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    Hermetically sealed microchip reservoir devices
    1.
    发明申请
    Hermetically sealed microchip reservoir devices 有权
    密封微芯片油藏装置

    公开(公告)号：US20050077584A1

    公开(公告)日：2005-04-14

    申请号：US11005391

    申请日：2004-12-06

    申请人： Scott Uhland ,  Benjamin Polito ,  Stephen Herman ,  John Santini ,  John Maloney

    发明人： Scott Uhland ,  Benjamin Polito ,  Stephen Herman ,  John Santini ,  John Maloney

    IPC分类号： B81C3/00 ,  A61K9/00 ,  A61K9/22 ,  B23K1/06 ,  B23K26/00 ,  B81B1/00 ,  H01L27/14

    CPC分类号： A61K9/0097

    摘要： Devices are provided for the controlled exposure or release of contents stored in hermetically sealed reservoirs. The devices comprise a primary substrate having a front side and a back side, and including one or more hermetic sealing materials; a plurality of reservoirs in the primary substrate positioned between the front side and the back side; reservoir contents, which comprise chemical molecules (such as drugs) or a secondary device (such as a glucose sensor), located inside the reservoirs; a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; and a hermetic seal formed between and joining the primary substrate and the hermetic sealing substrate, wherein the hermetic seal independently seals the reservoirs.

    摘要翻译： 提供了用于控制曝光或释放存储在密封储存器中的内容物的装置。 这些装置包括具有前侧和后侧的主基板，并且包括一个或多个密封材料; 位于前侧和后侧之间的主要基底中的多个储存器; 包括化学分子（如药物）或位于储存器内部的次级装置（如葡萄糖传感器）的储存器内容物; 具有由一种或多种密封材料构成的表面的气密密封基材; 以及形成在主基板和气密密封基板之间并与其接合的气密密封件，其中气密密封独立地密封储存器。

    Methods for accelerated release of material from a reservoir device
    2.
    发明申请
    Methods for accelerated release of material from a reservoir device 审中-公开
    从储存装置中加速释放材料的方法

    公开(公告)号：US20050055014A1

    公开(公告)日：2005-03-10

    申请号：US10911175

    申请日：2004-08-04

    申请人： Jonathan Coppeta ,  John Maloney ,  Benjamin Polito ,  John Santini ,  Norman Sheppard ,  Scott Uhland

    发明人： Jonathan Coppeta ,  John Maloney ,  Benjamin Polito ,  John Santini ,  Norman Sheppard ,  Scott Uhland

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0097 ,  A61K9/0009 ,  A61K9/0024 ,  A61M5/14276 ,  A61M2205/0266

    摘要： Methods and devices are provided for selective release or exposure of reservoir contents, such as a drug formulation or diagnostic reagent, sealed in a reservoir, e.g., a microreservoir. The devices comprise a substrate; one or more reservoirs located in and defined by the substrate; reservoir contents located inside the reservoirs; a reservoir cap or rupturable layer sealing an outlet of the reservoir; and means for disintegrating the reservoir cap or rupturing the rupturable layer; and means for accelerating the release of the reservoir contents from the reservoir through the outlet, or for enhancing diffusional mass transport of a material into or out of the reservoir. The means for accelerating can, for example, include a shape memory material. In a preferred embodiment, the device is adapted for implantation into a human or animal body and comprises an array of several discrete reservoir, each one being individually openable at a desired time.

    摘要翻译： 提供了用于选择性地释放或暴露储存器内容物的方法和装置，例如药物制剂或诊断试剂，密封在储存器例如微储存器中。 所述装置包括基底; 位于并由衬底限定的一个或多个储存器; 水库内容位于水库内; 储存器盖或可破裂层，密封储存器的出口; 以及用于分解储存器盖或破裂可破裂层的装置; 以及用于加速通过出口从储存器释放储存器内容物的装置，或用于增加材料进入或流出储存器的扩散质量输送的装置。 加速装置可以例如包括形状记忆材料。 在优选实施例中，该装置适于植入人体或动物体内并且包括几个离散储器的阵列，每个储存器可在期望的时间单独打开。

    Hermetically Sealed Devices for Controlled Release or Exposure of Reservoir Contents
    4.
    发明申请
    Hermetically Sealed Devices for Controlled Release or Exposure of Reservoir Contents 审中-公开
    用于控制释放或暴露储层内容的密封装置

    公开(公告)号：US20070036835A1

    公开(公告)日：2007-02-15

    申请号：US11537978

    申请日：2006-10-02

    申请人： Jonathan Coppeta ,  Scott Uhland ,  Benjamin Polito ,  Norman Sheppard ,  Christina Feakes ,  Douglas Snell ,  John Santini

    发明人： Jonathan Coppeta ,  Scott Uhland ,  Benjamin Polito ,  Norman Sheppard ,  Christina Feakes ,  Douglas Snell ,  John Santini

    IPC分类号： A61K9/22 ,  A61F2/00

    CPC分类号： B81C1/00269 ,  B81B2201/058 ,  B81C2203/0145 ,  B82Y30/00

    摘要： Methods are provided for hermetically sealing an opening in a reservoir of a containment device. The method comprises applying a polymeric material to an opening in a reservoir of a containment device, the reservoir comprising reservoir contents (such as a drug or a sensor) to be hermetically isolated within the reservoir, the applied polymeric material closing off the opening and forming a temporary seal; and adhering a hermetic sealing material onto the polymeric material to hermetically seal the opening. The reservoir can be a micro-reservoir. The containment device can comprises an array of two or more of reservoirs, and the method comprises hermetically sealing each of the two or more reservoirs.

    摘要翻译： 提供了用于气密地密封容纳装置的储存器中的开口的方法。 该方法包括将聚合物材料施加到容纳装置的储存器中的开口，所述储存器包括要在储存器内气密隔离的储存器内容物（例如药物或传感器），所施加的聚合物材料封闭开口并形成 临时印章 并将气密密封材料粘附到聚合物材料上以气密地密封开口。 储层可以是微储层。 容纳装置可以包括两个或更多个储存器的阵列，并且该方法包括气密地密封两个或更多储存器中的每一个。