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    Hermetically Sealed Devices for Controlled Release or Exposure of Reservoir Contents
    1.
    发明申请
    Hermetically Sealed Devices for Controlled Release or Exposure of Reservoir Contents 审中-公开
    用于控制释放或暴露储层内容的密封装置

    公开(公告)号：US20070036835A1

    公开(公告)日：2007-02-15

    申请号：US11537978

    申请日：2006-10-02

    申请人： Jonathan Coppeta ,  Scott Uhland ,  Benjamin Polito ,  Norman Sheppard ,  Christina Feakes ,  Douglas Snell ,  John Santini

    发明人： Jonathan Coppeta ,  Scott Uhland ,  Benjamin Polito ,  Norman Sheppard ,  Christina Feakes ,  Douglas Snell ,  John Santini

    IPC分类号： A61K9/22 ,  A61F2/00

    CPC分类号： B81C1/00269 ,  B81B2201/058 ,  B81C2203/0145 ,  B82Y30/00

    摘要： Methods are provided for hermetically sealing an opening in a reservoir of a containment device. The method comprises applying a polymeric material to an opening in a reservoir of a containment device, the reservoir comprising reservoir contents (such as a drug or a sensor) to be hermetically isolated within the reservoir, the applied polymeric material closing off the opening and forming a temporary seal; and adhering a hermetic sealing material onto the polymeric material to hermetically seal the opening. The reservoir can be a micro-reservoir. The containment device can comprises an array of two or more of reservoirs, and the method comprises hermetically sealing each of the two or more reservoirs.

    摘要翻译： 提供了用于气密地密封容纳装置的储存器中的开口的方法。 该方法包括将聚合物材料施加到容纳装置的储存器中的开口，所述储存器包括要在储存器内气密隔离的储存器内容物（例如药物或传感器），所施加的聚合物材料封闭开口并形成 临时印章 并将气密密封材料粘附到聚合物材料上以气密地密封开口。 储层可以是微储层。 容纳装置可以包括两个或更多个储存器的阵列，并且该方法包括气密地密封两个或更多储存器中的每一个。

    Methods for accelerated release of material from a reservoir device
    3.
    发明申请
    Methods for accelerated release of material from a reservoir device 审中-公开
    从储存装置中加速释放材料的方法

    公开(公告)号：US20050055014A1

    公开(公告)日：2005-03-10

    申请号：US10911175

    申请日：2004-08-04

    申请人： Jonathan Coppeta ,  John Maloney ,  Benjamin Polito ,  John Santini ,  Norman Sheppard ,  Scott Uhland

    发明人： Jonathan Coppeta ,  John Maloney ,  Benjamin Polito ,  John Santini ,  Norman Sheppard ,  Scott Uhland

    IPC分类号： A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0097 ,  A61K9/0009 ,  A61K9/0024 ,  A61M5/14276 ,  A61M2205/0266

    摘要： Methods and devices are provided for selective release or exposure of reservoir contents, such as a drug formulation or diagnostic reagent, sealed in a reservoir, e.g., a microreservoir. The devices comprise a substrate; one or more reservoirs located in and defined by the substrate; reservoir contents located inside the reservoirs; a reservoir cap or rupturable layer sealing an outlet of the reservoir; and means for disintegrating the reservoir cap or rupturing the rupturable layer; and means for accelerating the release of the reservoir contents from the reservoir through the outlet, or for enhancing diffusional mass transport of a material into or out of the reservoir. The means for accelerating can, for example, include a shape memory material. In a preferred embodiment, the device is adapted for implantation into a human or animal body and comprises an array of several discrete reservoir, each one being individually openable at a desired time.

    摘要翻译： 提供了用于选择性地释放或暴露储存器内容物的方法和装置，例如药物制剂或诊断试剂，密封在储存器例如微储存器中。 所述装置包括基底; 位于并由衬底限定的一个或多个储存器; 水库内容位于水库内; 储存器盖或可破裂层，密封储存器的出口; 以及用于分解储存器盖或破裂可破裂层的装置; 以及用于加速通过出口从储存器释放储存器内容物的装置，或用于增加材料进入或流出储存器的扩散质量输送的装置。 加速装置可以例如包括形状记忆材料。 在优选实施例中，该装置适于植入人体或动物体内并且包括几个离散储器的阵列，每个储存器可在期望的时间单独打开。

    Hermetically sealed microchip reservoir devices
    4.
    发明申请
    Hermetically sealed microchip reservoir devices 有权
    密封微芯片油藏装置

    公开(公告)号：US20050077584A1

    公开(公告)日：2005-04-14

    申请号：US11005391

    申请日：2004-12-06

    申请人： Scott Uhland ,  Benjamin Polito ,  Stephen Herman ,  John Santini ,  John Maloney

    发明人： Scott Uhland ,  Benjamin Polito ,  Stephen Herman ,  John Santini ,  John Maloney

    IPC分类号： B81C3/00 ,  A61K9/00 ,  A61K9/22 ,  B23K1/06 ,  B23K26/00 ,  B81B1/00 ,  H01L27/14

    CPC分类号： A61K9/0097

    摘要： Devices are provided for the controlled exposure or release of contents stored in hermetically sealed reservoirs. The devices comprise a primary substrate having a front side and a back side, and including one or more hermetic sealing materials; a plurality of reservoirs in the primary substrate positioned between the front side and the back side; reservoir contents, which comprise chemical molecules (such as drugs) or a secondary device (such as a glucose sensor), located inside the reservoirs; a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; and a hermetic seal formed between and joining the primary substrate and the hermetic sealing substrate, wherein the hermetic seal independently seals the reservoirs.

    摘要翻译： 提供了用于控制曝光或释放存储在密封储存器中的内容物的装置。 这些装置包括具有前侧和后侧的主基板，并且包括一个或多个密封材料; 位于前侧和后侧之间的主要基底中的多个储存器; 包括化学分子（如药物）或位于储存器内部的次级装置（如葡萄糖传感器）的储存器内容物; 具有由一种或多种密封材料构成的表面的气密密封基材; 以及形成在主基板和气密密封基板之间并与其接合的气密密封件，其中气密密封独立地密封储存器。

    Fabrication methods and structures for micro-reservoir devices
    5.
    发明申请
    Fabrication methods and structures for micro-reservoir devices 有权
    微储层装置的制造方法和结构

    公开(公告)号：US20060105275A1

    公开(公告)日：2006-05-18

    申请号：US10988667

    申请日：2004-11-15

    申请人： John Maloney ,  Zouhair Sbiaa ,  John Santini ,  Norman Sheppard ,  Scott Uhland

    发明人： John Maloney ,  Zouhair Sbiaa ,  John Santini ,  Norman Sheppard ,  Scott Uhland

    IPC分类号： G03F7/00

    CPC分类号： B01L3/50853 ,  A61K9/0024 ,  A61K9/0097 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2400/0677

    摘要： Methods are provided for making a multi-reservoir device comprising (i) patterning one or more photoresist layers on a substrate; (ii) depositing onto the substrate at least one metal layer by a sputtering process to form a plurality of reservoir caps and conductive traces; (iii) removing the photoresist layers using a liftoff process; (iv) forming a plurality of reservoirs in the substrate; (v) loading each reservoir with reservoir contents (such as a drug or sensor); and (vi) sealing each reservoir. Optionally, the reservoir cap comprises a first conductive metal layer coated with one or more protective noble metal films. To enhance the resistance of the substrate (e.g., a silicon substrate) to etching in vivo, the interior sidewalls of the reservoirs optionally can include a protective coating (e.g., gold, platinum, carbon, silicon carbide, silicon dioxide, and platinum silicide), or sidewalls comprising silicon can be doped with boron or another impurity.

    摘要翻译： 提供了用于制造多贮存器器件的方法，包括（i）在衬底上图案化一个或多个光致抗蚀剂层; （ii）通过溅射工艺在衬底上沉积至少一个金属层以形成多个储存器盖和导电迹线; （iii）使用剥离工艺除去光致抗蚀剂层; （iv）在所述基板中形成多个储存器; （v）向每个储存器装载储存器内容物（例如药物或传感器）; 和（vi）密封每个储存器。 可选地，储存器盖包括涂覆有一个或多个保护性贵金属膜的第一导电金属层。 为了增强衬底（例如，硅衬底）在体内蚀刻的电阻，存储器的内侧壁任选地可以包括保护涂层（例如金，铂，碳，碳化硅，二氧化硅和硅化铂） ，或者包含硅的侧壁可以掺杂硼或另一种杂质。

    MULTI-RESERVOIR PUMP DEVICE FOR DIALYSIS, BIOSENSING, OR DELIVERY OF SUBSTANCES
    7.
    发明申请
    MULTI-RESERVOIR PUMP DEVICE FOR DIALYSIS, BIOSENSING, OR DELIVERY OF SUBSTANCES 审中-公开
    用于透析，生物传感或输送物质的多储层泵装置

    公开(公告)号：US20080015494A1

    公开(公告)日：2008-01-17

    申请号：US11776351

    申请日：2007-07-11

    申请人： John Santini ,  Michael Cima ,  Jonathan Coppeta ,  James Prescott ,  Zouhair Sbiaa ,  Mark Staples

    发明人： John Santini ,  Michael Cima ,  Jonathan Coppeta ,  James Prescott ,  Zouhair Sbiaa ,  Mark Staples

    IPC分类号： A61M31/00

    CPC分类号： A61M37/0015 ,  A61M5/1409 ,  A61M5/14248 ,  A61M5/1452 ,  A61M5/14526 ,  A61M2005/14204 ,  A61M2005/14268 ,  A61M2037/0023

    摘要： A pump patch device is provided for drug delivery. The device may include a substrate having a plurality of discrete reservoirs, each reservoir having a reservoir opening; a drug disposed in the reservoirs; a pump for delivering a carrier fluid through or adjacent to the reservoir openings; a flow channel for receiving and combining the carrier fluid from the pump with the drug from the reservoirs to form a fluidized drug; and a needle for delivering the fluidized drug into the skin or another biological tissue of a patient. A device is provided for use in dialysis that includes a non-disposable module including a pump or pressure generator; and a disposable cassette operably connected to the pump or pressure generator and including a plurality of discrete reservoirs containing drug and sensors. A fluidics connection device is provided that includes a compression cold weld seal for a microfluidic via.

    摘要翻译： 提供泵补丁装置用于药物递送。 该装置可以包括具有多个分立储存器的基板，每个储存器具有储存器开口; 贮存在药物中的药物; 用于将载体流体输送通过或邻近储存器开口的泵; 流动通道，用于接收和组合来自泵的载体流体与来自储存器的药物以形成流化药物; 以及用于将流化药物输送到患者的皮肤或另一生物组织中的针。 提供用于透析的装置，其包括非一次性模块，其包括泵或压力发生器; 以及可操作地连接到泵或压力发生器并且包括多个包含药物和传感器的离散储存器的一次性盒。 提供一种流体连接装置，其包括用于微流体通孔的压缩冷焊缝。