公开(公告)号：US20050055014A1

公开(公告)日：2005-03-10

申请号：US10911175

申请日：2004-08-04

申请人： Jonathan Coppeta ,  John Maloney ,  Benjamin Polito ,  John Santini ,  Norman Sheppard ,  Scott Uhland

发明人： Jonathan Coppeta ,  John Maloney ,  Benjamin Polito ,  John Santini ,  Norman Sheppard ,  Scott Uhland

IPC分类号： A61K9/00 ,  A61K9/22

CPC分类号： A61K9/0097 ,  A61K9/0009 ,  A61K9/0024 ,  A61M5/14276 ,  A61M2205/0266

摘要： Methods and devices are provided for selective release or exposure of reservoir contents, such as a drug formulation or diagnostic reagent, sealed in a reservoir, e.g., a microreservoir. The devices comprise a substrate; one or more reservoirs located in and defined by the substrate; reservoir contents located inside the reservoirs; a reservoir cap or rupturable layer sealing an outlet of the reservoir; and means for disintegrating the reservoir cap or rupturing the rupturable layer; and means for accelerating the release of the reservoir contents from the reservoir through the outlet, or for enhancing diffusional mass transport of a material into or out of the reservoir. The means for accelerating can, for example, include a shape memory material. In a preferred embodiment, the device is adapted for implantation into a human or animal body and comprises an array of several discrete reservoir, each one being individually openable at a desired time.

摘要翻译： 提供了用于选择性地释放或暴露储存器内容物的方法和装置，例如药物制剂或诊断试剂，密封在储存器例如微储存器中。 所述装置包括基底; 位于并由衬底限定的一个或多个储存器; 水库内容位于水库内; 储存器盖或可破裂层，密封储存器的出口; 以及用于分解储存器盖或破裂可破裂层的装置; 以及用于加速通过出口从储存器释放储存器内容物的装置，或用于增加材料进入或流出储存器的扩散质量输送的装置。 加速装置可以例如包括形状记忆材料。 在优选实施例中，该装置适于植入人体或动物体内并且包括几个离散储器的阵列，每个储存器可在期望的时间单独打开。

公开(公告)号：US20070036835A1

公开(公告)日：2007-02-15

申请号：US11537978

申请日：2006-10-02

申请人： Jonathan Coppeta ,  Scott Uhland ,  Benjamin Polito ,  Norman Sheppard ,  Christina Feakes ,  Douglas Snell ,  John Santini

发明人： Jonathan Coppeta ,  Scott Uhland ,  Benjamin Polito ,  Norman Sheppard ,  Christina Feakes ,  Douglas Snell ,  John Santini

IPC分类号： A61K9/22 ,  A61F2/00

CPC分类号： B81C1/00269 ,  B81B2201/058 ,  B81C2203/0145 ,  B82Y30/00

摘要： Methods are provided for hermetically sealing an opening in a reservoir of a containment device. The method comprises applying a polymeric material to an opening in a reservoir of a containment device, the reservoir comprising reservoir contents (such as a drug or a sensor) to be hermetically isolated within the reservoir, the applied polymeric material closing off the opening and forming a temporary seal; and adhering a hermetic sealing material onto the polymeric material to hermetically seal the opening. The reservoir can be a micro-reservoir. The containment device can comprises an array of two or more of reservoirs, and the method comprises hermetically sealing each of the two or more reservoirs.

摘要翻译： 提供了用于气密地密封容纳装置的储存器中的开口的方法。 该方法包括将聚合物材料施加到容纳装置的储存器中的开口，所述储存器包括要在储存器内气密隔离的储存器内容物（例如药物或传感器），所施加的聚合物材料封闭开口并形成 临时印章 并将气密密封材料粘附到聚合物材料上以气密地密封开口。 储层可以是微储层。 容纳装置可以包括两个或更多个储存器的阵列，并且该方法包括气密地密封两个或更多储存器中的每一个。

公开(公告)号：US20050050859A1

公开(公告)日：2005-03-10

申请号：US10894265

申请日：2004-07-19

申请人： Jonathan Coppeta ,  Scott Uhland ,  Benjamin Polito ,  Norman Sheppard ,  Christina Feakes ,  Douglas Snell ,  John Santini

发明人： Jonathan Coppeta ,  Scott Uhland ,  Benjamin Polito ,  Norman Sheppard ,  Christina Feakes ,  Douglas Snell ,  John Santini

IPC分类号： A61K9/00 ,  B01L3/00 ,  B65B7/28 ,  H01L21/50

CPC分类号： B01L3/5085 ,  A61K9/0009 ,  A61K9/0097 ,  B01L3/5027 ,  B01L2400/0677 ,  B81B2201/058 ,  B81C1/00269 ,  B81C2203/0145 ,  H01L21/50

摘要： Methods are provided for hermetically sealing an opening in a reservoir of a containment device. The method comprises applying a polymeric material to an opening in a reservoir of a containment device, the reservoir comprising reservoir contents (such as a drug or a sensor) to be hermetically isolated within the reservoir, the applied polymeric material closing off the opening and forming a temporary seal; and adhering a hermetic sealing material onto the polymeric material to hermetically seal the opening. The reservoir can be a micro-reservoir. The containment device can comprises an array of two or more of reservoirs, and the method comprises hermetically sealing each of the two or more reservoirs.

摘要翻译： 提供了用于气密地密封容纳装置的储存器中的开口的方法。 该方法包括将聚合物材料施加到容纳装置的储存器中的开口中，所述储存器包括要在储存器内气密隔离的储存器内容物（例如药物或传感器），所施加的聚合物材料封闭开口并形成 临时印章 并将气密密封材料粘附到聚合物材料上以气密地密封开口。 储层可以是微储层。 容纳装置可以包括两个或更多个储存器的阵列，并且该方法包括气密地密封两个或更多储存器中的每一个。

公开(公告)号：US20060100608A1

公开(公告)日：2006-05-11

申请号：US11259301

申请日：2005-10-26

申请人： Scott Uhland ,  Benjamin Polito ,  John Maloney ,  Norman Sheppard ,  Stephen Herman ,  Barry Yomtov

发明人： Scott Uhland ,  Benjamin Polito ,  John Maloney ,  Norman Sheppard ,  Stephen Herman ,  Barry Yomtov

IPC分类号： A61K9/22

CPC分类号： A61M25/0082 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61M5/14276 ,  A61M25/0069 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/3653 ,  A61N1/32 ,  Y10T436/25

摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. In one embodiment, the controlled release system is incorporated into an implantable drug delivery device.

公开(公告)号：US20050077584A1

公开(公告)日：2005-04-14

申请号：US11005391

申请日：2004-12-06

申请人： Scott Uhland ,  Benjamin Polito ,  Stephen Herman ,  John Santini ,  John Maloney

发明人： Scott Uhland ,  Benjamin Polito ,  Stephen Herman ,  John Santini ,  John Maloney

IPC分类号： B81C3/00 ,  A61K9/00 ,  A61K9/22 ,  B23K1/06 ,  B23K26/00 ,  B81B1/00 ,  H01L27/14

CPC分类号： A61K9/0097

摘要： Devices are provided for the controlled exposure or release of contents stored in hermetically sealed reservoirs. The devices comprise a primary substrate having a front side and a back side, and including one or more hermetic sealing materials; a plurality of reservoirs in the primary substrate positioned between the front side and the back side; reservoir contents, which comprise chemical molecules (such as drugs) or a secondary device (such as a glucose sensor), located inside the reservoirs; a hermetic sealing substrate having a surface composed of one or more hermetic sealing materials; and a hermetic seal formed between and joining the primary substrate and the hermetic sealing substrate, wherein the hermetic seal independently seals the reservoirs.

摘要翻译： 提供了用于控制曝光或释放存储在密封储存器中的内容物的装置。 这些装置包括具有前侧和后侧的主基板，并且包括一个或多个密封材料; 位于前侧和后侧之间的主要基底中的多个储存器; 包括化学分子（如药物）或位于储存器内部的次级装置（如葡萄糖传感器）的储存器内容物; 具有由一种或多种密封材料构成的表面的气密密封基材; 以及形成在主基板和气密密封基板之间并与其接合的气密密封件，其中气密密封独立地密封储存器。

公开(公告)号：US20060105275A1

公开(公告)日：2006-05-18

申请号：US10988667

申请日：2004-11-15

申请人： John Maloney ,  Zouhair Sbiaa ,  John Santini ,  Norman Sheppard ,  Scott Uhland

发明人： John Maloney ,  Zouhair Sbiaa ,  John Santini ,  Norman Sheppard ,  Scott Uhland

IPC分类号： G03F7/00

CPC分类号： B01L3/50853 ,  A61K9/0024 ,  A61K9/0097 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2400/0677

摘要： Methods are provided for making a multi-reservoir device comprising (i) patterning one or more photoresist layers on a substrate; (ii) depositing onto the substrate at least one metal layer by a sputtering process to form a plurality of reservoir caps and conductive traces; (iii) removing the photoresist layers using a liftoff process; (iv) forming a plurality of reservoirs in the substrate; (v) loading each reservoir with reservoir contents (such as a drug or sensor); and (vi) sealing each reservoir. Optionally, the reservoir cap comprises a first conductive metal layer coated with one or more protective noble metal films. To enhance the resistance of the substrate (e.g., a silicon substrate) to etching in vivo, the interior sidewalls of the reservoirs optionally can include a protective coating (e.g., gold, platinum, carbon, silicon carbide, silicon dioxide, and platinum silicide), or sidewalls comprising silicon can be doped with boron or another impurity.

摘要翻译： 提供了用于制造多贮存器器件的方法，包括（i）在衬底上图案化一个或多个光致抗蚀剂层; （ii）通过溅射工艺在衬底上沉积至少一个金属层以形成多个储存器盖和导电迹线; （iii）使用剥离工艺除去光致抗蚀剂层; （iv）在所述基板中形成多个储存器; （v）向每个储存器装载储存器内容物（例如药物或传感器）; 和（vi）密封每个储存器。 可选地，储存器盖包括涂覆有一个或多个保护性贵金属膜的第一导电金属层。 为了增强衬底（例如，硅衬底）在体内蚀刻的电阻，存储器的内侧壁任选地可以包括保护涂层（例如金，铂，碳，碳化硅，二氧化硅和硅化铂） ，或者包含硅的侧壁可以掺杂硼或另一种杂质。

公开(公告)号：US09014799B2

公开(公告)日：2015-04-21

申请号：US12576124

申请日：2009-10-08

申请人： Scott Uhland ,  Eric Peeters ,  Serena Wong

发明人： Scott Uhland ,  Eric Peeters ,  Serena Wong

IPC分类号： A61N1/30 ,  A61N1/32 ,  A61N1/05 ,  A61N1/18

CPC分类号： A61N1/327 ,  A61N1/0512 ,  A61N1/0524 ,  A61N1/18 ,  A61N1/325

摘要： Intralumenal devices and methods are provided for transmucosal drug delivery. The device may comprise a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and an electrically-actuatable portion configured to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the electrically-actuatable portion.

摘要翻译： 提供管腔内装置和方法用于经粘膜药物递送。 该装置可以包括构造成用于腔内部署到人或动物受试者中的壳体; 包含至少一种药物的药物分配部分; 以及可电致动部分，其构造成在心脏手术部署在人或动物受试者中的选定时间内破坏邻近所述壳体的粘膜屏障的至少一个区域。 该装置可操作以将药物从壳体分配到由电致动部分破坏的粘膜屏障的区域。

公开(公告)号：US20110087192A1

公开(公告)日：2011-04-14

申请号：US12576087

申请日：2009-10-08

申请人： Scott Uhland ,  Eric Peeters ,  Hussain Fatakdawala

发明人： Scott Uhland ,  Eric Peeters ,  Hussain Fatakdawala

IPC分类号： A61M31/00 ,  A61K33/40 ,  A61K38/02 ,  A61K31/045 ,  A61K31/19 ,  A61K31/23 ,  A61K38/46 ,  A61K31/519 ,  A61K31/52

CPC分类号： A61M31/002 ,  A61K9/0036

摘要： Devices and methods are provided for transmucosal drug delivery. The transmucosal drug delivery device may include a housing configured for intralumenal deployment, such as intravaginally, into a human or animal subject; a drug-dispensing portion which contains at least one drug, the drug-dispensing portion being configured to dispense the drug from the housing by positive displacement; and a permeability enhancer-dispensing portion configured to release or generate a permeability enhancing substance to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the permeability enhancing substance.

摘要翻译： 提供了用于经粘膜药物递送的装置和方法。 透粘膜药物递送装置可以包括构造成用于腔内部署的壳体，例如阴道内部分入人或动物受试者; 药物分配部分，其包含至少一种药物，所述药物分配部分构造成通过正位移从所述壳体分配药物; 以及渗透性增强剂分配部分，被配置为释放或产生渗透性增强物质，以在选择的时间在脉管内部署在人或动物受试者中的同时破坏邻近所述壳体的粘膜屏障的至少一个区域。 该装置可操作以将药物从壳体分配到由渗透性增强物质破坏的粘膜屏障的区域。

公开(公告)号：US09017310B2

公开(公告)日：2015-04-28

申请号：US12576075

申请日：2009-10-08

申请人： Scott Uhland ,  Eric Peeters

发明人： Scott Uhland ,  Eric Peeters

IPC分类号： A61K9/22 ,  A61M37/00

CPC分类号： A61M37/0015 ,  A61M2037/0023

摘要： Devices and methods for transmucosal drug delivery are provided. A device includes a housing configured for intralumenal deployment into a human or animal subject; a drug-dispensing portion which contains at least one drug; and a plurality of microneedles extending, or being extendable from, the housing, the plurality of microneedles being configured to disrupt at least one region of a mucosal barrier adjacent the housing at a selected time after being intralumenally deployed in the human or animal subject. The device is operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the plurality of microneedles.

摘要翻译： 提供了经粘膜药物递送的装置和方法。 一种装置包括构造成用于腔内部署到人或动物受试者中的壳体; 包含至少一种药物的药物分配部分; 多个微针从外壳延伸或可从外壳延伸，所述多个微针被配置成在腔内部署在人或动物受试者中之后的选定时间内破坏邻近所述外壳的粘膜屏障的至少一个区域。 该装置可操作地将药物从壳体分配到由多个微针破坏的粘膜屏障的区域。

公开(公告)号：US20120271224A1

公开(公告)日：2012-10-25

申请号：US13089783

申请日：2011-04-19

申请人： Scott Uhland ,  Eric Peeters

发明人： Scott Uhland ,  Eric Peeters

IPC分类号： A61M37/00

CPC分类号： A61K9/0021 ,  A61M5/30 ,  A61M5/3015

摘要： Drug delivery device and methods are provided for transdermal drug delivery through a skin. The device includes a gas source comprising a gas or capable of selectively producing a gas. The device also includes a first collimator fluidly connected with the gas source adapted to form a first plurality of collimated gas streams comprising the gas. The first collimator has an inlet end and an outlet end. The device further includes a first drug source comprising a drug. The first drug source is configured to release the drug into the first plurality of collimated gas streams between the inlet end and outlet end of the first collimator.

摘要翻译： 提供药物递送装置和方法用于通过皮肤的透皮药物递送。 该装置包括气体源，其包括气体或能够选择性地产生气体。 该装置还包括与气体源流体连接的第一准直器，其适于形成包括气体的第一多个准直气流。 第一准直器具有入口端和出口端。 该装置还包括包含药物的第一药物源。 第一药源被配置为将药物释放到第一准直仪的入口端和出口端之间的第一多个准直气体流中。