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公开(公告)号：US08222288B2
公开(公告)日：2012-07-17
申请号：US12815113
申请日：2010-06-14
申请人： Shaomeng Wang , Dongguang Qin , Jianyong Chen , Shanghai Yu
发明人： Shaomeng Wang , Dongguang Qin , Jianyong Chen , Shanghai Yu
IPC分类号： A61K31/407 , C07D487/10
CPC分类号： C07D487/10 , C07D491/107 , C12N5/0693 , C12N2501/48
摘要： The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
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公开(公告)号：US20100317661A1
公开(公告)日：2010-12-16
申请号：US12815113
申请日：2010-06-14
申请人： Shaomeng Wang , Dongguang Qin , Jianyong Chen , Shanghai Yu
发明人： Shaomeng Wang , Dongguang Qin , Jianyong Chen , Shanghai Yu
IPC分类号： A61K31/5377 , C07D487/10 , A61K31/407 , C12N5/00 , A61P35/00 , A61P17/14 , A61P1/00 , A61K31/496 , A61K31/4178
CPC分类号： C07D487/10 , C07D491/107 , C12N5/0693 , C12N2501/48
摘要： The invention relates to small molecules which function as inhibitors of the interaction between p53 and MDM2. The invention also relates to the use of these compounds for inhibiting cell growth, inducing cell death, inducing cell cycle arrest and/or sensitizing cells to additional agent(s).
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3.发明申请Selective Ligands for the Dopamine 3 (D3) Receptor and Methods of using the Same 有权多巴胺3（D3）受体的选择性配体及其使用方法公开(公告)号：US20110184033A1
公开(公告)日：2011-07-28
申请号：US13060306
申请日：2009-08-27
申请人： Shaomeng Wang , Jianyong Chen , Gregory Collins , James H. Woods , Beth Levant
发明人： Shaomeng Wang , Jianyong Chen , Gregory Collins , James H. Woods , Beth Levant
IPC分类号： A61K31/427 , C07D277/82 , A61P25/28 , A61P25/08 , A61P25/30 , A61P25/22
CPC分类号： C07D277/82 , C07D417/12
摘要： Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula (I) wherein X is C═O or SO2, R1 is C1-6 alkyl, R2 is aryl, heteroaryl, aryl, —(CH2)1-3aryl, or —(CH2)1-3heteroaryl, and n is 0 or 1. Methods of using the D3 receptor ligands in the treatment of diseases and conditions wherein modulation of the D3 receptor provides a benefit also are disclosed.
摘要翻译： 公开了多巴胺3（D3）受体的有效和选择性配体。 D3受体配体具有结构式（I），其中X为C = O或SO 2，R 1为C 1-6烷基，R 2为芳基，杂芳基，芳基， - （CH 2）1-3芳基或 - （CH 2） 3杂芳基，n为0或1.D3受体配体在治疗其中D3受体的调节提供益处的疾病和病症方面也被公开。
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公开(公告)号：US20090082445A1
公开(公告)日：2009-03-26
申请号：US12242419
申请日：2008-09-30
申请人： Shaomeng Wang , Jianyong Chen
发明人： Shaomeng Wang , Jianyong Chen
CPC分类号： A61K31/11
摘要： This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
摘要翻译： 本发明涉及包含（ - ） - 棉酚与C 1-8羧酸或C 1-8磺酸的共晶体的组合物，其可用作Bcl-2家族蛋白质的抑制剂。 本发明还涉及（ - ） - 棉酚与C 1-8羧酸或C 1-8磺酸的共晶体在细胞中诱导细胞凋亡和促使细胞诱导凋亡细胞死亡的用途。
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5.发明申请SELECTIVE LIGANDS FOR THE DOPAMINE 3 (D3) RECEPTOR AND METHODS OF USING THE SAME 有权多巴胺3（D3）受体的选择性配体及其使用方法公开(公告)号：US20120232118A1
公开(公告)日：2012-09-13
申请号：US13406803
申请日：2012-02-28
申请人： Shaomeng Wang , Jianyong Chen , Gregory Collins , Beth Levant , James H. Woods
发明人： Shaomeng Wang , Jianyong Chen , Gregory Collins , Beth Levant , James H. Woods
IPC分类号： A61K31/4245 , C07D277/82 , A61K31/428 , A61K31/4439 , A61P25/30 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/22 , A61P3/00 , A61P25/32 , A61P25/00 , C07D417/12 , A61P25/16
CPC分类号： C07D277/82 , C07D417/12
摘要： Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula: wherein R1 is C1-6 alkyl or C3-6cycloalkyl; or wherein R2 is substituted with one or two halogen(s) or OC1-3alkyl.
摘要翻译： 公开了多巴胺3（D3）受体的有效和选择性配体。 D3受体配体具有结构式：其中R 1是C 1-6烷基或C 3-6环烷基; 或其中R 2被一个或两个卤素或OC 1-3烷基取代。
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公开(公告)号：US07674787B2
公开(公告)日：2010-03-09
申请号：US11632079
申请日：2005-07-11
申请人： Shaomeng Wang , Haiying Sun , Zaneta Nikolovska-Coleska , Chao-Yie Yang , Liang Xu , Naoyuki G. Saito , Jianyong Chen
发明人： Shaomeng Wang , Haiying Sun , Zaneta Nikolovska-Coleska , Chao-Yie Yang , Liang Xu , Naoyuki G. Saito , Jianyong Chen
IPC分类号： C07D223/16 , A01N43/00 , A61K31/55
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
摘要翻译： 本发明涉及Smac的构象约束模拟物，其作为细胞凋亡蛋白抑制剂的抑制剂。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。
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公开(公告)号：US20090118377A1
公开(公告)日：2009-05-07
申请号：US12352399
申请日：2009-01-12
IPC分类号： A61K31/122 , C12N5/00 , A61P35/00
CPC分类号： C07C50/30 , A45C11/00 , A45C11/04 , A45C13/42 , C07C39/14 , C07C46/00 , C07C50/32 , C07C67/08 , C07C67/29 , C07C69/017 , C07C69/21
摘要： The invention relates to the compound apogossypolone and salts and prodrugs thereof. Apogossypolone functions as an inhibitor of Bcl-2 family proteins. The invention also relates to the use of apogossypolone for inhibiting hyperproliferative cell growth, for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
摘要翻译： 本发明涉及化合物果糖酚及其盐和前药。 聚鸟苷酸作为Bcl-2家族蛋白的抑制剂起作用。 本发明还涉及用于抑制过度增殖细胞生长，用于诱导细胞凋亡和促进细胞诱导凋亡细胞死亡的用途。
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8.发明授权Selective ligands for the dopamine 3 (D3) receptor and methods of using the same 有权多巴胺3（D3）受体的选择性配体及其使用方法公开(公告)号：US08486981B2
公开(公告)日：2013-07-16
申请号：US13406803
申请日：2012-02-28
申请人： Shaomeng Wang , Jianyong Chen , Gregory Collins , Beth Levant , James H. Woods
发明人： Shaomeng Wang , Jianyong Chen , Gregory Collins , Beth Levant , James H. Woods
IPC分类号： A61K31/4245 , A61K31/428 , C07D271/06 , C07D277/82
CPC分类号： C07D277/82 , C07D417/12
摘要： Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula: wherein R1 is C1-6 alkyl or C3-6cycloalkyl; or wherein R2 is substituted with one or two halogen(s) or OC1-3alkyl.
摘要翻译： 公开了多巴胺3（D3）受体的有效和选择性配体。 D3受体配体具有结构式：其中R 1是C 1-6烷基或C 3-6环烷基; 或其中R 2被一个或两个卤素或OC 1-3烷基取代。
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公开(公告)号：US07557251B2
公开(公告)日：2009-07-07
申请号：US11729638
申请日：2007-03-29
申请人： Shaomeng Wang , Jianyong Chen , John F. W. Keana , Ming Guo
发明人： Shaomeng Wang , Jianyong Chen , John F. W. Keana , Ming Guo
CPC分类号： C07B57/00 , A61K31/192 , A61K31/78 , C07C45/516 , C07C45/79 , C07C45/85 , C07C47/57 , C07C51/487 , C07C53/08
摘要： This invention relates to relates to methods for producing gossypol acetic acid co-crystals and (−)-gossypol acetic acid co-crystals. The invention also relates to pharmaceutical compositions comprising gossypol acetic acid co-crystals and (−)-gossypol acetic acid co-crystals and the use of gossypol acetic acid co-crystals and (−)-gossypol acetic acid co-crystals for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
摘要翻译： 本发明涉及生产棉酚乙酸共晶体和（ - ） - 棉酚乙酸共晶体的方法。 本发明还涉及包含棉酚乙酸共晶和（ - ） - 棉酚乙酸共晶体的药物组合物，以及使用棉酚乙酸共晶体和（ - ） - 棉酚乙酸共晶体诱导细胞凋亡 细胞和致敏细胞诱导凋亡细胞死亡。
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公开(公告)号：US20080132485A1
公开(公告)日：2008-06-05
申请号：US11632079
申请日：2005-07-11
申请人： Shaomeng Wang , Haiying Sun , Zaneta Nikolovksa-Coleska , Chao-Yie Yang , Liang Xu , Naoyuki G. Saito , Jianyong Chen
发明人： Shaomeng Wang , Haiying Sun , Zaneta Nikolovksa-Coleska , Chao-Yie Yang , Liang Xu , Naoyuki G. Saito , Jianyong Chen
IPC分类号： A61K31/55 , A61P35/00 , C07D487/00 , A61K31/395 , A61K31/435 , C07D225/00 , C07D221/00
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
摘要翻译： 本发明涉及Smac的构象约束模拟物，其作为细胞凋亡蛋白抑制剂的抑制剂。 本发明还涉及这些模拟物用于诱导凋亡性细胞死亡和使细胞对细胞凋亡诱导剂敏感的用途。
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