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    METHOD AND APPARATUS FOR ASSESSING THE MOLECULAR WATER BINDING OF DEEP TISSUE IN VIVO USING NONIONIZING RADIATION
    1.
    发明申请
    METHOD AND APPARATUS FOR ASSESSING THE MOLECULAR WATER BINDING OF DEEP TISSUE IN VIVO USING NONIONIZING RADIATION 审中-公开
    使用非放射性辐射评估体内深层组织分子水结合的方法和装置

    公开(公告)号：US20070282179A1

    公开(公告)日：2007-12-06

    申请号：US11757673

    申请日：2007-06-04

    申请人： Sean Merritt ,  Bruce J. Tromberg ,  Albert E. Cerussi ,  Anthony J. Durkin ,  So Hyun Chung

    发明人： Sean Merritt ,  Bruce J. Tromberg ,  Albert E. Cerussi ,  Anthony J. Durkin ,  So Hyun Chung

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0059 ,  A61B5/0064 ,  A61B5/0075 ,  A61B5/0091 ,  A61B5/441 ,  A61B5/4875

    摘要： A method of optically analyzing tissue in vivo in an individual to obtain a unique spectrum for the tissue of the individual includes the steps of optically measuring the tissue of the individual using broadband diffuse optical spectroscopy (DOS) to measure a normalized tissue water spectrum of the individual or noninvasively optically line scanning a tissue site on the individual at a plurality of points, then determining spectral differences between the normalized tissue water spectrum and a pure water spectrum at each point of a line scan, generating a bound water index (BWI) corresponding to the spectral differences, and identifying a tissue state corresponding to the scanned tissue based on the BWI.

    摘要翻译： 在个体中光学分析体内组织以获得个体组织的唯一光谱的方法包括以下步骤：使用宽带漫射光谱（DOS）光学测量个体的组织，以测量标准化组织水谱 个体或非侵入式光线在多个点上扫描个体上的组织部位，然后确定标准化组织水谱与在线扫描的每个点处的纯水谱之间的光谱差异，生成对应的结合水指数（BWI） 并且基于BWI识别与扫描的组织相对应的组织状态。

    FINGER-PLACEMENT SENSOR
    2.
    发明申请
    FINGER-PLACEMENT SENSOR 审中-公开
    手指放置传感器

    公开(公告)号：US20150112169A1

    公开(公告)日：2015-04-23

    申请号：US14214633

    申请日：2014-03-14

    申请人： Marcelo M. Lamego ,  Hung The Vo ,  Cristiano Dalvi ,  Sean Merritt

    发明人： Marcelo M. Lamego ,  Hung The Vo ,  Cristiano Dalvi ,  Sean Merritt

    IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/1495 ,  A61B5/1455

    CPC分类号： A61B5/6838 ,  A61B5/02241 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/6826 ,  A61B5/6843

    摘要： A finger-placement sensor fixture aligns and removably secures a finger to a sensor pad of a reusable finger-clip optical sensor so as to assure the finger is repeatably aligned between the sensors emitters and detectors and that the finger stays aligned during a test procedure. The sensor fixture has a sensor pad configured to removably install within a sensor clip. The sensor pad has a sensor cavity custom molded to the shape of an individual's fingertip. A plurality of metal strips are embedded within the sensor pad. A plurality of magnets are embedded within the sensor clip. The sensor pad metal strips are configured to align with the sensor clip magnets so that the sensor pad can be removed, disposed of, replaced and consistently aligned with the sensor clip.

    摘要翻译： 手指放置传感器夹具将手指对准并可拆卸地固定到可重复使用的手指夹式光学传感器的传感器垫上，以确保手指在传感器发射器和检测器之间重复对准，并且手指在测试过程中保持对准。 传感器夹具具有被配置为可移除地安装在传感器夹内的传感器垫。 传感器垫具有定制模制成个人指尖形状的传感器腔。 多个金属条嵌入传感器垫内。 多个磁体嵌入在传感器夹中。 传感器焊盘金属条被配置成与传感器夹子磁体对准，使得传感器焊盘可以被移除，处置，替换并与传感器夹持一致地对准。

    Adaptive calibration system for spectrophotometric measurements
    4.
    发明授权
    Adaptive calibration system for spectrophotometric measurements 有权
    用于分光光度测量的自适应校准系统

    公开(公告)号：US08571618B1

    公开(公告)日：2013-10-29

    申请号：US12891428

    申请日：2010-09-27

    申请人： Marcelo Lamego ,  Sean Merritt ,  Massi Joe E. Kiani

    发明人： Marcelo Lamego ,  Sean Merritt ,  Massi Joe E. Kiani

    IPC分类号： A61B5/1455

    CPC分类号： A61B5/7221 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/1495 ,  A61B5/742 ,  A61B5/746

    摘要： This disclosure describes, among other features, systems and methods for customizing calibration curves, parameter algorithms, and the like to individual users. An initial calibration curve generated based on a population can be used as a starting point in an algorithm for measuring a physiological parameter such as glucose. The measurement algorithm can determine one or more initial measurement values for a user based on the initial calibration curve. In certain embodiments, one or more alternative measurements, such as invasive or minimally invasive measurements, can periodically or sporadically be input into the measurement algorithm. The algorithm can use the alternative measurements to adapt the calibration curve to the individual. As a result, measurements for the individual can more accurately reflect the individual's actual parameter values.

    摘要翻译： 本公开内容还描述了用于将校准曲线，参数算法等定制到个体用户的系统和方法。 基于群体生成的初始校准曲线可以用作用于测量诸如葡萄糖的生理参数的算法中的起始点。 测量算法可以基于初始校准曲线确定用户的一个或多个初始测量值。 在某些实施例中，可以周期地或偶尔地将一个或多个替代测量，例如侵入性或微创测量输入到测量算法中。 该算法可以使用替代测量来将校准曲线适应于个体。 因此，个人的测量可以更准确地反映个人的实际参数值。