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13 条记录 (耗时 0.026 秒)

    Epoxysuccinic acid derivatives, their production and use
    2.
    发明授权
    Epoxysuccinic acid derivatives, their production and use 失效
    环氧琥珀酸衍生物，其生产和使用

    公开(公告)号：US5679708A

    公开(公告)日：1997-10-21

    申请号：US513895

    申请日：1995-09-05

    申请人： Shigetoshi Tsubotani ,  Masayuki Takizawa ,  Junji Mizoguchi

    发明人： Shigetoshi Tsubotani ,  Masayuki Takizawa ,  Junji Mizoguchi

    IPC分类号： C07D303/48 ,  A61K31/335 ,  C07D405/12

    CPC分类号： C07D303/48

    摘要： The present invention relates to a compound of the formula: ##STR1## wherein R.sub.1 stands for an optionally esterified or amidated carboxyl group, X stands for an optionally substituted divalent hydrocarbon residue, R.sub.2 stands for hydrogen or an optionally substituted hydrocarbon residue, R.sub.3 stands for an alkyl group which is substituted with a group bonded through O or S(O).sub.n wherein n is 0, 1 or 2, with a proviso that when the partial structural formula: --NH--X--CO-- is leucine residue, R.sub.3 is not 3-hydroxy-3-methylbutyl group nor 4-hydroxy-3-methylbutyl group, or a salt thereof, which is useful as prophylactic and therapeutic agents of bone diseases and as inhibitory agents of thiol protease.

    摘要翻译： PCT No.PCT / JP95 / 01004 Sec。 371 1995年9月5日第 102（e）1995年9月5日PCT PCT 1995年5月25日PCT公布。 出版物WO95 / 32954 日期：1994年12月7日本发明涉及下式化合物：其中R1代表任意酯化或酰胺化的羧基，X代表任意取代的二价烃残基，R2代表氢或 任选取代的烃基，R3代表被O或S（O）n键合的基团取代的烷基，其中n为0,1或2，条件是当部分结构式为：-NH-X- CO-是亮氨酸残基，R3不是3-羟基-3-甲基丁基也不是4-羟基-3-甲基丁基，或其盐，其可用作骨疾病的预防和治疗剂，并且作为硫醇蛋白酶的抑制剂 。

    Explosive detection system
    7.
    发明授权
    Explosive detection system 有权
    爆炸检测系统

    公开(公告)号：US06844546B2

    公开(公告)日：2005-01-18

    申请号：US10229057

    申请日：2002-08-28

    申请人： Hisashi Nagano ,  Yasuaki Takada ,  Izumi Waki ,  Koushou Aikawa ,  Masayuki Takizawa ,  Shigenori Morishima

    发明人： Hisashi Nagano ,  Yasuaki Takada ,  Izumi Waki ,  Koushou Aikawa ,  Masayuki Takizawa ,  Shigenori Morishima

    IPC分类号： G01N27/62 ,  G01N1/22 ,  H01J49/00 ,  H01J49/04

    CPC分类号： H01J49/0031

    摘要： An explosive detection system including a sample injection region, an ion source region for generating ions of a sample injected by the ion injection region, a mass analysis region for analyzing mass of the ions, a heater for heating the sample injection region and the ion source region, a plurality of pumps for exhausting a chamber in which the mass analysis region is disposed, and a controller for controlling the regions and the plurality of pumps. The controller conducts control so as to heat the sample injection region and the ion source region with the heaters, then reduce heating electric power supplied to the heaters in order to prevent a predetermined electric power value from being exceeded, and drive the plurality of pumps successively to exhaust the chamber.

    摘要翻译： 一种爆炸检测系统，包括样品注入区域，用于产生由离子注入区域注入的样品的离子的离子源区域，用于分析离子质量的质量分析区域，用于加热样品注入区域的加热器和离子源 区域，用于排出其中设置质量分析区域的室的多个泵，以及用于控制区域和多个泵的控制器。 控制器进行控制，以便利用加热器加热样品注入区域和离子源区域，然后减少供给到加热器的加热电力，以防止超过预定的电功率值，并且依次驱动多个泵 排气室。

    Novel thiol derivative, process for producing the same and use thereof
    8.
    发明申请
    Novel thiol derivative, process for producing the same and use thereof 审中-公开
    新型硫醇衍生物，其制备方法及其用途

    公开(公告)号：US20050165064A1

    公开(公告)日：2005-07-28

    申请号：US10512285

    申请日：2003-04-24

    申请人： Masahiro Kajino ,  Masayuki Takizawa ,  Kohei Notoya ,  Hiroshi Nara ,  Tomomi Ikemoto ,  Atsuko Nishiguchi

    发明人： Masahiro Kajino ,  Masayuki Takizawa ,  Kohei Notoya ,  Hiroshi Nara ,  Tomomi Ikemoto ,  Atsuko Nishiguchi

    IPC分类号： A61K31/4439 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P19/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D401/06 ,  C07D401/14 ,  C07D43/02

    CPC分类号： C07D401/14 ,  A61K31/4439 ,  C07D401/06

    摘要： The present invention provides a novel thiol derivative [I] which has an excellent matrix metalloprotease inhibiting activity and is useful as a pharmaceutical composition, particularly a therapeutic agent or prophylactic agent for osteoarthritis and rheumatoid arthritis and a salt thereof, the thiol derivative being a compound represented by the formula [I]: wherein ring A represents an optionally substituted aromatic heterocyclic ring; ring B represents an optionally substituted homocyclic or heterocyclic ring; R1 represents a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group, an optionally substituted heterocyclic group or SR2 (wherein R2 represents a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group or an optionally substituted heterocyclic group); X represents an optionally substituted divalent C1-3 aliphatic hydrocarbon group; Y represents an optionally substituted hydrocarbon group, a halogen atom, a carboxy group, an acyl group, an optionally substituted hydroxy group, an optionally substituted amino group, SR3 (wherein R3 represents a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group or an optionally substituted heterocyclic group), an oxo group, a thioxo group, an optionally substituted imino group, a nitro group or a cyano group; and q represents an integer of 0 to 5.

    摘要翻译： 本发明提供一种具有优异的基质金属蛋白酶抑制活性的新型硫醇衍生物[I]，可用作药物组合物，特别是用于骨关节炎和类风湿性关节炎的治疗剂或预防剂及其盐，硫醇衍生物为化合物 由式[I]表示：其中环A表示任选取代的芳族杂环; 环B表示任选取代的杂环或杂环; R 1表示氢原子，任选取代的烃基，酰基，任选取代的杂环基或SR 2（其中R 2， 表示氢原子，任选取代的烃基，酰基或任选取代的杂环基）; X表示任选取代的二价C 1-3脂族烃基; Y表示任选取代的烃基，卤素原子，羧基，酰基，任选取代的羟基，任选取代的氨基，SR 3（其中R 3， SUP>表示氢原子，任选取代的烃基，酰基或任选取代的杂环基），氧代基，硫代基，任选取代的亚氨基，硝基或氰基; q表示0〜5的整数。

    Cell death inhibitor
    9.
    发明申请
    Cell death inhibitor 审中-公开
    细胞死亡抑制剂

    公开(公告)号：US20060034832A1

    公开(公告)日：2006-02-16

    申请号：US10512587

    申请日：2003-04-24

    申请人： Haruhide Kimura ,  Yoshimi Sato ,  Masayuki Takizawa ,  Takashi Horiguchi ,  Kohei Notoya

    发明人： Haruhide Kimura ,  Yoshimi Sato ,  Masayuki Takizawa ,  Takashi Horiguchi ,  Kohei Notoya

    IPC分类号： A61K39/395 ,  A61K31/5415

    CPC分类号： C07D417/04 ,  A61K31/00 ,  A61K31/5415 ,  C07D279/08 ,  G01N2333/52 ,  G01N2500/02

    摘要： The cell death inhibitor comprising a substance capable of binding to macrophage migration inhibitory factor is useful as a preventive/therapeutic agent for, e.g., heart diseases, neurodegenerative diseases, cerebrovascular diseases, central nervous infections, traumatic diseases, demyelinating diseases, bone/joint diseases, kidney diseases, liver diseases, myelodysplastic diseases, arteriosclerosis, diabetes, pulmonary hypertension, sepsis, inflammatory bowel diseases, autoimmune diseases, failure accompanying rejection in organ transplantation, AIDS, cancer, etc.

    摘要翻译： 包含能够结合巨噬细胞迁移抑制因子的物质的细胞死亡抑制剂可用作例如心脏病，神经变性疾病，脑血管疾病，中枢神经感染，创伤性疾病，脱髓鞘疾病，骨/关节疾病的预防/治疗剂 肾脏疾病，肝脏疾病，骨髓增生异常性疾病，动脉硬化，糖尿病，肺动脉高压，败血症，炎症性肠病，自身免疫疾病，器官移植排斥反应失败，艾滋病，癌症等。

    CELL DEATH INHIBITOR
    10.
    发明申请
    CELL DEATH INHIBITOR 有权
    细胞死亡抑制剂

    公开(公告)号：US20100099106A1

    公开(公告)日：2010-04-22

    申请号：US12576232

    申请日：2009-10-08

    申请人： Haruhide Kimura ,  Yoshimi Sato ,  Masayuki Takizawa

    发明人： Haruhide Kimura ,  Yoshimi Sato ,  Masayuki Takizawa

    IPC分类号： C12Q1/68

    CPC分类号： C07D417/04 ,  A61K31/00 ,  A61K31/5415 ,  C07D279/08 ,  G01N2333/52 ,  G01N2500/02

    摘要： The cell death inhibitor comprising a substance capable of binding to macrophage migration inhibitory factor is useful as a preventive/therapeutic agent for, e.g., heart diseases, neurodegenerative diseases, cerebrovascular diseases, central nervous infections, traumatic diseases, demyelinating diseases, bone/joint diseases, kidney diseases, liver diseases, myelodysplastic diseases, arteriosclerosis, diabetes, pulmonary hypertension, sepsis, inflammatory bowel diseases, autoimmune diseases, failure accompanying rejection in organ transplantation, AIDS, cancer, etc.

    摘要翻译： 包含能够结合巨噬细胞迁移抑制因子的物质的细胞死亡抑制剂可用作例如心脏病，神经变性疾病，脑血管疾病，中枢神经感染，创伤性疾病，脱髓鞘疾病，骨/关节疾病的预防/治疗剂 肾脏疾病，肝脏疾病，骨髓增生异常性疾病，动脉硬化，糖尿病，肺动脉高压，败血症，炎症性肠病，自身免疫疾病，器官移植排斥反应失败，艾滋病，癌症等。