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公开(公告)号：USRE34653E
公开(公告)日：1994-07-05
申请号：US909639
申请日：1992-07-07
IPC分类号： C07D491/107 , A61K31/435 , A61K31/55 , A61P25/02 , A61P25/28 , C07D211/48 , C07D405/06 , C07D453/00 , C07D471/10 , C07D487/10 , C07D491/10 , C07D491/20 , C07D491/22 , C07D495/10 , C07D495/20 , C07D495/22 , C07D497/20 , C07D497/22 , C07D705/02
CPC分类号： C07D471/10 , C07D211/48 , C07D491/10 , C07D495/10
摘要： Heterocyclic spiro compounds represented by the following general formula and salts thereof: ##STR1## The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.
摘要翻译： 由以下通式表示的杂环螺环化合物及其盐：上述化合物作用于毒蕈碱性乙酰胆碱受体，由此激活中枢神经系统中的乙酰胆碱神经功能。
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公开(公告)号：US5412096A
公开(公告)日：1995-05-02
申请号：US230625
申请日：1994-05-24
IPC分类号： C07D211/48 , C07D471/10 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/10 , C07D495/20 , C07D495/22 , C07D497/20 , C07D497/22 , C07D405/02
CPC分类号： C07D471/10 , C07D211/48 , C07D491/10 , C07D495/10
摘要： Hydrochloride salts of heterocyclic spiro compounds are provided and can be represented by the following general formula: ##STR1## wherein A represents piperidine or N alkyl piperidine or N alkylene attached to a non adjacent piperidine ring carbon, X is S or O, Y is carbonyl, thiocarbonyl, methylene, R.sup.5 methylene, ##STR2## alk in which R.sup.1 to R.sub.3,R.sub.6,R.sub.7 are H or alkyl, R.sub.4 is H, alkyl, COOH, or ester, or --C alkyl, R.sub.5 is halo, OH,SH, O alkyl, S alkyl, O acyl or S acyl, and Z, and Z.sub.2 are O or S. The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.
摘要翻译： 提供了杂环螺环化合物的盐酸盐，并且可以由以下通式表示：其中A表示哌啶或N烷基哌啶或连接于非相邻哌啶环碳的N亚烷基，X为S或O，Y为羰基 ，其中R 1至R 3，R 6，R 7为H或烷基，R 4为H，烷基，COOH或酯或-C烷基，R 5为卤素，OH，SH， O烷基，S烷基，O酰基或S酰基，Z和Z2是O或S.上述化合物作用于毒蕈碱性乙酰胆碱受体，从而激活中枢神经系统中的乙酰胆碱神经功能。
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公开(公告)号：US5041549A
公开(公告)日：1991-08-20
申请号：US470093
申请日：1990-01-25
IPC分类号： C07D491/107 , A61K31/435 , A61K31/55 , A61P25/02 , A61P25/28 , C07D211/48 , C07D405/06 , C07D453/00 , C07D471/10 , C07D487/10 , C07D491/10 , C07D491/20 , C07D491/22 , C07D495/10 , C07D495/20 , C07D495/22 , C07D497/20 , C07D497/22
CPC分类号： C07D471/10 , C07D211/48 , C07D491/10 , C07D495/10
摘要： Heterocyclic spiro compounds represented by the following general formula and salts thereof: ##STR1## wherein A represents piperidine or N alkyl piperidine or N alkylene attached to a non adjacent piperidine ring carbon, X is S or O, Y is carbonyl, thiocarbonyl, methylene, R.sup.5 methylene, ##STR2## in which R.sup.1 to R.sub.3, R.sub.6, R.sub.7 are H or alkyl, R.sub.4 is H, alkyl, --COOH, or ester, or ##STR3## R.sub.5 is halo, OH, SH, O alkyl, S alkyl, O acyl or S acyl, and Z.sub.1 and Z.sub.2 are O or S.The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.
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公开(公告)号：US4996210A
公开(公告)日：1991-02-26
申请号：US470091
申请日：1990-01-25
IPC分类号： C07D491/107 , A61K31/435 , A61K31/55 , A61P25/02 , A61P25/28 , C07D211/48 , C07D405/06 , C07D453/00 , C07D471/10 , C07D487/10 , C07D491/10 , C07D491/20 , C07D491/22 , C07D495/10 , C07D495/20 , C07D495/22 , C07D497/20 , C07D497/22
CPC分类号： C07D471/10 , C07D211/48 , C07D491/10 , C07D495/10
摘要： Heterocyclic spiro compounds represented by the following general formula and salts thereof ##STR1## The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.
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公开(公告)号：US4940795A
公开(公告)日：1990-07-10
申请号：US254375
申请日：1988-10-05
IPC分类号： C07D491/107 , A61K31/435 , A61K31/55 , A61P25/02 , A61P25/28 , C07D211/48 , C07D405/06 , C07D453/00 , C07D471/10 , C07D487/10 , C07D491/10 , C07D491/20 , C07D491/22 , C07D495/10 , C07D495/20 , C07D495/22 , C07D497/20 , C07D497/22
CPC分类号： C07D471/10 , C07D211/48 , C07D491/10 , C07D495/10
摘要： Heterocyclic spiro compounds represented by the following general formula and salts thereof: ##STR1## The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.
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公开(公告)号：US4719207A
公开(公告)日：1988-01-12
申请号：US747018
申请日：1985-06-20
申请人： Toshinari Tamura , Makoto Yoshida , Shin-ichi Tsukamoto , Hidenori Iwamoto , Minoru Yamamoto , Soichi Kagami
发明人： Toshinari Tamura , Makoto Yoshida , Shin-ichi Tsukamoto , Hidenori Iwamoto , Minoru Yamamoto , Soichi Kagami
IPC分类号： C07D205/08 , C07D205/085 , C07F7/10 , C07K5/097 , A61K31/415 , C07D403/12 , C07D403/14
CPC分类号： C07K5/0821 , C07D205/08 , C07D205/085 , C07F7/10
摘要： Substituted azetidinone compounds are provided which have the formula: ##STR1## wherein one of R.sup.1 and R.sup.2 represents a substituted lower alkyl group, an azido group, an amino group, a lower acylamino group, a mercapto group or a lower alkylthio group and the other represents a hydrogen group, or, both represent hydrogen atoms or lower alkyl groups; R.sup.3 represents a hydrogen atom or a group shown by formula: ##STR2## (wherein X represents ##STR3## (wherein R.sup.5 represents a hydrogen atom or a lower alkyl group) and Y represents a hydroxy group, a lower alkoxy group, an amino group, a mono- or di-lower alkylamino group); R.sup.4 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a group shown by formula: --CH.sub.2 CO--A (wherein A represents an amino group or a group shown by formula: ##STR4## (wherein X and Y are as defined above), provided that when R.sup.1 and R.sup.2 are both hydrogen atoms, at least R.sup.4 represents a group other than a hydrogen atom and provided that either R.sup.3 or R.sup.4 represents a group other than a hydrogen atom. The compounds have strong CNS action.
摘要翻译： 提供具有下式的取代的氮杂环丁酮化合物：其中R 1和R 2之一表示取代的低级烷基，叠氮基，氨基，低级酰氨基，巯基或低级烷硫基 另一个表示氢基团，或者都表示氢原子或低级烷基; R3表示氢原子或由下式表示的基团：其中X表示
（其中R5表示氢原子或低级烷基），Y表示羟基，低级烷氧基，氨基 ，一或二低级烷基氨基）; R 4表示氢原子，取代或未取代的低级烷基或由式-CH 2 CO-A（其中A表示氨基或由下式表示的基团：其中X和Y如上所定义） ），条件是当R 1和R 2均为氢原子时，至少R 4表示氢原子以外的基团，只要R 3或R 4表示除氢原子以外的基团，则该化合物具有强CNS作用。 -
7.发明授权
公开(公告)号：US4379158A
公开(公告)日：1983-04-05
申请号：US193742
申请日：1980-10-03
IPC分类号： C07D213/32 , C07D213/68 , C07D213/86 , C07D233/54 , C07D233/64 , C07D277/26 , C07D277/30 , C07D307/52 , A61K31/615 , C07D401/12
CPC分类号： C07D213/86 , C07D213/32 , C07D213/68 , C07D233/64 , C07D277/26 , C07D307/52
摘要： Novel heterocyclic compounds shown by the formula ##STR1## wherein Het represents a 5-membered or 6-membered heterocyclic group which may have substituent(s); Z represents a sulfur atom or oxygen atom; X represents an oxygen atom or the unsubstituted or substituted imino group shown by N--R.sub.1 (wherein R.sub.1 is a hydrogen atom, a lower alkyl group, a cyano group, an unsubstituted or alkyl substituted carbamoyl group, an unsubstituted or lower alkyl substituted thiocarbamoyl group, or a lower alkanoylamino group); Y represents a hydrogen atom, a lower alkyl group which may have substituent(s), a cycloalkyl group of 3-6 carbon atoms, a lower alkenyl group, a lower alkynyl group, an aryl group which may have substituent(s), an aralkyl group which may have substituent(s), a hydroxyl group, a cyano group, a carbamoyl group, an amidino group, an alkanoyl group which may have been substituted by halogen atom(s), an alkanoylamino group, an arylcarbonylamino group, an alkylamino group, an arylamino group, an arylsulfamoyl group, a lower alkoxycarbamoyl group, or an oxamoylamino group; and m and n represent an integer of 1-3; when X is N--R.sub.1, said X and Y may combine with each other to form a 5-membered or 6-membered heterocyclic ring containing 2-3 nitrogen atoms which may have substituent(s), and the pharmacologically acceptable acid addition salts thereof.The compounds of this invention are useful as gastric acid secretion inhibitors.
摘要翻译： 式中，Het表示可具有取代基的5元或6元杂环基的新型杂环化合物。 Z表示硫原子或氧原子; X表示氧原子或由N-R 1表示的未取代或取代的亚氨基（其中R 1为氢原子，低级烷基，氰基，未取代或烷基取代的氨基甲酰基，未取代或低级烷基取代的硫代氨基甲酰基 ，或低级烷酰氨基）; Y表示氢原子，可具有取代基的低级烷基，3-6个碳原子的环烷基，低级烯基，低级炔基，可具有取代基的芳基， 可以具有取代基的芳烷基，羟基，氰基，氨基甲酰基，脒基，可被卤素原子取代的烷酰基，烷酰基氨基，芳基羰基氨基， 烷基氨基，芳基氨基，芳基氨磺酰基，低级烷氧基氨基甲酰基或氨甲酰基氨基; m和n表示1-3的整数; 当X是N-R1时，所述X和Y可以彼此结合形成含有2-3个可具有取代基的氮原子的5元或6元杂环，其药理学上可接受的酸加成盐 。 本发明的化合物可用作胃酸分泌抑制剂。
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公开(公告)号：US4246280A
公开(公告)日：1981-01-20
申请号：US16070
申请日：1979-02-28
申请人： Noriyoshi Inukai , Masuo Murakami , Hidenori Iwamoto , Isao Yanagisawa , Toshinari Tamura , Yoshio Ishii , Kenichi Tomioka , Tetsuya Shiozaki, deceased
发明人： Noriyoshi Inukai , Masuo Murakami , Hidenori Iwamoto , Isao Yanagisawa , Toshinari Tamura , Yoshio Ishii , Kenichi Tomioka , Tetsuya Shiozaki, deceased
IPC分类号： C07C405/00 , C07D307/935 , C07D309/12 , A61K31/557
CPC分类号： C07D307/935 , C07C405/00 , C07D309/12
摘要： There are disclosed 20-alkoxy-16-alkyl-prostadienoic acid derivatives of the formula: ##STR1## wherein A represents ##STR2## R and R.sup.5, which may be the same or different, each represents a hydrogen atom or a lower alkyl group; and R.sup.1 and R.sup.4, which may be the same or different, each represents a lower alkyl group, and the pharmaceutically acceptable non-toxic salts thereof. These compounds have excellent pharmacological effects as prostaglandin E.sub.2 and prostaglandin F.sub.2.alpha..
摘要翻译： 公开了下式的20-烷氧基-16-烷基 - 前列腺烯酸衍生物：其中A表示R和R 5可以相同或不同，各自表示氢原子或低级烷基; 和可以相同或不同的R 1和R 4各自表示低级烷基及其药学上可接受的无毒盐。 这些化合物具有优异的药理作用，如前列腺素E2和前列腺素F2α。
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公开(公告)号：US07673536B2
公开(公告)日：2010-03-09
申请号：US11889476
申请日：2007-08-14
IPC分类号： B25J17/00
CPC分类号： B25J9/046 , B25J9/104 , Y10T74/20305
摘要： An industrial robot (10) comprising three power transmission units (21, 22, 23) arranged concentrically and three drive means for driving the three power transmission units, respectively, is disclosed. The drive means for at least one of the three power transmission units includes two motors (31, 34). Also, all of the three power transmission units and the three drive means are desirably built into the base (15) of the industrial robot. This configuration makes it possible to have high-duty operation with a comparatively compact structure.
摘要翻译： 公开了一种工业机器人（10），其包括同心设置的三个电力传输单元（21,22,23）和分别驱动三个电力传输单元的三个驱动装置。 用于三个动力传递单元中的至少一个的驱动装置包括两个马达（31,34）。 此外，三个动力传递单元和三个驱动装置中的所有三个驱动装置都希望内置在工业机器人的基座（15）中。 这种结构使得可以以比较紧凑的结构进行高功率操作。
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公开(公告)号：US20080056858A1
公开(公告)日：2008-03-06
申请号：US11889476
申请日：2007-08-14
IPC分类号： B65H29/02
CPC分类号： B25J9/046 , B25J9/104 , Y10T74/20305
摘要： An industrial robot (10) comprising three power transmission units (21, 22, 23) arranged concentrically and three drive means for driving the three power transmission units, respectively, is disclosed. The drive means for at least one of the three power transmission units includes two motors (31, 34). Also, all of the three power transmission units and the three drive means are desirably built into the base (15) of the industrial robot. This configuration makes it possible to have high-duty operation with a comparatively compact structure.
摘要翻译： 公开了一种工业机器人（10），其包括同心设置的三个电力传输单元（21,22,23）和分别驱动三个电力传输单元的三个驱动装置。 用于三个动力传递单元中的至少一个的驱动装置包括两个马达（31,34）。 此外，三个动力传递单元和三个驱动装置中的所有三个驱动装置都希望内置在工业机器人的基座（15）中。 这种结构使得可以以比较紧凑的结构进行高功率操作。
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