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公开(公告)号：US20070007218A1
公开(公告)日：2007-01-11
申请号：US11515813
申请日：2006-09-06
申请人： Ronald Hundley , Scott Whitney , Angela Griffin , Conrad Christel , Leonard Bensch , Kenneth Williamson , Joseph Adiletta
发明人： Ronald Hundley , Scott Whitney , Angela Griffin , Conrad Christel , Leonard Bensch , Kenneth Williamson , Joseph Adiletta
IPC分类号： C02F1/32
CPC分类号： B01D46/2414 , B01D29/21 , B01D29/52 , B01D29/58 , B01D46/0031 , B01D46/50 , B01D46/521 , B01D53/323 , B01D2201/0407 , B01D2201/0438 , B01D2201/50 , B01D2239/0241 , B01D2239/065 , B01D2275/10 , C02F1/004 , C02F2201/006
摘要： Fluid treatment elements substantially inhibit electrical charge imbalances and/or build-ups of electrical charges. A fluid treatment element may comprise a multilayer composite including an electrically conductive fibrous matrix, having an upstream side and a downstream side, disposed on a porous substrate, also having an upstream side and a downstream side, which supports the fibrous matrix. The fibrous matrix may include a combination of conductive and nonconductive fibers, wherein the conductive fibers include metal fibers and substantially inhibit an electrical charge and/or build-up of electrical charge. The conductive metal fibers of the electrically conductive fibrous matrix may comprise less than about 50% by weight of the conductive and nonconductive fibers and may have diameters in the range from about 1 μm or less to about 10 μm. The multilayer composite may also include a drainage layer positioned along one of the upstream side of the fibrous matrix and the downstream side of the porous substrate.
摘要翻译： 流体处理元件基本上抑制电荷不均衡和/或积聚电荷。 流体处理元件可以包括多层复合材料，其包括具有上游侧和下游侧的导电纤维基质，该导电纤维基质设置在多孔基底上，该多孔基底还具有支撑纤维基质的上游侧和下游侧。 纤维基质可以包括导电纤维和非导电纤维的组合，其中导电纤维包括金属纤维并且基本上抑制电荷和/或积聚电荷。 导电纤维基质的导电金属纤维可以包含小于约50重量％的导电和非导电纤维，并且可以具有在约1μm或更小至约10μm的范围内的直径。 多层复合材料还可以包括沿着纤维基质的上游侧和多孔基材的下游侧定位的排水层。
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公开(公告)号：US07144738B2
公开(公告)日：2006-12-05
申请号：US11094255
申请日：2005-03-31
申请人： Scott Whitney
发明人： Scott Whitney
IPC分类号： G01N33/68
CPC分类号： G01N33/542 , C12Q1/68 , G01N1/30 , G01N27/44721 , G01N27/44726 , Y10S435/81 , Y10T436/10 , Y10T436/143333 , Y10T436/24 , Y10T436/25 , C12Q2565/125 , C12Q2563/173 , C12Q2527/125
摘要： Methods for detecting biopolymers such as proteins, peptides, and nucleic acids in a matrix are provided, in which the methods include contacting the matrix with a sensitizing reagent that includes a substituted heteroaromatic compound; contacting the matrix with a reduceable metal salt to stain the biopolymer(s); and detecting the stained biopolymer(s). Compositions for performing the methods can include sensitizing agents, staining reagents, reducing agents, enhancing agents, and destaining agents. The compositions presented are compatible with mass spectrometry, and methods are provided for staining a biopolymer using the compositions of the invention and performing mass spectrometry on one or more biopolymers identified by the staining methods. Kits for staining biopolymers in matrixes can include a sensitizing reagent and a reduceable metal salt, and optionally, one or more enhancing agents, reducing agents, destaining agents, fixing reagents, chelating agents, biopolymers, matrices, cleavage reagents, buffers, or pH indicators.
摘要翻译： 提供了用于检测基质中生物聚合物如蛋白质，肽和核酸的方法，其中所述方法包括使基质与包含取代的杂芳族化合物的敏化试剂接触; 使基质与可还原金属盐接触以染色生物聚合物; 并检测染色的生物聚合物。 用于进行该方法的组合物可以包括敏化剂，染色试剂，还原剂，增强剂和脱色剂。 所提供的组合物与质谱法相容，提供了使用本发明组合物对生物聚合物进行染色的方法，并对通过染色方法鉴定的一种或多种生物聚合物进行质谱分析。 在基质中染色生物聚合物的试剂盒可以包括敏化试剂和可还原金属盐，以及任选的一种或多种增强剂，还原剂，脱色剂，固定剂，螯合剂，生物聚合物，基质，裂解试剂，缓冲液或pH指示剂 。
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3.发明申请Coalescing and separation arrangements systems and methods for liquid mixtures 审中-公开液体混合物的聚结和分离布置系统和方法公开(公告)号：US20050178718A1
公开(公告)日：2005-08-18
申请号：US10503814
申请日：2002-02-06
CPC分类号： B01D17/0211 , B01D17/045 , B01D17/08 , B01D17/10
摘要： Coalescing and/or separating arrangements for separating a discontinuous phase liquid from a continuous phase liquid may comprise two or more of a coalescer (30), a separator (50) and a flow director (70).
摘要翻译： 用于从连续相液体中分离不连续相液体的聚结和/或分离装置可以包括聚结器（30），分离器（50）和导流器（70）中的两个或更多个。
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公开(公告)号：US20050004852A1
公开(公告)日：2005-01-06
申请号：US10613515
申请日：2003-07-03
申请人： Scott Whitney
发明人： Scott Whitney
摘要： What is disclosed is a computer-implemented method for generating a right transfer instruction regarding a transferable right in a priced item. The process includes the steps of graphically presenting a chart of a price of the priced item versus time; and setting a trigger control overlaid on the chart that is responsive to the price to initiate the right transfer instruction when the price reaches a predetermined relationship to a particular price for the priced item. An apparatus includes a communications system for receiving and processing a series of price-indicators for one or more priced items; a presentation system for displaying the series of price-indicators in a graphic format; and a controller, coupled to the communications system, for overlaying one or more interface controls on the series of price-indicators, the controller responsive to user input instructions directed to the one or more overlaying controls for setting a parameter of the one or more controls and for initiating a right transfer process when one or more of price-indicators has a predetermined relationship to the parameter of the one or more controls. An article of manufacture, comprising a program storage medium readable by a computer and embodying one or more instructions executable by the computer for generating a right transfer instruction regarding a transferable right in a priced item presented by the computer, the computer having a computer program application that displays a graphical representation of price history of the priced item, the program storage medium including computer code including I/O access commands, wherein: computer program code presenting graphically a chart of a price of the priced item versus time; and setting a trigger control, using the I/O access commands, overlaid on the chart that is responsive to the price to initiate the right transfer instruction when the price reaches a predetermined relationship to a particular price for the priced item.
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公开(公告)号：USD665917S1
公开(公告)日：2012-08-21
申请号：US29400931
申请日：2011-09-02
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6.发明授权Methods and devices for synchronizing the timing of logic cards in a packet switching system without data loss 有权用于在分组交换系统中同步逻辑卡的定时而不丢失数据的方法和装置公开(公告)号：US07468991B2
公开(公告)日：2008-12-23
申请号：US10388438
申请日：2003-03-17
IPC分类号： H04J3/06
CPC分类号： H04J3/0688
摘要： Synchronous timing techniques provide redundant reference frequencies to enable a packet switching system to continuously generate one or more master clock frequencies when an original reference frequency is lost or unavailable.
摘要翻译： 同步定时技术提供冗余的参考频率，以便当原始参考频率丢失或不可用时，分组交换系统能够连续地产生一个或多个主时钟频率。
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公开(公告)号：US06878551B2
公开(公告)日：2005-04-12
申请号：US10648264
申请日：2003-08-27
申请人： Scott Whitney
发明人： Scott Whitney
CPC分类号： G01N33/542 , C12Q1/68 , G01N1/30 , G01N27/44721 , G01N27/44726 , Y10S435/81 , Y10T436/10 , Y10T436/143333 , Y10T436/24 , Y10T436/25 , C12Q2565/125 , C12Q2563/173 , C12Q2527/125
摘要： The present invention relates to a method for detecting biopolymers in a matrix, which includes contacting the matrix with a sensitizing reagent including on one or more optionally substituted heteroaromatic compounds; contacting the matrix with one or more reduceable metal salts to stain the biopolymer; and detecting the stained biopolymer. The invention also relates to compositions for carrying out the invention and compositions made according to the invention. The invention also relates to kits for carrying out the methods of the invention.
摘要翻译： 本发明涉及一种用于检测基质中的生物聚合物的方法，其包括使基质与包含一种或多种任选取代的杂芳族化合物的增感剂接触; 使基质与一种或多种可还原金属盐接触以染色生物聚合物; 并检测染色的生物聚合物。 本发明还涉及用于实施本发明的组合物和根据本发明制备的组合物。 本发明还涉及用于实施本发明方法的试剂盒。
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公开(公告)号：USD659848S1
公开(公告)日：2012-05-15
申请号：US29390267
申请日：2011-04-22
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公开(公告)号：US20060141554A1
公开(公告)日：2006-06-29
申请号：US10966536
申请日：2004-10-14
申请人： Kyle Gee , Courtenay Hart , Richard Haugland , Wayne Patton , Scott Whitney
发明人： Kyle Gee , Courtenay Hart , Richard Haugland , Wayne Patton , Scott Whitney
CPC分类号： C07D263/62 , A61K49/0021 , A61K49/0039 , A61K49/0041 , A61K49/0052 , C07D311/12 , C07D311/16 , C07D311/18 , C07D405/14 , C07F5/022 , G01N1/30 , G01N33/533 , G01N33/582
摘要： The present invention provides methods and fluorescent compounds that facilitate detecting and labeling of a fusion protein by being capable of selectively binding to an affinity tag. The fluorescent compounds have the general formula A(B)n, wherein A is a fluorophore, B is a binding domain that is a charged chemical moiety, a protein or fragment thereof and n is an integer from 1-6 with the proviso that the protein or fragment thereof not be an antibody or generated from an antibody. The present invention provides specific fluorescent compounds and methods used to detect and label fusion proteins that contain a poly-histidine affinity tag. These compounds have the general formula A(L)m(B)n wherein A is a fluorophore, L is a linker, B is an acetic acid binding domain, m is an integer from 1 to 4 and n is an integer from 1 to 6. The acetic acid groups interact directly with the positively charged histidine residues of the affinity tag to effectively label and detect a fusion protein containing such an affinity tag when present in an acidic or neutral environment.
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公开(公告)号：US20050034989A1
公开(公告)日：2005-02-17
申请号：US10861787
申请日：2004-06-04
申请人： Roumen Bogoev , Scott Whitney , Joseph Amshey
发明人： Roumen Bogoev , Scott Whitney , Joseph Amshey
IPC分类号： G01N33/48 , C07K1/34 , C12M1/00 , C12M1/33 , C12N15/09 , C12Q1/68 , G01N1/10 , G01N1/28 , G01L1/20
CPC分类号： C07K1/34 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： An apparatus and method for mincing a gel includes a gel mincing tube and a mesh material. The mesh material extends across the end of the tube. To subdivide a gel using the mincing apparatus, a gel is placed upon the mesh material in the mincing tube, the mincing tube, mesh material and the gel are spun in a centrifuge, forcing the gel through the mesh material so that the gel is subdivided into generally uniform smaller fragments. The mesh material may be secured to a tube in the form of a nesting tube. The nesting tube nests within the opening of a recovery vessel. The mesh material may be placed in series with a conditionally porous membrane in the nesting tube. Centrifuging the nesting tube and the recovery vessel subdivides gel material into fragments by forcing the gel through the mesh material. The gel subsequently falls upon the membrane, and may be treated on the membrane to extract or otherwise treat analytes in the gel material.
摘要翻译： 用于切割凝胶的设备和方法包括凝胶切割管和网状材料。 网状材料延伸穿过管的端部。 为了使用切碎装置对凝胶进行细分，将凝胶放置在打孔管中的网状材料上，在离心机中将切细管，网状材料和凝胶纺丝，迫使凝胶通过网状材料，使凝胶细分 变成大致均匀的较小碎片。 网状材料可以以嵌套管的形式固定到管。 嵌套管嵌套在回收容器的开口内。 网状材料可以与嵌套管中的条状多孔膜串联放置。 将嵌套管和回收容器离心通过使凝胶通过网状材料将凝胶材料细分成碎片。 凝胶随后落在膜上，并且可以在膜上处理以提取或以其它方式处理凝胶材料中的分析物。
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