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    Condensed cyclic compounds and their use
    7.
    发明授权
    Condensed cyclic compounds and their use 失效
    缩合的环状化合物及其用途

    公开(公告)号：US5698691A

    公开(公告)日：1997-12-16

    申请号：US311932

    申请日：1994-09-26

    申请人： Hidefumi Yukimasa ,  Ryuichi Tozawa ,  Yasuo Sugiyama ,  Masakuni Kori

    发明人： Hidefumi Yukimasa ,  Ryuichi Tozawa ,  Yasuo Sugiyama ,  Masakuni Kori

    IPC分类号： C12N9/99 ,  A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  A61P3/06 ,  A61P43/00 ,  C07D223/16 ,  C07D243/04 ,  C07D243/10 ,  C07D243/12 ,  C07D243/14 ,  C07D243/16 ,  C07D243/24 ,  C07D245/06 ,  C07D255/04 ,  C07D257/04 ,  C07D267/14 ,  C07D267/22 ,  C07D281/10 ,  C07D285/00 ,  C07D417/06 ,  C07D417/12 ,  C07D498/04 ,  C07D267/02

    CPC分类号： C07D223/16 ,  C07D243/04 ,  C07D243/12 ,  C07D243/24 ,  C07D255/04 ,  C07D267/14 ,  C07D281/10 ,  C07D417/06 ,  C07D417/12

    摘要： Disclosed is a squalene synthetase inhibitor which comprises the compound represented by the formula ##STR1## wherein R.sub.1 is hydrogen or an optionally substituted hydrocarbon group; R.sub.2 is hydrogen, an optionally substituted alkyl group, an optionally substituted phenyl group or an optionally substituted aromatic heterocyclic ring group; X' is a substituent comprising an optionally esterified carboxyl group, an optionally substituted carbamoyl group, an optionally substituted hydroxyl group, an optionally substituted amino group or an optionally substituted heterocyclic radical having a protonizable hydrogen; Ring A is an optionally substituted benzene ring or an optionally substituted aromatic heterocyclic ring; Ring J' is a 7- to 8-membered heterocyclic ring containing at most three ring constituting hetero atoms; D is C or N; the Ring J' optionally having, besides R.sub.1, R.sub.2 and X', a further substituent; provided that the condensed ring composed of Ring A and ring J' is not a 2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine ring, or a pharmaceutically acceptable salt thereof, and which is useful for the prophylaxis or therapy of hypercholesteremia or coronary sclerosis of mammals.

    摘要翻译： 公开了一种角鲨烯合成酶抑制剂，其包含由通式取代的烃基表示的化合物; R2是氢，任选取代的烷基，任选取代的苯基或任选取代的芳族杂环基; X'是包含任选酯化的羧基，任选取代的氨基甲酰基，任选取代的羟基，任选取代的氨基或具有可质子化氢的任选取代的杂环基的取代基; 环A是任选取代的苯环或任选取代的芳族杂环; 环J'是含有至多三个环构成杂原子的7-至8-元杂环; D为C或N; 除了R1，R2和X'之外，环J'还可以具有另外的取代基; 条件是由环A和环J'组成的稠环不是2-氧代-1,2,3,5-四氢-4,1-苯并氧氮杂环，或其药学上可接受的盐，并且其可用于 预防或治疗哺乳动物的高胆固醇血症或冠状动脉硬化。