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34 条记录 (耗时 0.027 秒)

    Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates
    3.
    发明申请
    Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates 失效
    用于制备蛋白酪氨酸激酶抑制剂中间体的对映选择性生物转化

    公开(公告)号：US20060046287A1

    公开(公告)日：2006-03-02

    申请号：US11213025

    申请日：2005-08-26

    申请人： Pei-Pei Kung ,  Carlos Martinez ,  Junhua Tao

    发明人： Pei-Pei Kung ,  Carlos Martinez ,  Junhua Tao

    IPC分类号： C12P7/62 ,  C12P7/22

    CPC分类号： C12P41/004 ,  C07B2200/07 ,  C07C33/46 ,  C12P7/22

    摘要： The invention relates to biocatalytic methods for preparing enantiomerically pure stereoisomers of 1-(2,6-dichloro-3-fluorophenyl)ethanol. Disclosed are methods of preparation of the desired (S)-enantiomer, which methods are based on a combination of enzymatic resolution, chemical esterification and chemical hydrolysis with inversion of 1-(2,6-dichloro-3-fluorophenyl)ethyl esters or stereoselective bio-reduction of 2,6-dichloro-3-fluoro-acetophenone with a biocatalyst such as an enzyme or a microorganism. The chiral (S)-enantiomer can be used in the synthesis of certain enantiomerically enriched, ether linked 2-aminopyridine compounds that potently inhibit auto-phosphorylation of human heptocyte growth factor receptor.

    摘要翻译： 本发明涉及制备1-（2,6-二氯-3-氟苯基）乙醇的对映体纯纯立体异构体的生物催化方法。 公开了制备所需（S） - 对映体的方法，该方法基于酶拆分，化学酯化和化学水解与1-（2,6-二氯-3-氟苯基）乙酯的倒置或立体选择性反应 用生物催化剂如酶或微生物生物还原2,6-二氯-3-氟 - 苯乙酮。 手性（S） - 对映体可用于合成某些对映异构体富集的醚连接的2-氨基吡啶化合物，其有效抑制人类肝细胞生长因子受体的自身磷酸化。

    Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates
    4.
    发明授权
    Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates 失效
    用于制备蛋白酪氨酸激酶抑制剂中间体的对映选择性生物转化

    公开(公告)号：US07465842B2

    公开(公告)日：2008-12-16

    申请号：US11213025

    申请日：2005-08-26

    申请人： Pei-Pei Kung ,  Carlos Martinez ,  Junhua Tao

    发明人： Pei-Pei Kung ,  Carlos Martinez ,  Junhua Tao

    IPC分类号： C07C21/18 ,  C07C25/08 ,  C07C25/00 ,  C12P41/00

    CPC分类号： C12P41/004 ,  C07B2200/07 ,  C07C33/46 ,  C12P7/22

    摘要： The invention relates to biocatalytic methods for preparing enantiomerically pure stereoisomers of 1-(2,6-dichloro-3-fluorophenyl)ethanol. Disclosed are methods of preparation of the desired (S)-enantiomer, which methods are based on a combination of enzymatic resolution, chemical esterification and chemical hydrolysis with inversion of 1-(2,6-dichloro-3-fluorophenyl)ethyl esters or stereoselective bio-reduction of 2,6-dichloro-3-fluoro-acetophenone with a biocatalyst such as an enzyme or a microorganism. The chiral (S)-enantiomer can be used in the synthesis of certain enantiomerically enriched, ether linked 2-aminopyridine compounds that potently inhibit auto-phosphorylation of human heptocyte growth factor receptor.

    摘要翻译： 本发明涉及制备1-（2,6-二氯-3-氟苯基）乙醇的对映体纯纯立体异构体的生物催化方法。 公开了制备所需（S） - 对映体的方法，该方法基于酶拆分，化学酯化和化学水解与1-（2,6-二氯-3-氟苯基）乙酯的倒置或立体选择性反应 用生物催化剂如酶或微生物生物还原2,6-二氯-3-氟 - 苯乙酮。 手性（S） - 对映体可用于合成某些对映异构体富集的醚连接的2-氨基吡啶化合物，其有效抑制人类肝细胞生长因子受体的自身磷酸化。

    System and method for detection of open connections between an integrated circuit and a multi-cell battery pack
    5.
    发明授权
    System and method for detection of open connections between an integrated circuit and a multi-cell battery pack 有权
    用于检测集成电路和多单元电池组之间的开路连接的系统和方法

    公开(公告)号：US08797043B2

    公开(公告)日：2014-08-05

    申请号：US13174040

    申请日：2011-06-30

    申请人： Edgardo Laber ,  Anthony Allen ,  Carlos Martinez

    发明人： Edgardo Laber ,  Anthony Allen ,  Carlos Martinez

    IPC分类号： G01R31/02 ,  G01R31/36

    CPC分类号： G01R31/026 ,  G01R31/043 ,  G01R31/3658

    摘要： An apparatus comprises an integrated circuit and an open connection detection circuit within the integrated circuit. The integrated circuit includes a plurality of inputs for connecting with a plurality of outputs of a multi-cell battery pack. The open connection detection circuit within the integrated circuit detects an open connection on at least one of the plurality of inputs from the multi-cell battery and generates a fault condition responsive thereto.

    摘要翻译： 一种装置包括集成电路内的集成电路和开路连接检测电路。 集成电路包括用于与多单元电池组的多个输出连接的多个输入。 集成电路内的开路连接检测电路检测来自多单元电池的多个输入中的至少一个上的开路连接，并响应于此产生故障状态。

    Robotic Picking Of Parts From A Bin
    6.
    发明申请
    Robotic Picking Of Parts From A Bin 有权
    从一个机器人拾取零件

    公开(公告)号：US20110223000A1

    公开(公告)日：2011-09-15

    申请号：US13061342

    申请日：2008-08-29

    申请人： Carlos Martinez ,  Thomas A. Fuhlbrigge ,  William Eakins ,  Heping Chen ,  Gregory Rossano ,  Steven West

    发明人： Carlos Martinez ,  Thomas A. Fuhlbrigge ,  William Eakins ,  Heping Chen ,  Gregory Rossano ,  Steven West

    IPC分类号： B25J9/16 ,  G05B19/00 ,  G06F19/00

    CPC分类号： B25J9/1687 ,  B23P19/007 ,  B25J13/085 ,  G05B2219/40035 ,  G05B2219/40053 ,  G05B2219/40537

    摘要： A robot is used to pick parts from a bin. The robot has a compliant apparatus and one or more tools are connected to the apparatus to perform the picking. The compliant apparatus has mechanisms for monitoring and/or controlling its compliance. The compliant apparatus can have various embodiments. Force sensing can be used during removal of grasped parts from the bin to determine the force exerted on the picking tool(s). The signal indicative of the exerted force can be used by the robot controller to determine the weight of the parts that may be held by the picking tool(s). The robot has one or more devices which can be the picking tool to stir the parts in the bin.

    摘要翻译： 机器人用于从垃圾桶中取出零件。 机器人具有柔性装置，并且一个或多个工具连接到该装置以执行拾取。 合规装置具有用于监视和/或控制其顺从性的机构。 兼容装置可以具有各种实施例。 在从仓中取出抓取的零件时可以使用力传感来确定施加在拾取工具上的力。 指示施加的力的信号可以由机器人控制器用于确定可由拾取工具保持的部件的重量。 机器人具有一个或多个装置，其可以是拾取工具来搅动箱中的部件。

    Lampholder having internal cooling passages
    9.
    发明授权
    Lampholder having internal cooling passages 失效
    灯座具有内部冷却通道

    公开(公告)号：US4596433A

    公开(公告)日：1986-06-24

    申请号：US761292

    申请日：1985-07-29

    申请人： Klaus Oesterheld ,  Michael Franovic ,  Carlos Martinez

    发明人： Klaus Oesterheld ,  Michael Franovic ,  Carlos Martinez

    IPC分类号： F21V19/00 ,  F21V29/00 ,  H01R33/08 ,  H01R13/533

    CPC分类号： F21V29/004 ,  F21V19/0095 ,  F21V29/83 ,  H01R33/0809 ,  F21Y2103/37

    摘要： A holder for a discharge lamp having a bi-pin base includes a housing with two pairs of opposed walls connected to form a lamp base receiving recess therebetween, a resilient clip and an opposed pair of electrical conductors. The clip and the conductor pair are disposed in the housing for gripping the lamp base and for electrically engaging the lamp pins, respectively, of a lamp received into the holder.The housing further includes four internal cooling passages partly formed by two directly facing and opposed rib pairs provided on the respective housing walls. The passages open to the ambient atmosphere. The resilient clip has good thermally conductive properties.

    摘要翻译： 用于具有双针座的放电灯的保持器包括具有两对相对的壁的壳体，所述两对相对的壁连接以在其间形成灯座容纳凹部，弹性夹子和相对的一对电导体。 夹子和导体对设置在壳体中，用于夹持灯座，并分别与接收到保持器中的灯的灯管电接合。 壳体还包括四个内部冷却通道，其部分地由设置在相应的壳体壁上的两个直接面对的肋对形成。 通道通向大气环境。 弹性夹具具有良好的导热性能。