利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

21 条记录 (耗时 0.024 秒)

    Nucleic acid encoding chimeric complement inhibitor proteins
    2.
    发明授权
    Nucleic acid encoding chimeric complement inhibitor proteins 失效
    编码嵌合补体抑制蛋白的核酸

    公开(公告)号：US5624837A

    公开(公告)日：1997-04-29

    申请号：US458084

    申请日：1995-06-01

    申请人： William L. Fodor ,  Scott Rollins ,  Stephen P. Squinto

    发明人： William L. Fodor ,  Scott Rollins ,  Stephen P. Squinto

    IPC分类号： A01K67/027 ,  A61K38/00 ,  A61K48/00 ,  A61P37/06 ,  C07H21/04 ,  C07K14/705 ,  C07K19/00 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12R1/92 ,  C12N5/16 ,  C12N15/62 ,  C12N15/63

    CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/00

    摘要： Chimeric complement inhibitor proteins are provided which include a first functional domain (first amino acid sequence) having C3 inhibitory activity and a second functional domain (second amino acid sequence) having C5b-9 inhibitory activity. The first functional domain is amino terminal to the second functional domain. In this way, the chimeric protein exhibits both C3 and C5b-9 inhibitory activity. The other orientation, i.e., the orientation in which the second amino acid sequence is amino terminal to the first amino acid sequence, only produces C3 inhibitory activity. Nucleic acid molecules encoding such proteins are also provided.

    摘要翻译： 提供了嵌合补体抑制蛋白，其包括具有C3抑制活性的第一功能结构域（第一氨基酸序列）和具有C5b-9抑制活性的第二功能结构域（第二氨基酸序列）。 第一功能域是第二功能结构域的氨基末端。 以这种方式，嵌合蛋白质表现出C3和C5b-9抑制活性。 另一取向即第二氨基酸序列与第一氨基酸序列氨基末端的取向仅产生C3抑制活性。 还提供了编码这种蛋白质的核酸分子。

    Methods and devices for storing and dispensing liquids
    3.
    发明授权
    Methods and devices for storing and dispensing liquids 失效
    用于储存和分配液体的方法和装置

    公开(公告)号：US06905657B2

    公开(公告)日：2005-06-14

    申请号：US09827570

    申请日：2001-04-05

    申请人： Allyn Hubbard ,  Samesh Kale ,  Scott Rollins ,  Jeremy P. Springhorn ,  Stephen P. Squinto ,  Prasad R. Akkapeddi

    发明人： Allyn Hubbard ,  Samesh Kale ,  Scott Rollins ,  Jeremy P. Springhorn ,  Stephen P. Squinto ,  Prasad R. Akkapeddi

    IPC分类号： B01J19/00 ,  B81B3/00 ,  C40B60/14 ,  C40B70/00 ,  G01N35/10 ,  B01L3/02 ,  B65B1/04 ,  G01N1/10

    CPC分类号： G01N35/1074 ,  B01J19/0046 ,  B01J2219/00369 ,  B01J2219/00378 ,  B01J2219/00547 ,  C40B60/14 ,  C40B70/00 ,  G01N2035/1039 ,  Y10T436/2575

    摘要： In a liquid handling system including a liquid handling substrate having a plurality of channels for conducting a liquid sample in said substrate, where the channels terminate in a plurality of exit ports in an outer surface of the substrate for transfer of a quantity of the liquid sample. The handling system also includes a liquid storage and dispensing substrate having a plurality of separable cartridges corresponding to the channels, with each cartridge terminating at a microelectro mechanical system (MEMS) comprising a laminate of glass, silicon and a piezoelectric substance. The handling system further includes a liquid detecting system comprising a light emitting diode and a photo-detector, where each channel includes a reservoir in communication with a corresponding cartridge creating an interface therebetween. The handling system enables a method for storing and dispensing liquids including drawing a liquid sample into the channels either by capillary action, vacuum, electrostatic flow, a minipump or any combination thereof, storing the liquid sample into the cartridge, and dispensing the liquid sample.

    摘要翻译： 在液体处理系统中，该液体处理系统包括液体处理基板，该液体处理基板具有用于在所述基板中传导液体样品的多个通道，其中所述通道终止于所述基板的外表面中的多个出口，用于转移一定数量的液体样品 。 处理系统还包括具有对应于通道的多个可分离盒的液体存储和分配基板，每个盒终止于包括玻璃，硅和压电物质的层叠体的微电子机械系统（MEMS）。 处理系统还包括液体检测系统，其包括发光二极管和光检测器，其中每个通道包括与相应的墨盒连通的储存器，其在其间形成界面。 处理系统实现了一种用于存储和分配液体的方法，包括通过毛细管作用，真空，静电流，微型泵或其任何组合将液体样品吸入通道，将液体样品储存在盒中并分配液体样品。

    Chimeric complement inhibitor proteins
    6.
    发明授权
    Chimeric complement inhibitor proteins 失效
    嵌合补体抑制蛋白

    公开(公告)号：US5627264A

    公开(公告)日：1997-05-06

    申请号：US205508

    申请日：1994-03-03

    申请人： William L. Fodor ,  Scott Rollins ,  Stephen P. Squinto

    发明人： William L. Fodor ,  Scott Rollins ,  Stephen P. Squinto

    IPC分类号： A01K67/027 ,  A61K38/00 ,  A61K48/00 ,  A61P37/06 ,  C07H21/04 ,  C07K14/705 ,  C07K19/00 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12R1/92 ,  C07K14/47

    CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/00

    摘要： Chimeric complement inhibitor proteins are provided which include a first functional domain (first amino acid sequence) having C3 inhibitory activity and a second functional domain (second amino acid sequence) having C5b-9 inhibitory activity. The first functional domain is amino terminal to the second functional domain. In this way, the chimeric protein exhibits both C3 and C5b-9 inhibitory activity. The other orientation, i.e., the orientation in which the second amino acid sequence is amino terminal to the first amino acid sequence, only produces C3 inhibitory activity. Nucleic acid molecules encoding such proteins are also provided.

    摘要翻译： 提供了嵌合补体抑制蛋白，其包括具有C3抑制活性的第一功能结构域（第一氨基酸序列）和具有C5b-9抑制活性的第二功能结构域（第二氨基酸序列）。 第一功能域是第二功能结构域的氨基末端。 以这种方式，嵌合蛋白质表现出C3和C5b-9抑制活性。 另一取向即第二氨基酸序列与第一氨基酸序列氨基末端的取向仅产生C3抑制活性。 还提供了编码这种蛋白质的核酸分子。

    Anti-P-selectin antibodies
    7.
    发明授权
    Anti-P-selectin antibodies 有权
    抗P-选择素抗体

    公开(公告)号：US09068001B2

    公开(公告)日：2015-06-30

    申请号：US13204508

    申请日：2011-08-05

    申请人： Scott Rollins ,  Richard Alvarez ,  Russell Rother ,  Rodger P. McEver ,  Ziad S. Kawar

    发明人： Scott Rollins ,  Richard Alvarez ,  Russell Rother ,  Rodger P. McEver ,  Ziad S. Kawar

    IPC分类号： A61K39/395 ,  C07K16/28

    CPC分类号： C07K16/2854 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76

    摘要： Antibodies are disclosed which bind specifically to P-selectin and which block the binding of PSGL-1 to P-selectin. These anti-P-selectin antibodies may also cause dissociation of preformed P-selectin/PSGL-1 complexes. The disclosure identifies a heretofore unrecognized, near N-terminal, antibody binding domain (a conformational epitope) of P-selectin to which the function-blocking antibodies (which may be chimeric, human or humanized antibodies for example) bind. Antibodies are disclosed which bind to the conformational epitope of P-selectin and which have a dual function in blocking binding of PSGL-1 to P-selectin, and in causing dissociation of preformed P-selectin/PSGL-1 complexes. Such single and dual function anti-P-selectin antibodies and binding fragments thereof may be used in the treatment of a variety of inflammatory and thrombotic disorders and conditions. Screening methods for identifying such antibodies are also disclosed.

    摘要翻译： 公开了与P-选择蛋白特异性结合并阻断PSGL-1与P-选择蛋白结合的抗体。 这些抗P-选择蛋白抗体也可能导致预先形成的P-选择素/ PSGL-1复合物的解离。 本公开内容鉴定了功能阻断抗体（其可能是嵌合体，人或人源化抗体）如此结合的P-选择素的迄今未被认识的近N末端抗体结合结构域（构象表位）。 公开了结合P型选择素的构象表位的抗体，其具有阻断PSGL-1与P-选择蛋白结合的双重功能，并引起预先形成的P-选择蛋白/ PSGL-1复合物的解离。 这种单功能和双重功能的抗P-选择蛋白抗体及其结合片段可用于治疗各种炎症和血栓形成障碍和病症。 还公开了用于鉴定此类抗体的筛选方法。

    Sleeve hydrocarbon trap
    9.
    发明授权
    Sleeve hydrocarbon trap 有权
    套筒烃陷阱

    公开(公告)号：US08191535B2

    公开(公告)日：2012-06-05

    申请号：US12560033

    申请日：2009-09-15

    申请人： Andrew George Bellis ,  Scott Rollins

    发明人： Andrew George Bellis ,  Scott Rollins

    IPC分类号： F02M33/02 ,  B01D59/26

    CPC分类号： F02M25/089 ,  F02M25/0854 ,  F02M35/02 ,  F02M35/10013 ,  F02M35/10019 ,  Y10T29/49345

    摘要： A sleeve hydrocarbon trap is provided. In some examples, the sleeve hydrocarbon trap includes a hydrocarbon adsorbing sleeve, the sleeve adapted to be positioned in a sensor bore and the sleeve including one or more hydrocarbon adsorbing layers, and a cage adapted to retain the hydrocarbon adsorbing sleeve in the sensor bore.

    摘要翻译： 提供套筒烃阱。 在一些实例中，套筒烃阱包括烃吸附套筒，套筒适于定位在传感器孔中，套筒包括一个或多个烃吸附层，以及适于将烃吸附套保持在传感器孔中的保持架。