公开(公告)号：US20230268171A1

公开(公告)日：2023-08-24

申请号：US17675059

申请日：2022-02-18

Applicant: SHIMADZU CORPORATION

Inventor： Tatsuki OKUBO ,  Yoshihiro Yamada

IPC: H01J49/16 ,  H01J49/00

CPC classification number: H01J49/164 ,  H01J49/0036

Abstract: In a mass spectrometer employing laser ionization to ionize a sample, a known sample is irradiated with laser light multiple times, and multiple sets of profile data are acquired each of which is a spectrum showing the relationship between the m/z values and intensities of ions generated from the known sample by one laser irradiation (Step S11). Those sets of profile data are sorted into groups so that one or more sets of profile data are included in each group (Step S12). For each group, a peak list is created which describes the m/z value and intensity of each peak originating from the known sample based on the one or more sets of profile data included in the group (Step S13). A discriminant model for discriminating an unknown sample is created using the peak lists of the plurality of groups and information concerning the kind of the known sample as training data.

公开(公告)号：US20210125815A1

公开(公告)日：2021-04-29

申请号：US17078344

申请日：2020-10-23

Applicant: SHIMADZU CORPORATION

Inventor： Tatsuki OKUBO ,  Chisato MIYAKE ,  Yuko OHASHI ,  Tomonori OSHIKAWA ,  Ritsuko YODA

IPC: H01J49/00 ,  H01J49/16 ,  G06T11/00

Abstract: A mass spectrometry device includes: an image generation unit that generates an image indicating a mass spectrometry sample arranged on each sample mounting portion in which each position of a plurality of sample mounting portions in a sample plate for laser desorption/ionization corresponds to each position of the plurality of sample mounting portions in an image, wherein: in the image, a display element indicating a direction is displayed at a position corresponding to the sample mounting portion.

公开(公告)号：US20240266158A1

公开(公告)日：2024-08-08

申请号：US18019626

申请日：2021-01-06

Applicant: Shimadzu Corporation

Inventor： Naoki KANEKO ,  Tatsuki OKUBO ,  Tomonori OSHIKAWA ,  Yuko KOBAYASHI ,  Yoshiki TAINAKA ,  Kohei SUZUKI ,  Takashi NISHIKAZE

IPC: H01J49/00

CPC classification number: H01J49/0009

Abstract: The present disclosure provides a method for calibrating a difference in signal intensity ratio between machines in mass spectrometry.

公开(公告)号：US20230314456A1

公开(公告)日：2023-10-05

申请号：US18040928

申请日：2021-04-26

Applicant: SHIMADZU CORPORATION

Inventor： Tatsuki OKUBO ,  Tomeonori OSHIKAWA ,  Yuko KOBAYASHI ,  Yoshiki TAINAKA ,  Kohei SUZUKI

IPC: G01N35/00 ,  G06F3/04842

CPC classification number: G01N35/00722 ,  G06F3/04842 ,  G01N2035/0091

Abstract: A device that supports analysis work of executing a protocol for disposing a predetermined sample in all or some predetermined sample disposing portions among a plurality of sample disposing portions provided in a sample housing member and for performing measurement, includes: a storage unit in which protocols are stored; a display unit; a protocol selection input reception unit to receive an input for selecting a protocol; a sample position display unit to display information on a position of the sample disposing portion and information on the sample corresponding to the protocol input to the protocol selection input reception unit on the display unit; a display item selection checkbox to receive selection of the information on the position of the sample disposing portion and/or the information on the sample; and a display switching unit to switch display by the sample position display unit depending on the selection.

公开(公告)号：US20220230708A1

公开(公告)日：2022-07-21

申请号：US17607080

申请日：2020-02-20

Applicant: SHIMADZU CORPORATION

Inventor： Tatsuki OKUBO

IPC: G16B40/00

Abstract: A representative value is decided from a theoretical mass group which is a set of theoretical masses regarding the same type of protein of a plurality of microorganisms (step S1), a reference sequence which is an amino acid sequence or a base sequence corresponding to the representative value is specified (step S2), an editing distance between an amino acid sequence or a base sequence corresponding to each of the theoretical masses included in the theoretical mass group and the reference sequence is calculated (step S3), and a theoretical mass corresponding to an amino acid sequence or a base sequence of which the editing distance is equal to or greater than a predetermined threshold value is decided, as an outlier, among the theoretical masses included in the theoretical mass group (step S4).

公开(公告)号：US20230343573A1

公开(公告)日：2023-10-26

申请号：US18007322

申请日：2021-03-18

Applicant: SHIMADZU CORPORATION

Inventor： Tatsuki OKUBO ,  Mamoru HONDA ,  Yuko OHASHI

IPC: H01J49/16 ,  G01N35/00

CPC classification number: H01J49/164 ,  G01N35/00613

Abstract: A mass spectrometer includes: a measurement unit to perform mass spectrometry on each of a plurality of target samples and a plurality of quality control samples in a predetermined order; a sample information storage unit which stores discrimination information capable of discriminating between the target sample and the quality control sample in a series of measurements of the target samples and the quality control samples; and a display processor to separate a measurement result for the target sample and/or an analysis result derived from the measurement result, and a measurement result for the quality control sample and/or an analysis result derived from the measurement result to create display information in a predetermined format, and display the two pieces of display information on a screen of a display unit by using the discrimination information.

公开(公告)号：US20230132727A1

公开(公告)日：2023-05-04

申请号：US17918648

申请日：2020-11-26

Applicant: SHIMADZU CORPORATION

Inventor： Akihito KORENAGA ,  Ritsuko YODA ,  Tatsuki OKUBO ,  Tomonori OSHIKAWA ,  Yuko KOBAYASHI ,  Yoshiki TAINAKA ,  Kohei SUZUKI

IPC: H01J49/16 ,  H01J49/00 ,  H01J49/04

Abstract: One mode of the present invention provides a laser power adjustment method for ionization in a laser desorption/ionization mass spectrometer, the laser power adjustment method including: a measurement step (S1) in which intensity information on ions derived from a specific component in a specimen are acquired while changing laser power in n stages (n is 3 or more) for the identical specimen; and a processing step (S2, S6, and S7) in which a slope of a straight line connecting two adjacent plot points on a laser power axis is calculated in a two-axis graph in which a relationship between n ionic intensities obtained by the measurement step or a signal value, which is an SN ratio obtained from the ionic intensities, and laser power is plotted; an index value reflecting a ratio between a forward slope value, which is a slope of a straight line on a front side of the plot point, and a backward slope value, which is a slope of a straight line on a rear side, is obtained for each plot point; and appropriate laser power is selected using the index value.

公开(公告)号：US20220065884A1

公开(公告)日：2022-03-03

申请号：US17376776

申请日：2021-07-15

Applicant: SHIMADZU CORPORATION

Inventor： Tomonori OSHIKAWA ,  Yuko KOBAYASHI ,  Yoshiki TAINAKA ,  Tatsuki OKUBO ,  Kohei SUZUKI

IPC: G01N35/00 ,  H01J49/16 ,  H01J49/40 ,  G01N33/49

Abstract: In a device (4) for assisting in analytical operations for correctly arranging samples in a plurality of sample-placement portions and implementing multiple protocols in the correct order, a storage section (41) holds sample information and analysis parameters for each protocol as well as the order of implementation. A protocol-selection-input receiver (42) receives an input of the selection of a protocol. A sample-position displayer (43) displays, on a display unit (6), sample information in the selected protocol along with the positions of the sample-placement portions. A protocol-implementation-information collector (45) collects information concerning the state of implementation of the protocols. A determiner (46) determines whether a protocol which must be implemented earlier was already implemented, based on the state of implementation and order of implementation of the protocols. A batch-file creator (47) creates a batch file when it is confirmed that the protocol which must be implemented earlier was already implemented.