公开(公告)号：US20180289776A1

公开(公告)日：2018-10-11

申请号：US15917742

申请日：2018-03-11

Applicant: Lloyd Johnston ,  Selecta Biosciences, Inc.

Inventor： Lloyd Johnston

IPC: A61K38/44 ,  A61K9/51

Abstract: Provided herein are methods and compositions, such as kits, related to compositions comprising synthetic nanocarriers comprising an immunosuppressant and compositions comprising an uricase and a composition comprising an anti-inflammatory therapeutic. Also provided herein are methods and compositions for the treatment of subjects in need of administration or treatment with the uricase.

公开(公告)号：US20150328300A1

公开(公告)日：2015-11-19

申请号：US14658040

申请日：2015-03-13

Applicant: Selecta Biosciences, Inc.

Inventor： Charles Zepp ,  Grayson B. Lipford ,  Yun Gao ,  Lloyd Johnston ,  Fen-ni Fu ,  Mark J. Keegan ,  Sam Baldwin

IPC: A61K39/00 ,  C08J3/24 ,  A61K47/48 ,  C07D473/34 ,  C07D471/04

CPC classification number: A61K39/385 ,  A61K9/5138 ,  A61K39/0013 ,  A61K39/39 ,  A61K47/58 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6925 ,  A61K47/6935 ,  A61K47/6937 ,  A61K2039/55511 ,  A61K2039/55544 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/6093 ,  A61K2039/62 ,  A61K2039/627 ,  B82Y5/00 ,  C07D471/04 ,  C07D473/34 ,  C08G63/06 ,  C08G63/08 ,  C08G63/912 ,  C08G64/42 ,  C08J3/24 ,  C08J2367/04

Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.

Abstract translation: 本发明涉及免疫调节剂和聚合物或其单元的缀合物的组合物及相关化合物和方法。 缀合物可以包含在合成纳米载体内，并且免疫调节剂可以以pH敏感的方式从合成纳米载体中释放。

公开(公告)号：US09006254B2

公开(公告)日：2015-04-14

申请号：US14138601

申请日：2013-12-23

Applicant: Selecta Biosciences, Inc.

Inventor： Charles Zepp ,  Grayson B. Lipford ,  Yun Gao ,  Lloyd Johnston ,  Fen-ni Fu ,  Mark J. Keegan ,  Sam Baldwin

IPC: A01N43/90 ,  A61K39/385 ,  A61K9/51 ,  A61K39/00 ,  A61K47/48 ,  B82Y5/00 ,  C08G63/06 ,  C08G63/91 ,  C08G64/42 ,  A61K39/39

CPC classification number: A61K39/385 ,  A61K9/5138 ,  A61K39/0013 ,  A61K39/39 ,  A61K47/58 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6925 ,  A61K47/6935 ,  A61K47/6937 ,  A61K2039/55511 ,  A61K2039/55544 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/6093 ,  A61K2039/62 ,  A61K2039/627 ,  B82Y5/00 ,  C07D471/04 ,  C07D473/34 ,  C08G63/06 ,  C08G63/08 ,  C08G63/912 ,  C08G64/42 ,  C08J3/24 ,  C08J2367/04

Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.

Abstract translation: 本发明涉及免疫调节剂和聚合物或其单元的缀合物的组合物及相关化合物和方法。 缀合物可以包含在合成纳米载体内，并且免疫调节剂可以以pH敏感的方式从合成纳米载体中释放。

公开(公告)号：US11426451B2

公开(公告)日：2022-08-30

申请号：US15917742

申请日：2018-03-11

Applicant: Selecta Biosciences, Inc. ,  Lloyd Johnston

Inventor： Lloyd Johnston

IPC: A61K38/44 ,  A61K31/436 ,  A61K9/51 ,  A61K45/00 ,  A61K38/43 ,  A61P29/00 ,  A61K31/165 ,  A61K31/192 ,  A61K31/445 ,  A61K31/573 ,  A61K45/06

Abstract: Provided herein are methods and compositions, such as kits, related to compositions comprising synthetic nanocarriers comprising an immunosuppressant and compositions comprising an uricase and a composition comprising an anti-inflammatory therapeutic. Also provided herein are methods and compositions for the treatment of subjects in need of administration or treatment with the uricase.

公开(公告)号：US20140030344A1

公开(公告)日：2014-01-30

申请号：US13948129

申请日：2013-07-22

Applicant: Selecta Biosciences, Inc.

Inventor： Charles Zepp ,  Yun Gao ,  Mark J. Keegan ,  Sam Baldwin ,  Fen-ni Fu ,  Lloyd Johnston ,  Grayson B. Lipford

IPC: A61K47/48

CPC classification number: A61K39/385 ,  A61K9/5138 ,  A61K39/0013 ,  A61K39/39 ,  A61K47/58 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6925 ,  A61K47/6935 ,  A61K47/6937 ,  A61K2039/55511 ,  A61K2039/55544 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/6093 ,  A61K2039/62 ,  A61K2039/627 ,  B82Y5/00 ,  C07D471/04 ,  C07D473/34 ,  C08G63/06 ,  C08G63/08 ,  C08G63/912 ,  C08G64/42 ,  C08J3/24 ,  C08J2367/04

Abstract: This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.

Abstract translation: 本发明涉及靶细胞中诸如抗原呈递细胞（APC）的作用位点的合成纳米载体的组合物和相关方法，并且包含以pH敏感的方式从合成纳米载体解离的免疫调节剂。 还公开了与合成纳米载体相关的组合物和方法，其包封以pH敏感方式从合成纳米载体解离的不稳定免疫调节剂。

公开(公告)号：US20210308058A1

公开(公告)日：2021-10-07

申请号：US17199130

申请日：2021-03-11

Applicant: Selecta Biosciences, Inc.

Inventor： Lloyd Johnston

IPC: A61K9/19 ,  A61K39/39 ,  A61K47/26 ,  A61K47/18 ,  A61K47/10 ,  A61K31/436

Abstract: This invention relates to synthetic nanocarriers, and related compositions and methods, including wherein the synthetic nanocarrier compositions can be lyophilized, are in a lyophilized form, or a reconstituted composition thereof.

公开(公告)号：US20210187081A1

公开(公告)日：2021-06-24

申请号：US17092148

申请日：2020-11-06

Applicant: Selecta Biosciences, Inc.

Inventor： Lloyd Johnston ,  Takashi Kei Kishimoto ,  Earl Sands ,  Werner Cautreels

IPC: A61K38/44 ,  A61P3/00 ,  A61K47/69 ,  A61K31/436 ,  A61K47/60 ,  A61K31/573 ,  A61K31/445

Abstract: Provided herein are methods and compositions related to the administration of uricase compositions and compositions comprising synthetic nanocarriers comprising an immunosuppressant for the treatment of subjects, including subjects with hyperuricemia, gout or a condition associated with gout.

公开(公告)号：US20170258927A1

公开(公告)日：2017-09-14

申请号：US15456520

申请日：2017-03-11

Applicant: Selecta Biosciences, Inc.

Inventor： Lloyd Johnston

IPC: A61K31/4355 ,  A61K9/00 ,  A61K31/436 ,  A61K38/44 ,  A61K9/16 ,  A61K39/00

CPC classification number: A61K9/0019 ,  A61K9/1647 ,  A61K9/5146 ,  A61K31/436 ,  A61K38/44 ,  A61K45/06 ,  A61K47/60 ,  B82Y5/00 ,  C12Y107/03003 ,  A61K2300/00

Abstract: Provided herein are methods and compositions and kits related to uricase compositions and/or compositions comprising synthetic nanocarriers comprising an immunosuppressant. Also provided herein are methods and compositions and kits for the treatment of subjects, including subjects with hyperuricemia, gout or a condition associated with gout, and for preventing gout flare.

公开(公告)号：US20140242173A1

公开(公告)日：2014-08-28

申请号：US14273099

申请日：2014-05-08

Applicant: Selecta Biosciences, Inc.

Inventor： Charles Zepp ,  Yun Gao ,  Mark J. Keegan ,  Sam Baldwin ,  Fen-ni Fu ,  Lloyd Johnston ,  Grayson B. Lipford

IPC: A61K39/385 ,  A61K39/39

CPC classification number: A61K39/385 ,  A61K9/5138 ,  A61K39/0013 ,  A61K39/39 ,  A61K47/58 ,  A61K47/59 ,  A61K47/593 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6925 ,  A61K47/6935 ,  A61K47/6937 ,  A61K2039/55511 ,  A61K2039/55544 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/6093 ,  A61K2039/62 ,  A61K2039/627 ,  B82Y5/00 ,  C07D471/04 ,  C07D473/34 ,  C08G63/06 ,  C08G63/08 ,  C08G63/912 ,  C08G64/42 ,  C08J3/24 ,  C08J2367/04

Abstract: This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.

Abstract translation: 本发明涉及靶细胞中诸如抗原呈递细胞（APC）的作用位点的合成纳米载体的组合物和相关方法，并且包含以pH敏感的方式从合成纳米载体解离的免疫调节剂。 还公开了与合成纳米载体相关的组合物和方法，其包封以pH敏感方式从合成纳米载体解离的不稳定免疫调节剂。

公开(公告)号：US20230119226A1

公开(公告)日：2023-04-20

申请号：US17869863

申请日：2022-07-21

Applicant: Selecta Biosciences, Inc.

Inventor： Lloyd Johnston

IPC: A61K38/44 ,  A61K45/00 ,  A61K38/43 ,  A61K9/51 ,  A61P29/00

Abstract: Provided herein are methods and compositions, such as kits, related to compositions comprising synthetic nanocarriers comprising an immunosuppressant and compositions comprising an uricase and a composition comprising an anti-inflammatory therapeutic. Also provided herein are methods and compositions for the treatment of subjects in need of administration or treatment with the uricase.