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1.发明申请公开(公告)号：US20120244079A1
公开(公告)日：2012-09-27
申请号：US13319012
申请日：2010-05-06
申请人： Shi Ke , Michel Mawad , Wei Wang
发明人： Shi Ke , Michel Mawad , Wei Wang
IPC分类号： C07D403/08 , A61K49/04 , A61K49/00
CPC分类号： A61K49/0052 , A61K49/0032 , G01N33/5008 , G01N33/5014 , G01N33/5088 , G01N33/574 , G01N33/582 , G01N2800/56
摘要： The present invention provides nonradioactive NIR optical imaging agents based up on the structure of retinoid acid derivatives. The nonradioactive NIR optical imaging agent has been evaluated at the cellular level by confocal microscopy, and in vivo in a whole animal using a various xenograft models. The specific uptake of this agent in human cancer cells and multiple xenograft models demonstrate that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for early stage cancer studies and diagnoses. Also, the present invention provides that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for visualization of drug redistribution within the body which is useful in determining the optimal biological dose. Ultimately, the visualization data can be used as an analytical tool to reduce any systemic toxicity.
摘要翻译： 本发明提供了基于类视黄酸衍生物结构的非放射性近红外光学成像剂。 已经通过共聚焦显微镜在细胞水平上评估了非放射性近红外光学成像剂，并且在使用各种异种移植模型的整个动物体内进行了评估。 该药物在人类癌细胞和多种异种移植物模型中的特异性摄取表明，非放射性近红外染料标记的类视黄醇代谢物和/或类似物可用于早期癌症研究和诊断。 此外，本发明提供非放射性近红外染料标记的类视黄醇代谢物和/或类似物可用于体内药物再分布的可视化，其可用于确定最佳生物剂量。 最终，可视化数据可用作分析工具，以减少任何全身毒性。
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公开(公告)号：US20130224115A1
公开(公告)日：2013-08-29
申请号：US13638060
申请日：2011-04-01
申请人： Wei Wang , Jason Shohet , Michel Mawad , Shi Ke
发明人： Wei Wang , Jason Shohet , Michel Mawad , Shi Ke
IPC分类号： C07D209/26
CPC分类号： C07D209/26 , A61K49/0032 , A61K49/0052 , C09B23/0025 , C09B23/0066 , C09B23/086
摘要： Multi-modal tumor imaging of neuroblastoma is essential for tumor staging, response evaluation and detection of relapsed diseased. The present invention provides a norepinephine analogue with a near-infrared (near-IR) dye, W765-BG, that efficiently and stably detects neuroblastoma in vivo using near-IR optical imaging. Confocal microscopy and optical imaging of neuroblastoma xenografts shows cell specific uptake and reveals exceptional tumor retention with a high tumor-to-tissue ratio up to 7 days after injection of W765-BG.
摘要翻译： 神经母细胞瘤的多形态肿瘤成像对肿瘤分期，应答评估和复发性疾病的检测至关重要。 本发明提供了具有近红外（近红外）染料W765-BG的去甲肾上腺素类似物，其使用近红外光学成像在体内有效且稳定地检测神经母细胞瘤。 神经母细胞瘤异种移植物的共聚焦显微镜和光学成像显示细胞特异性摄取，并在注射W765-BG后7天内显示具有高肿瘤组织比的特殊肿瘤保留。
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3.发明授权Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy 失效循环肽和成像化合物组合物和用于靶向成像和治疗的用途公开(公告)号：US07371364B2
公开(公告)日：2008-05-13
申请号：US10918009
申请日：2004-08-13
CPC分类号： A61K49/0032 , A61K49/0034 , A61K49/0056 , A61K51/08 , A61K51/082 , A61K51/088 , C07K7/56 , C07K14/8146
摘要： The present invention relates to novel cyclic peptides that may be conjugated with imaging agents, including novel imaging agents. Specifically, it includes c(KRGDf; SEQ ID NO. 3) NIR imaging compositions and novel cyclic HWGFTL (SEQ ID NO. 5) polypeptides which may be used inter alia in NIR, MRI and nuclear imaging as well as therapy. Additionally, the invention includes novel imaging agents, such as TS-ICG derivatives. The invention also relates to methods of making and using such compounds. Such uses include both pre-operative and intraoperative detection of tumor cells and treatment monitoring.
摘要翻译： 本发明涉及可与成像剂缀合的新型环肽，包括新型成像剂。 具体地说，它包括可以特别用于NIR，MRI和核成像以及治疗的c（KRGDf; SEQ ID NO.3）NIR成像组合物和新的循环HWGFTL（SEQ ID NO.5）多肽。 此外，本发明包括新型成像剂，例如TS-ICG衍生物。 本发明还涉及制备和使用这些化合物的方法。 这些用途包括手术前和术中检测肿瘤细胞和治疗监测。
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4.发明申请Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy 失效循环肽和成像化合物组合物和用于靶向成像和治疗的用途公开(公告)号：US20050069494A1
公开(公告)日：2005-03-31
申请号：US10918009
申请日：2004-08-13
CPC分类号： A61K49/0032 , A61K49/0034 , A61K49/0056 , A61K51/08 , A61K51/082 , A61K51/088 , C07K7/56 , C07K14/8146
摘要： The present invention relates to novel cyclic peptides that may be conjugated with imaging agents, including novel imaging agents. Specifically, it includes c(KRGDf) NIR imaging compositions and novel cyclic HWGFTL polypeptides which may be used inter alia in NIR, MRI and nuclear imaging as well as therapy. Additionally, the invention includes novel imaging agents, such as TS-ICG derivatives. The invention also relates to methods of making and using such compounds. Such uses include both pre-operative and intraoperative detection of tumor cells and treatment monitoring.
摘要翻译： 本发明涉及可与成像剂缀合的新型环肽，包括新型成像剂。 具体地说，它包括c（KRGDf）NIR成像组合物和可以特别用于NIR，MRI和核成像以及治疗的新型循环HWGFTL多肽。 此外，本发明包括新型成像剂，例如TS-ICG衍生物。 本发明还涉及制备和使用这些化合物的方法。 这些用途包括手术前和术中检测肿瘤细胞和治疗监测。
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公开(公告)号：US11590544B2
公开(公告)日：2023-02-28
申请号：US16993100
申请日：2020-08-13
申请人： Wei Wang
发明人： Wei Wang
摘要： A waste disposer comprising a primary dehydrating chamber, a grinding device, a secondary dehydrating chamber, and a storage chamber. The primary dehydrating chamber is adapted to allow waste to be heated therein to partly dehydrate the waste. The primary dehydrating chamber has: a first waste inlet for receiving the waste, a first vapor outlet for exhausting vapor from the waste, a drainage outlet for draining free liquid from the waste, and a first waste outlet for outputting the partly dehydrated waste. The grinding device is adapted to receive the waste from the first waste outlet and grind the waste to reduce the size thereof. The secondary dehydrating chamber is adapted to allow the ground waste to be heated therein to further dehydrate the waste. The secondary dehydrating chamber has a second waste inlet for receiving the ground waste, a second vapor outlet for exhausting vapor from the waste, and a second waste outlet for outputting the further dehydrated waste. The storage chamber is adapted to receive the waste from the second waste outlet and store the waste in the storage chamber.
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公开(公告)号：US11558715B2
公开(公告)日：2023-01-17
申请号：US17270935
申请日：2018-08-31
申请人： Zhuoqi Zeng , Steven Liu , Huajun Yu , Wei Wang , Robert Bosch GmbH
发明人： Zhuoqi Zeng , Steven Liu , Huajun Yu , Wei Wang
IPC分类号： H04W4/029 , G01S5/02 , H04B1/7163
摘要： The present invention relates to a method and apparatus for detecting a signal propagation type. The method comprises: calculating a similarity value of a currently received pulse response and a reference pulse response when a certain positioning base station of a UWB positioning system currently receives a pulse response from a certain positioning tag, the similarity value indicating the degree of similarity between the currently received pulse response and the reference pulse response, wherein the reference pulse response is a pulse response previously received by the positioning base station from the positioning tag; and determining the current type of signal propagation between the positioning base station and the positioning tag on the basis of the similarity value. The method and apparatus can detect the type of signal propagation between the positioning base station and positioning tag of the UWB positioning system.
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公开(公告)号：US20220061771A1
公开(公告)日：2022-03-03
申请号：US17445866
申请日：2021-08-25
申请人： Luyun Qin , Ke Liao , Xiaojing Fan , Jinting Hou , Wei Wang
发明人： Luyun Qin , Ke Liao , Xiaojing Fan , Jinting Hou , Wei Wang
IPC分类号： A61B5/00
摘要： Disclosed are a method and apparatus for processing physiological signals. The method is inclusive of steps of obtaining the physiological signals; grouping the physiological signals based on their sampling frequencies and/or generation mechanisms, so as to acquire grouping results; and compressing, based on the grouping results, each group of physiological signals.
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公开(公告)号：US20220027656A1
公开(公告)日：2022-01-27
申请号：US17381414
申请日：2021-07-21
申请人： Haijing Jia , Hong Yi , Liyan Liu , Wei Wang
发明人： Haijing Jia , Hong Yi , Liyan Liu , Wei Wang
摘要： Disclosed are an image matching method and apparatus. The image matching method is inclusive of steps of obtaining a panoramic image of at least one subspace in a 3D space and a 2D image of the 3D space; acquiring a 2D image of the at least one subspace in the 3D space; performing 3D reconstruction on the panoramic image of the at least one subspace, and procuring a projection image corresponding to the panoramic image of the at least one subspace; and attaining a matching relationship between the panoramic image of the at least one subspace and the 2D image of the at least one subspace, and establishing an association relationship between the panoramic image of the at least one subspace and the 2D image of the at least one subspace between which the matching relationship has been generated.
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公开(公告)号：US11055878B2
公开(公告)日：2021-07-06
申请号：US16655496
申请日：2019-10-17
申请人： Hong Yi , Haijing Jia , Weitao Gong , Wei Wang
发明人： Hong Yi , Haijing Jia , Weitao Gong , Wei Wang
摘要： A person counting method and a person counting system are provided. The method includes extracting a group of person images to obtain a first image set; dividing the first image set into first and second subsets based on whether a related image exists in a second image set, and reusing a person ID of the related image; estimating posture patterns of images in the first subset, and storing the images in the first subset into an image library based on person IDs and the posture patterns; and selecting a target image whose similarity to an image in the second subset is highest from the image library, reusing a person ID of the target image when the similarity is greater than a threshold, and assigning a new person ID and incrementing a person counter by 1 when the similarity is not greater than the threshold.
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公开(公告)号：US10907219B2
公开(公告)日：2021-02-02
申请号：US15119506
申请日：2015-02-18
申请人： STC.UNM , Fu-Sen Liang , Wei Wang
发明人： Fu-Sen Liang , Wei Wang
IPC分类号： C12Q1/68 , C12Q1/6897
摘要： This disclosure describes compositions and methods that involve a first modular component and a second modular component. The first modular component includes a first target molecule coupled to a first dimerizing moiety. The second modular component includes a second target molecule coupled to a second dimerizing moiety. The first dimerizing moiety dimerizes with the second dimerizing moiety when the first dimerizing moiety binds a chemical induced proximity (CIP) inducer.
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