公开(公告)号：US20230132727A1

公开(公告)日：2023-05-04

申请号：US17918648

申请日：2020-11-26

Applicant: SHIMADZU CORPORATION

Inventor： Akihito KORENAGA ,  Ritsuko YODA ,  Tatsuki OKUBO ,  Tomonori OSHIKAWA ,  Yuko KOBAYASHI ,  Yoshiki TAINAKA ,  Kohei SUZUKI

IPC: H01J49/16 ,  H01J49/00 ,  H01J49/04

Abstract: One mode of the present invention provides a laser power adjustment method for ionization in a laser desorption/ionization mass spectrometer, the laser power adjustment method including: a measurement step (S1) in which intensity information on ions derived from a specific component in a specimen are acquired while changing laser power in n stages (n is 3 or more) for the identical specimen; and a processing step (S2, S6, and S7) in which a slope of a straight line connecting two adjacent plot points on a laser power axis is calculated in a two-axis graph in which a relationship between n ionic intensities obtained by the measurement step or a signal value, which is an SN ratio obtained from the ionic intensities, and laser power is plotted; an index value reflecting a ratio between a forward slope value, which is a slope of a straight line on a front side of the plot point, and a backward slope value, which is a slope of a straight line on a rear side, is obtained for each plot point; and appropriate laser power is selected using the index value.

公开(公告)号：US20220065884A1

公开(公告)日：2022-03-03

申请号：US17376776

申请日：2021-07-15

Applicant: SHIMADZU CORPORATION

Inventor： Tomonori OSHIKAWA ,  Yuko KOBAYASHI ,  Yoshiki TAINAKA ,  Tatsuki OKUBO ,  Kohei SUZUKI

IPC: G01N35/00 ,  H01J49/16 ,  H01J49/40 ,  G01N33/49

Abstract: In a device (4) for assisting in analytical operations for correctly arranging samples in a plurality of sample-placement portions and implementing multiple protocols in the correct order, a storage section (41) holds sample information and analysis parameters for each protocol as well as the order of implementation. A protocol-selection-input receiver (42) receives an input of the selection of a protocol. A sample-position displayer (43) displays, on a display unit (6), sample information in the selected protocol along with the positions of the sample-placement portions. A protocol-implementation-information collector (45) collects information concerning the state of implementation of the protocols. A determiner (46) determines whether a protocol which must be implemented earlier was already implemented, based on the state of implementation and order of implementation of the protocols. A batch-file creator (47) creates a batch file when it is confirmed that the protocol which must be implemented earlier was already implemented.

公开(公告)号：US20190333750A1

公开(公告)日：2019-10-31

申请号：US16468075

申请日：2016-12-22

Applicant: SHIMADZU CORPORATION

Inventor： Maki SAITO ,  Yuko KOBAYASHI ,  Tohru SHIOHAMA

IPC: H01J49/42 ,  H01J49/04 ,  G01N30/72 ,  G01N27/62

Abstract: A display area 60 of a display unit of a mass spectrometer shows a result of tuning. The display area 60 includes: a tuning-item displaying section 62 configured to display all tuning items and a result of whether each tuning item has been tuned; and an analyzable-condition displaying section 63 configured to display a condition under which an analysis is possible based on the result. The tuning items may be displayed respectively and individually. Alternatively, the tuning items may be displayed in a grouped manner with a plurality of tuning items in a group. Consequently, a user knows, at a glance, whether the tuning necessary for an analysis that the user intends to perform has been performed. If a necessary tuning item has not been tuned, the user immediately starts to tune (only) the tuning item. Further, a user immediately knows in a current state of tuning whether the analysis that the user intends to perform is possible. Therefore, when the analysis is possible, the user can start the analysis. When the analysis is impossible, the user can tune only the tuning item that has not been tuned and is displayed on the tuning-item displaying section 62.

公开(公告)号：US20170328874A1

公开(公告)日：2017-11-16

申请号：US15527203

申请日：2014-11-17

Applicant: SHIMADZU CORPORATION

Inventor： Hideki YAMAMOTO ,  Yuko KOBAYASHI

IPC: G01N30/86 ,  G01N30/72 ,  G01N30/02

CPC classification number: G01N30/8693 ,  G01N30/72 ,  G01N30/8644 ,  G01N2030/022 ,  H01J49/0031 ,  H01J49/004

Abstract: A chromatograph mass spectrometer including: an MSn−1 analysis setter for setting an analysis execution period for performing an MSn−1 analysis, an execution time for the analysis and a loop time; an analysis period divider for dividing the analysis period into segments according to a change in number or analysis condition of MSn−1 analyses to be performed within the same time window; an MSn analysis setter for performing MSn−1 analysis to obtain mass spectrum data and for scheduling MSn analysis, an ion corresponding to a peak satisfying a set condition being designated as a precursor ion; an MSn analysis execution time allotter for allotting, in each segment, a time period for execution of the MSn analysis, the time period being calculated by subtracting an event execution time from the loop time; and an analysis executer for repeatedly performing MSn−1 analysis and MSn analysis in each segment.

公开(公告)号：US20160209378A1

公开(公告)日：2016-07-21

申请号：US14914354

申请日：2013-08-26

Applicant: SHIMADZU CORPORATION

Inventor： Yuko KOBAYASHI ,  Hiroshi SUGAWARA ,  Tairo OGURA

IPC: G01N30/72 ,  H01J49/42

CPC classification number: G01N30/72 ,  G01N30/8644 ,  H01J49/0031 ,  H01J49/4225

Abstract: When setting analysis conditions, an analysis operator sets, on a dwell-time calculation/loop-time listing window, the target value of a loop time corresponding to the measurement-time interval to repeat an analysis for one ion, and clicks a dwell time calculation button. Then, a dwell time calculator computes the dwell time for each event, based on the target value of the loop time, the arrangement of events set at that point in time, the number of target ion species set in each event, and other conditional factors. The calculated result is displayed in a dwell time calculation result display field in a listing table. The largest and smallest values of the dwell time are displayed in the largest/smallest dwell time display field. The analysis operator checks this display and changes the target value of the loop time and/or the measurement time of the event so as to achieve an appropriate dwell time.

Abstract translation: 在设置分析条件时，分析算子在停留时间计算/循环时间列表窗口上设置与测量时间间隔相对应的循环时间的目标值，以重复对一个离子的分析，并且点击停留时间 计算按钮。 然后，驻留时间计算器基于循环时间的目标值，在该时间点设置的事件的排列，每个事件中设定的目标离子种类的数量以及其他条件因子来计算每个事件的停留时间 。 计算结果显示在列表表中的停留时间计算结果显示字段中。 驻留时间的最大和最小值显示在最大/最小的停留时间显示字段中。 分析操作员检查该显示并改变循环时间的目标值和/或事件的测量时间，以便达到适当的停留时间。

公开(公告)号：US20240266158A1

公开(公告)日：2024-08-08

申请号：US18019626

申请日：2021-01-06

Applicant: Shimadzu Corporation

Inventor： Naoki KANEKO ,  Tatsuki OKUBO ,  Tomonori OSHIKAWA ,  Yuko KOBAYASHI ,  Yoshiki TAINAKA ,  Kohei SUZUKI ,  Takashi NISHIKAZE

IPC: H01J49/00

CPC classification number: H01J49/0009

Abstract: The present disclosure provides a method for calibrating a difference in signal intensity ratio between machines in mass spectrometry.

公开(公告)号：US20230314456A1

公开(公告)日：2023-10-05

申请号：US18040928

申请日：2021-04-26

Applicant: SHIMADZU CORPORATION

Inventor： Tatsuki OKUBO ,  Tomeonori OSHIKAWA ,  Yuko KOBAYASHI ,  Yoshiki TAINAKA ,  Kohei SUZUKI

IPC: G01N35/00 ,  G06F3/04842

CPC classification number: G01N35/00722 ,  G06F3/04842 ,  G01N2035/0091

Abstract: A device that supports analysis work of executing a protocol for disposing a predetermined sample in all or some predetermined sample disposing portions among a plurality of sample disposing portions provided in a sample housing member and for performing measurement, includes: a storage unit in which protocols are stored; a display unit; a protocol selection input reception unit to receive an input for selecting a protocol; a sample position display unit to display information on a position of the sample disposing portion and information on the sample corresponding to the protocol input to the protocol selection input reception unit on the display unit; a display item selection checkbox to receive selection of the information on the position of the sample disposing portion and/or the information on the sample; and a display switching unit to switch display by the sample position display unit depending on the selection.

公开(公告)号：US20170032947A1

公开(公告)日：2017-02-02

申请号：US15039924

申请日：2013-11-28

Applicant: SHIMADZU CORPORATION

Inventor： Yuko KOBAYASHI ,  Tairo OGURA

IPC: H01J49/00 ,  H01J49/42 ,  G01N30/72

CPC classification number: H01J49/005 ,  G01N30/7266 ,  H01J49/0036 ,  H01J49/0045 ,  H01J49/4215

Abstract: In a mass spectrometric method of the invention, a mass spectrometer (2) is used having a mass separation unit (231, 234) before and after a collision cell (232) for fragmenting ions. When a product ion corresponding to a precursor ion set for a sample is selected by performing product ion scan with respect to the precursor ion, an exclusion range of mass-to-charge ratios is set based on information on non-selection ions input by a user, and a product ion that satisfies a predefined criterion is selected within a range of mass-to-charge ratios excluding the exclusion range in a product ion spectrum. According to the mass spectrometric method of the invention, product ions suited for measurement on a target compound can be selected.

Abstract translation: 在本发明的质谱法中，使用质谱分离装置（2），在质子分离单元（231,234）之前和之后，用于使离子分离。 当通过相对于前体离子进行产物离子扫描来选择对应于为样品设定的前体离子的产物离子时，基于由输入的非选择离子的信息设置质荷比的排除范围 用户和满足预定标准的产物离子在除乘积离子谱中的排除范围之外的质荷比范围内选择。 根据本发明的质谱法，可以选择适合于目标化合物的测定的产物离子。