公开(公告)号：US5716640A

公开(公告)日：1998-02-10

申请号：US705348

申请日：1996-08-29

申请人： Shigeru Kamei ,  Minoru Yamada ,  Yasuaki Ogawa

发明人： Shigeru Kamei ,  Minoru Yamada ,  Yasuaki Ogawa

IPC分类号： A61K9/50 ,  A61K9/16 ,  A61K9/52 ,  A61K38/06 ,  A61K38/09 ,  A61K38/21 ,  A61K47/34 ,  B01J13/02 ,  B01J13/04 ,  A61K9/48 ,  A61K9/14 ,  B32B5/16

CPC分类号： A61K38/212 ,  A61K38/066 ,  A61K38/09 ,  A61K9/1647 ,  A61K9/1694 ,  B01J13/02 ,  Y10S514/963 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2985

摘要： A method of producing sustained-release microcapsules containing a biologically active substance from an W/O emulsion comprising an inner aqueous phase containing said biologically active substance and an external oil phase containing a biodegradable polymer, characterized in that microcapsules formed on microencapsulation of said biologically active substance with said biodegradable polymer are heated at a temperature not lower than the glass transition temperature of said biodegradable polymer but not so high as to cause aggregation of the microcapsules. This method enables the production of very useful sustained release microcapsules adapted to release a bologically active substance at a calculated rate over a protracted time period starting immediately following administration without an initial burst within one day following administration.

公开(公告)号：US5575987A

公开(公告)日：1996-11-19

申请号：US562634

申请日：1995-11-27

申请人： Shigeru Kamei ,  Minoru Yamada ,  Yasuaki Ogawa

发明人： Shigeru Kamei ,  Minoru Yamada ,  Yasuaki Ogawa

IPC分类号： A61K9/50 ,  A61K9/16 ,  A61K9/52 ,  A61K38/06 ,  A61K38/09 ,  A61K38/21 ,  A61K47/34 ,  B01J13/02 ,  B01J13/04 ,  A61K9/48 ,  A61K9/14 ,  B32B5/16

CPC分类号： A61K38/212 ,  A61K38/066 ,  A61K38/09 ,  A61K9/1647 ,  A61K9/1694 ,  B01J13/02 ,  Y10S514/963 ,  Y10T428/2982 ,  Y10T428/2984 ,  Y10T428/2985

摘要： A method of producing sustained-release microcapsules containing a biologically active substance from an W/O emulsion comprising an inner aqueous phase containing said biologically active substance and an external oil phase containing a biodegradable polymer, characterized in that microcapsules formed on microencapsulation of said biologically active substance with said biodegradable polymer are heated at a temperature not lower than the glass transition temperature of said biodegradable polymer but not so high as to cause aggregation of the microcapsules. This method enables the production of very useful sustained release microcapsules adapted to release a bologically active substance at a calculated rate over a protracted time period starting immediately following administration without an initial burst within one day following administration.

摘要翻译： 一种从W / O乳液制备含有生物活性物质的缓释微胶囊的方法，包括含有所述生物活性物质的内部水相和含有可生物降解的聚合物的外部油相，其特征在于，在所述生物活性物质的微胶囊化 与所述可生物降解聚合物的物质在不低于所述可生物降解聚合物的玻璃化转变温度的温度下加热，但不会高到使微胶囊聚集。 该方法使得能够生产非常有用的持续释放微胶囊，其适用于在给药后立即开始的持续时间段内以计算的速率释放勃起活性物质，而在给药后一天内没有初始爆发。

公开(公告)号：US5591713A

公开(公告)日：1997-01-07

申请号：US377392

申请日：1995-01-24

申请人： Yasutaka Igari ,  Minoru Yamada ,  Yasuaki Ogawa

发明人： Yasutaka Igari ,  Minoru Yamada ,  Yasuaki Ogawa

IPC分类号： A61K38/18 ,  A61K47/36 ,  A61K47/42 ,  A61K37/10

CPC分类号： A61K38/1816 ,  A61K47/36 ,  A61K47/42 ,  Y10S514/964

摘要： (1) A composition which comprises erythropoietin and hyaluronic acid shows a sustained-release of the medicine in a living body, and(2) A water-soluble composition which comprises (a) a pharmacologically active polypeptide secreted by an animal body or its derivative or a chemically synthesized pharmacologically active substance, (b) a water-soluble species' of hyaluronic acid or its nontoxic salt and (c) a water-soluble protein injectable into body fluids without showing any substantial pharmacological activity brings about a prolonged action in vivo of a pharmacologically active substance. In addition, the composition can be administered using a small-gauge needle and thereby contributes to relieving pain in patients.

摘要翻译： （1）包含促红细胞生成素和透明质酸的组合物，在活体中显示药物的持续释放，（2）水溶性组合物，其包含（a）动物体或其衍生物分泌的药理活性多肽 或化学合成的药理活性物质，（b）透明质酸或其无毒盐的水溶性物质，和（c）不显示任何实质药理学活性的体液可注射的水溶性蛋白质，导致体内延长的作用 的药理活性物质。 此外，组合物可以使用小规格的针管给药，从而有助于减轻患者的疼痛。

公开(公告)号：US5585460A

公开(公告)日：1996-12-17

申请号：US270791

申请日：1994-07-05

申请人： Minoru Yamada ,  Toshiro Heya ,  Yasuaki Ogawa

发明人： Minoru Yamada ,  Toshiro Heya ,  Yasuaki Ogawa

IPC分类号： A61K9/16 ,  A61K9/50 ,  A61K9/52 ,  C08G63/90 ,  C08G63/08

CPC分类号： A61K9/5031 ,  A61K9/1647 ,  C08G63/90

摘要： The invention provides a method of purifying biodegradable aliphatic polyesters which comprises dissolving, in a readily water-soluble organic solvent, a biodegradable aliphatic polyester which contains low-molecular substances and adding water to the resulting solution to thereby remove said low-molecular substances, biodegradable aliphatic polyesters obtained by said method and containing low-molecular substances with a molecular weight of 1,000 or less in an amount of not higher than 3%, and drug-containing compositions which comprise any of said biodegradable polyesters.

摘要翻译： 本发明提供一种纯化可生物降解的脂肪族聚酯的方法，该方法包括在容易水溶性的有机溶剂中将含有低分子物质的生物可降解的脂族聚酯溶解并向所得溶液中加入水，从而除去所述低分子物质，生物降解 通过所述方法获得并含有不高于3％的分子量为1,000以下的低分子物质的脂肪族聚酯和包含任何所述可生物降解聚酯的含药组合物。

公开(公告)号：US5304377A

公开(公告)日：1994-04-19

申请号：US986299

申请日：1992-12-07

申请人： Minoru Yamada ,  Seiko Ishiguro ,  Yasuaki Ogawa

发明人： Minoru Yamada ,  Seiko Ishiguro ,  Yasuaki Ogawa

IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/22 ,  A61K9/50 ,  A61K9/52 ,  A61K38/00 ,  A61K45/00 ,  A61K47/34 ,  C08G63/08 ,  C08L67/00 ,  C08L67/04 ,  A61K31/74

CPC分类号： A61K9/5031 ,  A61K9/1647 ,  C08L67/04

摘要： A polymer for a prolonged release preparation which comprises(A) a polylactic acid and(B) a copolymer of glycolic acid and a hydroxycarboxylic acid of general formula ##STR1## wherein R stands for an alkyl group having 2 to 8 carbons, wherein the weight ratio of (A) and (B) is in the range of 10/90 to 90/10. The drug is released at a constant rate from the preparation over the total release period without a large burst at the initial state. Furthermore, the drug release period of the preparation can be freely controlled by varying the blending ratio of (A) and (B).

摘要翻译： 一种用于延长释放制剂的聚合物，其包含（A）聚乳酸和（B）乙醇酸和通式为（*化学结构*）的羟基羧酸的共聚物，其中R表示具有2至8个碳原子的烷基， 其中（A）和（B）的重量比在10/90〜90/10的范围内。 药物以总释放期的制剂以恒定速率释放，而在初始状态下没有大的爆发。 此外，可以通过改变（A）和（B）的混合比例来自由地控制制剂的药物释放期。

公开(公告)号：US5416071A

公开(公告)日：1995-05-16

申请号：US909160

申请日：1992-07-06

申请人： Yasutaka Igari ,  Minoru Yamada ,  Yasuaki Ogawa

发明人： Yasutaka Igari ,  Minoru Yamada ,  Yasuaki Ogawa

IPC分类号： A61K38/18 ,  A61K47/36 ,  A61K47/42 ,  A61K38/14

CPC分类号： A61K38/1816 ,  A61K47/36 ,  A61K47/42 ,  Y10S514/964

摘要： (1) A composition which comprises erythropoietin and hyaluronic acid shows a sustained-release of the medicine in a living body, and(2) A water-soluble composition which comprises (a) a pharmacologically active polypeptide secreted by an animal body or its derivative or a chemically synthesized pharmacologically active substance, (b) a water-soluble species of hyaluronic acid or its nontoxic salt and (c) a water-soluble protein injectable into body fluids without showing any substantial pharmacological activity brings about a prolonged action in vivo of a pharmacologically active substance. In addition, the composition can be administered using a small-gauge needle and thereby contributes ot relieving pain in patients.

摘要翻译： （1）包含促红细胞生成素和透明质酸的组合物，在活体中显示药物的持续释放，（2）水溶性组合物，其包含（a）动物体或其衍生物分泌的药理活性多肽 或化学合成的药理活性物质，（b）透明质酸或其无毒盐的水溶性物质，和（c）不显示任何实质性药理学活性的体内液体注射的水溶性蛋白质，会导致体内延长的作用 药理活性物质。 此外，组合物可以使用小规格的针头施用，从而有助于减轻患者的疼痛。

公开(公告)号：US08895638B2

公开(公告)日：2014-11-25

申请号：US13471785

申请日：2012-05-15

申请人： Naoyuki Toyoda ,  Minoru Yamada ,  Masaya Shibatani ,  Toshiyuki Kobayashi ,  Hidekazu Moriyama ,  Taketoshi Kagose

发明人： Naoyuki Toyoda ,  Minoru Yamada ,  Masaya Shibatani ,  Toshiyuki Kobayashi ,  Hidekazu Moriyama ,  Taketoshi Kagose

IPC分类号： C09D11/10 ,  C09D11/101 ,  C09D7/12

CPC分类号： C09D11/38 ,  C08K5/3432 ,  C09D7/67 ,  C09D7/68 ,  C09D11/101 ,  C09D133/08 ,  Y10T428/24802 ,  Y10T428/24909

摘要： An ultraviolet ray curable ink jet composition of the present invention is characterized by being adapted to be ejected using an ink jet method and containing: a polymerizable compound; metal particles subjected to a surface treatment; and a substance A having a partial structure represented by the following formula (1), where R1 is a hydrogen atom, an oxygen radical, a hydrocarbon group or an alkoxy group, and each of R2, R3, R4 and R5 is independently a hydrogen atom or a hydrocarbon group.

摘要翻译： 本发明的紫外线固化型喷墨组合物的特征在于，使用喷墨法喷射并含有：聚合性化合物; 经过表面处理的金属颗粒; 和具有由下式（1）表示的部分结构的物质A，其中R 1是氢原子，氧原子，烃基或烷氧基，R 2，R 3，R 4和R 5各自独立地为氢 原子或烃基。

公开(公告)号：US20090322244A1

公开(公告)日：2009-12-31

申请号：US12307105

申请日：2007-07-20

申请人： Seiji Namiki ,  Yasuhiro Yokote ,  Minoru Yamada ,  Akira Mizutani ,  Atsushi Shimbo

发明人： Seiji Namiki ,  Yasuhiro Yokote ,  Minoru Yamada ,  Akira Mizutani ,  Atsushi Shimbo

IPC分类号： H05B41/285

CPC分类号： H05B41/2827

摘要： Provided is a light adjusting noise reduction circuit in which the vibration noise accompanying turning ON/OFF of a piezoelectric transformer. A full bridge circuit is controlled by a full bridge drive circuit so as to switch an input voltage (VB1) from an input voltage source and outputs it to a low pass filter. The output from the low pass filter is supplied to a piezoelectric transformer. The output current (IO) from the piezoelectric transformer is supplied to a discharge tube. Each of FET of the full bridge circuit has a drive frequency decided by a voltage control type oscillator. The full bridge circuit is connected to a duty variable circuit and a peak value control circuit. The peak value control circuit forms a rise and a fall of a waveform to be (1−cosωt).

摘要翻译： 提供了一种调节噪声降低电路，其中伴随着压电变压器的接通/断开的振动噪声。 全桥电路由全桥驱动电路控制，以便从输入电压源切换输入电压（VB1）并将其输出到低通滤波器。 来自低通滤波器的输出被提供给压电变压器。 来自压电变压器的输出电流（IO）被提供给放电管。 全桥电路的每个FET具有由电压控制型振荡器决定的驱动频率。 全桥电路连接到占空比可变电路和峰值控制电路。 峰值控制电路将波形的上升和下降形成为（1-cosomegat）。

公开(公告)号：US20090137713A1

公开(公告)日：2009-05-28

申请号：US12223066

申请日：2007-01-12

申请人： Mariko Muto ,  Minoru Yamada

发明人： Mariko Muto ,  Minoru Yamada

IPC分类号： C08K5/07

CPC分类号： C09D11/36

摘要： In each of an organic solvent, an oil-soluble dye and an oil-soluble resin to be contained in an ink for marking, and a resin adopted in an article to be marked with the ink for marking, it is necessary that absolute values of differences between mutual solubility parameters are not more than constant values, respectively.

摘要翻译： 在用于标记的油墨中包含的有机溶剂，油溶性染料和油溶性树脂中的任一种，以及待标记用于标记的油墨的制品中采用的树脂，需要绝对值 相互溶解度参数之间的差异分别不大于常数值。

公开(公告)号：US06636381B1

公开(公告)日：2003-10-21

申请号：US09643919

申请日：2000-08-23

申请人： Kiyoshi Sato ,  Hideki Gochou ,  Kiyoshi Kobayashi ,  Hisayuki Yazawa ,  Akira Koyama ,  Minoru Yamada

发明人： Kiyoshi Sato ,  Hideki Gochou ,  Kiyoshi Kobayashi ,  Hisayuki Yazawa ,  Akira Koyama ,  Minoru Yamada

IPC分类号： G11B5127

CPC分类号： G11B5/3116 ,  G11B5/312 ,  G11B5/313 ,  Y10T29/49048

摘要： A track width regulating section having a track width, which is smaller than the resolution obtained by the wavelength of the light used for exposure and development of a resist, is formed between a lower core layer and an upper core layer. Since the width of the upper core layer is larger than the track width, magnetic saturation can be effectively reduced. Inclined faces are formed on the upper surface of the lower core layer so as to be inclined in directions away from the track width regulating section, thereby adequately preventing write fringing.

摘要翻译： 在下芯层和上核层之间形成轨道宽度调节部分，其轨道宽度小于通过用于曝光和显影抗蚀剂的光的波长获得的分辨率。 由于上芯层的宽度大于轨道宽度，所以可以有效地降低磁饱和。 倾斜面形成在下芯层的上表面上，以便在远离轨道宽度调节部分的方向上倾斜，从而充分防止了写入边缘。