利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.031 秒)

    Carbapenem compounds and production thereof
    6.
    发明授权
    Carbapenem compounds and production thereof 失效
    碳青霉烯化合物及其生产

    公开(公告)号：US4962103A

    公开(公告)日：1990-10-09

    申请号：US325025

    申请日：1989-03-17

    申请人： Makoto Sunagawa ,  Haruki Matsumura ,  Takaaki Inoue ,  Masamoto Fukasawa ,  Masuhiro Kato

    发明人： Makoto Sunagawa ,  Haruki Matsumura ,  Takaaki Inoue ,  Masamoto Fukasawa ,  Masuhiro Kato

    IPC分类号： C07D207/12 ,  C07D207/16 ,  C07D403/06 ,  C07D477/20 ,  C07F7/18

    CPC分类号： C07D477/20 ,  C07D207/12 ,  C07D207/16 ,  C07D403/06 ,  C07F7/1856 ,  Y02P20/55

    摘要： A compound of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group, R.sub.2 is a hydrogen atom or a conventional protecting group for a carboxyl group, R.sub.0 is a hydrogen atom or a conventional protecting group for a hydroxyl group, X is a protected or unprotected amino group, a carboxyl group, a lower alkoxycarbonyl group, an ar(lower)alkyloxycarbonyl group, a cyano group, a hydroxyl group, a lower alkyloxy group, a lower alkylthio group, a lower alkylsulfonyl group or a group of either one of the following formulas: ##STR2## wherein R.sub.3 and R.sub.4, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, or they are taken together to represent an alkylene chain to form, in combination with the adjacent nitrogen atom, a 3- to 7-membered cyclic amino group,--ZCOR.sub.5 (2)wherein Z represents --NH-- or --O-- and R.sub.5 represents an amino group, a mono(lower)alkylamino group, a di(lower)alkylamino group, a lower alkyloxy group or a lower alkyl group, ##STR3## wherein R.sub.6 represents a hydrogen atom or a lower alkyl group,--CH=N--R.sub.7 (4)wherein R.sub.7 represents a mono(lower)alkylamino group, a di(lower)alkylamino group or a lower alkyloxy group, or ##STR4## wherein R.sub.8, R.sub.9 and R.sub.10, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, Y represents a hydrogen atom, a conventinal protecting group for an amino group or a group of either one of the following formulas: ##STR5## wherein R.sub.11 and R.sub.12, which may be the same or different, each represents a hydrogen atom or a lower alkyl group or ##STR6## wherein R.sub.6 is as defined above and n is an ingeter of 1 to 6, and a pharmacologically acceptable salt thereof, which is useful as an antimicrobial agent.

    摘要翻译： 下式的化合物：其中R 1是氢原子或低级烷基，R 2是氢原子或常规的羧基保护基，R 0是氢原子或常规的羟基保护基 ，X是被保护或未被保护的氨基，羧基，低级烷氧基羰基，芳（低级）烷氧基羰基，氰基，羟基，低级烷氧基，低级烷硫基，低级烷基磺酰基或 下列通式之一的一组：其中R 3和R 4可以相同或不同，各自表示氢原子或低级烷基，或者它们一起表示亚烷基链 与相邻的氮原子一起形成3-至7-元环氨基，-ZCOR5（2）其中Z表示-NH-或-O-，R5表示氨基，单（低级）烷基氨基 基团，二（低级）烷基氨基，低级烷氧基或低级烷基， （3）其中R6表示氢原子或低级烷基，-CH = N-R7（4）其中R7表示单（低级）烷基氨基，二（低级）烷基氨基或低级烷氧基 或者其中R 8，R 9和R 10可以相同或不同，各自表示氢原子或低级烷基，Y表示氢原子，氨基的常规保护基或 （6）其中R 11和R 12可以相同或不同，各自表示氢原子或低级烷基或（7），其中R 6如上所定义。 n为1〜6的锭剂及其药理学上可接受的盐，可用作抗菌剂。

    Cephem compounds
    8.
    发明授权
    Cephem compounds 失效
    头孢烯化合物

    公开(公告)号：US4705784A

    公开(公告)日：1987-11-10

    申请号：US682283

    申请日：1984-12-17

    申请人： Hirotada Yamada ,  Naruhito Masai ,  Sinji Ueda ,  Takao Okuda ,  Masatomo Fukasawa ,  Masuhiro Kato ,  Masataka Fukumura

    发明人： Hirotada Yamada ,  Naruhito Masai ,  Sinji Ueda ,  Takao Okuda ,  Masatomo Fukasawa ,  Masuhiro Kato ,  Masataka Fukumura

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/34

    CPC分类号： A61K31/545

    摘要： A cephem compound represent by the general formula ##STR1## wherein, R.sup.1 represents hydrogen or lower alkyl, R.sup.2 and R.sup.3 are the same or different and each represents hydrogen or lower alkyl, R.sup.4 represents carboxyl or esterified carboxyl, and n represents 0 or 1, a salt of the cephem compound, and a process for producing the cephem compound or a salt thereof. Compounds of the above formula and salts thereof are valuable as antibacterial agents and are especially useful as oral drugs in the prevention or treatment of bacterial infectious diseases.

    摘要翻译： 头孢烯化合物由通式表示，其中R1表示氢或低级烷基，R2和R3相同或不同，各自表示氢或低级烷基，R4表示羧基或酯化羧基，n表示0或1， 头孢烯化合物的盐，以及头孢烯化合物或其盐的制备方法。 上述式的化合物及其盐作为抗菌剂是有价值的，并且特别可用作预防或治疗细菌感染性疾病的口服药物。