申请号：US13812288
申请日：2011-07-26
申请人： Scott E. Whitney , Senait Ghirmai , Rolf Muller
发明人： Scott E. Whitney , Senait Ghirmai , Rolf Muller
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , A01N1/021 , C12Q2527/137
摘要： Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated saliva samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA following the storage period.
摘要翻译： 公开了在与本文公开的储存组合物混合之后基本上液体，凝胶，悬浮液，浆体，半固体和/或胶体储存生物样品的组合物和方法，允许在没有冷藏的情况下储存后基本恢复生物活性。 在某些实施方案中，未分级唾液样品可以以几个月，几个月或几年的形式储存而不冷却，其形式是允许在储存期后恢复完整的DNA。
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公开(公告)号：US09845489B2
公开(公告)日：2017-12-19
申请号：US13812288
申请日：2011-07-26
申请人： Scott E. Whitney , Senait Ghirmai , Rolf Muller
发明人： Scott E. Whitney , Senait Ghirmai , Rolf Muller
CPC分类号： C12Q1/6806 , A01N1/021 , C12Q2527/137
摘要： Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated saliva samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA following the storage period.
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7.发明授权Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures 有权用于在环境温度下运输和储存期间稳定血液和其他生物样品中的DNA和RNA的组合物公开(公告)号：US09376709B2
公开(公告)日：2016-06-28
申请号：US13191346
申请日：2011-07-26
申请人： Scott E. Whitney , Steven Wilkinson , Rolf Muller
发明人： Scott E. Whitney , Steven Wilkinson , Rolf Muller
CPC分类号： A01N1/021 , C12Q1/6806 , C12Q2527/125
摘要： Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration in a form that permits recovery of intact DNA or RNA components following the storage period.
摘要翻译： 公开了与本文公开的储存组合物混合后基本上液体，凝胶，悬浮液，浆体，半固体和/或胶体储存生物样品的组合物和方法，其允许在没有冷藏的情况下储存后基本恢复生物活性。 在某些实施方案中，未分级血液或组织样品可以在冷藏后以可以在储存期后回收完整DNA或RNA组分的形式储存。
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公开(公告)号：USD690025S1
公开(公告)日：2013-09-17
申请号：US29424290
申请日：2012-06-11
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公开(公告)号：US20100288059A1
公开(公告)日：2010-11-18
申请号：US12780508
申请日：2010-05-14
CPC分类号： A61B10/0096 , A61B10/0051 , A61B90/98 , B01L3/505 , B01L2200/0689 , B01L2300/021 , B01L2300/0864 , G01N2001/005
摘要： This invention relates to the collection and handling of biological or chemical specimens. The invention provides a device and a method for collecting and preparing patient samples, such as sputum, to be used in downstream diagnostics tests. The invention reduces the handling and exposure of healthcare workers to the sample by the use of a bag in which hermetic seals are utilized to separate sample aliquots.
摘要翻译： 本发明涉及生物或化学样品的收集和处理。 本发明提供了用于收集和制备用于下游诊断测试中的患者样品（例如痰液）的装置和方法。 本发明通过使用其中使用气密封来分离样品等分试样的袋子来减少医护人员对样品的处理和暴露。
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公开(公告)号：US20130078641A1
公开(公告)日：2013-03-28
申请号：US13700817
申请日：2011-06-01
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , B01L3/5023 , B01L3/5029 , B01L3/505 , B01L2300/0825
摘要： The present invention provides a method and device for treating and analyzing a biological specimen. The biological specimen is introduced into a processing device and treated thermally, mechanically, chemically or any combination thereof within the processing device to alter at least one constitutive characteristic of the biological specimen and to release or create one or more biological indicators from the biological specimen. The biological specimen is further contacted with a treated polymeric material so that at least a portion of the polymeric material binds to the one or more biological indicators.
摘要翻译： 本发明提供一种用于处理和分析生物样本的方法和装置。 将生物样品引入处理装置中并在加工装置内热处理，机械地，化学地或其任何组合进行处理，以改变生物样本的至少一个构成特征并从生物样品中释放或产生一个或多个生物指示剂。 生物样品进一步与经处理的聚合物材料接触，使得至少一部分聚合物材料与一种或多种生物指示剂结合。
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