公开(公告)号：US20230249181A1

公开(公告)日：2023-08-10

申请号：US17730035

申请日：2022-04-26

Applicant: Shanghai Tianma Micro-Electronics Co., Ltd.

Inventor： Kaidi ZHANG ,  Wei LI ,  Baiquan LIN ,  Yunfei BAI ,  Kerui XI ,  Feng QIN

IPC: B01L3/00

CPC classification number: B01L3/50273 ,  B01L3/502792 ,  B01L2300/0816

Abstract: A microfluidic apparatus, a driving method, and a formation method are provided in the present disclosure. The apparatus includes a first substrate and a second substrate. The first substrate and the second substrate are both smooth substrates. An electrode array layer is on a side of the first substrate; and a second electrode layer is on a side of the second substrate. The electrode array layer at least includes a plurality of first electrodes and a plurality of second electrodes. The first substrate includes a first region and a second region; the plurality of first electrodes is in the first region; and the plurality of second electrode is in the second region. A distance between the first substrate and the second substrate in the first region is D1 is greater than a distance between the first substrate and the second substrate in the second region is D2.

公开(公告)号：US20230151408A1

公开(公告)日：2023-05-18

申请号：US17580176

申请日：2022-01-20

Applicant: Shanghai Tianma Micro-Electronics Co., Ltd.

Inventor： Baiquan LIN ,  Kerui XI ,  Kaidi ZHANG ,  Wei LI ,  Yunfei BAI ,  Ping SU ,  Junting OUYANG

IPC: C12Q1/6825 ,  G01N27/414

CPC classification number: C12Q1/6825 ,  G01N27/4145

Abstract: A gene sequencing structure, a gene sequencing device and a gene sequencing method are provided. The gene sequencing structure includes a substrate, a thin-film transistor array layer located on the substrate and including thin-film transistors that include a first electrode, and a second electrode; an ion-sensitive layer located on a side of the semiconductor layer away from the substrate; a micro-hole layer located on a side of the ion-sensitive layer away from the substrate, including a through-hole passing through the micro-hole layer, at least partially overlapping the semiconductor layer, and used for receiving a to-be-tested single-stranded nucleic acid inside; a conductive structure, located on a side of the layer away from the substrate and electrically connected to the first electrode or the second electrode; and a detection chip, located on a side of the conductive structure away from the substrate and electrically connected to the conductive structure.

公开(公告)号：US20240157360A1

公开(公告)日：2024-05-16

申请号：US18124254

申请日：2023-03-21

Applicant: Shanghai Tianma Micro-electronics Co., Ltd.

Inventor： Kaidi ZHANG ,  Baiquan LIN ,  Wei LI ,  Yunfei BAI ,  Linzhi WANG ,  Yukun HUANG ,  Kerui XI

IPC: B01L3/00

CPC classification number: B01L3/50273 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/168 ,  B01L2400/0427

Abstract: Microfluidic substrate, microfluidic device, and driving method thereof are provided. The microfluidic substrate includes a plurality of detection units arranged in an array. A detection unit of the plurality of detection units at least includes a first switch transistor, a second switch transistor, a drive electrode, and a photosensitive element. The microfluid substrate includes a base; a transistor array layer on a side of the base, first switch transistors and second switch transistors being on the transistor array layer; a photosensitive element array layer on a side of the transistor array layer away from the substrate, photosensitive elements being on the photosensitive element array layer; a first electrode layer on a side of the photosensitive element array layer away from the base; and a second electrode layer on a side of the first electrode layer away from the base.

公开(公告)号：US20220314220A1

公开(公告)日：2022-10-06

申请号：US17743794

申请日：2022-05-13

Applicant: Shanghai Tianma Micro-Electronics Co., Ltd.

Inventor： Kaidi ZHANG ,  Boquan LIN ,  Yunfei BAI ,  Wei LI ,  Shun GONG ,  Linzhi WANG ,  Kerui XI

IPC: B01L3/00 ,  H03K17/725

Abstract: A driving circuit, a method for driving the same, and a microfluidic device are provided. The driving circuit includes a constant voltage writing module configured to transmit a constant voltage to an output terminal of the driving circuit, an AC voltage writing module configured to transmit an AC voltage to the output terminal of the driving circuit, a first switch, and a first capacitor. The first switch includes an input terminal electrically connected to a third signal line, an output terminal electrically connected to control terminals of the AC voltage writing module and the constant voltage writing module, and a control terminal electrically connected to a first scan line. The first capacitor is configured to stabilize a potential of the output terminal the first switch.

公开(公告)号：US20240165608A1

公开(公告)日：2024-05-23

申请号：US18114446

申请日：2023-02-27

Applicant: Shanghai Tianma Micro-electronics Co., Ltd.

Inventor： Kaidi ZHANG ,  Baiquan LIN ,  Yunfei BAI ,  Wei LI ,  Xiaojun CHEN ,  Qingsan ZHU

IPC: B01L3/00

CPC classification number: B01L3/502707 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/12

Abstract: Microfluidic device and application method thereof are provided. The microfluidic device includes a first substrate and a second substrate that are oppositely arranged along a first direction; and a first storage box and a second storage box that are oppositely arranged along the first direction. The first direction is a thickness direction of the microfluidic device. The first storage box includes a first storage cavity and a first opening communicating with the first storage cavity, and the first substrate is fixed in the first storage cavity. The second storage box includes a second storage cavity and a second opening communicating with the second storage cavity, and the second substrate is fixed in the second storage cavity. Along the first direction, the first opening is arranged opposite to the second opening and the first storage box is nested with the second storage box.

公开(公告)号：US20230211345A1

公开(公告)日：2023-07-06

申请号：US17684719

申请日：2022-03-02

Applicant: Shanghai Tianma Micro-Electronics Co., Ltd.

Inventor： Wei LI ,  Baiquan LIN ,  Kaidi ZHANG ,  Yunfei BAI ,  Ping SU ,  Kerui XI ,  Zhenyu JIA

IPC: B01L3/00 ,  B81B3/00 ,  B81C1/00

CPC classification number: B01L3/502784 ,  B81B3/0089 ,  B81C1/00714 ,  B01L2200/12 ,  B01L2300/161 ,  B01L2300/0819 ,  B01L2300/1805 ,  B01L2400/0415 ,  B81B2201/057 ,  B81B2203/0353 ,  B81C2201/013 ,  B81C2201/053 ,  B81C2201/0198

Abstract: A microfluidic chip and a fabrication method of the microfluidic chip are provided. The microfluidic chip includes an array substrate, and a hydrophobic layer disposed on a side of the array substrate. The hydrophobic layer includes at least one through-hole, and a through-hole of the at least one through-hole penetrates through the hydrophobic layer along a direction perpendicular to a plane of the array substrate. The microfluidic chip also includes at least one hydrophilic structure. A hydrophilic structure of the at least one hydrophilic structure is disposed in the through-hole.

公开(公告)号：US20230063019A1

公开(公告)日：2023-03-02

申请号：US17455148

申请日：2021-11-16

Applicant: Shanghai Tianma Micro-Electronics Co., Ltd.

Inventor： Kaidi ZHANG ,  Baiquan LIN ,  Wei LI ,  Yunfei BAI ,  Kerui XI ,  Feng QIN

IPC: B01L3/00 ,  G02B26/00 ,  G09G3/34

Abstract: A driving circuit, a driving method and a microfluidic substrate are provided. The driving circuit includes a first switching unit, a second switching unit, a reset unit, a first capacitor, and a second capacitor. In a first stage of a driving process of the driving circuit, the first switching unit is turned on, a first voltage signal is transmitted to a first node, the second switching unit is turned on, a second voltage signal is input to an output terminal of the driving circuit, and the driving circuit outputs an AC signal. In a second stage of the driving process, the first switching unit is turned off, the valid signal output by the second scan signal terminal controls the reset unit to be turned on, a third voltage signal is input to the output terminal of the driving circuit for reset, and the driving circuit outputs a DC signal.

公开(公告)号：US20240165616A1

公开(公告)日：2024-05-23

申请号：US17758359

申请日：2021-06-30

Applicant: Shanghai Tianma Micro-Electronics Co., Ltd.

Inventor： Baiquan LIN ,  Kerui XI ,  Yunfei BAI ,  Wei LI ,  Dengming LEI ,  Zhen LIU ,  Zhenyu JIA ,  Junting OUYANG

IPC: B01L3/00

CPC classification number: B01L3/50273 ,  B01L2200/10 ,  B01L2300/0645 ,  B01L2400/0427

Abstract: Provided is a microfluidic chip. The microfluidic chip includes a first substrate and a second substrate disposed opposite to each other and drive electrodes, first sensing electrodes and second sensing electrodes disposed on a side of the first substrate. A microfluidic channel is formed between the first substrate and the second substrate and configured to accommodate at least one droplet. Different drive voltage signals are applied to adjacent drive electrodes, so as to drive the at least one droplet to move. Detection signals are applied to the first sensing electrodes and the second sensing electrodes, and a position of the at least one droplet is determined according to a change in capacitance between one first sensing electrode and an electrode corresponding thereto and a change in capacitance between one second sensing electrode and an electrode corresponding thereto when the at least one droplet flows by.

公开(公告)号：US20230213474A1

公开(公告)日：2023-07-06

申请号：US17682979

申请日：2022-02-28

Applicant: Shanghai Tianma Micro-Electronics Co., Ltd.

Inventor： Kaidi ZHANG ,  Baiquan LIN ,  Huihui JIANG ,  Luning YANG ,  Wei LI ,  Yunfei BAI ,  Zhenyu JIA ,  Kerui XI ,  Feng QIN

IPC: G01N27/414 ,  G01N27/333 ,  H01L21/768

CPC classification number: G01N27/414 ,  G01N27/333 ,  H01L21/76829

Abstract: A detection device and a detection method are provided. The detection device includes at least one detection unit. The detection unit includes a first transistor, a second transistor, a third transistor and a fourth transistor that are electrically connected to each other, a gate is disposed above a channel of each of the first transistor, the second transistor, and the third transistor, and an ion-sensitive membrane is covered above a channel of the fourth transistor. The detection device also includes a first voltage signal terminal, a second voltage signal terminal, and a third voltage signal terminal. Further, the detection device includes a first power supply terminal, a first potential output terminal, a second potential output terminal, and a second power supply terminal.